Food Science & Nutrition最新文献

{"title":"Probiotic Dairy Dessert With Stevia and Sage Mucilage","authors":"Mohammad Mahdi Asadi Garmaroudi,&nbsp;Marjaneh Sedaghati,&nbsp;Mohamad Javad Shakouri","doi":"10.1002/fsn3.70986","DOIUrl":"https://doi.org/10.1002/fsn3.70986","url":null,"abstract":"<p>This study investigated the effects of different stevia-to-sugar ratios (SSR: 0, 0.001, and 0.006 <i>w/w</i>) and sage seed mucilage (SSM: 0%, 0.15%, and 0.3% <i>w/w</i>) on the physicochemical, microbial, and sensory properties of a probiotic dairy dessert during storage periods of 1, 10, and 20 days. Parameters assessed included pH, dry matter, fat, protein, total sugar, caloric content, phase separation, viscosity, color, total phenolic content (TPC), antioxidant activity (AO), probiotic viability, and sensory characteristics. Replacing sugar with stevia significantly reduced sugar content and calories, enhancing the health profile of the dessert. However, higher stevia levels (SSR 0.006) adversely affected texture by decreasing viscosity and increasing syneresis. In contrast, increasing the concentration of SSM improved viscosity and reduced syneresis, contributing to better texture stability. Both stevia and sage seed mucilage increased total phenolic content and antioxidant activity, thus adding nutritional value. The viability of <i>Lactobacillus casei</i> (<i>L. casei</i>) was maintained at the lower SSR (0.001), while the higher stevia substitution (0.006) reduced probiotic survival. Higher SSM concentrations positively influenced probiotic viability over storage, although a gradual decline was observed in all samples. Sensory evaluation indicated that the sample containing 0.001 SSR and 0.3% SSM on day 10 achieved the most favorable balance of taste, texture, and overall acceptability, closely resembling the control. These findings demonstrate that moderate sugar substitution with stevia and the addition of sage seed mucilage can enhance both the functional and sensory qualities of probiotic dairy desserts, promoting consumer acceptance and healthier product development.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70986","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Blood Metal Exposure and Hypertriglyceridemia Among Adults in NHANES, 2011–2018","authors":"Xue Zhao,&nbsp;Bin Liu,&nbsp;Hongqi He,&nbsp;Linwei Zhou,&nbsp;Xinjie Gong,&nbsp;Yuhan Fan,&nbsp;Xin Xu,&nbsp;Xu Chai,&nbsp;Shuli An,&nbsp;Xia Chu","doi":"10.1002/fsn3.71001","DOIUrl":"https://doi.org/10.1002/fsn3.71001","url":null,"abstract":"<p>Growing evidence indicates associations between blood metal exposure and dyslipidemia. However, the relationships between hypertriglyceridemia (HTG), the most prevalent form of dyslipidemia, and blood metal exposure remain unclear. Our study aimed to evaluate both single and combined effects of blood metals on HTG risk. This study included 4182 adults from the 2011–2018 National Health and Nutrition Examination Survey. We assessed single and combined associations between blood metals (cadmium, mercury, lead, selenium, and manganese) and HTG. In single metal analysis, elevated blood selenium concentrations were significantly associated with increased HTG risk and triglyceride (TG) levels, with OR (95% CI) and β (95% CI) of 1.78 (1.36, 2.32) and 0.21 (0.13, 0.29), respectively, in the highest tertile group. Restricted cubic splines revealed a positive linear correlation between selenium and HTG. No significant associations were observed between HTG and blood cadmium, mercury, lead, or manganese in the overall population. In metal mixture analysis, blood metal co-exposure was positively related to HTG risk across WQS, qgcomp, and BKMR models, particularly in females and individuals under 60 years old. Furthermore, selenium was identified as the primary contributor to the overall mixture effect. The positive directional influence of selenium was further confirmed on the overall effect. Collectively, these findings indicate that elevated blood selenium concentrations are associated with increased HTG risk and higher TG levels. The results provide novel epidemiological evidence for the associations between multi-metal co-exposure and HTG risk, particularly in females and individuals under 60 years old.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.71001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145110839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling the Growth of Listeria monocytogenes Isolates in Low-Temperature Environments","authors":"Yue Cheng,&nbsp;Peter Myintzaw,&nbsp;Francis Butler","doi":"10.1002/fsn3.70987","DOIUrl":"https://doi.org/10.1002/fsn3.70987","url":null,"abstract":"<p>The research explored the growth dynamics of <i>Listeria monocytogenes</i> at 4°C and 7°C using five microbial growth models, identifying significant variability in growth rates among isolates. The Spline model exhibited greater variability and less reliability, leading to the selection of average growth rates from the other four models for further analysis. The study found that isolates from seafood environments exhibited higher growth rates at both temperatures compared to those from meat and mixed food environments. Moreover, the growth rate of isolates from vegetables increased more rapidly when the temperature was raised from 4°C to 7°C, compared to isolates from clinical settings, highlighting the influence of environmental factors on the growth behavior of <i>L. monocytogenes</i> in cold environments.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70987","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Optimization of Culture Media for Enhanced β-Glucan Production by Limosilactobacillus fermentumSH2 (MW897962) and Its Bioactivity Assessment","authors":"Tarek Gamal Abedelmaksoud,&nbsp;Shatha A. Allaith,&nbsp;Ammar B. Altemimi,&nbsp;Mohamed E. Abdel-aziz,&nbsp;Zaid Akram Thabit,&nbsp;Mohammad Ali Hesarinejad,&nbsp;Reda Mahgoub Mohamed","doi":"10.1002/fsn3.70960","DOIUrl":"https://doi.org/10.1002/fsn3.70960","url":null,"abstract":"<p>This study optimized β-glucan production from the local isolate <i>Limosilactobacillus fermentum</i> SH2 (MW897962) and evaluated its bioactivity. Using Response Surface Methodology (RSM) with a Central Composite Design (CCD), exopolysaccharide (EPS) production was optimized in Semi-Defined Media (SDM) and Chemically Defined Media (CDM). Predicted optimal β-glucan yields were 2.42 g/100 mL for PYE and 29.65 g/100 mL for molasses, with molasses doubling EPS production under optimal conditions. The actual EPS yield (950.65 mg/100 mL) exceeded the predicted yield (931.54 mg/100 mL), while cell mass (129.95 mg/100 mL) was slightly lower than predicted (131 mg/100 mL). High R² values for β-glucan production (91.3%) and cell mass (90.2%) validated the optimization model. The β-glucan demonstrated potent bioactivity, including 91% DPPH radical scavenging at 200 μg/mL. Cytotoxicity against Caco-2 colorectal cancer cells showed 85.64% viability at 100 μg/mL, comparable to the β-glucan standard (84.89%). At 1.0 and 10 μg/mL, β-glucan from LAB showed greater inhibition of Caco-2 cell proliferation than the standard. Antibacterial activity against four pathogens revealed the highest inhibition zone (14.00 mm) at 100 mg/mL against <i>Staphylococcus aureus</i> ATCC. This study highlighted the potential of <i>L. fermentum</i> SH2 as a cost-effective source of β-glucan with significant antioxidant, antitumor, and antibacterial properties.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70960","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction Optimization and Characterization of Antioxidant Polysaccharides From Suillus bovinus","authors":"Zhuang Li,&nbsp;Shuting Fan,&nbsp;Xueqi Wang,&nbsp;Li-an Wang,&nbsp;Jianhua Lv,&nbsp;Jinxiu Zhang","doi":"10.1002/fsn3.70995","DOIUrl":"https://doi.org/10.1002/fsn3.70995","url":null,"abstract":"<p>A three-variable, three-level Box–Behnken design combined with response surface methodology (BBD-RSM), based on single-factor experiments, was employed to optimize the extraction parameters of crude polysaccharides (SubPs) from <i>Suillus bovinus</i>. SubPs were purified using a DEAE-52 cellulose column and a Sephadex G-100 chromatography column, yielding four homogeneous fractions (S-1, S-2, Y-1, Y-2) with molecular weights from 47.34 to 97.07 kDa. Among these fractions, Y-1 exhibited superior antioxidant activity, demonstrating a 34.73% ± 1.31% reduction in reactive oxygen species (ROS) levels at 50 μg/mL compared to the tert-butyl hydroperoxide (<i>t</i>-BHP)-treated model group in HepG2 cells, along with enhanced activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), as well as reduced malondialdehyde (MDA) content. The chemical structure of Y-1 was further characterized through monosaccharide composition analysis, methylation analysis, and nuclear magnetic resonance (NMR) spectroscopy. These findings provide structural insights into Y-1 and highlight its potential as a natural antioxidant.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70995","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Widely Targeted Metabolomics of Morchella Sextelata After Hot-Air Drying","authors":"Jingfang Yi,&nbsp;Hongbo Guo,&nbsp;Zihan Cao,&nbsp;Ruiheng Yang,&nbsp;Ying Song,&nbsp;Ying Lin,&nbsp;Aiguo Xu,&nbsp;Xiaodan Yu","doi":"10.1002/fsn3.70826","DOIUrl":"https://doi.org/10.1002/fsn3.70826","url":null,"abstract":"<p><i>Morchella sextelata</i> is a valuable and popular commercial edible fungus in China. Hot-air drying can enhance the flavor and quality of edible mushrooms; however, the resulting changes in volatile and non-volatile metabolites have not been investigated for <i>M. sextelata</i>. In the present study, we used a widely targeted metabolomics approach combining ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) and gas chromatography–mass spectrometry (GC–MS) to explore the dynamic variations in metabolites after hot-air drying and the influence of drying treatment on the flavoromics of different sections of the fruiting bodies of <i>M. sextelata</i>. In total, we identified 1419 non-volatile and 270 volatile metabolites. Based on multivariate statistical analysis, we identified 511 metabolites with significant differences between fresh and dry products, revealing that hot-air drying resulted in more nutty, toasty, and fatty flavors, particularly in the pileus. Moreover, hot-air drying enriched the beneficial dietary components of the pileus. Through the elucidation of the metabolite changes that occur in <i>M. sextelata</i> after hot-air drying, this study provides theoretical support for the higher commercial value of the pileus after drying and can be applied to improve the quality of dried morels.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70826","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Geographical Origin and Processing Methods on Biopreservatives, Heavy Metals, Lipid Quality Indices, and Aflatoxin M1 in Imported Cheeses: A Public Health Concern","authors":"Mohammed A. Falih,&nbsp;Qausar Hamed Alkaisy,&nbsp;Ammar B. Altemimi,&nbsp;Mohammad Ali Hesarinejad,&nbsp;Tarek Gamal Abedelmaksoud","doi":"10.1002/fsn3.70981","DOIUrl":"https://doi.org/10.1002/fsn3.70981","url":null,"abstract":"<p>In this study, some safety and quality parameters such as biopreservatives, heavy metals, lipid quality indices, and levels of aflatoxin M1 of imported cheeses in the Babylon Governorate of Iraq were examined by focusing on how processing methods and geographical origins. A total of 3 different cheese types and 27 samples from Iran, Saudi Arabia, and Turkey were analyzed by novel techniques such as High-Performance Liquid Chromatography and Liquid Chromatography-Mass Spectrometry. The findings showed the presence of nisin A and nisin Z presence in a few samples, while natamycin was detected in only one soft cheese in an amount below the regulatory limit. Analysis of fatty acid composition revealed high variability as well as high levels of SFA among samples from different countries. Detectable levels of cadmium, lead, copper, and arsenic were also found in some cheeses, in some cases exceeding the maximum permitted levels. Aflatoxin M1 contamination was also found in a handful of cheese samples, with several exceeding the maximum permitted levels. These findings revealed significant differences in the quality and safety of cheeses based on origin and processing methods, raising potential public health concerns related to the consumption of imported cheeses. The current study also strongly emphasized the need for improved quality control measures and regular monitoring of dairy products to ensure consumer safety and compliance with international health standards. In addition, it strongly recommends further research to better understand the long-term effects of these pollutants on public health.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70981","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel High-Throughput Anaerobic Culture Method to Evaluate Food Health Effects via Gut Microbiota Modulation","authors":"Xin-Yue Liu,&nbsp;Ling-Qin Zhu,&nbsp;Qun-Ying Jin,&nbsp;Hua-Zheng Peng,&nbsp;Tang-Jun Zhu","doi":"10.1002/fsn3.70978","DOIUrl":"https://doi.org/10.1002/fsn3.70978","url":null,"abstract":"<p>As health demands grow, nutritional evaluation now extends beyond nutrient supply, and health-effect–based methods are gradually gaining traction. However, assessing food impacts on gut microbiota remains complex and costly. This study developed a cost-effective in vitro method for evaluating food effects on individual gut microbiota, integrating 96-well microplates, multilayer liquid sealing, and high-throughput multiomics (16S rRNA sequencing + untargeted metabolomics) to enable large-scale anaerobic culture and dynamic growth monitoring under aerobic conditions. Using this method, the fermented products of <i>Pichia fermentans</i> were shown to significantly boost <i>Bifidobacterium</i> abundance (4.6-fold to 5.6-fold vs. control) by Day 4, though microbial diversity decreased. Testing raw (RA) versus cooked (CO) pecan kernels, RA significantly promoted health-associated genera: <i>Blautia</i>, which showed progressive enrichment (rising 17-fold from Day 2 to Day 4 in RA) and reached 193.8 times the control level (5.1%, <i>p</i> = 0.0127), with potential anti-inflammatory implications; <i>Fusicatenibacter</i>, surging to 1274.3 times the control (3.3%, <i>p</i> = 0.001) and 5.6 times higher than CO (<i>p</i> = 0.0332), suggesting potential cognitive benefits; and <i>Bacteroides</i>, whose reduction was significantly attenuated in RA compared to control (<i>p</i> = 0.0002), potentially supporting bile acid metabolism relevant to ulcerative colitis management. In contrast, CO favored opportunistic pathogens: <i>Raoultella</i> was exclusively elevated in CO relative to both control and RA (<i>p</i> &lt; 0.05); <i>Klebsiella</i> abundance was notably higher in CO than in RA (<i>p</i> &lt; 0.05), though increased in both groups versus control. Untargeted metabolomics indicated RA upregulated C5-branched dibasic acid metabolism and secondary bile acid biosynthesis, accumulating metabolites (e.g., CLA, 7-KDA) associated with these pathways. This method aids in optimizing food processing and guiding precision nutrition strategies.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70978","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Euglena gracilis Suppresses Cold Symptoms in Healthy Individuals: A Double-Blind, Randomized, Placebo-Controlled Trial","authors":"Ayaka Nakashima,&nbsp;Kengo Suzuki,&nbsp;Masafumi Nagata,&nbsp;Tsuyoshi Takara","doi":"10.1002/fsn3.70935","DOIUrl":"https://doi.org/10.1002/fsn3.70935","url":null,"abstract":"<p>The immune system functions to eliminate pathogens, such as viruses, and regulate physiological responses and pathways. General immunity is affected by various factors, including fatigue, stress, and aging. A weakened immune system reduces the ability of the body to eliminate pathogens, thereby increasing the risk of infections, including the common cold. <i>Euglena gracilis</i> is a microalga rich in various nutrients, including β-1,3-glucan paramylon, which aids in maintaining and regulating immune function. In the present study, we aimed to investigate the effects of <i>E. gracilis</i> administration on cold symptoms in healthy individuals. <i>Euglena gracilis</i> was administered orally in capsule form (once daily, in the morning) continuously for 8 weeks to healthy adult Japanese men and women. Evaluation of the effects of <i>E. gracilis</i> administration on alleviating cold symptoms revealed significantly fewer cumulative days with cold-like symptoms over 8 weeks in the <i>E. gracilis</i> group than those in the placebo group. Participants in the <i>E. gracilis</i> group also demonstrated significantly fewer severe cold-like symptoms, such as nasal congestion, sore throat, fatigue, and myalgia, than the placebo group in the second half of the trial (weeks 5–8). In conclusion, this study demonstrated that the continuous intake of <i>E. gracilis</i> could suppress cold-like symptoms. Moreover, the consumption of the test food under the conditions used in this study was deemed safe.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70935","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olive Oil Polyphenols: A Promising Approach for Cancer Prevention and Therapy","authors":"Muhammad Junaid Anwar,&nbsp;Muhammad Hammad Anwar,&nbsp;Muhammad Imran,&nbsp;Ahmad Mujtaba Noman,&nbsp;Muzzamal Hussain,&nbsp;Hassan Raza,&nbsp;Hagar M. Mohamed,&nbsp;Gamal A. Mohamed,&nbsp;Sabrin R. M. Ibrahim,&nbsp;Tadesse Fenta Yehuala,&nbsp;Suliman A. Alsagaby,&nbsp;Waleed Al Abdulmonem,&nbsp;Mohamed A. Abdelgawad,&nbsp;Ehab M. Mostafa,&nbsp;Mohammed M. Ghoneim,&nbsp;Samy Selim","doi":"10.1002/fsn3.70976","DOIUrl":"https://doi.org/10.1002/fsn3.70976","url":null,"abstract":"<p>Cancer is emerging as a leading cause of death globally. Considering the disease burden, scientists are working to develop various strategies by exploring natural sources for cancer treatment. The use of olive oil (OO) and its phytochemicals, specifically oleuropein and hydroxytyrosol (HT), as a remedy against various types of cancer is gaining attention among scientists and researchers. The current review aimed to highlight the antioxidant potential and summarize the various pathways and markers involved in the prevention and treatment of different human cancers. The databases, including Google Scholar, PubMed, and Web of Science, were searched to collect relevant data. The studies showed that some markers are specifically linked to particular types of cancers (such as 27-OHC, ATF-2, TNFRSF10B, HER2, and MET, which are linked to breast cancer; iNOS and NO, which are linked to thyroid cancer; GLUT1 and GLUT4, HIF-1α, MCT4, PKM2, PD-1, PD-L1, and CTLA-4, which are linked to colorectal cancer). Olive oil is involved in the management of these markers to prevent and/or treat all types of cancers by upregulating tumor suppressor genes, downregulating oncogenes, and modulating different pathways (PI3K/AKT/mTOR, Wnt/β-catenin, and MAPK). Taken together, it can be concluded that olive oil and its components have prominent potential to cure cancers in the human body. However, further investigations can be carried out to suggest the lethal doses of olive oils as a whole and its phytochemicals individually for the treatment of cancer.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70976","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}