Food Science & Nutrition最新文献

{"title":"Preliminary Characterization of Monofloral Helianthus annuus L. Bee Pollen Using Advanced Analytical Techniques: A Comparative Study With Polyfloral Pollen","authors":"Nazlıcan Yıldırım,&nbsp;Yusuf Can Gerçek","doi":"10.1002/fsn3.71016","DOIUrl":"https://doi.org/10.1002/fsn3.71016","url":null,"abstract":"<p>In recent years, there has been an increased interest in the characterization of monofloral bee pollen of different botanical origins as it offers a more homogeneous and traceable component profile compared to polyfloral bee pollen. In this study, we aimed to verify the botanical origin of monofloral <i>Helianthus annuus</i> (sunflower) pollen and polyfloral bee pollen samples collected from the same geographical region and to evaluate their metabolomic profiles comparatively. The botanical origins of the pollen samples were confirmed by palynological analysis and DNA barcoding. Then, physicochemical, phytochemical, and advanced chromatographic analyses (LC–MS/MS) were performed to reveal the bioactive compound contents and nutrient profiles of the samples in detail. When the polyphenol profile was analyzed, the highest level of hyperoside (11,071.28 mg/kg) was detected in monofloral sunflower pollen and rutin (1287.16 mg/kg) in the polyfloral sample. The most dominant amino acid in both pollen types was proline, which was measured as 4652.08 mg/kg (monofloral) and 12,476.82 mg/kg (polyfloral), respectively. Moreover, both samples contained remarkable levels of folic acid (vitamin B9; 20.80 and 20.77 mg/kg). The results obtained from this study reveal that bee pollen derived from the widely cultivated sunflower plant also possesses remarkable potential for the development of functional foods and nutraceutical products. However, as the study was conducted solely with monofloral and polyfloral bee pollen samples collected from a single geographical region, it can be stated that the findings should be considered as part of a preliminary evaluation. Despite this limitation, the data obtained through comprehensive analytical methods provide a scientific basis for the functional applications of monofloral sunflower pollen with its biologically valuable components.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.71016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dietary Phytochemical Index Is Inversely Associated With the Odds of Premature Coronary Artery Disease (PCAD) in Iranian Adults: Iran Premature Coronary Artery Disease (IPAD) Study","authors":"Motahare Bateni,&nbsp;Ehsan Zarepur,&nbsp;Fahimeh Haghighatdoost,&nbsp;Noushin Mohammadifard,&nbsp;Minoo Dianatkhah,&nbsp;Alireza Khosravi Farsani,&nbsp;Nahid Azdaki,&nbsp;Nahid Salehi,&nbsp;Masoud Lotfizadeh,&nbsp;Samad Ghaffari,&nbsp;Arsalan Salari,&nbsp;Mostafa Cheraghi,&nbsp;Ahmadreza Assareh,&nbsp;Mehrnoosh Arefianjazi,&nbsp;Nizal Sarrafzadegan","doi":"10.1002/fsn3.70943","DOIUrl":"https://doi.org/10.1002/fsn3.70943","url":null,"abstract":"<p>There is no evidence to prove the relationship between Dietary Phytochemical Index (DPI) and the incidence of premature coronary artery disease (PCAD) among the Iranian population. Therefore, this research investigates the association between the DPI score and the odds of PCAD within a nationally representative Iranian population. This case-control study was performed on 3161 (<i>n</i> = 2006 case and <i>n</i> = 1155 control) Iranian population &lt; 70 y in women and &lt; 60 y in men. Subjects showing normal results on coronary angiography comprised the control group, and those with stenotic lesions exceeding 75% in at least one coronary artery or over 50% in the left main coronary artery were identified as the case group. Information on dietary intake was collected using a validated 110-item food frequency questionnaire. Using the McCarthy equation, the DPI was calculated. A binary logistic regression model was used to evaluate the association between DPI and PCAD. The mean age of the study population was 53.7 (SD = 7.6) years, and 45.1% of them were female. In the unadjusted model, individuals in the highest quartile of DPI exhibited a significantly reduced likelihood of developing PCAD compared to those in the lowest quartile (OR = 0.25, 95% CI: 0.20–0.31, <i>P</i> trend &lt; 0.001). Adjustment for potential confounders further reinforced the relationship, indicating that participants in the top DPI quartile had 89% reduced odds of PCAD relative to those in the first quartile (95% CI: 0.08–0.17, <i>P</i> trend &lt; 0.001). Our findings revealed a significant negative association between the DPI and the odds of PCAD. However, more research is necessary to determine this association.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70943","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Target Modulation of Polyphenols in Diabetic Kidney Disease Therapeutics: A Comprehensive Review","authors":"Esienanwan E. Efiong,&nbsp;Emmanuel Effa,&nbsp;Esther Peters,&nbsp;Ochuko L. Erukainure,&nbsp;Peter U. Amadi,&nbsp;Joshua Onyeka Ikebuiro,&nbsp;Sapna Sharma,&nbsp;Christoph Schmaderer,&nbsp;Kathrin Maedler,&nbsp;Emmy Tuenter,&nbsp;Harald Grallert","doi":"10.1002/fsn3.70882","DOIUrl":"https://doi.org/10.1002/fsn3.70882","url":null,"abstract":"<p>Diabetic kidney disease (DKD) is a severe complication of diabetes that presents as progressive kidney dysfunction and is the primary cause of end-stage kidney failure. Despite therapeutic advances, including the use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, sodium-glucose co-transporter-2 inhibitors, glucagon-like peptide-1 agonists, and non-steroidal mineralocorticoid receptor antagonists, managing DKD remains challenging. Current therapies mainly focus on glycemic control, hypertension management, and albumin reduction to mitigate kidney damage. Nevertheless, these approaches often fail to halt disease progression or restore renal function. There is therefore an urgent need for therapies with safer profiles that can be used singly to target the disease's underlying pathophysiology or integrated into traditional care. Polyphenols possess biological properties capable of addressing these unmet needs by targeting multiple underlying mechanisms involved in DKD pathogenesis. The literature search occurred between September 2024 and April 2025, with most articles sourced from the last 5 years. This review explores polyphenol classes that have demonstrated nephroprotective effects in vitro, in vivo, and in clinical trials. It also highlights the interconnected multi-pathways and molecular mediators potentially regulated by specific polyphenols for kidney function improvement. This multi-target therapeutic approach is especially beneficial for DKD, where several metabolic dysfunctions underlie its pathogenesis. Identifying polyphenols as a therapeutic option could lead to integrative patient care that embraces the strengths of conventional medicine and phytomedicine for better disease management and outcomes. There is therefore a need for more clinical trials to assess polyphenols' safety and efficacy in managing DKD.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70882","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized Nutrition in the Era of Digital Health: A New Frontier for Managing Diabetes and Obesity","authors":"Muhammad Tayyab Arshad,&nbsp;M. K. M. Ali,&nbsp;Sammra Maqsood,&nbsp;Ali Ikram,&nbsp;Faiyaz Ahmed,&nbsp;A. I. Aljameel,&nbsp;Ammar AL-Farga,&nbsp;Md. Sakhawot Hossain","doi":"10.1002/fsn3.71006","DOIUrl":"https://doi.org/10.1002/fsn3.71006","url":null,"abstract":"<p>The integration of digital health technologies with personalized nutrition offers a transformative approach for managing diabetes and obesity. This emerging paradigm extends beyond generic dietary recommendations by tailoring interventions based on genetic, epigenetic, microbiome, and real-time metabolic data. Tools such as continuous glucose monitors (CGMs), artificial intelligence (AI)-driven meal planning, and mobile health applications enable dynamic dietary adjustments and improved disease monitoring. Data privacy, cost disparities, and the need for robust clinical validation are challenges that remain to be overcome, even if there is a potential benefit. This review examines the synergy between digital health technologies and precision medicine by elucidating the potential of personalized nutrition in chronic disease management. Our literature review demonstrates that tailored diet programs can enhance metabolic well-being and overcome theoretical and practical challenges to their widespread implementation.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.71006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alpha Linolenic and Stearic Acids Modulate Genes Related to Viral Entry and Inflammatory Response in THP-1 Derived Macrophages Exposed to SARS-CoV-2","authors":"Aline Rosa Maia,&nbsp;Bruna Rafaela dos Santos Silva,&nbsp;Pierina Lorencini Parise,&nbsp;Camila Lopes Simeoni,&nbsp;Luana Satelis Meira,&nbsp;José Luiz Proença Módena,&nbsp;Eliana Pereira Araújo,&nbsp;Licio Augusto Velloso,&nbsp;Gabriel Forato Anhê,&nbsp;Joseane Morari","doi":"10.1002/fsn3.70529","DOIUrl":"https://doi.org/10.1002/fsn3.70529","url":null,"abstract":"<p>Obesity plays a role in the poor prognosis of COVID-19. The study was designed to elucidate if alpha linolenic (Ala) and stearic (Est) acids could modulate the inflammatory response to SARS-CoV-2. Firstly, scRNA-seq data analysis from COVID-19 patients revealed that major changes in the expression of genes related to virus entry to the cell and inflammatory response were found in macrophages rather than in alveolar epithelial cells. In vitro experiments were performed with Beas2B (human bronchial epithelial cells) and THP-1 (human monocytes/macrophages) cells to verify the putative effects of Ala and Est in the response to either Spike protein (S3) or the full SARS-CoV-2. Both Ala and Est exacerbated the increase in the expression of genes related to virus entry into the cell and pro-inflammatory cytokines in THP-1 derived macrophages. These data suggest that NEFAs may play a role in the poor prognosis seen in individuals with obesity affected by COVID-19.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70529","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Tea Consumption Timing and Kidney Function: Insights From a National Survey","authors":"Xuetong Tang,&nbsp;Jiankui Guo,&nbsp;Wen Hu,&nbsp;Yuan Liu,&nbsp;Yunying Shi","doi":"10.1002/fsn3.70787","DOIUrl":"https://doi.org/10.1002/fsn3.70787","url":null,"abstract":"<p>Tea consumption has garnered significant attention due to its rich polyphenolic compounds and associated health benefits. However, existing research primarily focuses on the quantity of tea intake, while studies examining tea consumption timing remain limited. Given the circadian rhythm of kidney function and its metabolic implications, this study investigated the association between tea consumption timing, estimated glomerular filtration rate (eGFR), and chronic kidney disease (CKD) risk. Based on NHANES data from 2005 to 2018, 40,496 participants were included. Participants were grouped into high, medium, low, and non-tea intake groups. Additionally, tea consumption timing was categorized into four periods: dawn to noon, noon to afternoon, afternoon to night, and night to dawn. Multivariate regression models and restricted cubic spline models were employed to evaluate the associations between tea consumption timing, intake levels, and eGFR. Tea consumption timing showed a significant time-dependent association with eGFR levels. After adjusting for confounders, dawn-to-noon tea consumption demonstrated the strongest positive association with higher eGFR (3.18 mL/min/1.73 m², <i>p</i> &lt; 0.001), followed by noon to afternoon (1.12, <i>p</i> &lt; 0.001) and afternoon to night (0.71, <i>p</i> &lt; 0.01). Stratified analyses revealed that daytime tea consumption was significantly associated with higher eGFR levels in middle-aged and older groups, whereas nighttime tea consumption in the younger group showed a slight adverse association. Analyses by tea type showed consistently positive associations for black tea, while green and other teas showed more variable results. This study underscores the significant association of tea consumption timing on kidney function, with the strongest associations observed during the dawn-to-noon period. Given the cross-sectional design of this study, only associations were identified; thus, future longitudinal studies are necessary to confirm these findings. Adjusting tea timing may be a potential dietary consideration for CKD prevention, but further studies are warranted.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70787","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Metabolomics Revealed the Differential Metabolites of Different Broomcorn Millet Varieties in Shanxi”","authors":"","doi":"10.1002/fsn3.71036","DOIUrl":"https://doi.org/10.1002/fsn3.71036","url":null,"abstract":"<p>Jiang, C., J. Mao, X. Song, H. Li, and X. Cao. 2025. “Metabolomics Revealed the Differential Metabolites of Different Broomcorn Millet Varieties in Shanxi.” <i>Food Science &amp; Nutrition</i> 13, no. 9: e70902. https://doi.org/10.1002/fsn3.70902.</p><p>In “4.1 Identification of DAMs in Different Broomcorn Millet Varieties” of the “Discussion” section, Figure 9 is incorrect. We erroneously used the original version during the revision and proofreading of the article, resulting in the error. The correct figure appears below.</p><p>We apologize for this error.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.71036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Processed Food Consumption Based on the NOVA Classification Is Associated With Elevated Cardiometabolic Risk in Turkish Adults","authors":"Irem Ozkan,&nbsp;Tugce Ozlu Karahan,&nbsp;Hande Seven Avuk","doi":"10.1002/fsn3.71014","DOIUrl":"https://doi.org/10.1002/fsn3.71014","url":null,"abstract":"<p>The global rise in ultra-processed food consumption is associated with increased prevalence of cardiometabolic disorders such as obesity, diabetes, and cardiovascular diseases. This study aimed to evaluate the relationship between processed food intake and cardiometabolic risk factors among adults in Türkiye. A cross-sectional study was conducted among 171 adults aged 18–65 years attending an internal medicine outpatient clinic between March and April 2024. Data collected included dietary habits, physical activity levels, anthropometric measurements, and biochemical parameters. Processed food intake was classified according to the NOVA system and divided into tertiles. Cardiometabolic risk was assessed using the Framingham risk score. The median age was 44.0 (29.0–52.0) years; 67.9% were female. Participants in the T2 tertile with the highest processed food intake had a higher median waist/hip ratio [0.88; (0.82–0.90)] compared to those in the lowest tertile (T1) [0.82 (0.76–0.88); <i>p</i> = 0.003]. Similarly, the median Framingham risk score was higher in the highest tertile of T2 [11.0; (5.0–15.0)] compared to those in the lowest tertile [5.0; (−1.0–9.5); <i>p</i> &lt; 0.001]. These differences suggest a positive correlation between processed food intake and cardiometabolic risk. Increased processed food consumption is associated with higher obesity and cardiometabolic risk among Turkish adults. Promoting healthy dietary habits and reducing processed food intake could have significant public health benefits. Future longitudinal studies with larger samples are needed to confirm these findings and clarify causality.</p><p><b>Trial Registration:</b> ClinicalTrials.gov: NCT06996262</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.71014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol Improves Cognitive Function in Sleep-Deprived Mice by Inhibiting p38 MAPK Signaling Pathway","authors":"Yijie Tang,&nbsp;Xiyuan Xie,&nbsp;Haixing Wu,&nbsp;Xinlei Huang,&nbsp;Jiapeng Qiu,&nbsp;Yupeng Han,&nbsp;Peng Ke,&nbsp;Kai Zeng,&nbsp;Xiaodan Wu","doi":"10.1002/fsn3.70816","DOIUrl":"https://doi.org/10.1002/fsn3.70816","url":null,"abstract":"<p>Resveratrol (RES) is a naturally occurring polyphenolic compound possessing neuroprotective properties. This study aims to examine the potential of RES to ameliorate sleep disorder-associated cognitive deficits induced by sleep deprivation (SD) in mice. Adult male C57/BL6 mice were subjected to SD for 72 h, and RES were administrated. Behavioral tests were performed to quantify the cognitive behaviors. RNA-sequencing coupled with bioinformatic analysis was executed to examine gene expression patterns in the hippocampus. Furthermore, the levels of apoptosis and synaptic plasticity were measured by western blotting and histological staining techniques, including the TUNEL and Nissl methods. Morris water maze, novel object recognition and open field tests demonstrated that RES swiftly attenuated the cognitive impairment induced by SD. RNA-sequencing indicated that the mitogen-activated protein kinase (MAPK) pathways were significantly downregulated by RES administration following SD. Additionally, the impaired synaptic plasticity and apoptosis elicited by SD in the hippocampus were improved by RES. SD causes cognitive dysfunction and hippocampal neuronal damage in mice. Treatment with RES improves cognitive function and attenuates neuronal damage in the hippocampus of sleep-deprived mice. Furthermore, the MAPK signaling pathway has been identified as a pivotal target in these neuroprotective effects. These findings will contribute to providing theoretical support for dietary supplementation of RES to prevent or improve cognitive dysfunction caused by sleep problems.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70816","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradable Active Packaging With Improved Functionality Through PVA, Itaconic Acid, Chitosan, Nanoparticles, and Lemon Peel for Sustainable Solutions","authors":"Bernadette-Emőke Teleky,&nbsp;Silvia Amalia Nemes,&nbsp;Diana Plamada,&nbsp;Laura Mitrea,&nbsp;Calina Ciont,&nbsp;Mădălina Medeleanu,&nbsp;Mădălina-P. Plosca,&nbsp;Bianca Obreja,&nbsp;Răzvan Odocheanu,&nbsp;Loredana Leopold,&nbsp;Lucian Barbu-Tudoran,&nbsp;Floricuța Ranga,&nbsp;Dan C. Vodnar","doi":"10.1002/fsn3.70911","DOIUrl":"https://doi.org/10.1002/fsn3.70911","url":null,"abstract":"<p>The growing demand for sustainable and eco-friendly packaging has driven research into developing biodegradable materials with enhanced functionality. This study develops and evaluates biodegradable polyvinyl alcohol (PVA)-based films incorporating itaconic acid (IA), chitosan (Ch), lemon peel extract (Lp), and silver nanoparticles (Np's) for active food packaging applications. In a controlled 11-day storage study at 4°C, when used to coat blueberries, these bioactive films showed reduced weight loss by up to 13.3%, maintained visual quality, and exhibited significantly lower microbial loads (***<i>p</i> &lt; 0.001) compared to uncoated controls. The films exhibited pH-responsive swelling, peaking at pH 9 (92.95% for PVA + Ch) and reduced water vapor permeability (1.6% ± 1.2% for PVA + IA + Np + Lp). Biodegradability tests revealed up to 61.8% degradation in 8 weeks, confirming their environmental benefits. Adding IA and Ch enhanced mechanical strength and moisture resistance, while Lp and Np's provided antioxidant properties, making these films promising alternatives to conventional plastic packaging. This study presents a scalable approach to developing multifunctional, biodegradable films with potential for real-world adoption in sustainable food packaging systems.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70911","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}