Food Science & Nutrition最新文献

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Treatment of onion skin waste using dielectric barrier discharge cold plasma processing 利用介质阻挡放电冷等离子体处理洋葱皮废料
IF 3.5 2区 农林科学
Food Science & Nutrition Pub Date : 2024-09-03 DOI: 10.1002/fsn3.4448
Berna Senguler, Celale Kirkin, Hilal Donmez, Senanur Unal
{"title":"Treatment of onion skin waste using dielectric barrier discharge cold plasma processing","authors":"Berna Senguler,&nbsp;Celale Kirkin,&nbsp;Hilal Donmez,&nbsp;Senanur Unal","doi":"10.1002/fsn3.4448","DOIUrl":"10.1002/fsn3.4448","url":null,"abstract":"<p>Onion skin constitutes a major part of industrial food waste, and cold plasma technology can be employed in the treatment of onion skin. Onion skin waste was ground and exposed to dielectric barrier discharge cold plasma (DBDCP) at 40 kV for 10 or 20 min. Samples that were not DBDCP treated were used as the control. The changes in the color, microbial load, total phenolic content (TPC), and antioxidant activity of the onion skin waste upon treatment were evaluated. An increase in the <i>b</i>* and <i>C</i>* values of the onion skin powder (OSP) was obtained after the DBDCP treatment. The DBDCP process also decreased the total mesophilic aerobic bacteria and yeast–mold counts of the OSP by up to 0.92 and 0.97 log cfu/g (colony-forming units per gram), respectively. In addition, the TPC and antioxidant activity, as determined by 2,2-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity and ferric-reducing antioxidant power (FRAP) methods, were increased for up to 59% and 28%, respectively, depending on the treatment time. In conclusion, the findings of the study show that using DBDCP processing in the treatment of onion skin waste can reduce microbial count while enhancing TPC and antioxidant activity.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4448","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142210643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physicochemical properties of oleaster extract and the role of oleaster antioxidants on oxidative induced DNA damage 油桐提取物的理化特性以及油桐抗氧化剂对氧化诱导的 DNA 损伤的作用
IF 3.5 2区 农林科学
Food Science & Nutrition Pub Date : 2024-09-03 DOI: 10.1002/fsn3.4443
Saliha Şahin, Önder Aybastıer
{"title":"Physicochemical properties of oleaster extract and the role of oleaster antioxidants on oxidative induced DNA damage","authors":"Saliha Şahin,&nbsp;Önder Aybastıer","doi":"10.1002/fsn3.4443","DOIUrl":"10.1002/fsn3.4443","url":null,"abstract":"<p>Oleaster (<i>Elaeagnus angustifolia</i> L.) is a plant with high medicinal value and economic and nutritional importance, which has been used in traditional medicine for a long time. Oleaster contains phenolic compounds that have the ability to prevent a wide variety of diseases. In this study antioxidant capacity, total phenolic content, and total carbohydrate content were found as 108.70 ± 0.20 μg GAE/g of oleaster extract, 28.80 ± 0.01 μg TE/g of oleaster extract, and 15.40 ± 0.01 mg D-glucose/g of oleaster extract, respectively. The oleaster extract was analyzed using the HPLC-DAD system. The results showed rutin, caffeic acid, protocatechuic acid, and ferulic acid. The protective abilities of rutin, caffeic acid, protocatechuic acid, ferulic acid, and oleaster extract were tested against the oxidation of DNA. The mix of phenolic compounds (inhibited about 93.29% of the damage) and oleaster extract (inhibited about 94.14% of the damage) showed better protect DNA against oxidation than phenolic compounds. The results obtained from this study are guiding for new applications involving the physicochemical properties of oleaster extract with high antioxidant properties for food applications.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142210640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Walnut extract protects against hepatic inflammation and toxicity induced by a high-fat diet 核桃提取物可防止高脂饮食引起的肝脏炎症和中毒
IF 3.5 2区 农林科学
Food Science & Nutrition Pub Date : 2024-09-02 DOI: 10.1002/fsn3.4405
Gauhar Ali, Alam Zeb, Muhammad Usman, Salim Al-Babili
{"title":"Walnut extract protects against hepatic inflammation and toxicity induced by a high-fat diet","authors":"Gauhar Ali,&nbsp;Alam Zeb,&nbsp;Muhammad Usman,&nbsp;Salim Al-Babili","doi":"10.1002/fsn3.4405","DOIUrl":"10.1002/fsn3.4405","url":null,"abstract":"<p>A high-fat diet (HFD) is one of the main causes of obesity and metabolic diseases. The liver is particularly affected by HFD causing metabolic dysfunction associated with fatty liver disease. Therefore, different strategies are used to mitigate the negative effects of HFD. This study aimed to assess the protective effects of walnut extract against HFD-induced toxicity in mice. The mice were fed HFD and walnut extract alone or in combination. The walnut extract was analyzed for composition using high-performance liquid chromatography with a diode array detector (HPLC-DAD) and ultra-high-performance liquid chromatography with mass spectrometry (UHPLC–MS/MS). Serum lipid profile; liver histology; hepatic antioxidants such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), lipid peroxidation (TBARS), and reduced glutathione (GSH); inflammatory markers like IL-6 and TNF-α; and phospholipids were determined. Results showed that phenolic acids, epicatechin, catechin, benzaldehyde, and juglone were the main constituents in the extract. The HFD group showed increased hepatic fat accumulation as evidenced by biochemical and histopathological examinations compared to the control animals. The HFD group mice also showed increased body and cardiac weights, modified lipid profiles, decreased antioxidant status, and increased levels of hepatic inflammatory markers. The weights of the body and heart, lipid profiles, antioxidant contents (CAT, SOD, GSH-Px, TBARS, and GSH), and pro-inflammatory cytokines (IL-6 and TNF-α) were all normalized by consuming walnut extract. Similarly, the HFD group had significantly high amounts of hepatic lipase, phospholipid, and lysophospholipid levels, which were improved by walnut extract. In conclusion, walnut extract has been shown to play a unique role in promoting the recovery of liver damage caused by a high-fat diet.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142210641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recovery and characterization of cellulose microfibers from fallen leaves and evaluation of their potential as reinforcement agents for production of new biodegradable packaging materials 从落叶中回收纤维素微纤维并确定其特性,评估其作为生产新型生物可降解包装材料的增强剂的潜力
IF 3.5 2区 农林科学
Food Science & Nutrition Pub Date : 2024-09-02 DOI: 10.1002/fsn3.4439
Sudenur Celik, Gozde Kutlu, Fatih Tornuk
{"title":"Recovery and characterization of cellulose microfibers from fallen leaves and evaluation of their potential as reinforcement agents for production of new biodegradable packaging materials","authors":"Sudenur Celik,&nbsp;Gozde Kutlu,&nbsp;Fatih Tornuk","doi":"10.1002/fsn3.4439","DOIUrl":"10.1002/fsn3.4439","url":null,"abstract":"<p>In the present work, cellulose microfibers (CMFs) isolated from fallen autumn leaves of cherry plum (<i>Prunus cerasifera pissardii nigra</i>), white mulberry (<i>Morus alba)</i> and plane (<i>Platanus orientalis</i>) trees were characterized and used as reinforcement agents in sodium alginate-based biodegradable films. Fourier transform infrared spectroscopy (FT-IR) characterization showed that the CMFs were successfully isolated from the leaves with high purity. The extracted CMFs had a particle size ranging from 321.20 nm to 632.26 nm and negative zeta potential values (−27.33 to −21.40). The extraction yield of CMFs ranged from 19.53% to 26.00%. Incorporation of the leaf-derived CMFs into sodium alginate based films (1%, w:w) increased their tensile strength (from 153.73 to 187.78 MPa) and elongation at break values (from 105.97% to 89.90%) and significantly decreased oxygen (from 121.46 to 75.56 meq kg<sup>-1</sup>) and water vapor permeabilities (from 2.36 to 1.60 g mm h<sup>−1</sup> m<sup>−2</sup> kPa<sup>−1</sup>)(<i>p</i> &lt; 0.05). Furthermore, the supplementation of CMFs into the biopolymer matrix had no significant effect on the color (<i>L*:</i> 85.35–85.67; <i>a*:</i> −0.75-0.71; <i>b*</i>: 4.23–4.94) and moisture content (44.64–48.42%) of the film samples, although the thickness increased (40.33–94.66 μm). Scanning electron microscopy (SEM) images showed that CMFs were homogeneously dispersed in the film matrix. Overall, this study confirms that fallen cherry plum, white mulberry, and plane leaves are valuable sources of CMFs which could be used in the manufacturing of biodegradable nanocomposite films as reinforcement agents.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4439","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of volatile flavor compounds in Antarctic krill paste with different processing methods based on GC-IMS 基于 GC-IMS 的不同加工方法的南极磷虾膏挥发性风味化合物分析
IF 3.5 2区 农林科学
Food Science & Nutrition Pub Date : 2024-09-02 DOI: 10.1002/fsn3.4425
Pengfei Jiang, Yang Liu, Jiabo Huang, Baoshang Fu, Kaihua Wang, Zhe Xu
{"title":"Analysis of volatile flavor compounds in Antarctic krill paste with different processing methods based on GC-IMS","authors":"Pengfei Jiang,&nbsp;Yang Liu,&nbsp;Jiabo Huang,&nbsp;Baoshang Fu,&nbsp;Kaihua Wang,&nbsp;Zhe Xu","doi":"10.1002/fsn3.4425","DOIUrl":"10.1002/fsn3.4425","url":null,"abstract":"<p>In this study, shrimp paste was prepared using Antarctic krill and fermented Antarctic krill shrimp paste as raw materials. Two commonly used heating methods, stir-fried and steaming, were analyzed, the main difference between the two methods being that stir-frying involves putting the shrimp paste into a wok and stir-frying it for different periods of time, while steaming involves putting the shrimp paste into a steamer and steaming it for different periods of time. The effects of different salt concentrations and processing techniques on the volatile flavor compounds of shrimp paste were also observed. Electronic nose and gas chromatography–ion mobility spectrometry (GC-IMS) were employed to analyze the volatile flavor compounds. A total of 52 volatile flavor compounds were detected by GC-IMS, of which 38 were identified (including monomers, dimers, and polymers). The identified compounds included 11 aldehydes, 6 ketones, 14 alcohols, 2 esters, 2 acids, 1 pyridine compound, and 2 sulfur compounds. In addition, 14 compounds were identifiable. Using the results of the electronic nose analysis, we were also able to differentiate between the volatile flavor compounds in shrimp pastes produced by different processing methods.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142210642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ameliorative effects of humic acid and L-tryptophan on enzyme activity, mineral content, biochemical properties, and plant growth of spinach cultivated in saline conditions 腐殖酸和 L-色氨酸对盐碱地栽培菠菜的酶活性、矿物质含量、生化特性和植物生长的改善作用
IF 3.5 2区 农林科学
Food Science & Nutrition Pub Date : 2024-08-30 DOI: 10.1002/fsn3.4435
Nezahat Turfan, Beyhan Kibar, Nazakat Davletova, Hakan Kibar
{"title":"Ameliorative effects of humic acid and L-tryptophan on enzyme activity, mineral content, biochemical properties, and plant growth of spinach cultivated in saline conditions","authors":"Nezahat Turfan,&nbsp;Beyhan Kibar,&nbsp;Nazakat Davletova,&nbsp;Hakan Kibar","doi":"10.1002/fsn3.4435","DOIUrl":"10.1002/fsn3.4435","url":null,"abstract":"<p>Salinity poses a significant abiotic stress that limits plant productivity, thereby posing a serious threat to agricultural sustainability and worldwide food security. Techniques that can overcome this problem are needed. Recent focus has been placed on employing organic substances like humic acid (HA) and amino acids, including L-tryptophan (L-TRP), to mitigate the negative effects of salt stress on cultivated plants. Accordingly, in this research, the impact of foliar applications of HA and L-TRP, both separately and combined, on the growth parameters and biochemical properties of spinach subjected to salt stress was investigated. In the present study, eight treatments (1. control, 2. salt (NaCl), 3. HA, 4. L-TRP, 5. HA + NaCl, 6. L-TRP + NaCl, 7. HA + L-TRP, and 8. HA + L-TRP + NaCl) were investigated. The study showed that salt stress markedly reduced several growth properties in spinach, including plant height, number of leaves, leaf dimensions, and both fresh and dry weight. Additionally, it significantly lowered contents of chlorophyll (<i>a</i>, <i>b</i>, and total), carotenoid, polyphenol, lutein, anthocyanin, polyphenol oxidase, glycine betaine, relative water content, and the antioxidant enzyme activities (ascorbate peroxidase, catalase, peroxidase, and superoxide dismutase). On the other hand, significant increases were observed in sodium, chlorine, potassium, sulfur, zinc, nickel, proline, malondialdehyde, and hydrogen peroxide levels of spinach with salinity. Individual and combined applications of HA and L-TRP positively influenced plant growth, relative water content, activities of antioxidant enzyme, chlorophyll, and mineral contents of spinach under both normal and saline conditions. In conclusion, the combined use of HA and L-TRP under salt stress conditions is promising in mitigating the negative impacts of salinity and can be suggested as an effective alternative approach for cultivating spinach in saline environments.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4435","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142210662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiomics analysis reveals the potential mechanism of high-fat diet in dextran sulfate sodium-induced colitis mice model 多组学分析揭示高脂饮食在葡聚糖硫酸钠诱导的结肠炎小鼠模型中的潜在作用机制
IF 3.5 2区 农林科学
Food Science & Nutrition Pub Date : 2024-08-30 DOI: 10.1002/fsn3.4426
Yuyang Zhao, Zhimin Chen, Ruiyi Dong, Yufan Liu, Yixin Zhang, Yan Guo, Meiyi Yu, Xiang Li, Jiangbin Wang
{"title":"Multiomics analysis reveals the potential mechanism of high-fat diet in dextran sulfate sodium-induced colitis mice model","authors":"Yuyang Zhao,&nbsp;Zhimin Chen,&nbsp;Ruiyi Dong,&nbsp;Yufan Liu,&nbsp;Yixin Zhang,&nbsp;Yan Guo,&nbsp;Meiyi Yu,&nbsp;Xiang Li,&nbsp;Jiangbin Wang","doi":"10.1002/fsn3.4426","DOIUrl":"10.1002/fsn3.4426","url":null,"abstract":"<p>A high-fat diet (HFD) is recognized as an important contributor to inflammatory bowel disease (IBD). However, the precise underlying mechanism of HFD on IBD remains elusive. This study aimed to investigate the potential mechanism by which HFD affects IBD using 16S rRNA-sequencing and RNA-seq technology. Results indicated that HFD-treated mice exhibited notable alternations in the structure and composition of the gut microbiota, with some of these alternations being associated with the pathogenesis of IBD. Analysis of the colon transcriptome revealed 11 hub genes and 7 hub pathways among control, DSS-induced colitis, and HFD + DSS-treated groups. Further analysis explores the relationship between the hub pathways and genes, as well as the hub genes and gut microbiota. Overall, the findings indicate that the impact of HFD on DSS-induced colitis may be linked to intestinal dysbiosis and specific genes such as <i>Abca8b</i>, <i>Ace2</i>, <i>Apoa1</i>, <i>Apoa4</i>, <i>Apoc3</i>, <i>Aspa</i>, <i>Dpp4</i>, <i>Maob</i>, <i>Slc34a2</i>, <i>Slc7a9</i>, and <i>Trpm6</i>. These results provide valuable insights for determining potential therapeutic targets for addressing HFD-induced IBD.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4426","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142210671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison effects of PEF and SC-CO2 treatments on lycopene, β-carotene, lutein, β-cryptoxanthin, total polyphenols values, and antioxidant activity of tomato fruits 比较 PEF 和 SC-CO2 处理对番茄果实番茄红素、β-胡萝卜素、叶黄素、β-隐黄素、多酚总值和抗氧化活性的影响
IF 3.5 2区 农林科学
Food Science & Nutrition Pub Date : 2024-08-29 DOI: 10.1002/fsn3.4225
Saba Belgheisi, Ali Motamedzadegan, Ladan Rashidi, Jafar M. Milani, Ali Rafe
{"title":"Comparison effects of PEF and SC-CO2 treatments on lycopene, β-carotene, lutein, β-cryptoxanthin, total polyphenols values, and antioxidant activity of tomato fruits","authors":"Saba Belgheisi,&nbsp;Ali Motamedzadegan,&nbsp;Ladan Rashidi,&nbsp;Jafar M. Milani,&nbsp;Ali Rafe","doi":"10.1002/fsn3.4225","DOIUrl":"10.1002/fsn3.4225","url":null,"abstract":"<p>Since the recycling of composites from plant tissues is difficult, extraction of bioactive compounds from plant sources requires pre-treatment by new technology such as pulsed electric fields (PEF). Due to the reduced consumption of organic solvents, the extractive techniques such as using supercritical CO<sub>2</sub> (SC-CO<sub>2</sub>) are of interest to researchers. This work aimed to investigating the influences of different parameters of SC-CO<sub>2</sub> (pressure, modifier volume, temperature, and dynamic time) and PEF (frequency and field strength) treatments on the amount extraction of β-carotene, lycopene, lutein, β-cryptoxanthin, total phenol content (TPC), and also antioxidant activity percentage of tomato to obtain the optimum circumstances extraction via PEF and SC-CO<sub>2</sub> methods. PEF data showed that treatments with moderate intensity (1 Hz and 0. 25 kV/cm) enhanced the extractability of lycopene (88%), β-carotene (69%), and β-cryptoxanthin (24%). The maximum recovery in total polyphenols was achieved at a 1 Hz and 1.75 kV/cm, leading to a 41.68% growth. The SC-CO<sub>2</sub> results showed that extraction at 55°C and 35 MPa, and in a short time of 20 min (without any modifier: methanol) resulted in the highest levels of carotenoids (100% recovery), especially lycopene, and antioxidant activity. Largest value of total polyphenols was obtained at 35 MPa, 35°C, during 30 min, and 250 μL methanol as a modifier (58.79% recovery). Results showed that the extraction of polyphenols, unlike carotenoids, required a modifier. Organic solvents, often called modifiers, are sometimes added to the supercritical fluid to increase the polarity range of the extraction process and to help overcome analyte retention in the matrix. In this study, methanol was used as a modifier in different volumes. Therefore, the SC-CO<sub>2</sub> gentle processing conditions, compared with PEF, improved the recovery of tomato bioactive compounds and antioxidant activity. Nevertheless, further studies are needed to optimize such treatments.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142210667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updated aspects of alpha-Solanine as a potential anticancer agent: Mechanistic insights and future directions 作为潜在抗癌剂的 alpha-Solanine 的最新情况:机理认识和未来方向
IF 3.5 2区 农林科学
Food Science & Nutrition Pub Date : 2024-08-29 DOI: 10.1002/fsn3.4221
Sudeshna Nandi, Rimpa Sikder, Anish Nag, Somanjana Khatua, Surjit Sen, Nilanjan Chakraborty, Arghya Naskar, Kairat Zhakipbekov, Krishnendu Acharya, Solomon Habtemariam, Dilek Arslan Ateşşahin, Tamar Goloshvili, Afaf Ahmed Aldahish, Javad Sharifi-Rad, Daniela Calina
{"title":"Updated aspects of alpha-Solanine as a potential anticancer agent: Mechanistic insights and future directions","authors":"Sudeshna Nandi,&nbsp;Rimpa Sikder,&nbsp;Anish Nag,&nbsp;Somanjana Khatua,&nbsp;Surjit Sen,&nbsp;Nilanjan Chakraborty,&nbsp;Arghya Naskar,&nbsp;Kairat Zhakipbekov,&nbsp;Krishnendu Acharya,&nbsp;Solomon Habtemariam,&nbsp;Dilek Arslan Ateşşahin,&nbsp;Tamar Goloshvili,&nbsp;Afaf Ahmed Aldahish,&nbsp;Javad Sharifi-Rad,&nbsp;Daniela Calina","doi":"10.1002/fsn3.4221","DOIUrl":"10.1002/fsn3.4221","url":null,"abstract":"<p>Cancer remains a critical global health challenge, with limited progress in reducing mortality despite advancements in diagnosis and treatment. The growing resistance of tumors to existing chemotherapy exacerbates this burden. In response, the search for new anticancer compounds from plants has intensified, given their historical success in yielding effective treatments. This review focuses on α-solanine, a glycoalkaloid primarily derived from potato tubers and nightshade family plants, recognized for its diverse biological activities, including anti-allergic, antipyretic, anti-inflammatory, anti-diabetic, and antibiotic properties. Recently, α-solanine has gained attention as a potential anticancer agent. Utilizing resources like PubMed/MedLine, ScienceDirect, Web of Science, Scopus, the American Chemical Society, Google Scholar, Springer Link, Wiley, and various commercial websites, this review consolidates two decades of research on α-solanine's anticancer effects and mechanisms against nine different cancers, highlighting its role in modulating various signaling pathways. It also discusses α-solanine's potential as a lead compound in cancer therapy. The abundant availability of potato peel, often discarded as waste or sold cheaply, is suggested as a sustainable source for large-scale α-solanine extraction. The study concludes that α-solanine holds promise as a standalone or adjunctive cancer treatment. However, further research is necessary to optimize this lead compound and mitigate its toxicity through various strategies.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.4221","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142210665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical composition, anti-hypertensive properties, and sensory attributes of salt extracted from ash of Hygrophilia schulli 从五味子灰烬中提取的盐的化学成分、抗高血压特性和感官属性
IF 3.5 2区 农林科学
Food Science & Nutrition Pub Date : 2024-08-29 DOI: 10.1002/fsn3.4217
Degsew Mengistu, Paulos Getachew
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