Food Science & Nutrition最新文献

{"title":"Kinetic Modeling of Microbial Inactivation in Juices Treated With Pulsed Electric Fields (PEF): A Comparative Study on Microbial Heterogeneity and Food Matrix Effects.","authors":"Fotios Lytras, Georgios Psakis, Matthew Xuereb, Frederick Lia, Ruben Gatt, Javier Raso, Vasilis Valdramidis","doi":"10.1002/fsn3.72408","DOIUrl":"10.1002/fsn3.72408","url":null,"abstract":"<p><p>Pulsed electric field (PEF) processing is a promising technology for preserving fruit and vegetable juices. This research study evaluated the effect of pulsed electric fields (PEF) at 20 kV/cm on the microbial and quality parameters of pomegranate, tomato, and carrot juices. The inactivation kinetics of <i>Escherichia coli</i> strains (K12 and FAM 21843) and <i>Saccharomyces cerevisiae</i> strains (AD1890 and 130.0014) were fitted using a global model, which combined a log-linear primary model with a second-order polynomial. for describing the polyphasic inactivation kinetics. Maximum microbial inactivation rates (<i>k</i> _<i>max</i> ) increased with the increase of <i>Wτ</i>, reaching > 5-log reductions for <i>E. coli</i> strains in pomegranate and carrot juice, and > 3.85-log reduction in tomato juice. Among strains, <i>S. cerevisiae</i> 130.0014 showed the highest <i>k</i> _<i>max</i> values above > 80 kJ/kg in pomegranate and tomato juices. Minor differences were observed at high <i>Wτ</i> levels among <i>E. coli</i> strains in pomegranate juice and among <i>S. cerevisiae</i> strains across all the food matrices. Furthermore, the occurrence of sublethal injury was low to <i>E. coli</i> strains under PEF, independent of the food matrix, within pomegranate juice, showing the highest levels. Quality analysis of all juices revealed that PEF did not affect antioxidant compounds or their antioxidant activities, as no statistically significant values (<i>p</i> < 0.05) were identified. Overall, the effectiveness of PEF in microbial inactivation is primarily governed by <i>Wτ</i>, with some food-matrix-dependent variations. These findings highlight PEF's potential as a food processing alternative that preserves quality while achieving microbial inactivation.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 10","pages":"e72408"},"PeriodicalIF":5.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Vitamin E Administration on Serum Lipid Profile in Adult Patients With Dyslipidemia: A GRADE-Assessed Systematic Review and Dose–Response Meta-Analysis of RCTs","authors":"Mehdi Karimi,&nbsp;Kimia Kazemi,&nbsp;Fatemeh Ziyafati,&nbsp;Fereshteh Valizadeh,&nbsp;Niyousha Shirsalimi,&nbsp;Sepehr Ramezanipour,&nbsp;Ali Estifa,&nbsp;Omid Asbaghi","doi":"10.1002/fsn3.72428","DOIUrl":"10.1002/fsn3.72428","url":null,"abstract":"<p>Dyslipidemia is a major risk factor for cardiovascular disease. Studies have shown that vitamin E has therapeutic effects on lipid metabolism; however, findings remain inconsistent. This meta-analysis aims to assess the effectiveness of vitamin E administration on the serum lipid panel in patients with dyslipidemia. A database search through January 2026 was conducted to identify relevant randomized controlled trials (RCTs). Relevant data, including triglycerides (TG), total cholesterol (TC), and low- and high-density lipoprotein cholesterol (LDL-C and HDL-C), were extracted. The overall effect size was estimated using weighted mean differences (WMDs) with 95% confidence intervals (CIs) via a random-effects model. The pooled analysis of 22 RCTs (33 intervention arms) demonstrated that vitamin E significantly lowered TG (WMD: −8.14 mg/dL, <i>p</i> = 0.021) and raised HDL-C (WMD: 1.08 mg/dL, <i>p</i> = 0.037) in patients with dyslipidemia, whereas reductions in TC (WMD: −6.48 mg/dL, <i>p</i> = 0.097) and LDL-C (WMD: −9.06 mg/dL, <i>p</i> = 0.063) were not significant overall. Exploratory subgroup analyses suggested that tocotrienols may exert greater lipid-modifying effects than tocopherols, with potentially larger benefits observed at lower doses, among individuals with more pronounced baseline lipid abnormalities, and during shorter intervention periods. In conclusion, vitamin E supplementation in patients with dyslipidemia shows modest improvements in lipid profiles, mainly lowering TG and increasing HDL-C, with less consistent effects on TC and LDL-C. Tocotrienols may be more effective than tocopherols, suggesting possible isoform-specific effects, but overall clinical impact appears limited and requires further confirmation.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 10","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effects of Chia Seeds and Vitamin E Against Benzo[a]Pyrene-Induced Toxicity in Male Mice: A Comparison of co-Administration and Pre-Treatment Strategies","authors":"Mohammad Rezaei,&nbsp;Maryam Karimi-Dehkordi","doi":"10.1002/fsn3.72405","DOIUrl":"10.1002/fsn3.72405","url":null,"abstract":"<p>Due to its carcinogenic and toxic effects, benzo[a]pyrene, which belongs to the family of polycyclic aromatic hydrocarbons, is a major health concern, primarily from sources such as tobacco smoke and grilling. This study investigated chia seeds and vitamin E as protective agents against benzo[a]pyrene toxicity in male mice. A total of 70 male mice were randomly assigned to 14 experimental groups (<i>n</i> = 5 per group): a negative control group, a vehicle control group (olive oil), a benzo[a]pyrene-only group (20 mg/kg), a vitamin E-only group (250 mg/kg), a vitamin E + benzo[a]pyrene co-administration group, three chia seed-only groups (10%, 20%, and 30% in diet), three chia seed + benzo[a]pyrene co-administration groups, and three chia seed pre-treatment groups (2 weeks of chia seeds alone followed by 4 weeks of chia seeds + benzo[a]pyrene). Biomarkers of oxidative stress, lipid profiles, and liver function were measured. Benzo[a]pyrene exposure significantly decreased superoxide dismutase and total antioxidant capacity, and altered lipid metabolism, increasing triglyceride (TG) and low-density lipoprotein (LDL) levels. Interestingly, compared with those of the benzo[a]pyrene group, the total antioxidant capacity and superoxide dismutase activity of the chia seeds enriched with 20% and 30% benzo[a]pyrene notably increased, and the malondialdehyde level decreased. Moreover, the level of aspartate aminotransferase decreased. However, vitamin E had a minimal protective effect and did not reduce oxidative damage. In summary, chia seeds, unlike vitamin E, enhanced antioxidant defenses, improved liver function, and ameliorated lipid metabolism disturbances caused by benzo[a]pyrene. Chia seeds are a promising dietary option to counteract environmental toxicants such as benzo[a]pyrene.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 10","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating the Gut-Ovarian Axis: Mechanistic Rationale and the Limits of Current Evidence for Probiotics in Female Reproductive Aging.","authors":"Meiqi Chen, Qi Su, Mengshuang Sun, He Zhang, Jin Xu, Chenxi Zhang, Yanbo Wang","doi":"10.1002/fsn3.72454","DOIUrl":"10.1002/fsn3.72454","url":null,"abstract":"<p><p>Female reproductive aging is characterized by progressive follicular depletion, deterioration of oocyte quality, and endocrine decline, with oxidative stress, mitochondrial dysfunction, immune-inflammatory remodeling, and granulosa-cell loss contributing to ovarian functional deterioration. This critical narrative review, supported by a structured literature search, evaluates mechanistic, preclinical, and human evidence for probiotic and microbiota-targeted modulation of the gut-ovarian axis. The current evidence base remains predominantly preclinical. In premature ovarian insufficiency (POI), polycystic ovary syndrome (PCOS), chemotherapy-induced ovarian injury, and reproductive-aging models, selected interventions have modified intestinal microbial ecology, barrier function, microbial metabolites, and systemic immune-metabolic-endocrine signaling, with model-specific effects on ovarian redox homeostasis, granulosa-cell survival, follicular development, mitochondrial function, and oocyte-related outcomes. Mechanistic support is strongest where gut dependency, metabolite supplementation, or related causal approaches have been demonstrated, but responses remain highly strain-, model-, dose-, route-, and host-dependent. Human trials in PCOS and menopause-related or reproductive settings have reported changes in selected metabolic, hormonal, menstrual, symptom, quality-of-life, and fertility-related outcomes; however, our structured literature and trial-registry searches did not identify a randomized human trial specifically designed to test whether probiotic or microbiota-targeted intervention slows the longitudinal physiological loss of ovarian reserve or delays physiological ovarian aging. Findings from disease models, fecal microbiota transplantation, or other experimental interventions should therefore not be equated with the efficacy of oral probiotic foods or supplements. Current evidence supports biological plausibility and translational potential rather than established ovarian anti-aging efficacy. Future studies should evaluate well-characterized oral strains using prespecified ovarian-aging-relevant endpoints, mechanistic biomarkers, and standardized safety assessment.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 10","pages":"e72454"},"PeriodicalIF":5.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Associations of Dietary Inflammatory Index and Dietary Antioxidant Indices With Mortality Risk From MASLD/MetALD: Results From a Large Population-Based Study.","authors":"Haixin Lyu, Haiyan Chen, Zegeng Zhan, Yangyang Qin, Lifang Mao, Meiyan Guo, Yaxian Mo, Tianran Shen","doi":"10.1002/fsn3.72429","DOIUrl":"10.1002/fsn3.72429","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) and its subtype, metabolic dysfunction and alcohol-associated liver disease (MetALD), represent escalating global health challenges. Despite the central role of dietary intervention in current guidelines, evidence remains limited regarding the synergistic impact of anti-inflammatory and antioxidant diets on the survival benefits of steatotic liver disease (SLD) populations, particularly those with moderate alcohol consumption. This study aims to elucidate the associations between dietary inflammatory/antioxidant quality and mortality across SLD subtypes, and provide insights into dietary recommendations for this patient group. Data from 3048 individuals (2146 MASLD, 902 MetALD) who participated in the 2005-2018 National Health and Nutrition Examination Survey were analyzed. Weighted Cox regression analysis was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality risk assessment. The mediation effects of inflammation-related indicators were explored by mediation analysis. During the follow-up period, a total of 306 deaths were documented. In MASLD patients, higher DII (T3) correlated with increased all-cause mortality (HR = 1.97, 95% CI: 1.12-3.47, <i>p</i> = 0.019). Both CDAI and DAQS showed negative associations, with HRs of 0.50 (0.28-0.89) and 0.47 (0.24-0.93) for T3, respectively (both <i>p</i> < 0.05). In MetALD patients, higher DII was associated with increased mortality risk (T2 HR = 4.95, T3 HR = 3.91, both <i>p</i> < 0.05). Joint analysis suggested that higher dietary antioxidant quality was associated with lower mortality risks across SLD subtypes compared with the MASLD group with low dietary antioxidant quality. Mediation analysis suggested that inflammation-related markers (platelets and PHR) may be involved in the associations between dietary indices and mortality in MASLD patients, whereas no statistically significant mediation effects were observed in the MetALD subgroup. Our findings show the key role of dietary quality in reducing mortality among patients with SLD, suggesting that anti-inflammatory and antioxidant-rich diets can improve long-term survival across the SLD spectrum. The findings of this study are expected to provide a new perspective on dietary interventions as a complement to current international guidelines for MASLD/MetALD.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 10","pages":"e72429"},"PeriodicalIF":5.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Roasting on the Antioxidant and Lipid-Modulating Activities of <i>Argania spinosa</i> Oil Under Diabetic Conditions.","authors":"Nour Elhouda Daoudi, Mohammed Aziz, Mohammed Choukri, Youssouf Ali Younous, Amir Bouallegue, Gehan M Elossaily, Abdel-Rhman Z Gaafar, Musa A Said, Hina Ali, Mohamed Bnouham","doi":"10.1002/fsn3.72441","DOIUrl":"10.1002/fsn3.72441","url":null,"abstract":"<p><p><i>Argania spinosa</i> L. is endemic to a small region in southwestern Morocco and has been used for food and medicinal purposes for decades. This study evaluates the hepatoprotective and potential cardioprotective effects of roasted Argan seed oil (HGAT) and non-roasted Argan seed oil (HGANT) in a streptozotocin-induced experimental diabetic model. An experimental approach in diabetic rats treated with HGAT or HGANT was used to assess oxidative stress, liver enzymes, and lipid metabolism. Diabetic rats were administered 2 mL/kg body weight/day of HGAT or HGANT. Biochemical analyses measured blood glucose levels, liver enzyme activity (ALT, AST, LDH), oxidative stress markers (MDA, GSH, CAT), lipid profiles, and hepatic glycogen content. Histopathological examinations assessed collagen deposition and fibrosis in liver and heart tissues. Both HGAT and HGANT significantly reduce oxidative stress and improve lipid profiles in diabetic rats. Notably, 2 mL/kg body weight/day of HGAT treatments decreased blood sugar levels to values comparable to those observed with metformin (<i>p</i> > 0.05). Histopathological analysis revealed that both oils improved hepatic architecture, reduced lipid droplet accumulation, and decreased collagen deposition in the liver. In cardiac tissue, HGAT and HGANT improved myocardial structure and significantly reduced collagen deposition, indicating attenuation of cardiac fibrosis. The roasting process did not affect total cholesterol, triglycerides, hepatic glycogen, or oxidative stress markers. Argan oil demonstrates promising hepatoprotective and lipid-modulating effects in diabetic conditions, with additional cardioprotective potential, supporting its ethnomedicinal use in metabolic disorders. Further studies are warranted to clarify its underlying mechanisms, long-term effects, and potential interactions with standard antidiabetic therapies.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 10","pages":"e72441"},"PeriodicalIF":5.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteolytic Activity of <i>Zingiber officinale</i> Extract: Interaction With Myofibrillar Proteins of Different Origins and Functional Effects in Meat Systems.","authors":"Alessandro Crinò, Chiara Fabrizi, Andrea Menci, Katia Liburdi","doi":"10.1002/fsn3.72459","DOIUrl":"10.1002/fsn3.72459","url":null,"abstract":"<p><p>Plant-derived proteases are widely investigated as sustainable tools for meat tenderization; however, their efficacy depends on enzyme characteristics, concentration, and muscle origin. This study compared a crude <i>Zingiber officinale</i> extract with bromelain and papain, two of the most established plant proteases in the food industry, integrating kinetic analysis on isolated myofibrils with technological and sensory evaluation in marinated chicken breast (CB) and pork loin (PL). Proteolytic kinetics were assessed using CB-MF and PL-MF at increasing enzyme protein concentrations. Based on catalytic efficiency, the most active preparations (B-III, P-III, ZR-III) were selected for validation in whole muscle systems. Chicken myofibrils exhibited greater susceptibility to proteolysis than pork, while ginger extract showed substrate-dependent behavior with preferential activity toward CB-MF. Enzymatic marination increased myofibrillar fragmentation in both species without altering pH, confirming that structural modifications were enzyme-driven. Ginger treatment induced rapid early-stage fragmentation (6 h), whereas bromelain and papain promoted more extensive degradation at longer times (12 h). Cooking yield and water-holding capacity were primarily influenced by muscle type and marination time. Chicken consistently showed higher moisture retention than pork. Ginger extract promoted controlled proteolysis, preserving cooking performance relative to bromelain and papain. Sensory evaluation under optimal conditions (6 h) demonstrated enhanced juiciness, tenderness, flavor perception, and overall acceptability in ginger-treated samples, particularly in chicken. Overall, the integrated experimental evidence identifies ginger protease as a selective and moderate proteolytic system capable of enhancing meat quality while preventing excessive structural breakdown.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 10","pages":"e72459"},"PeriodicalIF":5.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trigonelline Alleviates Neuroinflammation in AAV-SynA53T Parkinson's Disease Model Mice: Involvement of PI3K/AKT-NF-κB Signaling and Gut Microbial-Metabolic Remodeling.","authors":"Mozi Chen, Yiyao Dong, Jie Zheng, Yan Lin, Qiyao Li, Chuhua Wei, Linpei Zhuo, Yan He, Jing Sun, Feng Fu, Jiaming Liu","doi":"10.1002/fsn3.72451","DOIUrl":"10.1002/fsn3.72451","url":null,"abstract":"<p><p>Trigonelline (TG), a major alkaloid in fenugreek seed and coffee, has anti-inflammatory and antioxidant activities. We investigated whether TG ameliorates Parkinson's disease (PD)-related synucleinopathy and whether these effects are associated with inflammatory signaling and gut microbial-metabolic alterations. Two-sample Mendelian randomization (MR) was used to examine the relationship between genetically predicted circulating TG and α-synuclein. In vivo, AAV-SynA53T C57BL/6J mice received oral TG (5 mg/kg/day) for 30 days, followed by assessment of motor behavior, pSer129-α-syn pathology, dopaminergic markers, inflammatory readouts, intestinal barrier proteins, 16S rRNA profiles, and colon-content metabolomics. MR supported a potential protective association between genetically predicted serum TG and reduced α-synuclein. TG improved motor performance, reduced midbrain pSer129-α-syn signals, preserved dopaminergic markers, and attenuated inflammatory responses, accompanied by modulation of PI3K/AKT and NF-κB signaling. TG also improved intestinal barrier-associated features and altered the gut microbiota and metabolomic profile. A metabolomic feature tentatively annotated as Ganolucidic acid B was increased following TG treatment and correlated with several taxa enriched in the TG group; conditional network pharmacology suggested that its predicted targets were enriched in PD-relevant inflammatory and PI3K-AKT-related pathways. Overall, TG may ameliorate synucleinopathy-associated phenotypes in AAV-SynA53T mice, accompanied by attenuated inflammation and gut microbiota-metabolism remodeling. Further targeted metabolomic validation and causal intervention studies are warranted to clarify the contributions of specific metabolites and gut-associated mechanisms.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 10","pages":"e72451"},"PeriodicalIF":5.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzyme-Digested Edible Bird's Nest Promotes NGF-Induced Differentiation of PC12 Cells by Activating the TrkA-ERK1/2-CREB-BDNF Signaling Pathway","authors":"Wen Zhang,&nbsp;Xintong Wang,&nbsp;Huiqing Zhu,&nbsp;Xiaoxian Lin,&nbsp;Rongzi Li,&nbsp;Man Yuan,&nbsp;Baocai Xu,&nbsp;Dongliang Wang,&nbsp;Wei Xiong,&nbsp;Yixuan Li","doi":"10.1002/fsn3.72419","DOIUrl":"10.1002/fsn3.72419","url":null,"abstract":"<p>The neuroprotective properties of edible bird's nest (EBN) are well established; however, its effects on neuronal growth remain unclear. In this study, we investigated the effects of enzyme-digested EBN (EBND) on neurogenesis in the PC12 neuronal cell line. Although treatment with EBND alone did not significantly promote the differentiation of PC12 cells, it increased neurite outgrowth and neurofilament expression when co-administered with nerve growth factor (NGF). Moreover, EBND significantly augmented the NGF-induced phosphorylation of TrkA and ERK1/2, which in turn activated CREB and increased brain-derived neurotrophic factor (BDNF) expression. Notably, these effects of EBND were diminished by the TrkA inhibitor GW441756. Taken together, these findings suggest that combined treatment with EBND and NGF enhances neurogenesis in PC12 cells by activating the TrkA-ERK-CREB-BDNF signaling pathway.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 10","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Gluten-Free Biscuits From Rice Flour-Pineapple Stem Starch Blends: Physicochemical Properties, In Vitro Starch Digestibility, Estimated Glycemic Index, Sensory Evaluation, and Storage Stability.","authors":"Jiratthitikan Sriprablom, Phenphop Phansuea, Yuraporn Sahasakul, Sasapin Disnil, Amornrat Aursalung, Nuttarat Srisangwan, Arisa Keeratichamroen, Supatcha Srisungwan, Rungtiwa Wongsagonsup","doi":"10.1002/fsn3.72449","DOIUrl":"10.1002/fsn3.72449","url":null,"abstract":"<p><p>Pineapple stem starch (PSS) is a valuable source of nutritional resistant starch (RS), offering great potential as an alternative ingredient for producing functional gluten-free biscuits. This study aimed to develop healthy gluten-free biscuits using blends of all-purpose rice flour (RF) and PSS and to evaluate their physicochemical properties, in vitro starch digestibility, estimated glycemic index (eGI), sensory attributes, and storage stability. The biscuits were prepared by combining RF and PSS at various ratios of 25:75, 50:50, 75:25, and 0:100, in comparison to gluten-free control biscuits made with 100% RF. As the PSS content increased, the biscuit thickness increased, whereas hardness decreased. In terms of starch digestibility, the RS content of biscuits increased but eGI decreased with increasing PSS incorporation. Sensory evaluation revealed that biscuits containing 75% PSS received the highest liking scores across all assessed parameters. This optimum formulation (25:75 RF-to-PSS ratio) had an eGI of 60.04, which falls within the medium-GI category. In addition, both the control biscuits and the 75% PSS biscuits maintained peroxide value (PV) and thiobarbituric acid reactive substances (TBARS) within the acceptable limits throughout the storage period. The findings demonstrate that PSS is a promising functional ingredient for gluten-free biscuits. Incorporating 75% PSS and 25% RF into the biscuit formula effectively produced reduced-GI gluten-free biscuits, demonstrating their potential as a functional food.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"14 10","pages":"e72449"},"PeriodicalIF":5.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}