Food Science & Nutrition最新文献

{"title":"Cornus officinalis Extract Ameliorates Fructose-Induced Hepatic Steatosis in Mice by Sustaining the Homeostasis of Intestinal Microecology and Lipid Metabolism","authors":"Liang Chen,&nbsp;Yingying Song,&nbsp;Yurou Huang,&nbsp;Junjie Hu,&nbsp;Yan Meng,&nbsp;Ming Yuan,&nbsp;Guohua Zheng,&nbsp;Xuanbin Wang,&nbsp;Cong Zhang,&nbsp;Zhenpeng Qiu","doi":"10.1002/fsn3.70425","DOIUrl":"https://doi.org/10.1002/fsn3.70425","url":null,"abstract":"<p><i>Cornus officinalis</i> Sieb. et Zucc. (<i>Cornus officinalis</i>), an edible natural plant fruit, has beneficial effects on a multitude of metabolic diseases, but the mechanism to improve hepatic steatosis remains elusive. In this study, the curative effect of <i>Cornus officinalis</i> extract (COE) is evaluated in a fructose-induced NAFLD mouse model using biochemical indicators monitoring, histological staining, 16S rRNA sequencing analysis, and fecal microbiota transplantation. Our results showed that COE attenuates hepatic steatosis in fructose-fed mice. Mechanistically, COE repairs intestinal barrier damage and gut flora dysbiosis to suppress proinflammatory microbe-derived metabolite transportation to the liver, thus inhibiting the hepatic inflammation and lipid metabolic dysfunction. Notably, transplantation of fecal microbiota isolated from the fructose-fed mice could reverse the beneficial effect of COE on attenuating NAFLD. Therefore, our study demonstrates that COE delays the progression of fructose-driven NAFLD by suppressing lipid metabolic dysfunction and gut microbiota-mediated liver inflammation, highlighting the potential of <i>C. officinalis</i> as a resource for the treatment of NAFLD drugs.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Effects of Resveratrol on Intestinal Flora and Metabolism in Rats With Non-Steroidal Anti-Inflammatory Drug-Induced Intestinal Injury Under Plateau Hypoxia Environment”","authors":"","doi":"10.1002/fsn3.70417","DOIUrl":"https://doi.org/10.1002/fsn3.70417","url":null,"abstract":"<p>Xue, S., T. Shi, W. Liu, Y. Feng, A. Tuerxuntayi, N. Li, and F. Gao. 2025. “Effects of Resveratrol on Intestinal Flora and Metabolism in Rats With Non-Steroidal Anti-Inflammatory Drug-Induced Intestinal Injury Under Plateau Hypoxia Environment.” <i>Food Science &amp; Nutrition</i> 13: e70228.</p><p>This correction is necessary because the images corresponding to Figure 2E and Figure 2F in the article were reversed. In fact, Figure 2E in the original article should represent the medium dose rescue treatment group (RSVM), and Figure 2F should represent the low dose rescue treatment group (RSVL). Therefore, we propose a revision to swap Figure 2E and Figure 2F after the revision. Except for the error in the picture, there are no other errors in the content, which do not affect the conclusion and results of the article.</p><p>We apologize for this error.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70417","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Consumption of Black Soybean Seed Coat Extract on Sleep Quality in Healthy Japanese: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Comparison Study","authors":"Ryota Akagi,&nbsp;Toshinari Maruo,&nbsp;Tsuyoshi Takara,&nbsp;Kentaro Maruyama","doi":"10.1002/fsn3.70156","DOIUrl":"https://doi.org/10.1002/fsn3.70156","url":null,"abstract":"<p>This study examined the effect of the intake of a test food containing black soybean seed coat extract (BE) on the sleep quality of healthy Japanese adults with poor sleep quality. This double-blind, placebo-controlled, randomized, parallel-group trial included 94 participants. We randomly assigned 64 eligible participants to either (<i>n</i> = 32 per group) (i) the BE group receiving a BE-containing capsule daily or (ii) the Placebo group receiving a placebo capsule daily. The primary outcome was sleepiness on rising score in the Oguri–Shirakawa–Azumi sleep inventory MA (OSA-MA) at 12 weeks after intake, and the secondary outcomes were OSA-MA, PSQI-J, original questionnaire (visual analog scale), POMS2 scores, sleep test, blood flow, palmar surface temperature, and blood test data. The final analysis included data from 64 participants. The sleepiness on rising score was significantly higher in the BE group than in the placebo group. In the BE group, sleep-onset latency and subjective dry mouth significantly decreased, and palmar surface temperature significantly increased. Furthermore, BE effectively reduced sleepiness on rising in men and increased the total sleep duration in women. For participants aged ≥ 40 years, BE improved age-related decline in sleep quality and dry mouth. Increased deep sleep and reduced sleepiness on rising were observed in those with poor sleep quality. No adverse events were reported. BE intake promoted vasodilation and increased skin temperature, decreasing the sleep-onset latency and significantly improving rising sleepiness. The mechanism is attributed to BE's antioxidant and autonomic neuromodulatory effects.</p><p><b>Trial Registration:</b> UMIN-CTR: UMIN000051261</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Susceptibility to Causal Relationship Between Iron Metabolism Disorder Involving Immunocytes and Risk of Pneumonia and Sepsis","authors":"Zhenchao Wu,&nbsp;Taikang Yao,&nbsp;Zhongyu Han,&nbsp;Zilu Wang,&nbsp;Beibei Liu,&nbsp;Ming Lu,&nbsp;Jiajia Zheng,&nbsp;Ning Shen","doi":"10.1002/fsn3.70422","DOIUrl":"https://doi.org/10.1002/fsn3.70422","url":null,"abstract":"<p>Recent studies showed ferritin increase and hemoglobin decrease to COVID-19 severity and sepsis mortality. However, the potential relationship between iron metabolism disorders and susceptibility to pneumonia remains unclear. This study explores the association between iron metabolism disorder and susceptibility to bacterial pneumonia, viral pneumonia, and sepsis. GWAS data from the FinnGen and UK biobank is used for a two-sample Mendelian randomization (MR) analysis, followed by MR meta-analysis. Low serum iron levels were negatively associated with the risk of bacterial pneumonia (OR, 0.85; <i>p</i> = 0.04), influenza pneumonia (OR, 0.86; <i>p</i> = 0.03), and sepsis (OR, 0.81; <i>p</i> = 0.0004). Increased transferrin saturation and decreased total iron-binding capacity were linked to higher risks of bacterial pneumonia and sepsis. Elevated liver iron content correlated positively with susceptibility to bacterial pneumonia (OR, 1.11; <i>p</i> = 0.007), influenza pneumonia (OR, 1.08; <i>p</i> = 0.03), and sepsis (OR, 1.13; <i>p</i> = 0.0007), but negatively with pneumococcal pneumonia (OR, 37.62; <i>p</i> = 0.0013). Neutrophils mediated the impact of serum iron and transferrin saturation on susceptibility to bacterial pneumonia and sepsis. This MR study confirms that disruptions in iron metabolism, including low serum iron levels and elevated liver iron content, increase susceptibility to bacterial and viral pneumonia as well as sepsis by affecting neutrophil function and cytokine levels. The findings emphasize the need for monitoring iron metabolism indicators in high-risk populations and provide valuable insights for further mechanistic research and clinical intervention.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70422","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Buckwheat and Rosemary as Antioxidants in Soybean Oil: Comparison With Synthetic Antioxidant","authors":"Behnam Alizadeh-Salmani,&nbsp;Masoumeh Arab,&nbsp;Jalal Sadeghizadeh-yazdi,&nbsp;Mojtaba Yousefi,&nbsp;Sara Jambarsang","doi":"10.1002/fsn3.70416","DOIUrl":"https://doi.org/10.1002/fsn3.70416","url":null,"abstract":"<p>This study examines the antioxidant potential of buckwheat and rosemary as an alternative to synthetic antioxidants in the oil industry. The methanolic extracts were analyzed for total phenol and flavonoid content, as well as antioxidant activity using the FRAP and DPPH methods. These extracts, along with the synthetic antioxidant TBHQ, were incorporated into soybean oil at varying concentrations (0 + 800, 200 + 600, 400 + 400, 600 + 200, 800 + 0 ppm (buckwheat + rosemary) and 50 and 75 ppm TBHQ) and oxidation tests conducted during 35 days storage at 60°C. Results showed that the extract of 800 ppm rosemary had the highest levels of phenolic (82.53 ± 6.39 mg GAE/g DW) and flavonoid (37.88 ± 3.08 mg RE/g DW) compounds. Antioxidant capacity of rosemary and buckwheat (800 ppm) were not significantly different from the TBHQ. Oil treatments with 800 ppm rosemary and buckwheat were more effective in postponing oxidation than the combination treatments. Oil samples with 800 ppm natural extracts were combined with synthetic antioxidant TBHQ at concentrations of 75 and 50 ppm, and oxidation indexes were evaluated. Findings demonstrated that this combination had a synergistic effect in postponing oxidation. The most effective treatment was 800 ppm buckwheat extract combined with 75 ppm of TBHQ for delaying oxidation.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70416","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifactorial Optimization of Gluten-Free Cookie With Artichoke Bracts as Rice Flour Substitute and Transglutaminase","authors":"Ceyda Dadalı,&nbsp;Yağmur Özcan,&nbsp;İrem Cansu Ensari","doi":"10.1002/fsn3.70420","DOIUrl":"https://doi.org/10.1002/fsn3.70420","url":null,"abstract":"<p>The disposal of food waste represents a significant concern within the food industry. Artichoke waste accounts for over 80% of the total mass of artichokes, and artichoke bracts are also a significant component of this waste. This study aimed to utilize artichoke bracts as a substitute for rice flour in gluten-free cookies, with a focus on optimizing the usage ratio of rice flour substitute and transglutaminase enzyme. Rice flour substitute, designated as an independent variable, was configured within the range of 0%–30%, while transglutaminase was set at 0%–1% using a Face Centered Central Composite Design. The optimization process resulted in gluten-free cookies containing 18.65% artichoke bracts as a rice flour substitute and 0.99% transglutaminase enzyme. The study established that the optimum gluten-free cookie exhibited higher antioxidant activity (2.89 μmol TE/g) and total phenolic content (0.74 mg GAE/g) and could be categorized as a high fiber content food (7.97 g/100 g), in comparison to the control gluten-free cookie (<i>p</i> &lt; 0.05). Furthermore, an increase was observed in the hardness (23.38 N) and fracturability (42.21 mm) values of the optimum gluten-free cookie (<i>p</i> &lt; 0.05). While <i>L</i>* and <i>b</i>* values from the color properties were lower than the control gluten-free cookie, the <i>a</i>* value was higher (<i>p</i> &lt; 0.05). The artichoke bracts and transglutaminase enzyme were effective in the development of the sensory properties (color, texture, flavor, and overall acceptability) of gluten-free cookies. This study demonstrated that artichoke bracts and transglutaminase can enhance the quality of gluten-free cookies while concurrently promoting sustainable food production and generating a value-added product by utilizing artichoke bracts as a substitute for rice flour.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Thermal Food Processing for Plant Protein Allergenicity Reduction: A Systematic Review","authors":"Susana Arteaga-Marin,&nbsp;Dona Ayala-Larrea,&nbsp;Anaberta Cardador-Martínez,&nbsp;Carmen Tellez-Perez,&nbsp;Juan Alberto Resendiz-Vazquez,&nbsp;Maritza Alonzo-Macias","doi":"10.1002/fsn3.70430","DOIUrl":"https://doi.org/10.1002/fsn3.70430","url":null,"abstract":"<p>The global incidence of food allergies has increased in the last decade. Compared with thermal processing techniques, non-thermal food processing poses an effective solution for reducing allergenicity while preserving the nutrient content of the food. This study aims to compile the latest advances in modifying plant allergens through non-thermal technologies. The information presented provides useful references for the potential production of hypoallergenic foods. We searched for original articles and reviews in databases published in English from January 2019 to August 2024. The databases used were ProQuest Central, ASC Journals, SAGE Journals, EBSCO Academic Search Ultimate, ScienceDirect, Web of Science, Springer Link, LILACS, Scopus, Cambridge University Press, and WIPO. Targeted allergen reduction and general protein structural modification were considered eligible for inclusion. Articles that did not determine structural or allergenicity modifications were excluded. Thirty-five original research articles and three patents were included for review. No risk of bias assessment was performed. Results were synthesized manually in tables highlighting the principal results and confidence intervals for quantitative results. Findings indicate that non-thermal processing technologies have the potential to effectively reduce plant protein's immunoreactivity by more than 50% compared to untreated plants when adequate conditions are selected. Allergenicity reduction is most probably achieved through protein structural modifications. Therefore, evidence of changes in secondary and tertiary structures produced after non-thermal processing could represent the potential to use these techniques for future research on producing hypoallergenic foods. However, there are limitations in this relation as the structural changes could still not be sufficient to destroy protein epitopes or generate new antigenic sites. Treatments should be optimized for maximum immunoreactivity reduction while maintaining the plant's nutritional value and organoleptic properties.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70430","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2′-Fucosyllactose Modulates the Intestinal Immune Response to Gut Microbiota and Buffers Experimental Colitis in Mice: An Integrating Investigation of Colonic Proteomics and Gut Microbiota Analysis","authors":"Jiamin Dong,&nbsp;Minyan Qian,&nbsp;Dong Zhou,&nbsp;Aoshuang Zhu,&nbsp;Wenting Zhang","doi":"10.1002/fsn3.70418","DOIUrl":"https://doi.org/10.1002/fsn3.70418","url":null,"abstract":"<p>Inflammatory bowel disease (IBD), a recurrent gastrointestinal disease, is characterized by dysbiosis and inflammation. 2′-fucosyllactose (2′-FL) shows benefits in maintaining gut microenvironment homeostasis. This study aims to investigate the protective mechanism of 2′-FL against experimental IBD using integrated analysis of colonic proteomics and microbiota 16S rRNA sequencing technologies. A murine model of experimental colitis was induced by dextran sodium sulfate (DSS) for 7 days (day 0-day 7). 2′-FL (250 mg/kg/d) was orally administered for 7 days. On day 7, all mice were sacrificed and their colon tissues were collected for morphological examination and label-free quantitative proteomics analysis. The fecal samples were collected for microbiota 16S rRNA sequencing. 2′-FL significantly ameliorated DSS-induced pathological damage and restored the epithelial integrity of colon tissues in mice. Colonic proteomics and GO analysis showed 681 differentially expressed proteins (DEPs) in response to 2′-FL administration. These DEPs were mainly enriched to GO terms of <i>response to bacterium</i> and <i>acute-phase response</i>. In addition, 2′-FL reversed the compensatory increase of haptoglobin, serpina3n, Arg2 and Reg3. It also reduced the accumulation of pro-oxidant indicator Cyp2e1, in the colon of colitis mice. Moreover, 2′-FL ameliorated colonic dysbiosis by suppressing the overgrowth of pathogenic <i>Proteobacteria</i> and reversed the reduction in abundance of prebiotic bacterial genus including <i>Lachnospiraceae_NK4A136_group</i>. Notably, the expression of Arg2 and Cyp2e1 showed strong correlation; Reg3b and Reg3g were significantly associated with <i>Lactobacillus</i>. 2′-FL prevented DSS-induced intestinal inflammatory damage through exerting prebiotic capacity and regulating the intestinal immune response to gut microbiota.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderating Role of Multiple Screen Addiction on High Body Mass","authors":"Burak Mete,&nbsp;Hakan Demirhindi,&nbsp;Tuba Makca","doi":"10.1002/fsn3.70383","DOIUrl":"https://doi.org/10.1002/fsn3.70383","url":null,"abstract":"<p>Today, the increasing use of multiple media has led to an increase in the concern of screen addiction. This study aimed to evaluate the direct and indirect dimensions of the relationship between multiple screen addiction and body mass. This cross-sectional study was conducted on 728 university students. The Multiple Screen Addiction Scale, the Hedonistic Eating Scale, and the International Physical Activity Questionnaire were used to measure screen addiction and its effects. Direct and indirect factors were analyzed to evaluate the relationship between screen addiction and body mass index (BMI). The mean age of the students included in the study was 20.78± 3.94 years (min. 18—max. 54). The prevalence of multiple screen addiction was 13%. It was found that hedonic eating scale scores were higher in people with multiscreen addiction. While there was a weak positive correlation between the multiscreen addiction score and hedonistic eating, no significant correlation was found between BMI and physical activity level. Logistic regression analysis showed that the direct effect of multiscreen addiction on BMI was not significant. Multiscreen addiction was an important moderator in the relationship between hedonistic eating and BMI; increasing the mean of multiscreen addiction by one standard deviation led to an increase of 0.073 units in BMI. The moderator effect of multiscreen addiction was significant at high addiction scores. The direct and moderator effects of physical activity on BMI were not found to be significant. High levels of multiple screen addiction are an important moderator in the relationship between high BMI and hedonistic eating. Elucidating the relationship between screen addiction and hedonia will help solve the problem.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Therapeutic Potential of Probiotics in Sepsis: A Review","authors":"Zhaopeng Wang,&nbsp;Jiaqi Huang,&nbsp;Peng Zhao","doi":"10.1002/fsn3.70364","DOIUrl":"https://doi.org/10.1002/fsn3.70364","url":null,"abstract":"<p>Sepsis continues to be among the most significant causes of mortality and morbidity globally, as defined by an exaggerated host response to infection resulting in a peak of systemic inflammation, organ dysfunction, and unnecessary mortality. The many complexities of sepsis, such as its pathophysiology, current treatments, and its evolving place within nutrition care, are debated. The major etiologies of sepsis are bacterial, viral, and fungal infections leading to an inappropriate immune response with cytokine storm, endothelial damage, and multiorgan failure. Although there has been advancement in medical management, the current treatment approaches, like antibiotic therapy, fluid therapy, and organ support, are insufficient to decrease mortality; therefore, there is a pressing need for effective treatment. Current studies target the central position of nutrition in sepsis treatment, that is, gut microbiota in immune function and systemic inflammation. Nutritional treatment, encompassing enteral and parenteral nutrition, is designed to support metabolic homeostasis, boost immune resistance, and modulate catabolic stress in critically ill patients. The gut-sepsis axis is also emphasized, since dysbiosis and intestinal barrier dysfunction lead to systemic inflammation and aggravate sepsis outcomes. Recent evidence indicates that probiotics can provide adjunct benefits via gut microbiota manipulation, immune system augmentation, and anti-inflammatory effects. This review accentuates the requirement for integrative therapeutic strategies in the form of conventional sepsis treatment augmented by specific nutritional interventions to optimize patient survival and recovery. Follow-up studies must focus on improving individualized nutrition therapy, clarifying the role of gut microbiota in the pathogenesis of sepsis, and finding new therapeutic targets for preventing complications of sepsis.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70364","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}