Food Science & Nutrition最新文献

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Dietary Supplementation With Yeast Cell Wall Modulates Gut Microbiota and SCFAs Production to Improve Intestinal Health in Adult Cats 饲粮中添加酵母细胞壁可调节肠道微生物群和短链脂肪酸的产生,改善成年猫肠道健康
IF 3.8 2区 农林科学
Food Science & Nutrition Pub Date : 2025-09-26 DOI: 10.1002/fsn3.71007
Xiaoxi Liu, Haotian Wang, Yuqing Lu, Guoqing Jin, Le Fu, Hongxia Mao, Yi Wu, Pan Liu
{"title":"Dietary Supplementation With Yeast Cell Wall Modulates Gut Microbiota and SCFAs Production to Improve Intestinal Health in Adult Cats","authors":"Xiaoxi Liu,&nbsp;Haotian Wang,&nbsp;Yuqing Lu,&nbsp;Guoqing Jin,&nbsp;Le Fu,&nbsp;Hongxia Mao,&nbsp;Yi Wu,&nbsp;Pan Liu","doi":"10.1002/fsn3.71007","DOIUrl":"https://doi.org/10.1002/fsn3.71007","url":null,"abstract":"<p>Yeast cell wall (YCW) has shown several probiotic activities, including modifying intestinal flora structure, decreasing the abundance of pathogenic bacteria, and regulating intestinal morphology. However, the effect of dietary addition of YCW on intestinal health in cats has not been fully studied. In this study, 20 healthy adult cats were split into a control group (CON) and a YCW addition group (YCW) for a 42-day trial. On Day 21 of the experiment, the fecal Calprotectin level in the YCW group was significantly lower than that in the control group (<i>p</i> &lt; 0.05). By measuring the content of short-chain fatty acids (SCFAs), we found that YCW supplementation elevated the propionate level in cats' feces (<i>p</i> &lt; 0.05). On Day 42 of the experiment, the serum levels of interleukin-1β (IL-1β) and diamine oxidase (DAO), as well as the fecal level of Calprotectin, were markedly declined in the YCW group when compared to the control group (<i>p</i> &lt; 0.05). We further discovered that the YCW treatment significantly enriched several intestinal beneficial genera in cats, such as Bacteroidaceae, Ruminococcaceae, <i>Blautia</i>, and <i>Lachnoclostridium</i> (<i>p</i> &lt; 0.05). Additionally, cats in the YCW group showed higher levels of acetate and propionate (<i>p</i> &lt; 0.05). This study suggested that ingestion of YCW could relieve intestinal inflammation and enhance intestinal barrier function in cats, which may be related to its capacity to enhance the gut microbiota composition and the SCFAs concentrations.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.71007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trans-Fatty Acids (TFA) Induced Vascular Injury Through the Regulation of the Sirt1-Ppargc1a-Nfe2l2 Signaling Pathway in Male Rats 反式脂肪酸通过调节Sirt1-Ppargc1a-Nfe2l2信号通路诱导雄性大鼠血管损伤
IF 3.8 2区 农林科学
Food Science & Nutrition Pub Date : 2025-09-26 DOI: 10.1002/fsn3.70975
Huanting Pei, Ran Li, Yadong Zhang, Xiaoya Sun, Siqi Zhu, Simeng Qiao, Chongyue Zhang, Xiaolong Zhang, Jingyi Ren, Yuxia Ma
{"title":"Trans-Fatty Acids (TFA) Induced Vascular Injury Through the Regulation of the Sirt1-Ppargc1a-Nfe2l2 Signaling Pathway in Male Rats","authors":"Huanting Pei,&nbsp;Ran Li,&nbsp;Yadong Zhang,&nbsp;Xiaoya Sun,&nbsp;Siqi Zhu,&nbsp;Simeng Qiao,&nbsp;Chongyue Zhang,&nbsp;Xiaolong Zhang,&nbsp;Jingyi Ren,&nbsp;Yuxia Ma","doi":"10.1002/fsn3.70975","DOIUrl":"https://doi.org/10.1002/fsn3.70975","url":null,"abstract":"<p>Dietary trans-fatty acids (TFA) elevate cardiovascular disease (CVD) risk by driving vascular injury, yet the mechanisms underlying this effect remain largely unexplored. Eighteen male Sprague–Dawley (SD) rats were randomly assigned to three groups: control group, a low-dose TFA diet group, and a high-dose TFA diet group. During the 12-week experiment, body weight, food intake, and blood pressures were monitored. Post-experiment, serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were quantified using assay kits. Network pharmacology, molecular docking, and western blotting were employed to predict and validate the toxicological mechanisms underlying TFA-induced vascular injury. TFA significantly induced mitochondrial damage in the vascular tissues of rats. TFA consumption increased serum TC, TG, and LDL-C levels while reducing HDL-C levels in rats. Network pharmacology analysis revealed significant enrichment in apoptotic pathways, highlighting the pivotal roles of Sirt1, Ppargc1a, and Nfe2l2 in the mechanistic network underlying TFA-induced vascular injury. Furthermore, molecular docking and western blotting analyses validated substantial changes in protein expression linked to apoptosis and the Sirt1-mediated signaling pathway. TFA induces mitochondrial damage, elevating reactive oxygen species levels and triggering vascular apoptosis in rats. This process is mediated by modulation of the Sirt1/Ppargc1a/Nfe2l2 signaling pathway. These findings clarify a critical mechanism of TFA-induced vascular injury, highlighting dietary TFA as a modifiable risk factor for cardiovascular health.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70975","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exocarpium Citri Grandis Attenuates Lipopolysaccharide-Induced Acute Liver Injury Through Suppression of Inflammatory, Apoptotic, Oxidative, and Ferroptotic Pathways 柑桔外皮通过抑制炎症、凋亡、氧化和嗜铁途径减轻脂多糖诱导的急性肝损伤
IF 3.8 2区 农林科学
Food Science & Nutrition Pub Date : 2025-09-26 DOI: 10.1002/fsn3.71012
Guoni Zhang, Jiayu Li, Zaibin Xu, Kaili Zhou, Xinyi Zhao, Xiaoqin Wu, Chao Liang, Zhijun Lai, Yi Cheng, Cong Meng, Jiawen Huang, Zhitong Deng
{"title":"Exocarpium Citri Grandis Attenuates Lipopolysaccharide-Induced Acute Liver Injury Through Suppression of Inflammatory, Apoptotic, Oxidative, and Ferroptotic Pathways","authors":"Guoni Zhang,&nbsp;Jiayu Li,&nbsp;Zaibin Xu,&nbsp;Kaili Zhou,&nbsp;Xinyi Zhao,&nbsp;Xiaoqin Wu,&nbsp;Chao Liang,&nbsp;Zhijun Lai,&nbsp;Yi Cheng,&nbsp;Cong Meng,&nbsp;Jiawen Huang,&nbsp;Zhitong Deng","doi":"10.1002/fsn3.71012","DOIUrl":"https://doi.org/10.1002/fsn3.71012","url":null,"abstract":"<p>This study aimed to elucidate the therapeutic mechanisms of Exocarpium Citri Grandis (ECG) against lipopolysaccharide (LPS)-induced acute liver injury (ALI) using an integrated approach combining network pharmacology and experimental validation. The chemical profile of ECG was characterized via UHPLC-Q-Exactive MS. Male C57BL/6J mice were employed to establish an LPS-induced ALI murine model for evaluating hepatoprotective effects of ECG. Serum AST/ALT levels, histopathology changes, and inflammatory, apoptotic, oxidative, and ferroptotic markers were analyzed. Additionally, network pharmacology was used to identify the targets and pathways of ECG, while molecular docking validated interactions between bioactive compounds and key regulatory molecules. ECG treatment significantly reduced serum AST/ALT levels (<i>p</i> &lt; 0.05–0.001) and alleviated hepatic inflammation and necrosis. Moreover, qPCR and Western blotting revealed that ECG markedly downregulated pro-inflammatory cytokines (IL-6, IL-1β, TNFα), inhibited cellular inflammation by downregulating the expression of proteins related to the TLR4/MyD88 pathway, counteracted oxidative stress by increasing Nrf2 nuclear translocation and the expression of genes such as NQO1, GCLC, and GCLM, suppressed apoptosis via modulation of Bax/Bcl2/CASP3, and inhibited ferroptosis by normalizing iron content and GPX4/SLC7A11 expression. Network pharmacology identified 127 shared targets between ECG and sepsis, highlighting critical pathways including TNF, p53, and IL-17 signaling. Molecular docking confirmed strong binding affinities (e.g., naringin with TP53: −13.23 kcal/mol) between ECG-derived flavonoids and coumarins with apoptosis and inflammation regulators. ECG mitigates LPS-induced ALI through coordinated anti-inflammatory, anti-apoptotic, anti-oxidative, and anti-ferroptotic mechanisms, mediated via multi-target modulation of critical pathways. These findings underscore the potential of ECG as a natural therapeutic candidate for ALI, thus warranting further clinical exploration.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.71012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Phytochemical Screening and Antidiabetic Potential of Paeonia emodi in Alloxan-Induced Diabetic Rats: Investigative Study Toward Possible Mechanism” 对“四氧嘧啶诱导的糖尿病大鼠的植物化学筛选和降糖潜力:可能机制的调查研究”的更正
IF 3.8 2区 农林科学
Food Science & Nutrition Pub Date : 2025-09-26 DOI: 10.1002/fsn3.71033
{"title":"Correction to “Phytochemical Screening and Antidiabetic Potential of Paeonia emodi in Alloxan-Induced Diabetic Rats: Investigative Study Toward Possible Mechanism”","authors":"","doi":"10.1002/fsn3.71033","DOIUrl":"https://doi.org/10.1002/fsn3.71033","url":null,"abstract":"<p>Fan, J., M. Ibrar, M. A. Khan, et al. 2025. “Phytochemical Screening and Antidiabetic Potential of <i>Paeonia emodi</i> in Alloxan-Induced Diabetic Rats: Investigative Study Toward Possible Mechanism.” <i>Food Science &amp; Nutrition</i> 13, no. 9: e70870. https://doi.org/10.1002/fsn3.70870.</p><p>In section 3.9. “Liver function tests,” the sentence “Animals treated with Pe.BT 150 mg/kg reduced the levels of ALT, AST, and ALP to 68.74 ± 1.06, 83.85 ± 1.33, 223.98 ± 3.02 U/L and decreased the serum level of TP to 06.03 ± 0.73 g/dL.” was incorrect; this should have read as “Animals treated with Pe.BT 150 mg/kg reduced the levels of ALT, AST, and ALP to 228 ± 1.06 U/L, 223.85 ± 1.33 U/L, and 323.98 ± 3.02 U/L and decreased the serum level of TP to 06.92 ± 0.64 g/dl.”</p><p>We apologize for these errors.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.71033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eco-Friendly Innovation: Biodegradable and Oil-Resistant Bags From Lotus halophilus Extract, Polyvinyl Alcohol, and Guar Gum for Sustainable Food Packaging 环保创新:可生物降解和耐油袋,由莲花盐嗜菌提取物、聚乙烯醇和瓜尔胶制成,可用于可持续食品包装
IF 3.8 2区 农林科学
Food Science & Nutrition Pub Date : 2025-09-26 DOI: 10.1002/fsn3.71017
Osama Magouz, Eman Fayed, Khadija S. Radhi, Fayez Althobaiti, Ahmed Aboueloyoun Taha, Reham M. Kamel, Lamiaa I. El-Nawasany, Mohamed Abdin, Diaeldin Omer Abdelkarim, Yahya S. Hamed, Mahmoud Younis
{"title":"Eco-Friendly Innovation: Biodegradable and Oil-Resistant Bags From Lotus halophilus Extract, Polyvinyl Alcohol, and Guar Gum for Sustainable Food Packaging","authors":"Osama Magouz,&nbsp;Eman Fayed,&nbsp;Khadija S. Radhi,&nbsp;Fayez Althobaiti,&nbsp;Ahmed Aboueloyoun Taha,&nbsp;Reham M. Kamel,&nbsp;Lamiaa I. El-Nawasany,&nbsp;Mohamed Abdin,&nbsp;Diaeldin Omer Abdelkarim,&nbsp;Yahya S. Hamed,&nbsp;Mahmoud Younis","doi":"10.1002/fsn3.71017","DOIUrl":"https://doi.org/10.1002/fsn3.71017","url":null,"abstract":"<p>Clear or improperly designed packaging can allow nonconvenient conditions to degrade the oil, leading to rancidity and loss of flavor. Biodegradable and effective packaging solutions are essential to maintaining the quality of olive oil and extending its shelf life. This study aimed to examine the production of biodegradable small sachets utilizing a blend of polyvinyl alcohol (PVA), Guar Gum (GG), and pure extract of <i>Lotus halophiles</i> (LHE). The study assessed these films' color, mechanical, thermal, and crystallinity characteristics, and their physical and surface shape. According to the findings, adding LHE up to a 1% concentration produced an opaque hue and raised the opacity to 4.132. Furthermore, the films exhibited reduced moisture content (9.87%), solubility (18.71%), water contact angle (WCA) (84.1%), and water vapor permeability (<i>WVP</i>) (2.121 × 10<sup>−10</sup> g.m<sup>−1</sup> s<sup>−1</sup> pa<sup>−1</sup>). Incorporating 1% LHE led to smoother film surfaces, while higher concentrations (1.5% of LHE) resulted in rougher surfaces. Fourier transform infrared (FT-IR) analyses verified that the PG matrix and the LHE extract physically interacted. The films also demonstrated excellent thermal stability; adding LHE enhanced their storage capacity to maintain olive oil quality.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 10","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.71017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GC–MS Profiling and In Vitro and Silico Evaluation of Biological Propensities of Saudi Cultivar of Sugar Apple (Annona squamosa L.): A Preliminary Multidimensional Approach for the Development of Nutraceuticals 沙特苹果品种的GC-MS分析及生物倾向的体外和计算机评价:为营养品开发提供初步的多维途径
IF 3.8 2区 农林科学
Food Science & Nutrition Pub Date : 2025-09-24 DOI: 10.1002/fsn3.70723
Hanan Y. Aati, Renad Al-Arifi, Chitchamai Ovatlarnporn, Khloud AlYami, Abdul Rauf, Abdul Basit, Huma Rao, Maria Batool, Kashif ur Rehman Khan
{"title":"GC–MS Profiling and In Vitro and Silico Evaluation of Biological Propensities of Saudi Cultivar of Sugar Apple (Annona squamosa L.): A Preliminary Multidimensional Approach for the Development of Nutraceuticals","authors":"Hanan Y. Aati,&nbsp;Renad Al-Arifi,&nbsp;Chitchamai Ovatlarnporn,&nbsp;Khloud AlYami,&nbsp;Abdul Rauf,&nbsp;Abdul Basit,&nbsp;Huma Rao,&nbsp;Maria Batool,&nbsp;Kashif ur Rehman Khan","doi":"10.1002/fsn3.70723","DOIUrl":"https://doi.org/10.1002/fsn3.70723","url":null,"abstract":"<p><i>Annona squamosa L.</i>, commonly known as sugar apple or custard apple, is a well-known medicinal plant recently introduced for cultivation in Saudi Arabia. However, the pharmaceutical potential of the Saudi cultivar remains unexplored. This study aimed to evaluate the phytochemical composition and biological activities of the ethanolic extract of Saudi <i>A. squamosa</i> fruit (EASF) through comprehensive in vitro and in silico analyses. Phytochemical screening revealed a high content of phenolics, flavonoids, and tannins.GC-MS analysis identified 34 bioactive compounds, including fatty acid esters and terpenoids. EASF exhibited strong anti-oxidant activity, particularly in the ABTS assay, and demonstrated significant thrombolytic potential (90.21% ± 0.90%) along with moderate hemolytic activity (14.1% ± 1.01%). Notably, the extract showed effective antibacterial activity against <i>Staphylococcus epidermidis</i> with an inhibition zone of 11 mm at 150 mg/mL. Enzyme inhibition assays revealed potent activity against urease (95.65%), tyrosinase (85.50%), and α-amylase (47.88%). In silico molecular docking supported these findings, with selected phytoconstituents showing strong binding affinities toward the target enzymes. ADMET profiling further confirmed their drug-like properties. These results suggest that the Saudi cultivar of <i>A. squamosa</i> possesses significant therapeutic potential and may serve as a promising candidate for developing nutraceuticals and pharmaceutical agents.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70723","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Interplay Between Picky Eating, Other Eating Behaviors, and Obesity Indicators in Preschool Children 学龄前儿童挑食、其他饮食行为与肥胖指标的相互作用
IF 3.8 2区 农林科学
Food Science & Nutrition Pub Date : 2025-09-24 DOI: 10.1002/fsn3.70967
Melika Mahmoudizadeh, Mina Babashahi, Milad Rajabzadeh-Dehkordi, Mehran Nouri, Shiva Faghih
{"title":"The Interplay Between Picky Eating, Other Eating Behaviors, and Obesity Indicators in Preschool Children","authors":"Melika Mahmoudizadeh,&nbsp;Mina Babashahi,&nbsp;Milad Rajabzadeh-Dehkordi,&nbsp;Mehran Nouri,&nbsp;Shiva Faghih","doi":"10.1002/fsn3.70967","DOIUrl":"https://doi.org/10.1002/fsn3.70967","url":null,"abstract":"<p>Picky eating (PE) during early childhood strongly affects children's food preferences. This research aimed to assess the association of eating behaviors with obesity indices among preschoolers. Our cross-sectional analysis included 436 pre-school children. For data collection, parents were interviewed face-to-face, using the Child Eating Behavior Questionnaire and the Food Frequency Questionnaire for children eating behaviors and dietary intakes, respectively. Additionally, their BMI-for-age <i>z</i>-score, waist circumference, and waist-to-height ratio were measured. The association between eating behaviors and obesity indicators was evaluated via logistic regression models. The prevalence of overweight and obesity (OW/OB) was 12.4%. Higher intake of ultra-processed foods and lower intakes of energy and staple meals were found among children with high PE. PE was associated with 76%, 67%, and 60% lower risk of OW/OB, abdominal, and central obesity, respectively (OR = 0.238, 95% CI 0.135–0.420 OW/OB; OR = 0.332, 95% CI 0.220–0.502 abdominal obesity; OR = 0.398, 95% CI 0.278–0.571 central obesity). All food avoidance behaviors were negatively associated with the three obesity indicators. In contrast, food approach behaviors, except for desire to drink, had positive associations with obesity risk. All three obesity indicators were negatively associated with PE and food avoidance behaviors but positively associated with food approach behaviors. Since picky eaters commonly have unhealthy diets, being attentive to children's emotional and sensory challenges during mealtime could help nurture a healthier relationship with food.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70967","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applicability of Hibiscus sabdariffa L. Extract With Anti-Inflammatory Potential in Human Health: A Review 具有抗炎作用的芙蓉提取物在人体健康中的适用性综述。
IF 3.8 2区 农林科学
Food Science & Nutrition Pub Date : 2025-09-23 DOI: 10.1002/fsn3.70938
Anne Caroline Silva Nogueira da Cruz, Michelline Joana Tenório Albuquerque Madruga Mesquita, Guilherme kauan Rocha Dantas, Eduardo Rodrigues Silva, Victória Carvalho Falcone De Oliveira, Heitor Martins Rezende, Gustavo Medeiros Frota, Mariana Cavalcante, José Renzo Castro Garcês, Marcelo Souza de Andrade, Maria do Socorro de Sousa Cartagenes
{"title":"Applicability of Hibiscus sabdariffa L. Extract With Anti-Inflammatory Potential in Human Health: A Review","authors":"Anne Caroline Silva Nogueira da Cruz,&nbsp;Michelline Joana Tenório Albuquerque Madruga Mesquita,&nbsp;Guilherme kauan Rocha Dantas,&nbsp;Eduardo Rodrigues Silva,&nbsp;Victória Carvalho Falcone De Oliveira,&nbsp;Heitor Martins Rezende,&nbsp;Gustavo Medeiros Frota,&nbsp;Mariana Cavalcante,&nbsp;José Renzo Castro Garcês,&nbsp;Marcelo Souza de Andrade,&nbsp;Maria do Socorro de Sousa Cartagenes","doi":"10.1002/fsn3.70938","DOIUrl":"10.1002/fsn3.70938","url":null,"abstract":"<p>Studies demonstrate the health benefits of <i>H. sabdariffa</i> L., highlighting its anti-inflammatory activity. Therefore, it is essential to expand studies on this plant and its various applications, aiming to maximize its benefits for human health, especially through the use of the bioactive compounds present in <i>Hibiscus sabdariffa</i> L. To prepare this review article, we conducted a literature search through virtual libraries of scientific articles, such as LILACS, PUBMED, and BVS, using the following descriptors: <i>Hibiscus sabdariffa</i> L. and anti-inflammatory. The selected publications cover the period 2019 to 2024 (5 years). A total of 25 articles were found, distributed as follows: PUBMED: 24 articles, of which 11 were excluded. The exclusion was because these articles did not meet the research objective or were review articles that did not meet the established criteria. No articles were found in the LILACS database, indicating that the search did not return relevant results within the search criteria. One article was found in the VHL database, but it was excluded due to duplication with an article already found in the PUBMED database. Analysis of the studies selected in the scientific database highlights the benefits of using <i>Hibiscus sabdariffa</i> L. in the treatment of various pathologies, such as degenerative diseases, intestinal dysfunctions, and atherosclerosis, among others, with a particular emphasis on its anti-inflammatory activities. However, the results did not demonstrate benefits in a study focused on wound healing, indicating that further studies are needed to investigate its specific application.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetes-Specific Serum Calcium Thresholds for Mortality Risk: A NHANES Nutritional Epidemiology Study 死亡风险的糖尿病特异性血清钙阈值:一项NHANES营养流行病学研究
IF 3.8 2区 农林科学
Food Science & Nutrition Pub Date : 2025-09-23 DOI: 10.1002/fsn3.71034
Ling Li, Shuangyu Yang, Xiao Ran, Sudong Liu
{"title":"Diabetes-Specific Serum Calcium Thresholds for Mortality Risk: A NHANES Nutritional Epidemiology Study","authors":"Ling Li,&nbsp;Shuangyu Yang,&nbsp;Xiao Ran,&nbsp;Sudong Liu","doi":"10.1002/fsn3.71034","DOIUrl":"https://doi.org/10.1002/fsn3.71034","url":null,"abstract":"<p>This retrospective cohort study aimed to characterize diabetes-stratified associations between serum calcium levels and all-cause, cardiovascular (CVD), and cancer mortality, addressing a critical gap in nutritional epidemiology. Leveraging the National Health and Nutrition Examination Survey (NHANES) database, we conducted Cox proportional hazards regression with restricted cubic splines to model non-linear calcium–mortality relationships. Mediation analysis was conducted in diabetes. The T2DM group presented a J-shaped relationship, with relatively stable and low mortality risk at lower calcium concentrations, followed by a significant increase at higher concentrations. In contrast, the group without diabetes exhibited a U-shaped relationship, indicating that both low and high serum calcium levels are associated with increased mortality risk, with an optimal range in the middle where the risk is minimized. Mediation analysis indicated that, in individuals with T2DM, the relationship between serum calcium levels and mortality was partially mediated by markers of renal function and total cholesterol. Our findings support personalized calcium monitoring as a cost-effective strategy in diabetic care. Serum calcium thresholds for mortality risk differ fundamentally by diabetes status, underscoring the need for precision nutrition strategies. Integration of calcium monitoring into routine diabetic care—particularly targeting high-risk subgroups—may mitigate mortality.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.71034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional Traits and Physicochemical Parameters of Dry Aged-In-Bag and Cooked Serpentina Goat Meat 干制袋装陈化和熟制蛇纹山羊肉的营养特性和理化参数
IF 3.8 2区 农林科学
Food Science & Nutrition Pub Date : 2025-09-23 DOI: 10.1002/fsn3.70538
Menalda V. André, Vítor D. Alves, Catarina Prista, Luísa L. Martins, Mariana Mota, Miguel P. Mourato, André M. de Almeida, Rui J. B. Bessa, Susana P. Alves, Teresa J. S. Matos
{"title":"Nutritional Traits and Physicochemical Parameters of Dry Aged-In-Bag and Cooked Serpentina Goat Meat","authors":"Menalda V. André,&nbsp;Vítor D. Alves,&nbsp;Catarina Prista,&nbsp;Luísa L. Martins,&nbsp;Mariana Mota,&nbsp;Miguel P. Mourato,&nbsp;André M. de Almeida,&nbsp;Rui J. B. Bessa,&nbsp;Susana P. Alves,&nbsp;Teresa J. S. Matos","doi":"10.1002/fsn3.70538","DOIUrl":"https://doi.org/10.1002/fsn3.70538","url":null,"abstract":"<p><i>Serpentina</i> goat is an autochthonous breed from the Alentejo region in Southern Portugal. Meat from kids is a low-fat protein food that meets consumer demand for healthier and leaner meat options. However, meat from older and heavier animals is less appreciated and often sold at low prices or processed. To promote adult goat meat value, a dry aging process in a bag permeable to water vapor was applied. Effects of aging on cooking loss and of aging and cooking on nutritional properties (minerals, protein, ashes, water content, fatty acids and total fat), pH, color, water activity, nutritional claims, reference intakes and nutrition declaration were investigated. <i>Longissimus thoracis et lumborum</i> from five female goats at the end of productive life (8–12 years) were aged 46 days at 2°C ± 2°C and 60%–90% relative humidity. Samples were analyzed after aging, trimming, and cooking in an oven at 150°C until core temperature reached 68°C. Both aging (yield of 72.61% ± 15.2%) and thermal processing led to increased pH values. Aged meat exhibited higher lightness and redness values than regular meat, but cooking increased brightness. In what concerns minerals, potassium content decreased significantly with aging (from 339 to 258 mg/100 g fresh weight), but did not significantly change when cooking the aged meat. The same was observed for magnesium, decreasing only with aging (from 24.7 to 15.2 mg/100 g fresh weight). Minerals like Ca, S and Cu did not change significantly with both processes. A higher concentration of total fatty acids was observed in aged meat, but cooking equalized values between meat samples, with 18:1c9 being the predominant. The n-6/n-3 ratio remained within recommended limits (&lt; 4), generally recognized to have a positive impact on the human diet. Regarding nutritional claims, according to the Regulation (EC) n° 1924 (2006), <i>Serpentina</i> chevon can be considered as “high protein” and as “low saturated fat” food, with exception for the raw aged meat, slightly above the regulatory limit of 1.5/100 g of meat (1.645/100 g of meat). Both aging and cooking processes affected meat attributes, providing important information to optimize meat quality and consumer demands.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 9","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70538","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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