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New approaches in the pharmacotherapy of dyslipidemia and atherosclerosis 血脂异常和动脉粥样硬化药物治疗的新途径
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-06-20 DOI: 10.33920/med-13-2303-01
M. Maksimov, K. O. Shnaider, A. A. Zvegintseva
{"title":"New approaches in the pharmacotherapy of dyslipidemia and atherosclerosis","authors":"M. Maksimov, K. O. Shnaider, A. A. Zvegintseva","doi":"10.33920/med-13-2303-01","DOIUrl":"https://doi.org/10.33920/med-13-2303-01","url":null,"abstract":"Cardiovascular diseases are the leading cause of death worldwide. Dyslipidemia is one of the most significant modifiable risk factors for the CVD development and potentiation. The main drugs in the treatment of dyslipidemia in modern clinical practice are statins, although there are other effective hypolipidemic drugs that are gaining popularity, such as ezetimibe, proprotein convertase subtilisin/kexin type inhibitors - PCSK9 inhibitors, antisense oligonucleotide (pelacarsen), small interfering RNA - siRNA (inclisiran), and some others. In real clinical practice, the most effective approach to achieve LDL-C targets is adding ezetimibe to a statin (simvastatin, atorvastatin, rosuvastatin, etc.), rather than titrating the statin dose to the maximum possible. The addition of siRNA to statin therapy resulted in a stable, significant reduction in LDL levels by an average of 50% in all groups compared with statin monotherapy.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88000412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital solutions in pharmaceutical marketing to combat the COVID-19 pandemic 应对COVID-19大流行的药品营销数字解决方案
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-06-20 DOI: 10.33920/med-13-2303-05
K. Koshechkin, I. Marinich, O. Lebed
{"title":"Digital solutions in pharmaceutical marketing to combat the COVID-19 pandemic","authors":"K. Koshechkin, I. Marinich, O. Lebed","doi":"10.33920/med-13-2303-05","DOIUrl":"https://doi.org/10.33920/med-13-2303-05","url":null,"abstract":"The COVID-19 pandemic has had a great impact on many areas of people's lives. States faced the tasks of stopping the spread of the virus, treating the already sick, informing the population, creating vaccines, and much more. In addition to protecting the health of citizens, support for business and production was required. The global spread of the coronavirus affected both the industrial and financial spheres of individual countries, and the entire global economy. Logistics chains of supply of various finished goods and components, including pharmaceutical ones, were disrupted. At the same time, the demand for medicines and other goods of the pharmaceutical market increased, and the production of drugs and vaccines augmented. The market needed new marketing tools: the creation, promotion, and provision of pharmaceutical and medical products. The resulting problems required prompt and modern solutions. Digital solutions were most often used as novel methods in the conditions of isolation and reduction of personal contacts. The pandemic significantly accelerated the change in the approach to marketing and contributed to the rapid transformation of its processes, i.e. digital transformation, both in the management of the pharmaceutical services market and in the field of medical care.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83267180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current state of research in the field of transdermal dosage forms 透皮剂型的研究现状
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-04-05 DOI: 10.33920/med-13-2302-04
V. V. Tokaev
{"title":"Current state of research in the field of transdermal dosage forms","authors":"V. V. Tokaev","doi":"10.33920/med-13-2302-04","DOIUrl":"https://doi.org/10.33920/med-13-2302-04","url":null,"abstract":"Transdermal therapeutic systems (TTS) open up new opportunities for targeted delivery of long-acting drugs. One of the urgent and high-tech problems in the TTS creation has been the search for biocompatible TTS components, including drug transfer activators. Despite the complexity of creating transdermal forms, the number of medicinal substances delivered by percutaneous diffusion is gradually increasing. A significant disadvantage of nifedipine is its low solubility in water, which significantly affects the degree of release of the pharmaceutical substance from the base of the drug. Due to the absence of nifedipine-based transdermal therapeutic systems on the pharmaceutical market, their development in order to improve the biopharmaceutical properties of a pharmaceutical substance is an urgent problem of modern pharmacy.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79350499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Element composition of extracts of common spruce cones 普通云杉球果提取物的元素组成
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-04-05 DOI: 10.33920/med-13-2302-02
D.O. Semakin, D. K. Gulyaev, V. D. Belonogova, A. Soboleva, V. Svetlakova
{"title":"Element composition of extracts of common spruce cones","authors":"D.O. Semakin, D. K. Gulyaev, V. D. Belonogova, A. Soboleva, V. Svetlakova","doi":"10.33920/med-13-2302-02","DOIUrl":"https://doi.org/10.33920/med-13-2302-02","url":null,"abstract":"Trace elements are an integral part of any plant and animal organism.The pharmacological effect of herbal raw materials is due not only to the main active substance, but also to the chemical elements that make up herbal medicinal preparations. Previously, studies were carried out on the wood composition, as well as the polysaccharide complex from spruce cones [1], [2]. The object of this study are common spruce cones harvested on the territory of the Ilyinsky district, Perm Region. The determination of the qualitative and quantitative composition of elements in extracts of common spruce cones was carried out on the X-ray fluorescence QUANT’X spectrometer from Thermo Scientific. The results obtained by the authors demonstrate the content of microelements and ultramicroelements of a fractional extract from the raw material of the studied plant.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89512469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and validation of the dissolution test method for a combination of lamivudine and zidovudine adapted to the requirements of the EAEU pharmacopoeia 拉米夫定与齐多夫定联合溶出度试验方法的开发与验证，以适应EAEU药典的要求
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-04-05 DOI: 10.33920/med-13-2302-01
A. Marakhova, A. M. Kuliková
{"title":"Development and validation of the dissolution test method for a combination of lamivudine and zidovudine adapted to the requirements of the EAEU pharmacopoeia","authors":"A. Marakhova, A. M. Kuliková","doi":"10.33920/med-13-2302-01","DOIUrl":"https://doi.org/10.33920/med-13-2302-01","url":null,"abstract":"The dissolution test is intended to determine the amount of a medicinal substance, which should be released into the dissolution medium from a solid dosage form over a certain period of time under the conditions specified in the pharmacopoeial article for the drug. Developing the method indicated for the combination of antiretroviral drugs lamivudine and zidovudine in a dosage form is crucial as this will allow, along with the assessment of pharmaceutical equivalence, at least an approximate assessment of the bioequivalence of the drug/","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72816968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
State of the art report on wet granulation technology 湿造粒技术的最新进展报告
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-04-05 DOI: 10.33920/med-13-2302-03
V. Bueva, E. V. Blynskaya, K. Alekseev, S. Tishkov, S. V. Minaev
{"title":"State of the art report on wet granulation technology","authors":"V. Bueva, E. V. Blynskaya, K. Alekseev, S. Tishkov, S. V. Minaev","doi":"10.33920/med-13-2302-03","DOIUrl":"https://doi.org/10.33920/med-13-2302-03","url":null,"abstract":"Granulation technologies are commonly used in the production of granular powders and tablets. The main purpose of this technology is to obtain granules, due to which the pharmaceutical substance dosing uniformity and an increase in tapped density essential during transportation and storage are achieved. In addition, it allows minimizing dust formation, thus increasing the safety of the production process. The article presents the results of a theoretical study of recent advances in wet granulation technology, namely, a brief description of the modifications of this technology, accompanied by schematic illustrations of the key stages of the process, as well as the advantages and limitations. of these modifications. The prerequisite for the emergence of alternative modifications of wet granulation technology was the limitations associated with the instability of pharmaceutical substances and the desire to reduce the time frame of the manufacturing process.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"360 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80217820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cetirizine-based soft dosage forms 西替利嗪软剂型
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-02-25 DOI: 10.33920/med-13-2301-05
D. G. Magomedova
{"title":"Cetirizine-based soft dosage forms","authors":"D. G. Magomedova","doi":"10.33920/med-13-2301-05","DOIUrl":"https://doi.org/10.33920/med-13-2301-05","url":null,"abstract":"The development of rational dosage forms with cetirizine is an urgent task. Cetirizine is a second-generation antihistamine. In patients suffering from allergies, the use of cetirizine leads to a significant improvement in the course of the disease. Even in veterinary practice, taking cetirizine orally once a day provides sufficient antihistamine effect in animals. Currently, the following drugs with cetirizine are available: film-coated tablets, orodispersible tablets, as well as drops for oral administration. There are no transdermal dosage forms with cetirizine in Russia. The transdermal therapeutic system (TTS) is a metered-dose soft dosage form for external use in the form of gels, patches, or films, which releases the drug slowly. The TTS advantages are as follows: ease of use, the ability of the medicinal substance to quickly enter the bloodstream, the ability to regulate the release rate of the active substance and use hydrophilic and lipophilic substances. We have developed two transdermal therapeutic systems with cetirizine — a gel and a patch, and studied the pharmacological effects. The purpose of the study. The purpose of this work is to create external dosage forms containing cetirizine. The scientific novelty of the research is the design of formulations for antiallergic dosage. Materials and methods. Technological and pharmacological research methods were used. Results. The study showed that the developed gel and the patch with cetirizine have antiallergic properties comparable to the comparison drug (Psilo-balsam gel), while surpassing the reference drug in its effect on the formation of allergic exudative edema. Conclusion. External dosage forms — a transdermal therapeutic gel and a patch containing cetirizine have been created.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"138 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74131879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Excipients used for the creation of self-emulsifying drug delivery systems 用于制造自乳化药物输送系统的辅料
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-02-25 DOI: 10.33920/med-13-2301-02
D. I. Gavrilov, S. Tishkov, E. V. Blynskaya, K. Alekseev, S. V. Minaev, D.M. Abramova
{"title":"Excipients used for the creation of self-emulsifying drug delivery systems","authors":"D. I. Gavrilov, S. Tishkov, E. V. Blynskaya, K. Alekseev, S. V. Minaev, D.M. Abramova","doi":"10.33920/med-13-2301-02","DOIUrl":"https://doi.org/10.33920/med-13-2301-02","url":null,"abstract":"This review provides a classification of excipients that are used in the creation of self-emulsifying drug delivery systems (SEDDS). The criteria for their selection and their characteristics are also described.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73512059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Main approaches to evaluating the quality of chewable tablets and medicated chewing gums 咀嚼片和含药口香糖质量评价的主要方法
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-02-25 DOI: 10.33920/med-13-2301-01
V. Bueva, E. V. Blynskaya, K. Alekseev, S. Tishkov, S. V. Minaev, M. S. Vykhristyuk
{"title":"Main approaches to evaluating the quality of chewable tablets and medicated chewing gums","authors":"V. Bueva, E. V. Blynskaya, K. Alekseev, S. Tishkov, S. V. Minaev, M. S. Vykhristyuk","doi":"10.33920/med-13-2301-01","DOIUrl":"https://doi.org/10.33920/med-13-2301-01","url":null,"abstract":"Chewable tablets and medicated chewing gums are currently gaining importance in the pharmaceutical market due to their numerous advantages such as the ease of use, rapid onset of pharmacological effect, and high patients’ compliance, in particular, of dysphagia patients. The usage of chewable tablets and medicated chewing gums involves special methods for evaluating their textural, structural and mechanical characteristics, as well as individual methods for studying the drug release. The review provides an analysis of the main methods for studying structural, mechanical, and technological characteristics of chewable tablets and medicated chewing gums. In addition, the principles of operation and design of test devices, as well as pharmacopoeial methods for evaluating the drug release, are shown.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82452840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of adding an organic solvent to povidone aqueous solution on the size of MCC granules obtained by wet granulation 在聚维酮水溶液中加入有机溶剂对湿法造粒制备的MCC颗粒粒径的影响
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-02-25 DOI: 10.33920/med-13-2301-04
V. Markeev, S. Tishkov, E. V. Blynskaya, K. S. Kochetov, M. S. Vykhristyuk, А. Maksat
{"title":"The effect of adding an organic solvent to povidone aqueous solution on the size of MCC granules obtained by wet granulation","authors":"V. Markeev, S. Tishkov, E. V. Blynskaya, K. S. Kochetov, M. S. Vykhristyuk, А. Maksat","doi":"10.33920/med-13-2301-04","DOIUrl":"https://doi.org/10.33920/med-13-2301-04","url":null,"abstract":"Most of the developed new pharmaceutical substances are insoluble in water, which makes it difficult to create solid dosage forms. This makes researchers use solubilization approaches for poorly soluble molecules. In our study, the applicability of ethyl alcohol as a cosolvent in the technology of wet granulation of tablets was analyzed.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78987553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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