Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)最新文献

{"title":"Search for active candidates in a range of flavonoids regarding SARS-CoV-2 by the method of molecular docking","authors":"S. V. Pechinskii, E. Oganesyan, A. G. Kuregyan","doi":"10.33920/med-13-2101-02","DOIUrl":"https://doi.org/10.33920/med-13-2101-02","url":null,"abstract":"Molecular docking is a convenient and cost-effective tool for targeted screening of biologically active structures. This method makes it possible to reveal the relationship between structure and activity, as well as to search for new active compounds. Due to the fact that the antiviral activity of flavonoids and their derivatives has been shown experimentally and clinically, the study of their antiviral activity against SARS-CoV-2 is a promising study. In an in silico experiment, the possibility of binding 20 flavonoid ligands and the main protease SARS-CoV-2 was studied. The structural features of flavone and flavanone derivatives have been determined, which determine their ability to block the main protease of the SARS-CoV-2 virus. Structures of eight new candidates that bind the main protease SARS-CoV-2, which have the prospect of synthesis and further pharmacological research, have been proposed.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82005902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Film coatings in the development of dosage forms","authors":"V. N. Shestakov, S. V. Polyakov, L. Persanova, T. Andreevicheva, M. Veretennikova, A. Ulyanov, V. Skupchenko, A. Lobov, D. Mamedova, K. Miranyan, T.A. Dzhafarova","doi":"10.33920/med-13-2006-04","DOIUrl":"https://doi.org/10.33920/med-13-2006-04","url":null,"abstract":"The article provides information about polymers and excipients used for film coating. The main manufacturers, groups of substances used in the compositions, as well as the complexity of the technology and possible defects in the application of coatings, are indicated.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"190 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72761671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative assessment of commodity indicators of alder leaves of different types","authors":"G. V. Nesterov, T. M. Litvinova","doi":"10.33920/med-13-2006-06","DOIUrl":"https://doi.org/10.33920/med-13-2006-06","url":null,"abstract":"The article presents data on the study of commodity indicators of black, gray and heart-leaved alder leaves harvested from wild plants. The moisture content was determined for all the studied samples. Common ash. Ash insoluble in a 10% solution of hydrochloric acid, organic and mineral impurities, parts of the plant that have lost their natural color. The complexometric titration method determined the content of tannins in the raw material, the content of which in the amount of 4.56 to 8.59%, allows considering this type of raw material as a promising additional source of phytopreparations.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81606187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Training of pharmaceutical personnel: the fundamentals and current trends","authors":"L. A. Korol, S. Zavadskiy","doi":"10.33920/med-13-2006-02","DOIUrl":"https://doi.org/10.33920/med-13-2006-02","url":null,"abstract":"The development of biomedical science in recent decades (a personalized approach to the creation of medicines, the emergence of biotechnological and biosimilar drugs, the transition from empirical to directed drug development using drug design methods - information technologies for their modeling and studying their behavior in biological systems) has a significant impact on the formation of the pharmaceutical education system worldwide. New drugs are being developed such as gene therapeutics and biomedical cell products, and biotechnological production of medicines is developing [1-3]. One of the most important tasks of modern pharmaceutical education is the training of highly qualified personnel in the pharmaceutical industry [4-6]. Global trends in pharmaceutical education are aimed at improving educational programs, introducing new disciplines to the educational process in the light of scientific and technological progress in the industry, developing scientific activities, using digital technologies, interacting actively with industry organizations, and internationalizing education. The state policy of the Russian Federation in the field of medical and pharmaceutical education strives to meet these challenges.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76070465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wound dressings and soft dosage forms based on collagen for the treatment of wounds of various etiologies","authors":"S. Melnik, V. D. Torikashvili, K. D. Yakuta, S. Lebedeva","doi":"10.33920/med-13-2006-01","DOIUrl":"https://doi.org/10.33920/med-13-2006-01","url":null,"abstract":"Collagen is a promising auxiliary substance in the manufacture of soft dosage forms (DF). Wound dressings and gels based on collagen are of great interest, as they allow speeding up the healing process, are completely utilized by the body, and can serve as a carrier for various medicinal and biologically active substances. An important advantage of using collagen is a large number of sources of its acquisition, which minimizes the risks of missing the necessary basis for the production of new medicines.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78888299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binder for colored asphalt based on light hydrogenated petroleum polymer resins","authors":"V. Kochetkova","doi":"10.33920/med-13-2006-03","DOIUrl":"https://doi.org/10.33920/med-13-2006-03","url":null,"abstract":"The article provides an overview of the production of binders, sets out the requirements for the quality indicators of colored asphalt, the technology of production of binders, and also considers promising areas in the production of colorless binders. The purpose of the work was to create an affordable organic binder based on light hydrogenated petroleum polymer resins and use the developed binder for colored asphalt. To achieve this goal, we analyzed patents for the production of binders, on the basis of which the composition of raw materials was selected, and studied the physical and mechanical characteristics of the obtained samples on both hydrogenated and non-hydrogenated petroleum polymer resin.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"170 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75927535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the kinetics of benzidamine hydrochloride release from topical sprays in an in vitro experiment","authors":"E. Stepanova, V. V. Vernikovskiy, A. Morozov","doi":"10.33920/med-13-2006-05","DOIUrl":"https://doi.org/10.33920/med-13-2006-05","url":null,"abstract":"Inflammatory processes accompanied by a sore throat are a widespread symptom of both infectious and non-infectious genesis. In this case, topical therapy with medications that combine anti-inflammatory and analgesic effects, in the form of comfortable dosage forms — sprays, is the most effective. In this case, the used drug has a complex effect on contact tissues, due to both the actual pharmacological activity of the pharmaceutical substance and the physico-chemical properties of the excipients forming the dosage form. A study of the release of the active substance from sprays in the perspective of their topical application, as well as their osmotic activity in an in vitro experiment that simulates the process of application to the throat mucosa, was carried out. The real influence of the osmotic activity of the dosage form on the degree of release of the active substance due to the multidirectional nature of the resulting diffusion flows is shown.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75948467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a lyophilized liposomal dosage form indolocarbazole derivative — LHS-1208","authors":"I. Gulyakin, L. Nikolaeva, M. Dmitrieva, N. Oborotova, O. Orlova, A. P. Polozkova","doi":"10.33920/med-13-2005-04","DOIUrl":"https://doi.org/10.33920/med-13-2005-04","url":null,"abstract":"Aim. The aim of this work was to create a lyophilized liposomal dosage form of native hydrophobic antitumor compound from the group of indolocarbazole derivatives — LHS-1208. Materials and methods. Quantitative determination of the drug content was carried out on a Cary 100 spectrophotometer using a standard sample at λ = 320 ± 2 nm. The analysis of the average diameter of liposomes was carried out by the method of correlation spectroscopy of light scattering using devices Nicomp-380 nanosizer and Zetasizer Nano ZS zetasizer, using the latter, the zeta potential of the liposomal dispersion was also measured. To measure the pH of the solution, a HANNA pH 211 pH meter was used. The dynamic viscosity was measured on a Vibro Viscometer SV-10 viscometer. Lyophilization was carried out in an Edwards Minifast DO.2 freeze-drying chamber. Results. Experimental models of compositions of lyophilized liposomal dosage form LHS-1208 with various molar ratios of components were obtained and analyzed. TLC analysis using several solvent systems can be used to detect and identify LHS-1208 in a liposomal dosage form. According to the results of the study, a spectrophotometric method was developed for the quantitative determination of the LHS-1208 content in the composition of a liposomal dosage form. Based on the studies carried out, quality indicators were selected for standardization of lyophilized liposomal dosage form LHS-1208 and subsequent development of the draft regulatory documentation. Conclusion. As a result of the complex pharmaceutical research, the optimum composition of the components was determined, and the technology for production of liposomal dosage form LHS-1208 was developed.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72868636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The classification and modern use of magnetic dosage forms in medicine","authors":"S. Zavadskiy","doi":"10.33920/10.33920/med-13-2005-02","DOIUrl":"https://doi.org/10.33920/10.33920/med-13-2005-02","url":null,"abstract":"Currently, quite a large variety of magnetic therapy products, including magnetic dosage forms (MDF), is used in medicine. MDF contain different magnetic materials. MDF either contain or do not contain medicinal substances (MS) in their composition. The therapeutic action of MDF is produced by either a biotropic effect of magnetic field (MF) in case MDF is a source of permanent magnetic field, or mechanic action of MDF based on their interaction with an external source of MF, or a combination of the biotropic and mechanic actions. MDF used in medicine have been reviewed, and their classification by magnetic filler type has been provided.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89437212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and characteristics of W/O microemulsion stabilized with polyglycerylpolyricinoleate as a potential system for oral insulin delivery","authors":"Nataliya E. Sedyakina, V. Kuryakov, N. B. Feldman, S. Lutsenko","doi":"10.33920/med-13-2005-03","DOIUrl":"https://doi.org/10.33920/med-13-2005-03","url":null,"abstract":"Aim. The aim of the present work was to develop the composition and study the characteristics of water-in-oil microemulsion stabilized with polyglycerylpolyricinoleate — Tween 80 — ethanol mixture as a potential system for oral insulin delivery. Materials and methods. To determine the boundaries of the regions of existence of water-in-oil microemulsion in the pseudo-three component systems water — polyglycerylpolyricinoleate (PG-3-PR, Gobiotics BV, Netherlands)/ Tween 80/ethanol — paraffin oil, mixtures of paraffin oil and surfactants with oil — surfactant ratios from 9.5:0.5 to 0.5: 9.5 (wt.) were thoroughly mixed and titrated with an aqueous phase (distilled water).Compositions with the value of hydrophilic-lipophilic balance of the PG-3-PR — Tween 80 mixture equal to 6.15 were studied. Among several types of formed systems, a single-phase region corresponding to a homogeneous, optically transparent, liquid water-in-oil microemulsion was determined. The kinetic and thermodynamic stability of a number of compositions, including those containing insulin (Actrapid HM, Novo Nordisk А/С, Denmark), was studied. The values of the effective viscosity of microemulsions at different ratios of surfactant — oil and surfactant — co-surfactant were determined using a vibration viscometer. Based on the results obtained, a composition was selected to study the kinetics of insulin release into a model environment that simulated the environment of the small intestine. Insulin solution (the control sample) and the insulin-containing microemulsion were placed in the dialysis bags and immersed in 50 mL of PBS (pH 7.4) in a shaking incubator at 180 rpm and 37 ° С. At predetermined intervals, the aliquots of dissolution media were withdrawn, and the concentration of the released peptide was determined by the Bradford assay using a UV spectrophotometer at 595 nm. Results. The composition with 9:1 surfactant — co-surfactant ratio, containing 10 % of the aqueous phase (an insulin solution with a concentration of 100 IU / ml), which remained stable both during three cycles of freezing/thawing and heating/cooling, and after long-term storage at room temperature, was selected to study the kinetics of in vitro release of the peptide into the model medium. The effective viscosity of the sample was 2.4±0.04 Pa.s. The microemulsion sample demonstrated a prolonged release of insulin within 48 hours of the experiment (43 %). Conclusions. As a result, the boundaries of the existence of microemulsion regions in pseudo-three — component systems water — polyglycerylpolyricinoleate / Tween 80 / ethanol — paraffin oil were established, as well as the values of the effective viscosity of a number of compositions were determined. The study of the kinetic and thermodynamic stability of the obtained systems, including those containing insulin, as well as the study of the kinetics of the release of biologically active substance from the microemulsion into the model medium, allowed us to de","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87448438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}