Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)最新文献

{"title":"Peculiarities of patent marketing research in the development of medical preparations","authors":"A. O. Popova","doi":"10.33920/med-13-2102-05","DOIUrl":"https://doi.org/10.33920/med-13-2102-05","url":null,"abstract":"Patent marketing research refers to a special part of marketing research using patent information as the main information base. Conducting patent marketing research is especially important in the highly competitive pharmaceutical field.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88750136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of morphological features and preliminary assessment of arbutin content in food varieties of pears","authors":"N. Nesterova, A.Zh. Dosaeva","doi":"10.33920/med-13-2102-06","DOIUrl":"https://doi.org/10.33920/med-13-2102-06","url":null,"abstract":"In this article, the authors conducted a macro-diagnostic study of pear fruits of three varieties. A qualitative analysis of raw materials was carried out using color reactions, thin-layer chromatography in pear fruits most widely cultivated in the territory of the Russian Federation. Arbutin was identified in the raw material, which allows us to consider this type of raw material as a promising alternative to lingonberry and bearberry leaves used in official medicine and actualizes further research aimed at developing modern methods of standardization with subsequent inclusion in the developed regulatory documentation.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"128 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88114841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of metal nanoparticles using yeast strains Saccharomyces Cerevisae and Saccharomyces Boulardi","authors":"Ekaterina A. Pukhovskaya, E. V. Kalinin, Y. Stanishevskiy","doi":"10.33920/med-13-2102-03","DOIUrl":"https://doi.org/10.33920/med-13-2102-03","url":null,"abstract":"The development of an environmentally friendly process for the synthesis of metal nanoparticles is an important step in the field of nanotechnology. One way to achieve this goal is to use biological systems. In this study, silver nanoparticles were obtained using extracellular enzymes of organisms of the Saccharomyces boulardi strain. The effect of the pH of the medium on the synthesis of nanoparticles was studied. The antimicrobial activity of the obtained nanoparticles was investigated.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80183474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticles of cerium oxide. The application and cerium oxide toxicity assessment","authors":"M. N. Kuznetsova, V. Zhilkina","doi":"10.33920/med-13-2102-02","DOIUrl":"https://doi.org/10.33920/med-13-2102-02","url":null,"abstract":"Nanotechnology is the most perspective direction in the modern science and technic. The great interest in entire world has been observing to nanoparticles properties and their fields of use investigation. Cerium dioxide is a perspective oxide material which has wide use in different branches of industry due to its unique physical and chemical properties. Burst of interest to cerium oxide nanoparticles development and use in biology and medicine takes has been taking place recently. Scientists in many countries have been carrying out cerium oxide nanoparticles efficiency of use against various diseases.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86757962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacotechnological study of extractions on common wormwood basis","authors":"Ekaterina O. Abyzova, E. Molokhova, V. D. Belonogova","doi":"10.33920/med-13-2102-04","DOIUrl":"https://doi.org/10.33920/med-13-2102-04","url":null,"abstract":"Common wormwood herb and its extracted meal for obtaining substance enriched by flavonoids, polysaccharides and pectins were analysed. There was carried out consecutive extraction by using extragents with different polarity. The assay content of flavonoids in obtained fractions was carried out. The assay content of polysaccharides and pectins in extracted meal was conducted. Toxicological study of obtained substances was carried out.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91307187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of soft dosage forms of pyrimidine derivatives based on carbopols","authors":"M. Boldina, V. Grikh, A. Gubanova, Maxim Stantsov, A. Kozlova","doi":"10.33920/med-13-2101-03","DOIUrl":"https://doi.org/10.33920/med-13-2101-03","url":null,"abstract":"In the process of improving the technology for obtaining and expanding the range of dosage forms of known pharmaceutical substances, an important aspect is to reduce side effects and ensure ease of use. At the same time, medicines should provide the most important properties of pharmaceutical substances, namely, their most rapid and complete release from the base of the dosage form and penetration into the target organ, which should serve as factors in justifying formulations and technologies of effective and safe medicines [3, 4]. Due to the lesser manifestation of side effects and ease of use, soft dosage forms (gels, ointments) are among the most demanded dosage forms on the modern pharmaceutical market. The trend towards replacing hydrophobic bases in soft dosage forms with hydrophilic ones has been traced in pharmacy for quite a long time, since gels provide higher efficiency in application due to better penetration of pharmaceutical substances through the skin barrier relative to hydrophobic ointments. The presence of a polymer-gelling agent in gels determines not only the rheological properties of medicines, but also allows a highly dispersed solid phase of a pharmaceutical substance to be included in the network structure of a polymer and to maintain the dispersion of a pharmaceutical substance poorly soluble in water during storage. Methyluracil, also known as dioxomethyltetrahydropyrimidine, is a derivative of pyrimidine, a structural element of nucleic acids and is used in the treatment of diseases of various etiologies, mainly to improve the course of regeneration in damaged tissues. A significant disadvantage of methyluracil is its low solubility in water, which significantly affects the degree of release of the pharmaceutical substance from the base of the drug [1]. Due to the lack of methyluracil gels on the pharmaceutical market, their development using acrylic acid derivatives in order to improve the biopharmaceutical properties of a pharmaceutical substance is an important problem in pharmacy.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78144116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The factor patent of invention when drafting the text of the pharmacopoeic article","authors":"S. V. Pechinskii, E. Oganesyan, A. G. Kuregyan","doi":"10.33920/med-13-2101-01","DOIUrl":"https://doi.org/10.33920/med-13-2101-01","url":null,"abstract":"Molecular docking is a convenient and cost-effective tool for targeted screening of biologically active structures. This method makes it possible to reveal the relationship between structure and activity, as well as to search for new active compounds. Due to the fact that the antiviral activity of flavonoids and their derivatives has been shown experimentally and clinically, the study of their antiviral activity against SARS-CoV-2 is a promising study. In an in silico experiment, the possibility of binding 20 flavonoid ligands and the main protease SARS-CoV-2 was studied. The structural features of flavone and flavanone derivatives have been determined, which determine their ability to block the main protease of the SARS-CoV-2 virus. Structures of eight new candidates that bind the main protease SARS-CoV-2, which have the prospect of synthesis and further pharmacological research, have been proposed.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83280380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the results of the implementation of the information management system for chromatographic equipment in the testing center of on expert institution in the sphere of medicinal products circulation","authors":"N. I. Burmistrova, K. Koshechkin, N. Preferanskaya","doi":"10.33920/med-13-2101-04","DOIUrl":"https://doi.org/10.33920/med-13-2101-04","url":null,"abstract":"Modern laboratory equipment helps to effectively solve the tasks of the examination of medicines. It is impossible to conduct mass analysis of samples without high-quality software and quickly obtain information about their quality characteristics. This article describes the results of evaluating the implementation of the Agilent OpenLab CDS-2 laboratory information management system for chromatographic equipment at the testing center of an Expert institution in the sphere of Medicinal Products Circulation. Purpose of work. Development and testing of a methodology for assessing the effectiveness of the implementation of modern software for chromatographic equipment. Materials and methods. Analysis of scientific publications of domestic and foreign specialized literature on the problem of evaluating the effectiveness of implementing an information system for managing chromatographic equipment. An analysis of the data of an expert survey was carried out with further graphic processing of the results. Results. A survey was conducted; data were analyzed reporting on the effectiveness of implementing modern software for chromatographic equipment. Conclusion. The result of the analysis of the survey materials is a statement about the high degree of effectiveness of implementing the information management system for chromatographic equipment in the testing center of an Expert institution in the sphere of Medicinal Products Circulation.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74250564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesics from the history to contemporary times","authors":"E. Grigorevskikh, Fam Tkhi Khong Zung, S. Lebedeva, S. Sologova","doi":"10.33920/med-13-2101-06","DOIUrl":"https://doi.org/10.33920/med-13-2101-06","url":null,"abstract":"Pain is an important signal of almost all pathological processes. At the same time, in the presence of painful sensations, a person tried to eliminate them to improve the quality of life. Therefore, at all times, painkillers are played a very important role in the pharmaceutical market. The search for new molecules with analgesic properties and the development of dosage forms for already acting drugs are still important tasks in the pharmaceutical environment. In this review, we tried to show development path of the search for a new painkillers.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84449934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studying of anatomic structure of Amaranthus retroflexus L. herb","authors":"T. Kovaleva, Larisa Dmitrievna Makaryants, Margarita Mikhailovna Dbay, Yulia Airatovna Lukmanova","doi":"10.33920/med-13-2101-05","DOIUrl":"https://doi.org/10.33920/med-13-2101-05","url":null,"abstract":"Amaranthus retroflexus L. is a perspective medical plant. We studied anatomic structure specialities of its stems and leaves. We visualized anomocytic stomatas and simple thin-walled multicellular trichomes on both sides of leaves. Big amount of calcium oxalate druses and cells with crystal sand along leaf ribes were found in mesophyll. Many conducting bundles (xylem, phloem and sclerenchyma) were detected on sectional cross of culm. We didn’t detected sclerenchymatous belt, angular collenchyma, simple thin-walled multicellular trichomes and crystalic inclusions.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85673777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}