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Cloning of recombinant thyroglobulin 重组甲状腺球蛋白的克隆
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2024-01-30 DOI: 10.33920/med-13-2401-03
B. W. Khreim Wael, A. V. Zubkov
{"title":"Cloning of recombinant thyroglobulin","authors":"B. W. Khreim Wael, A. V. Zubkov","doi":"10.33920/med-13-2401-03","DOIUrl":"https://doi.org/10.33920/med-13-2401-03","url":null,"abstract":"The aim of the study is to clone cDNA fragments of mRNA of the thyroglobulin gene into а vector and introduce it into prokaryotic cell lines for possible use in the diagnosis of autoimmune and oncological diseases of the human thyroid gland. Thyroid hormones are synthesized by thyrocytes of mammalian thyroid tissue from the large protein thyroglobulin having a molecular weight of 330 kDa. The thyroid hormones thyroxine and triiodothyronine are small molecules that have large biological effects. They regulate metabolism in almost all cells, and are important for the development of the central nervous system, musculoskeletal system and lungs. These are also the only hormones that contain iodine and are synthesized partly inside and partly outside of cells. A dimeric glycoprotein is called thyroglobulin.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"227 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140480345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment of quality standards for syrup from viburnum fruit meal 制定紫云英果粉糖浆的质量标准
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2024-01-30 DOI: 10.33920/med-13-2401-01
Z. A. Kadilaeva
{"title":"Establishment of quality standards for syrup from viburnum fruit meal","authors":"Z. A. Kadilaeva","doi":"10.33920/med-13-2401-01","DOIUrl":"https://doi.org/10.33920/med-13-2401-01","url":null,"abstract":"An adjusted dosage form has been developed in the form of a syrup using low-waste technology — from the meal of the fruits of Viburnum viburnum. Viburnum fruit meal contains higher fatty acids, triterpenoids, phytosterols, and carotenoids. Medicines of plant origin have a number of undeniable advantages compared to synthetic ones, since their composition ensures safety and better tolerability due to the variety of biologically active substances (BAS) of plants, they can have a complex effect on the body, and they can be used for a long time. However, the main issue is that, despite their high bioavailability and cost-effectiveness, herbal medicines are complex to design and require the development of a number of technological solutions. Equally important are the issues of establishing quality standards — standardization of the developed dosage form. The syrup was prepared from simple sugar syrup with the addition of dry extract from viburnum fruit meal. Purpose of work. Development and establishment of quality standards for the developed dosage form — syrup from viburnum fruit meal. Materials and methods. High performance liquid chromatography (HPLC) method. Let us use it to establish standards in quantitative terms for chlorogenic acid. Permanganatometry. This technique was used to determine the quantitative content of the amount of tannins in terms of gallic acid. Results. It was established that the content of chlorogenic acid in the developed syrup is 0.214 ± 0.006 %, the content of tannins in terms of gallic acid is 0.494 ± 0.014 %. Indicators acidity (pH) — 3–5, density — 1,360 to 1,420 g/cm3, microbiological purity — category 3 B. Conclusion. The result of the research was the establishment of the main indicators of syrup quality, namely the quantitative content of the main biologically active substances — chlorogenic acid and tannins in terms of gallic acid. In addition, such indicators as acidity (pH), density, and microbiological purity were determined.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"146 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140481323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New polymorphic modification of calcium carbonate — monoclinic aragonite CaCO3 碳酸钙的新多晶形态--单斜文石 CaCO3
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2024-01-30 DOI: 10.33920/med-13-2401-02
O. N. Kazheva, S. Aksenov, I. A. Vasilenko
{"title":"New polymorphic modification of calcium carbonate — monoclinic aragonite CaCO3","authors":"O. N. Kazheva, S. Aksenov, I. A. Vasilenko","doi":"10.33920/med-13-2401-02","DOIUrl":"https://doi.org/10.33920/med-13-2401-02","url":null,"abstract":"The work discusses the polymorphism of calcium carbonate, the crystal structure of its various polymorphic forms, and the analysis of structure- property correlations. The existence of a novel polymorphic modification of calcium carbonate, monoclinic aragonite CaCO3, has been experimentally discovered. Its crystal structure has been deciphered and its crystal structure has been discussed.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"297 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140484594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selection of excipients for the formulation of varenicline tablet cores 选择用于配制伐尼克兰片芯的辅料
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2024-01-30 DOI: 10.33920/med-13-2401-04
V. Eremin, E. V. Blynskaya, S. Tishkov
{"title":"Selection of excipients for the formulation of varenicline tablet cores","authors":"V. Eremin, E. V. Blynskaya, S. Tishkov","doi":"10.33920/med-13-2401-04","DOIUrl":"https://doi.org/10.33920/med-13-2401-04","url":null,"abstract":"The active pharmaceutical ingredient (APS) of varenicline is a tartrate with the chemical name 7,8,9,10‑Tetrahydro-6,10‑Methano-6H-pyrazino(2,3‑h) (3)benzazepine (as tartrate). Varenicline free base is an achiral molecule, however varenicline tartrate, which is formed by the reaction of varenicline free base and L-tartaric acid, is optically active and has an absolute counterion configuration of 2R, 3R. At the moment, only the drug Champix, produced by the pharmaceutical company Pfizer, is represented among direct analogues, so the development of a domestic analogue is an urgent topic of research. The purpose is to develop the optimal composition of varenicline tablet cores to create a finished dosage form.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"177 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140485243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current state of research in the field of intranasal dosage forms and the possibility of using piracetam as an intranasal gel 鼻内剂型领域的研究现状以及将吡拉西坦用作鼻内凝胶的可能性
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2024-01-30 DOI: 10.33920/med-13-2401-05
M. I. Dadu Monib
{"title":"Current state of research in the field of intranasal dosage forms and the possibility of using piracetam as an intranasal gel","authors":"M. I. Dadu Monib","doi":"10.33920/med-13-2401-05","DOIUrl":"https://doi.org/10.33920/med-13-2401-05","url":null,"abstract":"The intranasal method of administration has been known for a long time and until recently was regarded only as a method of local treatment of nasal cavity diseases. However, nowadays it is increasingly being considered as a promising and convenient way to deliver many drugs with a resorptive effect into the body. This is not surprising: this method of administration has a number of advantages and can be used for drugs produced only in the form of injectable solutions. The drug will not be metabolized in the liver, since it will enter the blood directly through the epithelium of the nasal cavity, which is abundantly supplied with blood. In addition, compared with injectable dosage forms, this method is less traumatic and does not require the participation of medical personnel and special training. The use of intranasal dosage forms, primarily for the treatment of cerebral pathologies, is a promising direction in medicine and pharmacy.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"686 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140482960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative analysis of modern digital services for the purchase of medicines 现代数字化购药服务的比较分析
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-08-28 DOI: 10.33920/med-13-2304-02
Т. Shakhovskiy, N. Vyatkina
{"title":"Comparative analysis of modern digital services for the purchase of medicines","authors":"Т. Shakhovskiy, N. Vyatkina","doi":"10.33920/med-13-2304-02","DOIUrl":"https://doi.org/10.33920/med-13-2304-02","url":null,"abstract":"Currently, the online pharmacy market is represented by a number of large pharmaceutical players, including apteka.ru, eapteka.ru, and ozon.ru. Given the high density of the market, as well as the fact that medicines are commodities, it becomes obvious that the pharmacy brand needs to increase its competitiveness. Today, such factors are essential for the client of online pharmacies as: the ability to choose the best price offer, the availability of a large range of products, convenient search and comparison of drugs in various categories, as well as the possibility of delivery and customer pickup. Modern services for the search and purchase of medicines have a variety of capabilities that allow making the Internet service convenient for use, as well as to increase the competitive advantages of the pharmacy brand. Thus, the modern online pharmacy consumer is guided by a service (brand) that will satisfy his or her needs, including the use of cartographic services for a comfortable search.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83004093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative dosage forms of nifedipine: assortment and development prospects 硝苯地平创新剂型:分类与发展前景
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-08-28 DOI: 10.33920/med-13-2304-01
V. V. Tokaev, L. Lobanova
{"title":"Innovative dosage forms of nifedipine: assortment and development prospects","authors":"V. V. Tokaev, L. Lobanova","doi":"10.33920/med-13-2304-01","DOIUrl":"https://doi.org/10.33920/med-13-2304-01","url":null,"abstract":"Nifedipine is one of the most commonly prescribed drugs in the treatment of diseases of the cardiovascular system. Due to the relatively small number of dosage forms of this drug and its minimal production in the Russian Federation, the creation of new dosage forms of nifedipine represented by a transdermal patch and transdermal gel is a feasible and urgent task. Nifedipine has a fairly wide use in cardiological practice; according to the results of many years of research, it has been proved that this drug is used in such areas of medicine as mountain medicine, psychiatry, gynecology, and gerontology. Despite the complexity of creating transdermal forms, the number of medicinal substances delivered by percutaneous diffusion is gradually increasing. A significant disadvantage of nifedipine is its low solubility in water, which significantly affects the degree of release of the pharmaceutical substance from the drug base. Owing to the absence of nifedipine-based transdermal therapeutic systems on the pharmaceutical market, their development is an urgent problem of modern pharmacy in order to improve the biopharmaceutical properties of a pharmaceutical substance.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89367891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The possibilities of using 3D printing in pharmaceutical industry 3D打印在制药行业的应用前景
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-06-20 DOI: 10.33920/med-13-2303-02
K. Koshechkin, O. Lebed, Yu.A. Levushkina
{"title":"The possibilities of using 3D printing in pharmaceutical industry","authors":"K. Koshechkin, O. Lebed, Yu.A. Levushkina","doi":"10.33920/med-13-2303-02","DOIUrl":"https://doi.org/10.33920/med-13-2303-02","url":null,"abstract":"This article discusses the possibilities of using 3D printing technologies in the pharmaceutical industry, including concrete examples that are already applied in practice. The advantages and problems that arise with active spread of these technologies are described. In addition, after the emergence of any new technology, its introduction into social and public life is crucial, therefore, this article provides specific examples of the legal status and regulation of 3D printed products and discusses its general principles. The importance of the development of 3D printing in the medical and pharmaceutical industries is highlighted from various perspectives, including medical and economic ones. This article is devoted to the use of 3D printing technology for medical purposes. It considers the potential of using 3D printing in various pharmaceutical fields. The paper describes some examples of various applications of 3D printing in medicine and examines the advantages and disadvantages of this technology. Finally, we suggest a prognosis for the future use of 3D printing in medicine and the principles of designating its legal status, with specific examples.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76905701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric Vaccination: Exploring the Views of Pediatricians on the Implementation of a Feedback Module 儿科疫苗接种:探讨儿科医生对实施反馈模块的看法
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-06-20 DOI: 10.33920/med-13-2303-04
N. Vyatkina, V. O. Kotrunov
{"title":"Pediatric Vaccination: Exploring the Views of Pediatricians on the Implementation of a Feedback Module","authors":"N. Vyatkina, V. O. Kotrunov","doi":"10.33920/med-13-2303-04","DOIUrl":"https://doi.org/10.33920/med-13-2303-04","url":null,"abstract":"Preventive vaccination is particularly important in children as their bodies are highly susceptible to infectious diseases. However, despite significant achievements in the field of vaccination, it is crucial to note that preventive vaccination is not without complications. This necessitates careful monitoring and evaluation of the effectiveness of used vaccines, as well as the implementation of effective feedback mechanisms to collect data on potential post-vaccination reactions and complications. Currently, the level of feedback within pediatric vaccination is limited, and healthcare professionals often face limitations in providing information and support to parents and patients. Therefore, it is essential toconduct an interview analysis to assess the current situation, identify issues, and determine the necessary measures for the development of a feedback module that meets the needs of patients, their parents, and medical professionals in terms of information, support, and timely response to post-vaccination reactions and complications.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82160973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studying the use of a first aid kit and developing recommendations on the contents and use of a home first aid kit 研究急救箱的使用方法，并就家庭急救箱的内容和使用提出建议
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-06-20 DOI: 10.33920/med-13-2303-03
K. Abbakumov, O. Nesterova, D. Dobrokhotov, S. Zavadskiy, A. K. Z. Zhevlakova
{"title":"Studying the use of a first aid kit and developing recommendations on the contents and use of a home first aid kit","authors":"K. Abbakumov, O. Nesterova, D. Dobrokhotov, S. Zavadskiy, A. K. Z. Zhevlakova","doi":"10.33920/med-13-2303-03","DOIUrl":"https://doi.org/10.33920/med-13-2303-03","url":null,"abstract":"The article presents the results of a study of the contents of first aid kits used in enterprises and organizations, as well as automobile and other types of first aid kits used by professionals in the field of activity, which involves first aid. The survey on home first aid kits was conducted, the results of which showed that insufficient attention is paid to monitoring the expiration dates of drugs. The suggestions on the contents of the first-aid kit, as well as the recommendations for storing and maintaining the first aid kit up to date are given.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"436 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83637435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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