Innovative dosage forms of nifedipine: assortment and development prospects

Nifedipine is one of the most commonly prescribed drugs in the treatment of diseases of the cardiovascular system. Due to the relatively small number of dosage forms of this drug and its minimal production in the Russian Federation, the creation of new dosage forms of nifedipine represented by a transdermal patch and transdermal gel is a feasible and urgent task. Nifedipine has a fairly wide use in cardiological practice; according to the results of many years of research, it has been proved that this drug is used in such areas of medicine as mountain medicine, psychiatry, gynecology, and gerontology. Despite the complexity of creating transdermal forms, the number of medicinal substances delivered by percutaneous diffusion is gradually increasing. A significant disadvantage of nifedipine is its low solubility in water, which significantly affects the degree of release of the pharmaceutical substance from the drug base. Owing to the absence of nifedipine-based transdermal therapeutic systems on the pharmaceutical market, their development is an urgent problem of modern pharmacy in order to improve the biopharmaceutical properties of a pharmaceutical substance.