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Historical experience and prospects of using quince fruit in medicine 木瓜果实药用的历史经验与展望
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2021-09-15 DOI: 10.33920/med-13-2110-01
Darya Aleksandrovna Koshman, Anastasiya Evgenievna Sayapina, N. Nesterova
{"title":"Historical experience and prospects of using quince fruit in medicine","authors":"Darya Aleksandrovna Koshman, Anastasiya Evgenievna Sayapina, N. Nesterova","doi":"10.33920/med-13-2110-01","DOIUrl":"https://doi.org/10.33920/med-13-2110-01","url":null,"abstract":"In this article, a study of the scientific literature was conducted, proving the prospects of using in medical practice a plant widely used in the food industry — common quince. Despite its popularity and a large number of studies proving the presence of valuable biologically active substances in the raw materials of this plant, today, it is not medicinal and is not used in medicine and pharmacy, due to the lack of necessary regulatory documentation.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74396466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
World Health Organization guidelines on transfer of analytical methods of quality control for medical preparation 世界卫生组织关于转让医药制剂质量控制分析方法的准则
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2021-09-15 DOI: 10.33920/med-13-2112-05
M. A. Razborova
{"title":"World Health Organization guidelines on transfer of analytical methods of quality control for medical preparation","authors":"M. A. Razborova","doi":"10.33920/med-13-2112-05","DOIUrl":"https://doi.org/10.33920/med-13-2112-05","url":null,"abstract":"This review contains the recommendations of the World Health Organization for the transfer of analytical methods of quality control for medical preparation. Due to the absence of the Russian documents describing in detail the technology transfer process, pharmaceutical developers and manufacturers should refer to international guidelines. One of the main documents which fully describes the process of pharmaceutical technologies transfer is World Health Organization guidelines on transfer of technology in pharmaceutical manufacturing. The recommendations are presented both for the transfer of medical preparation manufacturing and transfer of analytical methods for quality control for a medical preparation. This review contains the recommendations for the transfer of analytical methods only.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"117 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86187107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
International Society for Pharmaceutical Engineering guidelines on transfer of analytical methods of quality control for medical preparation 国际制药工程学会医药制剂质量控制分析方法转移指南
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2021-09-15 DOI: 10.33920/med-13-2110-07
M. A. Razborova
{"title":"International Society for Pharmaceutical Engineering guidelines on transfer of analytical methods of quality control for medical preparation","authors":"M. A. Razborova","doi":"10.33920/med-13-2110-07","DOIUrl":"https://doi.org/10.33920/med-13-2110-07","url":null,"abstract":"This review contains the recommendations of International Society for Pharmaceutical Engineering for the transfer of analytical methods of quality control for medical preparation. Due to the absence of the Russian documents describing in detail the technology transfer process, pharmaceutical developers and manufacturers should refer to international guidelines. One of the main documents which fully describes the process of pharmaceutical technologies transfer is International Society for Pharmaceutical Engineering guidelines on transfer of technology in pharmaceutical manufacturing. This review contains the recommendations for the transfer of analytical methods only. International Society for Pharmaceutical Engineering also have recommendations for the transfer of medical preparation manufacturing.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78390587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of the high-resolution HPLC–MS/MS method for identification and quantitative determination of impurities in the substance of the drug «Lomustine» 应用高分辨率HPLC-MS /MS方法对药物“洛莫司汀”物质中的杂质进行鉴定和定量测定
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2021-09-15 DOI: 10.33920/med-13-2110-05
I.O. Reshetnikova, S. V. Metlitskikh, N. D. Stekleneva, A. Volov
{"title":"Application of the high-resolution HPLC–MS/MS method for identification and quantitative determination of impurities in the substance of the drug «Lomustine»","authors":"I.O. Reshetnikova, S. V. Metlitskikh, N. D. Stekleneva, A. Volov","doi":"10.33920/med-13-2110-05","DOIUrl":"https://doi.org/10.33920/med-13-2110-05","url":null,"abstract":"Due to the state program of the Russian Federation \"Development of the pharmaceutical and medical industry\" (Pharma-2020), extended until 2024, the interest in the possibility of organizing the production and quality control of imported medicinal substances directly on the territory of the Russian Federation has significantly increased. In this case, the drugs included in the lists of \"Indispensible and essential drugs\" and \"Provision of necessary drugs\" [1] are of particular importance. One of the drugs often used in the chemotherapy of malignant tumors is the drug \"Lomustine\", which includes 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea as an active ingredient [1-3].","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87801941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the mechanism of nanoparticle coagulation 纳米颗粒混凝机理研究
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2021-09-15 DOI: 10.33920/med-13-2110-03
V. Kononov, Yaroslav Stanishevsky, A. Timofeev
{"title":"On the mechanism of nanoparticle coagulation","authors":"V. Kononov, Yaroslav Stanishevsky, A. Timofeev","doi":"10.33920/med-13-2110-03","DOIUrl":"https://doi.org/10.33920/med-13-2110-03","url":null,"abstract":"The article presents the results of an in situ study of the final stage of coagulation — the fusion of gold nanoparticles on an amorphous carbon film under the influence of highenergy electrons. It is shown that the nature of the fusion of interacting particles is affected by their orientation ratio at the moment of contact formation.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78033236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polymorphism control of active pharmaceutical ingredients 有效药物成分的多态性控制
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2021-09-15 DOI: 10.33920/med-13-2112-03
R. Terekhov, Denis I. Pankov, E. Anfinogenova, I. Selivanova
{"title":"Polymorphism control of active pharmaceutical ingredients","authors":"R. Terekhov, Denis I. Pankov, E. Anfinogenova, I. Selivanova","doi":"10.33920/med-13-2112-03","DOIUrl":"https://doi.org/10.33920/med-13-2112-03","url":null,"abstract":"Рolymorphism is receiving increasing attention due to its influence on the physicochemical and pharmacological properties of the active pharmaceutical ingredients (API) while maintaining the molecular structure. This review is devoted to the problem of APIs phase state control both at the development stage and during the circulation of the drug. The term «polymorphism» has different definitions depending on the branch of science. There is no unambiguous solution to this issue in the regulatory documentation of pharmaceutical industry either. Based on the analysis of literary sources, the article presents a comparison of pharmacopeia methods, recommended in Russian and foreign regulatory documents for the analysis of polymorphism of medicinal substances, including state pharmacopeias of Russia, Belarus, Kazakhstan, the USA, and Japan, as well as international pharmacopeias of the European Economic Union and the Eurasian Economic Union. The trend on using a complex of high-tech equipment is revealed. A systematic approach to analysis based on X-ray diffraction, thermal, spectral, microscopic, biological, and physical methods for determining constants makes it possible not only to identify the polymorphic modification of API, but also to characterize its structure, morphology, physicochemical properties and pharmacological activity. In the Russian Federation, the phenomenon of polymorphism is being studied especially intensively, and some control methods, such as biological methods, are validated only in Russian pharmacopeia. A promising direction for further research is the improvement and harmonization of regulatory documentation within the framework of this chemical and technological field of pharmacy. A global approach will help to reduce not only the probability of poor-quality products entering the market, but also the costs of establishing the authenticity of the active pharmaceutical ingredient produced.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73674342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The choice of excipients in the development of a soft dosage form of phleboprotective action containing a micronized flavonoid fraction 在开发含有微粉类黄酮成分的静脉保护作用软剂型中辅料的选择
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2021-09-15 DOI: 10.33920/med-13-2110-04
V. K. Maltseva, E. Stepanova, E. O. Kulichenko, M. Makieva
{"title":"The choice of excipients in the development of a soft dosage form of phleboprotective action containing a micronized flavonoid fraction","authors":"V. K. Maltseva, E. Stepanova, E. O. Kulichenko, M. Makieva","doi":"10.33920/med-13-2110-04","DOIUrl":"https://doi.org/10.33920/med-13-2110-04","url":null,"abstract":"Varicose veins are called one of the diseases of the 21st century, caused by a sedentary lifestyle and genetics. The purpose of this study was the development of ointment compositions containing the micronized flavonoid fraction and the study of the degree of release of the micronized fraction by the flavonoid from the ointment compositions with penetrating components. With the obtained ointment compositions, a complex of biopharmaceutical studies in vitro was carried out: release from ointment compositions by diffusion into a gelatin gel and dialysis through a semipermeable membrane, while the quality indicators of the ointment compositions were established. The conducted in vitro biopharmaceutical studies helped to determine the final composition of the ointment in relation to the auxiliary composition: active ingredient — 2%, PEG 1500:PEG 400 (7:3), propylene glycol — 1%.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72777469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modern trends in the development of organic chemistry 有机化学的现代发展趋势
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2021-09-15 DOI: 10.33920/med-13-2112-06
I. Selivanova, R. Terekhov, A. Taldaev
{"title":"Modern trends in the development of organic chemistry","authors":"I. Selivanova, R. Terekhov, A. Taldaev","doi":"10.33920/med-13-2112-06","DOIUrl":"https://doi.org/10.33920/med-13-2112-06","url":null,"abstract":"The role of organic chemistry and other chemical disciplines in the system of training qualified personnel for the pharmaceutical industry is indisputable. In what direction is chemistry developing in the modern world? What innovative directions does chemistry offer to drug developers? Can a robot synthesize a new compound? How to achieve practically significant results of scientific research? How may the obtained results be published in highly rated journals? These and many other topics were widely discussed at the XII International Conference of Students and Young Scientists in Chemistry «Mendeleev-2021» held in the fall of 2021. This article is published to attract young researchers’ attention to topical issues at the interface of chemistry and pharmacy and assist them in realizing their creative scientific potential.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87934488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computer modeling of the interaction between flavonoids and biological targets 类黄酮与生物靶点相互作用的计算机模拟
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2021-02-01 DOI: 10.33920/med-13-2102-01
R. Terekhov, I. Nikitin, A. Taldaev, I. Selivanova
{"title":"Computer modeling of the interaction between flavonoids and biological targets","authors":"R. Terekhov, I. Nikitin, A. Taldaev, I. Selivanova","doi":"10.33920/med-13-2102-01","DOIUrl":"https://doi.org/10.33920/med-13-2102-01","url":null,"abstract":"Computer modeling is a method that is widely used in the scientific investigations. Every year it’s getting more and more popular and becomes an integral part of a number of scientific disciplines, including medical chemistry. Thanks to this method, specialists in the field of drug design can predict the biological activity of a compound and its toxicity, based on the structure of the molecule. This work is a systematic review of articles performed in accordance with the recommendations of PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and contains information on computer modeling of the interaction of flavonoids with biological targets.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77188979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The study of NMR spectroscopy use in pharmaceutical analysis 核磁共振波谱在药物分析中的应用研究
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2021-02-01 DOI: 10.33920/med-13-2102-07
M. N. Kuznetsova, V. Zhilkina
{"title":"The study of NMR spectroscopy use in pharmaceutical analysis","authors":"M. N. Kuznetsova, V. Zhilkina","doi":"10.33920/med-13-2102-07","DOIUrl":"https://doi.org/10.33920/med-13-2102-07","url":null,"abstract":"Drug products are specific goods. A customer cannot determine quality and authenticity of any tablet, ointment or ampule content himself. As number of registered drugs has been increasing the actuality of quality assurance and standardization of drugs becomes much important. At the same time highly active substances belonging to new natural and synthetic drugs classes has been coming in medicinal practice. NMR spectroscopy approach has wide opportunities in increasing number of drugs analysis which must meet constantly increasing demands.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"559 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74712455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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