Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)最新文献

{"title":"Review of the use of the drug «Lomustin» in the treatment of oncological diseases","authors":"I.O. Reshetnikova, Vera Yurievna Zhilkina","doi":"10.33920/med-13-2204-04","DOIUrl":"https://doi.org/10.33920/med-13-2204-04","url":null,"abstract":"The relevance of the formation of enterprises for the production of substances and drugs in the territory of the Russian Federation is substantiated. On the example of a review of clinical cases of unintentional overdose of «Lomustine», the need to regulate the design of the package and the possible adjustment of the composition of the dosage form is shown.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85294480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of anti–inflammatory activity and target synthesis of benzothiazolylpyrazole derivatives","authors":"P. S. Bobrov, D. Anenko, I. Kodonidi, G. A. Suboch","doi":"10.33920/med-13-2202-01","DOIUrl":"https://doi.org/10.33920/med-13-2202-01","url":null,"abstract":"This work analyzes drug-likeness and predicts the pharmacokinetic properties of virtual structures of benzothiazolylpyrazole derivatives. Anti-inflammatory activity was predicted using the Molegro Virtual Docker 6.0.1 program. The condensation of benzothiazolyl-substituted 4-aminopyrazole with benzaldehyde, p-hydroxybenzaldehyde and benzoyl chloride has been described for the first time. As a result of targeted synthesis, a number of new benzothiazolylpyrazoles have been obtained. The structure of the products was confirmed by the data of IR spectroscopy.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83258738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Types of modified release dosage forms","authors":"Ranim Alrouhayyah, S. Suslina","doi":"10.33920/med-13-2202-06","DOIUrl":"https://doi.org/10.33920/med-13-2202-06","url":null,"abstract":"The article is devoted to modified release dosage forms. It talks about the importance and benefits of these dosage forms. The authors consider the development of technologies for different dosage forms, from traditional forms to forms with various release modifications, including controlled release.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86390621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory external medicines: use in dentistry","authors":"E. Samoshina, E. Stepanova, S. V. Poroiskiy","doi":"10.33920/med-13-2202-07","DOIUrl":"https://doi.org/10.33920/med-13-2202-07","url":null,"abstract":"The article provides an overview of drugs for use in dental practice. The issue of diseases of the oral mucosa remains relevant at the present time. There are various methods and drugs for the treatment of inflammatory diseases of the oral cavity. The purpose of this work was to study the current state of research in the development of the composition and technology of external soft dosage forms. In this regard, the promising area are phytocompositions that have been used successfully for a long time. However, currently, the drug Tizol, an aquacomplex of titanium glycerosolvate, is of great interest, which, in addition to positive characteristics, has certain properties of a penetrator, which is very important when used in dentistry.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88640824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of colored siloxane somonomers for use in immunodiagnostics","authors":"N. Lobanova, A. N. Lobanov","doi":"10.33920/med-13-2202-04","DOIUrl":"https://doi.org/10.33920/med-13-2202-04","url":null,"abstract":"The article presents approaches to the preparation of copolymers of polymethylmethacrylate using azo dyes, as well as data obtained as a result of a number of reactions to obtain methacryloxy-functionalized dyes and their copolymerization with methyl methacrylate. Synthesis of such polymer particles can be useful in the field of medicine — immunodiagnostics, latex agglutination reaction, flow cytometry, microspheric multiplex analysis.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89124628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on obtaining of a pharmaceutical substance for the complex therapy of inflammatory bowel diseases","authors":"Alkheder Ranim, Mussa Ramadan, S. Suslina","doi":"10.33920/med-13-2202-02","DOIUrl":"https://doi.org/10.33920/med-13-2202-02","url":null,"abstract":"According to medical data, inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), are global diseases of the 21st century, characteristic of developed countries, the treatment of which requires a systematic approach with an emphasis on safety, which may be implemented through the use of anti-inflammatory phytosubstances. Prospects for the medical use of raw materials Matricaria aurea (L.) Schultz-Bip. (M.aurea), which grows in Syria, are due to the wide use in ethnomedicine for the treatment of various inflammatory diseases, including in the complex therapy of IBD. For the development of phytopreparations, some numerical indicators of M.aurea raw materials were determined: fractional composition, moisture content, bulk density of crushed dried material, 70 % alcohol was chosen as an extractant, the content of extractives, the absorption coefficient of the extractant and the ash content were determined.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89236620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting Women’s Health in the Menstrual Cycle Using Herbal Nanopharmacy","authors":"Mirzaee Negin","doi":"10.33920/med-13-2202-08","DOIUrl":"https://doi.org/10.33920/med-13-2202-08","url":null,"abstract":"Holistic medicine is a form of healing that considers the whole person-body, mind, spirit, and emotions in the quest for optimal health and wellness. Holistic Gynecology means a holistic outlook or approach to gynecological treatment and care, which means it utilizes the principles of holistic medicine. The specific events that occur during the menstrual cycle can be divided into four phases: The menses phase, The follicular phase, Ovulation, The luteal phase. Cycle syncing is when adapting the diet, exercise routine, social calendar, and even important work engagements to the different phases of the monthly menstrual cycle. Seed cycling is the rotation of different edible seeds into the diet at different times in the menstrual cycle. It is a practice believed to help regulate reproductive hormones. During the follicular phase, pumpkin seeds and flax seeds help improve estrogen levels while preventing excess estrogen. During the luteal phase, sesame seeds and sunflower seeds help boost progesterone production. According to some articles, it was extracted seeds oil (Flaxseeds, pumpkin seeds, Sunflower seeds, and Sesame) with the help of nanotechnology. Given the advances in nanotechnology oils, and essential materials of these grains can be extracted to improve their effectiveness in different phases of a menstrual cycle.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78902268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability study of Celecoxib tablets 200 mg and Celecoxib sustained release tablets 200 mg by quality indicators during storage","authors":"Ahmed Alkhodri Ahmed Alkhodri, S. Suslina","doi":"10.33920/med-13-2202-05","DOIUrl":"https://doi.org/10.33920/med-13-2202-05","url":null,"abstract":"Drafts of original documents have developed for tablets of the latest generation of non-steroidal anti-inflammatory drug celecoxib with traditional and modified release for the treatment of inflammatory diseases. To establish the shelf life of tablets, the assessment of stability by quality indicators during storage under accelerated conditions was carried out.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"272 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73370573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the flavonoid content in the cormus of some species of the genus Crataegus L.","authors":"V. Kurkin, N. Volkova, O. Pravdivtseva","doi":"10.33920/med-13-2202-03","DOIUrl":"https://doi.org/10.33920/med-13-2202-03","url":null,"abstract":"The hawthorn (Crataegus L.) flowers and fruits are successfully used in medical practice as the cardiotonic drugs. The promising hawthorn raw materials are cormus collected at the flowering stage of the plant. A comparative analysis of the electronic spectra of extracts from the raw materials of three hawthorn types showed that extracts from the cormus of Crataegus monogyna Jacq. and Crataegus sanguinea Pall. are characterized by a maximum of absorption at 392 nm, while for extracts of Crataegus submollis Sarg. the maximum of absorption is 412 nm. The cormus of the Crataegus monogyna Jacq. harvested at the flowering stage of the plant are characterized by the highest content of flavonoids — 3.58 ± 0.18% (calculated on vitexin 2II-O-rhamnoside). The hawthorn cormus are a promising species of medicinal plant raw materials. Crataegus submollis Sarg. is a promising type of medicinal plants.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86491003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal compositions based on natural vegetal raw materials and individual substances for prevention and treatment of urolithiasis: substantiation of composition and biological screening","authors":"V. V. Davydova, E. Stepanova, M. A. Ogay","doi":"10.33920/med-13-2112-02","DOIUrl":"https://doi.org/10.33920/med-13-2112-02","url":null,"abstract":"Kidney and urinary tract diseases are an urgent problem of our time. An increase in the level of kidney and urinary tract diseases occurs with a decrease in the quality of life and ecology. Recently, due to changes in nutrition, sedentary lifestyle, and the impact of various adverse environmental factors, the formation of kidney stones has become increasingly common. Numerous metabolic disorders in urolithiasis require the use of various drugs. At the same time, despite the constant expansion of the range of synthetic drugs, herbal drugs occupy a significant place in the treatment and prevention of kidney pathology. Therefore, the creation of combinations of medicinal plant raw materials and individual chemical substances that are effective in urolithiasis is an urgent issue of modern medicine and pharmacy. Purpose. Establishing optimal ratios within constructed combinations for membrane-stabilizing and antioxidant activity as an indirect measure of specific activity The scientific novelty of the study is the design of compositions effective for dissolving urinary calculus. Materials and methods. We used technological methods for designing compositions based on natural plant raw materials and individual chemical substances — indapamide, ketoprofen, and mexidol. Biological methods: the effect of the developed combinations on daphnia was studied. Biological screening characterizes the presence of membrane-stabilizing and antioxidant effects in the developed formulations and can be a preliminary indicator for determining specific activity. Results. It was found that the most effective compositions for the vital activities of daphnia were: Composition 1: Sum of individual dry extracts + Indapamide Composition 2: Sum of individual dry extracts + Ketoprofen Composition 3: Sum of individual dry extracts + Mexidol Conclusion. We have developed the following compositions: 1. Sum of individual phytoextracts (dyer’s madder rhizomes with roots (extractant — 70 % ethanol), Orthosiphon stamineus leaves (extractant — 40 % ethanol), knot grass (extractant — 70 % ethanol), birch buds (extractant — 70 % ethanol), peppermint leaves (extractant — 96 % ethanol), bay laurel leaves (extractant — 40 % ethanol), common licorice rhizomes with roots (extractant — 0.25 % ammonia solution) + indapamide. 2. Sum of individual phytoextracts (dyer’s madder rhizomes with roots (extractant — 70 % ethanol), Orthosiphon stamineus leaves (extractant — 40 % ethanol), knot grass (extractant — 70 % ethanol), birch buds (extractant — 70 % ethanol), peppermint leaves (extractant — 96 % ethanol), bay laurel leaves (extractant — 40 % ethanol), common licorice rhizomes with roots (extractant — 0.25 % ammonia solution) + ketoprofen. 3. Sum of individual phytoextracts (dyer’s madder rhizomes with roots (extractant — 70 % ethanol), Orthosiphon stamineus leaves (extractant — 40 % ethanol), knot grass (extractant — 70 % ethanol), birch buds (extractant — 70 % ethanol), peppermint leaves (extracta","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81349598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}