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Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)最新文献

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Pharmacovigilance as a key component of drug regulatory systems 药物警戒是药物监管系统的关键组成部分
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-06-15 DOI: 10.33920/med-13-2206-02
Igor Valerievich Korobkin
{"title":"Pharmacovigilance as a key component of drug regulatory systems","authors":"Igor Valerievich Korobkin","doi":"10.33920/med-13-2206-02","DOIUrl":"https://doi.org/10.33920/med-13-2206-02","url":null,"abstract":"Information for control objects that are assigned risk categories is collected, processed, analyzed and recorded. The pharmaceutical manufacturer enters into an agreement with the recipient of the products on the exchange of data on the safety of such products in order to identify and study possible problems related to the safety of use, as well as to confirm social responsibility for the safety of drugs put into circulation.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82117285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
General aspects of extrusion-spheronisation as a pellet production technique 作为球团生产技术的挤压滚圆的一般方面
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-06-15 DOI: 10.33920/med-13-2206-01
Viktorija Vladimirovna Bueva, E. V. Blynskaja, S. V. Tishkov, Viktor Konstantinovich Alekseev, K. Alekseev
{"title":"General aspects of extrusion-spheronisation as a pellet production technique","authors":"Viktorija Vladimirovna Bueva, E. V. Blynskaja, S. V. Tishkov, Viktor Konstantinovich Alekseev, K. Alekseev","doi":"10.33920/med-13-2206-01","DOIUrl":"https://doi.org/10.33920/med-13-2206-01","url":null,"abstract":"Various aspects of the extrusion-spheronisation technique as one of the most popular pellets production methods was considered in this review. The advantages of extrusion-spheronization in comparison with other methods are the ability to include high-dose pharmaceutical substances, combine two or more substances, as well as change the physical characteristics of initial material. In addition, the method allows to obtain particles with excellent flowability, low hygroscopicity, high sphericity, narrow particle size distribution and smooth surface The main advantages and disadvantages of the equipment used are shown, and the process initial parameters influence on the obtained material final properties is noted. Particular attention is paid to such stages of extrusion-spheronization as obtaining a wet mass and it’s following extrusion-spheronization, varying parameters of which is possible to change the pellets morphological and technological properties.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78520705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
State of the market for specific prophylaxis against colibacillosis in animals 针对动物大肠杆菌病的特定预防措施的市场状况
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-06-15 DOI: 10.33920/med-13-2206-04
A. Galiakbarova
{"title":"State of the market for specific prophylaxis against colibacillosis in animals","authors":"A. Galiakbarova","doi":"10.33920/med-13-2206-04","DOIUrl":"https://doi.org/10.33920/med-13-2206-04","url":null,"abstract":"Infectious diseases cause huge damage to the country's agriculture due to a decrease in the productivity of sick animals, the cost of their treatment, as well as the death of young animals. The paper provides a brief description of the disease and the history of the development of vaccines against colibacillosis and analyzes the composition and method of application of domestic and foreign biological products registered for immunization against colibacillosis in the Russian Federation and in the world.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75259438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New cyanothioacetamide derivatives as potential pain relievers 新的氰硫乙酰胺衍生物作为潜在的止痛药
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-06-14 DOI: 10.33920/med-13-2208-02
E. Bibik, I. S. Oleĭnik, K. Frolov, V. Dotsenko, S. Krivokolysko
{"title":"New cyanothioacetamide derivatives as potential pain relievers","authors":"E. Bibik, I. S. Oleĭnik, K. Frolov, V. Dotsenko, S. Krivokolysko","doi":"10.33920/med-13-2208-02","DOIUrl":"https://doi.org/10.33920/med-13-2208-02","url":null,"abstract":"The purpose of the research: to study the analgesic activity of the synthesized samples of new cyanothioacetamide derivatives in the classic hot plate test on white rats.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82904577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and validation of a methodology for quantifying the amount of flavonoids in a multivitamin collection 一种定量测定多种维生素中黄酮类化合物含量的方法的建立和验证
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-03-28 DOI: 10.33920/med-13-2204-03
Victoria Maksimovna Babyshkina, M. S. Smirnova, A. Marakhova
{"title":"Development and validation of a methodology for quantifying the amount of flavonoids in a multivitamin collection","authors":"Victoria Maksimovna Babyshkina, M. S. Smirnova, A. Marakhova","doi":"10.33920/med-13-2204-03","DOIUrl":"https://doi.org/10.33920/med-13-2204-03","url":null,"abstract":"Development and validation of a methodology for quantifying the amount of flavonoids in a multivitamin collection","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86624728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technological aspects and method of using fast-dissolving films in veterinary medicine 兽药用速溶膜的技术方面和方法
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-03-28 DOI: 10.33920/med-13-2204-06
A. Karamyan
{"title":"Technological aspects and method of using fast-dissolving films in veterinary medicine","authors":"A. Karamyan","doi":"10.33920/med-13-2204-06","DOIUrl":"https://doi.org/10.33920/med-13-2204-06","url":null,"abstract":"In modern veterinary medicine, solid and liquid dosage forms are most commonly used. Prescribing drugs in these dosage forms is often associated with already known difficulties and side effects. Fast-dissolving films developed in pharmacy are gaining more and more popularity today.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84698723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of phenol carboxylic acids in echinacea grass and echinacea tablets in order to develop a technique for their quantitative determination using high-performance liquid chromatography (HPLC) 紫锥菊草和紫锥菊片中酚羧酸含量的高效液相色谱法研究
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-03-28 DOI: 10.33920/med-13-2204-02
Anastasia Yuryevna Romarchuk
{"title":"Study of phenol carboxylic acids in echinacea grass and echinacea tablets in order to develop a technique for their quantitative determination using high-performance liquid chromatography (HPLC)","authors":"Anastasia Yuryevna Romarchuk","doi":"10.33920/med-13-2204-02","DOIUrl":"https://doi.org/10.33920/med-13-2204-02","url":null,"abstract":"Echinacea herb and preparations based on it have the immunomodulatory and anti-inflammatory properties necessary for today, which is due to the presence of phenolcarboxylic acids in their composition. At the moment, the quantitative determination of phenolcarboxylic acids in echinacea tablets requires time-consuming sample preparation and determination by a spectrophotometric method that does not have sufficient specificity. In this regard, it is proposed to standardize the quantitative determination of phenolcarboxylic acids in echinacea tablets by HPLC, which will effectively separate the components of the mixture to study its composition, establish the dominant of chicory acid in the water-ethanol extract, and also reduce the time spent on analysis.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90940849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biotechnological preparations based on monoclonal antibodies 基于单克隆抗体的生物技术制备
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-03-28 DOI: 10.33920/med-13-2204-05
Igor Valerievich Korobkin
{"title":"Biotechnological preparations based on monoclonal antibodies","authors":"Igor Valerievich Korobkin","doi":"10.33920/med-13-2204-05","DOIUrl":"https://doi.org/10.33920/med-13-2204-05","url":null,"abstract":"The current biopharmaceutical industry depends on the development of bioinformatics in the search and optimization of the properties of drugs. Compounds and their derivatives, whose metabolism influence, stability, and immunogenicity are confirmed by analytical and computational tools, are the candidates for becoming the drugs against antibodies.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"44 10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75696577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activities for the validation of processes, qualification of equipment and systems used in the industrial manufacture of medicines 用于药品工业生产的工艺、设备和系统的验证活动
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-03-28 DOI: 10.33920/med-13-2204-07
Igor Valerievich Korobkin
{"title":"Activities for the validation of processes, qualification of equipment and systems used in the industrial manufacture of medicines","authors":"Igor Valerievich Korobkin","doi":"10.33920/med-13-2204-07","DOIUrl":"https://doi.org/10.33920/med-13-2204-07","url":null,"abstract":"The quality of the finished product must be laid down before the production process. It seems relevant to create guarantees that the finished medicinal product not only meets regulatory conditions, but is also manufactured in accordance with the same procedure and under the same conditions every time it is released. Validation, as a section of the GMP rules, describes the control of a given process.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89130725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a procedure for sterilizing filtration validation 过滤验证灭菌程序的制定
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-03-28 DOI: 10.33920/med-13-2204-01
I. Vasilenko, Pavel Romanovich Kozin, Yu. V. Krasnova
{"title":"Development of a procedure for sterilizing filtration validation","authors":"I. Vasilenko, Pavel Romanovich Kozin, Yu. V. Krasnova","doi":"10.33920/med-13-2204-01","DOIUrl":"https://doi.org/10.33920/med-13-2204-01","url":null,"abstract":"Validation of sterilizing filtration is extremely difficult in the realities of a working production. To prevent the negative impact of sterilizing filtration validation on the quality of the environment, a model of the process has been developed in the laboratory. On the basis of the developed model, validation tests were carried out to the extent that allows assessing the stability and reproducibility of the process. The obtained results showed the suitability of the process of sterilizing filtration of sodium luminol, as part of the process of aseptic production of the medicinal product.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72642575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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