Viktorija Vladimirovna Bueva, E. V. Blynskaja, S. V. Tishkov, Viktor Konstantinovich Alekseev, K. Alekseev
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General aspects of extrusion-spheronisation as a pellet production technique
Various aspects of the extrusion-spheronisation technique as one of the most popular pellets production methods was considered in this review. The advantages of extrusion-spheronization in comparison with other methods are the ability to include high-dose pharmaceutical substances, combine two or more substances, as well as change the physical characteristics of initial material. In addition, the method allows to obtain particles with excellent flowability, low hygroscopicity, high sphericity, narrow particle size distribution and smooth surface The main advantages and disadvantages of the equipment used are shown, and the process initial parameters influence on the obtained material final properties is noted. Particular attention is paid to such stages of extrusion-spheronization as obtaining a wet mass and it’s following extrusion-spheronization, varying parameters of which is possible to change the pellets morphological and technological properties.