作为球团生产技术的挤压滚圆的一般方面

Viktorija Vladimirovna Bueva, E. V. Blynskaja, S. V. Tishkov, Viktor Konstantinovich Alekseev, K. Alekseev
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引用次数: 0

摘要

作为最流行的球团生产方法之一,挤出球化技术的各个方面都被认为在这篇综述中。与其他方法相比,挤出滚圆的优点是能够包含高剂量的药物物质,结合两种或两种以上的物质,以及改变初始材料的物理特性。此外,该方法可获得流动性好、吸湿性低、球形度高、粒径分布窄、表面光滑的颗粒。文中给出了所用设备的主要优缺点,并指出了工艺初始参数对所得材料最终性能的影响。特别要注意的是挤出-球化的这些阶段,如获得湿质量和随后的挤出-球化,不同的参数可能会改变球团的形态和技术特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
General aspects of extrusion-spheronisation as a pellet production technique
Various aspects of the extrusion-spheronisation technique as one of the most popular pellets production methods was considered in this review. The advantages of extrusion-spheronization in comparison with other methods are the ability to include high-dose pharmaceutical substances, combine two or more substances, as well as change the physical characteristics of initial material. In addition, the method allows to obtain particles with excellent flowability, low hygroscopicity, high sphericity, narrow particle size distribution and smooth surface The main advantages and disadvantages of the equipment used are shown, and the process initial parameters influence on the obtained material final properties is noted. Particular attention is paid to such stages of extrusion-spheronization as obtaining a wet mass and it’s following extrusion-spheronization, varying parameters of which is possible to change the pellets morphological and technological properties.
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