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Possible pharmacotherapy methods in post-COVID encephalopathy covid - 19后脑病可能的药物治疗方法
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-07-30 DOI: 10.33920/med-13-2208-08
D. V. Rakhmankulov
{"title":"Possible pharmacotherapy methods in post-COVID encephalopathy","authors":"D. V. Rakhmankulov","doi":"10.33920/med-13-2208-08","DOIUrl":"https://doi.org/10.33920/med-13-2208-08","url":null,"abstract":"Recently, there has been great interest in studying the complications of the novel coronavirus infection COVID-19 in the form of the so-called post-COVID syndrome (long COVID — U09.9). One of the main manifestations of this syndrome is encephalopathy, occurring due to disorders in microcirculation and functioning of the neuronal network, pathways, and synaptic apparatus at the cortical, subcortical and stem levels caused by direct viral invasion, as well as non-specific reactions of cerebral structures to ischemia, hypoxia and viral invasion, determined by the degree of compensatory mechanisms. The purpose of this work is to select possible methods of treating this complication using pharmacotherapy. The tasks are: to study the pathogenesis of this complication; to research literature on the subject of morphological macro- and micro-changes; to review existing treatments; to conduct a study with a control group and analyze the data obtained.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87174985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organotoxicity study of new 1,4 dihydrothiopyridine derivatives with analgesic activity 具有镇痛活性的新型1,4二氢硫代吡啶衍生物的有机毒性研究
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-07-30 DOI: 10.33920/med-13-2208-09
D. R. Rupengey, E. Bibik, D. Krivokolysko, K. Frolov, V. Dotsenko, S. Krivokolysko
{"title":"Organotoxicity study of new 1,4 dihydrothiopyridine derivatives with analgesic activity","authors":"D. R. Rupengey, E. Bibik, D. Krivokolysko, K. Frolov, V. Dotsenko, S. Krivokolysko","doi":"10.33920/med-13-2208-09","DOIUrl":"https://doi.org/10.33920/med-13-2208-09","url":null,"abstract":"Recently, there has been great interest in studying the complications of the novel coronavirus infection COVID-19 in the form of the so-called post-COVID syndrome (long COVID — U09.9). One of the main manifestations of this syndrome is encephalopathy, occurring due to disorders in microcirculation and functioning of the neuronal network, pathways, and synaptic apparatus at the cortical, subcortical and stem levels caused by direct viral invasion, as well as non-specific reactions of cerebral structures to ischemia, hypoxia and viral invasion, determined by the degree of compensatory mechanisms. The purpose of this work is to select possible methods of treating this complication using pharmacotherapy. The tasks are: to study the pathogenesis of this complication; to research literature on the subject of morphological macro- and micro-changes; to review existing treatments; to conduct a study with a control group and analyze the data obtained.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91023931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacoepidemiological analysis of antifungal therapy in pregnant patients 妊娠患者抗真菌治疗的药物流行病学分析
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-07-30 DOI: 10.33920/med-13-2208-24
O. Eshonkhuzhaev, A. N. Khalilov
{"title":"Pharmacoepidemiological analysis of antifungal therapy in pregnant patients","authors":"O. Eshonkhuzhaev, A. N. Khalilov","doi":"10.33920/med-13-2208-24","DOIUrl":"https://doi.org/10.33920/med-13-2208-24","url":null,"abstract":"The ongoing antifungal therapy for pregnant patients is one of the poorly studied sections of pharmacotherapy, and in particular, clinical pharmacology. As it is known, large clinical studies are not conducted in pregnant women for ethical reasons. In addition, when prescribing antifungal drugs to pregnant women, doctors often forget that the physiological changes that occur in a woman's body can lead to changes in the pharmacokinetics of these drugs and, consequently, to a change in their effectiveness and safety, which is fraught with consequences not only for the fetus, but also for mother. The purpose of the studies is to evaluate the frequency and quality of using antifungal agents during pregnancy.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84858428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placebo in clinical practice and new drugs testing 安慰剂在临床实践和新药试验中的应用
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-07-30 DOI: 10.33920/med-13-2208-13
N. S. Umurzakova, M. Turgunov, O. Eshonkhuzhaev
{"title":"Placebo in clinical practice and new drugs testing","authors":"N. S. Umurzakova, M. Turgunov, O. Eshonkhuzhaev","doi":"10.33920/med-13-2208-13","DOIUrl":"https://doi.org/10.33920/med-13-2208-13","url":null,"abstract":"The aim of the work was to study modern methods of treatment of substance abuse with various psychoactive substances. Materials and methods. Analysis of literature data on the pharmacotherapy of various forms of substance abuse.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74096519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative analysis of C-section outcomes with antibiotic prophylaxis and antibiotic therapy in the Regional Perinatal Center 地区围产期中心预防使用抗生素与抗生素治疗的剖腹产结局比较分析
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-07-30 DOI: 10.33920/med-13-2208-11
C. B. Tashtanbekova, E. G. A. E. G. Aleksandrova, A. Evstratov, E. A. Chuenkova, L. E. Ziganshina
{"title":"Comparative analysis of C-section outcomes with antibiotic prophylaxis and antibiotic therapy in the Regional Perinatal Center","authors":"C. B. Tashtanbekova, E. G. A. E. G. Aleksandrova, A. Evstratov, E. A. Chuenkova, L. E. Ziganshina","doi":"10.33920/med-13-2208-11","DOIUrl":"https://doi.org/10.33920/med-13-2208-11","url":null,"abstract":"Prophylactic prescription of antibiotics before C-section prevents maternal infectious morbidity in the postoperative period, while irrational prescription leads to the development of adverse outcomes [1]. Postpartum infections are becoming the main cause of prolonged hospital stay and increase the costs of the healthcare system [2]. The aim: to conduct a comparative pharmacoepidemiological analysis of the caesarean section outcomes with antibiotic prophylaxis and antibiotic therapy.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84807000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paracetamol efficacy in children 对乙酰氨基酚对儿童的疗效
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-07-30 DOI: 10.33920/med-13-2208-14
G. E. Khakberdieva, N. F. Bakhtiyorova
{"title":"Paracetamol efficacy in children","authors":"G. E. Khakberdieva, N. F. Bakhtiyorova","doi":"10.33920/med-13-2208-14","DOIUrl":"https://doi.org/10.33920/med-13-2208-14","url":null,"abstract":"Hyperthermia is one of the main reasons for seeking medical care in pediatrics, accounting for up to 30 % of all doctor visits by children in general and up to 2/3 of visits by children under the age of three years. The aim of the study is to investigate paracetamol antipyretic efficacy and tolerability in order to identify the possibility of recommending the drug for clinical use.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74048441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A clinical case of infection caused by association of multidrug-resistant K. pneumoniae and mucormycosis in a child with drug immunosuppression 多药耐药肺炎克雷伯菌与毛霉菌病联合感染1例药物免疫抑制患儿
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-07-30 DOI: 10.33920/med-13-2208-04
R. A. Osokina, A. Ziatdinov, L. I. Basanova, M. S. Pospelov, E. M. Kvitko, A. V. Berdnikova, I. Valiullina
{"title":"A clinical case of infection caused by association of multidrug-resistant K. pneumoniae and mucormycosis in a child with drug immunosuppression","authors":"R. A. Osokina, A. Ziatdinov, L. I. Basanova, M. S. Pospelov, E. M. Kvitko, A. V. Berdnikova, I. Valiullina","doi":"10.33920/med-13-2208-04","DOIUrl":"https://doi.org/10.33920/med-13-2208-04","url":null,"abstract":"The article demonstrates a case of infection caused by the association of multidrug-resistant (MDR) K.pneumoniae and mucormycosis in a child with a transplanted liver after the novel coronavirus infection/","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75626344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacoepidemiological analysis of antibiotic therapy for pathologies in women during pregnancy 妊娠期妇女疾病抗生素治疗的药物流行病学分析
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-07-30 DOI: 10.33920/med-13-2208-23
O. Eshonkhuzhaev, F.T. Usmanova
{"title":"Pharmacoepidemiological analysis of antibiotic therapy for pathologies in women during pregnancy","authors":"O. Eshonkhuzhaev, F.T. Usmanova","doi":"10.33920/med-13-2208-23","DOIUrl":"https://doi.org/10.33920/med-13-2208-23","url":null,"abstract":"The aim of the work was to assess the quality of antibiotic therapy for pathologies in women during pregnancy. Materials and methods: Retrospective analysis of case histories of pregnant women who received antibiotic therapy (ABT) in one of the maternity complexes in the Andijan Region.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74458639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypotheses for isotretinoin mechanisms of action in acne treatment 异维甲酸在痤疮治疗中的作用机制假说
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-07-30 DOI: 10.33920/med-13-2208-06
A. G. Okhtyarkina
{"title":"Hypotheses for isotretinoin mechanisms of action in acne treatment","authors":"A. G. Okhtyarkina","doi":"10.33920/med-13-2208-06","DOIUrl":"https://doi.org/10.33920/med-13-2208-06","url":null,"abstract":"Currently, the problem of acne does not lose its relevance not only among adolescents, but also in adult women and men. One of the most effective drugs in the treatment of severe and resistant forms of acne are isotretinoin preparations, i.e. systemic retinoids, the instructions for which do not indicate the mechanism of action. The purpose of the work: to consider the hypotheses of the mechanism of action of systemic retinoids on various pathogenetic acne factors.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89594262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Features of the marketing policy of a pharmaceutical enterprise 医药企业营销策略的特点
Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2022-06-15 DOI: 10.33920/med-13-2206-03
Igor Valerievich Korobkin
{"title":"Features of the marketing policy of a pharmaceutical enterprise","authors":"Igor Valerievich Korobkin","doi":"10.33920/med-13-2206-03","DOIUrl":"https://doi.org/10.33920/med-13-2206-03","url":null,"abstract":"Marketing strategies to promote medicines can become illegal if used off-label. Nevertheless, many types of marketing promotion of medicines for diseases not previously described can be approved by pharmaceutical regulatory authorities when these medications are effective and safe.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74962213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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