Study of the kinetics of benzidamine hydrochloride release from topical sprays in an in vitro experiment

Inflammatory processes accompanied by a sore throat are a widespread symptom of both infectious and non-infectious genesis. In this case, topical therapy with medications that combine anti-inflammatory and analgesic effects, in the form of comfortable dosage forms — sprays, is the most effective. In this case, the used drug has a complex effect on contact tissues, due to both the actual pharmacological activity of the pharmaceutical substance and the physico-chemical properties of the excipients forming the dosage form. A study of the release of the active substance from sprays in the perspective of their topical application, as well as their osmotic activity in an in vitro experiment that simulates the process of application to the throat mucosa, was carried out. The real influence of the osmotic activity of the dosage form on the degree of release of the active substance due to the multidirectional nature of the resulting diffusion flows is shown.