在聚维酮水溶液中加入有机溶剂对湿法造粒制备的MCC颗粒粒径的影响

Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-02-25 DOI:10.33920/med-13-2301-04

V. Markeev, S. Tishkov, E. V. Blynskaya, K. S. Kochetov, M. S. Vykhristyuk, А. Maksat

{"title":"在聚维酮水溶液中加入有机溶剂对湿法造粒制备的MCC颗粒粒径的影响","authors":"V. Markeev, S. Tishkov, E. V. Blynskaya, K. S. Kochetov, M. S. Vykhristyuk, А. Maksat","doi":"10.33920/med-13-2301-04","DOIUrl":null,"url":null,"abstract":"Most of the developed new pharmaceutical substances are insoluble in water, which makes it difficult to create solid dosage forms. This makes researchers use solubilization approaches for poorly soluble molecules. In our study, the applicability of ethyl alcohol as a cosolvent in the technology of wet granulation of tablets was analyzed.","PeriodicalId":12259,"journal":{"name":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","volume":"39 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of adding an organic solvent to povidone aqueous solution on the size of MCC granules obtained by wet granulation\",\"authors\":\"V. Markeev, S. Tishkov, E. V. Blynskaya, K. S. Kochetov, M. S. Vykhristyuk, А. Maksat\",\"doi\":\"10.33920/med-13-2301-04\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Most of the developed new pharmaceutical substances are insoluble in water, which makes it difficult to create solid dosage forms. This makes researchers use solubilization approaches for poorly soluble molecules. In our study, the applicability of ethyl alcohol as a cosolvent in the technology of wet granulation of tablets was analyzed.\",\"PeriodicalId\":12259,\"journal\":{\"name\":\"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)\",\"volume\":\"39 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-02-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33920/med-13-2301-04\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33920/med-13-2301-04","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

大多数已开发的新药不溶于水，这使得难以制造固体剂型。这使得研究人员对难溶分子使用增溶方法。本研究分析了乙醇作为助溶剂在片剂湿制粒工艺中的适用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The effect of adding an organic solvent to povidone aqueous solution on the size of MCC granules obtained by wet granulation

Most of the developed new pharmaceutical substances are insoluble in water, which makes it difficult to create solid dosage forms. This makes researchers use solubilization approaches for poorly soluble molecules. In our study, the applicability of ethyl alcohol as a cosolvent in the technology of wet granulation of tablets was analyzed.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)

自引率

0.00%

发文量