透皮剂型的研究现状

Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology) Pub Date : 2023-04-05 DOI:10.33920/med-13-2302-04

V. V. Tokaev

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引用次数: 0

摘要

透皮治疗系统(TTS)为长效药物的靶向递送开辟了新的机会。在TTS的创建中，一个紧迫的高科技问题是寻找生物相容性的TTS成分，包括药物转移激活剂。尽管创造透皮形式很复杂，但经皮扩散传递的药用物质的数量正在逐渐增加。硝苯地平的一个显著缺点是它在水中的溶解度低，这严重影响了药物物质从药物底部的释放程度。由于医药市场上缺乏以硝苯地平为基础的透皮治疗系统，因此开发其以提高原料药的生物制药性能是现代药学急需解决的问题。

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Current state of research in the field of transdermal dosage forms

Transdermal therapeutic systems (TTS) open up new opportunities for targeted delivery of long-acting drugs. One of the urgent and high-tech problems in the TTS creation has been the search for biocompatible TTS components, including drug transfer activators. Despite the complexity of creating transdermal forms, the number of medicinal substances delivered by percutaneous diffusion is gradually increasing. A significant disadvantage of nifedipine is its low solubility in water, which significantly affects the degree of release of the pharmaceutical substance from the base of the drug. Due to the absence of nifedipine-based transdermal therapeutic systems on the pharmaceutical market, their development in order to improve the biopharmaceutical properties of a pharmaceutical substance is an urgent problem of modern pharmacy.

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Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology)

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