Cetirizine-based soft dosage forms

Abstract

The development of rational dosage forms with cetirizine is an urgent task. Cetirizine is a second-generation antihistamine. In patients suffering from allergies, the use of cetirizine leads to a significant improvement in the course of the disease. Even in veterinary practice, taking cetirizine orally once a day provides sufficient antihistamine effect in animals. Currently, the following drugs with cetirizine are available: film-coated tablets, orodispersible tablets, as well as drops for oral administration. There are no transdermal dosage forms with cetirizine in Russia. The transdermal therapeutic system (TTS) is a metered-dose soft dosage form for external use in the form of gels, patches, or films, which releases the drug slowly. The TTS advantages are as follows: ease of use, the ability of the medicinal substance to quickly enter the bloodstream, the ability to regulate the release rate of the active substance and use hydrophilic and lipophilic substances. We have developed two transdermal therapeutic systems with cetirizine — a gel and a patch, and studied the pharmacological effects. The purpose of the study. The purpose of this work is to create external dosage forms containing cetirizine. The scientific novelty of the research is the design of formulations for antiallergic dosage. Materials and methods. Technological and pharmacological research methods were used. Results. The study showed that the developed gel and the patch with cetirizine have antiallergic properties comparable to the comparison drug (Psilo-balsam gel), while surpassing the reference drug in its effect on the formation of allergic exudative edema. Conclusion. External dosage forms — a transdermal therapeutic gel and a patch containing cetirizine have been created.