Advanced Synthesis & Catalysis最新文献_第8页

Construction of meta-Disubstituted Triaryls via Iodine-Catalyzed Oxidative Aromatization Coupling of Cycloalkenes with Indoles 碘催化环烯烃与吲哚氧化芳构偶联构建间二取代三芳基

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2025-09-19 DOI: 10.1002/adsc.70130

Yang Yang, Heng Liu, Zhi-Hui Wang, Yilitabaier Julaiti, Yanhua Lu, Boshun Wan, Xiao-Feng Wu, Qing-An Chen

{"title":"\u0000Construction of meta-Disubstituted Triaryls via Iodine-Catalyzed Oxidative Aromatization Coupling of Cycloalkenes with Indoles","authors":"Yang Yang, Heng Liu, Zhi-Hui Wang, Yilitabaier Julaiti, Yanhua Lu, Boshun Wan, Xiao-Feng Wu, Qing-An Chen","doi":"10.1002/adsc.70130","DOIUrl":"https://doi.org/10.1002/adsc.70130","url":null,"abstract":"meta-Disubstituted triaryls are privileged scaffolds in bioactive molecules and functional materials, but their efficient synthesis remains challenging, due to limitations in regioselectivity and reliance on prefunctionalized substrates or transition metals. Herein, an iodine-catalyzed oxidative aromatization strategy is reported for the construction of meta-triaryls via direct coupling of readily available cycloalkenes with indoles. This protocol enables regioselective CC bond formation at the indole C3-position and a subsequent dehydrogenative desaturation of the cycloalkene component to form the meta-substituted arene motif. The method features broad substrate scope, accommodating diverse substituted cycloalkenes and indoles. Key advantages include economical catalyst (HI as iodine source), avoidance of precious metals, and operational simplicity. Additionally, the products can undergo an array of synthetic transformations, including heterocycle skeleton editing to quinolines, halogenations, and photoredox functionalizations, which highlight the potential applications of this strategy.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"22 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Ene Reactions with Carbon Enophiles 烯与亲碳亲烯试剂反应的最新进展

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2025-09-18 DOI: 10.1002/adsc.70122

Thomas J. J. Müller

{"title":"Recent Advances in Ene Reactions with Carbon Enophiles","authors":"Thomas J. J. Müller","doi":"10.1002/adsc.70122","DOIUrl":"https://doi.org/10.1002/adsc.70122","url":null,"abstract":"Ene reactions are inter- or intramolecular addition reactions between a four-electron \"ene\" component and a two-electron enophile functionality, in which two π-bonds and a C–H (or metal–C) σ-bond are rearranged into one π-bond and two σ-bonds. One of the newly formed σ-bonds is a carbon–carbon bond, while the other is the rearranged a C–H (or metal–C) bond. This transformation enables the formation of structurally and functionally complex ene products in a single step. Originally, ene reactions were discovered as concerted and stepwise pericyclic elementary processes. However, increasing mechanistic insight—gained through both experimental and computational studies—along with extensive empirical methodological work, has paved the way to a plethora of ene-type reactions involving carbon enophiles. Since 2012, the already well-established transition metal-catalyzed variants of ene reactions have significantly expanded. Moreover, highly reactive aryne intermediates—generated in situ either by fluoride induced elimination from ortho-silyl aryltriflates at room temperature, or by hexadehydro-Diels–Alder reaction of a 1,3-diyne with an alkyne (both inter- and intramolecularly)—find increasing application in novel ene-type sequences. Propargyl ene reactions also gain traction, particularly because the resulting ene-allenes serve as highly valuable intermediates in the design of domino sequences that lead to complex polycyclic fused structures. Finally, the implementation of ene reactions in polymer chemistry for the synthesis of functionalized polymers and renewable unsaturated raw materials has emerged as a promising alternative to the use of purely petrochemistry based substrates.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"22 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145078497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Versatile Route to 3,3-Disubstituded Phthalides Via Arylogous Michael Addition Catalyzed by Organic Base 有机碱催化芳基迈克尔加成制备3,3-二取代邻苯二甲酸酯的通用途径

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2025-09-18 DOI: 10.1002/adsc.70128

Enzo Eddebbarh, Lou Mazoyer, Jérôme Thibonnet, Julien Petrignet

引用次数: 0

Chemodivergent Higher-Order Annulation of Azaheptafulvenes with Enals Through N-Heterocyclic Carbene Catalysis 氮杂环碳催化氮杂七富尔烯与烯醛的高阶化学发散环化

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2025-09-18 DOI: 10.1002/adsc.70127

Yiwen Zhang, Yangjie Yu, Min Xia, Zhen Wang, Manman Sun, Weijun Yao

引用次数: 0

Visible-Light Photocatalyzed Selective Synthesis of 1,2- or 1,3-Dithianes From Thietanes: An Experimental and Theoretical Study 可见光催化从硫烷选择性合成1,2-或1,3-二硫烷的实验和理论研究

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2025-09-18 DOI: 10.1002/adsc.70125

Gabriel Cormier, Manuel Pedrón, Maria I. Lapuh, Regis Guillot, Ilaria Ciofini, Thomas Boddaert

{"title":"Visible-Light Photocatalyzed Selective Synthesis of 1,2- or 1,3-Dithianes From Thietanes: An Experimental and Theoretical Study","authors":"Gabriel Cormier, Manuel Pedrón, Maria I. Lapuh, Regis Guillot, Ilaria Ciofini, Thomas Boddaert","doi":"10.1002/adsc.70125","DOIUrl":"https://doi.org/10.1002/adsc.70125","url":null,"abstract":"Unlike other sulfur-containing heterocycles, the potential applications of functionalized dithianes have been less explored to date due to their challenging synthesis. To address this issue, we herein leverage the straightforward access to functionalized thietanes and describe a selective photochemical ring enlargement of the latter to 1,2- or 1,3-dithianes using thiocarbonyl substrates, which are in situ generated via a Norrish-type II fragmentation reaction. The library of dithianes obtained by this photocatalyzed domino sequence between diversely substituted thietanes and various thiocarbonyls revealed regioselectivity rules: excited thioketones lead exclusively to 1,2-dithianes, while excited thioaldehydes selectively yield 1,3-dithianes, where 1,2-dithianes serve as precursors to their regioisomers. The ring expansion reaction leading to 1,2-dithianes was also integrated into a triple photochemical cascade, where the thietane intermediates were obtained via a thia-Paternò_Büchi reaction between Norrish-II thiocarbonyl products and various alkene partners. These experimental results were complemented with time-dependent density functional theory calculations, which support the complex chemical pathway, rationalize the observed regioselectivity, and further substantiate mechanistic proposals related to the photolysis of disulfide bridges in peptides.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"155 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145078493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active‐Site Microenvironments Design of Hydrogenation Catalysts for Enhanced Hydrocracking of Heavy Oil 重油加氢裂化催化剂活性位点微环境设计

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2025-09-17 DOI: 10.1002/adsc.70121

Peng Xue, Guangxun Sun, Qian Zhang, Yingying Liu, Shiwen Zhang, Zhidong Wang, Lei Wang, Jiaye Li, Hong Yin, Haifeng Gong, Yuan Pan

{"title":"Active‐Site Microenvironments Design of Hydrogenation Catalysts for Enhanced Hydrocracking of Heavy Oil","authors":"Peng Xue, Guangxun Sun, Qian Zhang, Yingying Liu, Shiwen Zhang, Zhidong Wang, Lei Wang, Jiaye Li, Hong Yin, Haifeng Gong, Yuan Pan","doi":"10.1002/adsc.70121","DOIUrl":"https://doi.org/10.1002/adsc.70121","url":null,"abstract":"Slurry phase hydrocracking (SPHC) is one of the effective ways to achieve efficient conversion of low‐quality heavy oil. The active‐site structural design of catalysts is crucial to improve the performance but is still challenging. However, up to now, few reviews on the active‐site microenvironments design of catalyst for enhancing SPHC performance have been reported. Herein, this review summarizes the research progress on the active‐site microenvironments regulation strategies of hydrogenation catalysts at the molecular scale for SPHC systematically. Then, based on the problem of low hydrogenation efficiency due to the easy aggregation and low atomic utilization of molecular catalysts, the design strategies for catalysts on the atomic scale are proposed systematically. Subsequently, the design principles of active‐site microenvironment for hydrogenation catalysts to enhance the SPHC are revealed. Finally, the opportunities and challenges of atomically dispersed catalyst for SPHC are prospected. This review provides an important reference for the design and development of high‐performance hydrogenation catalysts for SPHC of heavy oil.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"16 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fe‐Photocatalyzed Decarboxylative Giese‐Type Reaction of α‐N, O or S Carboxylic Acids: Insight into the Mechanism of the Radical Formation 铁光催化α - N， O或S羧酸脱羧型反应：自由基形成机制的研究

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2025-09-16 DOI: 10.1002/adsc.70114

Fernando Pérez‐Maseda, María Martín, Jorge Labrador‐Santiago, Inés Corral, Diego J. Cárdenas

引用次数: 0

Recent Advances in the Application of Dioxazolones in Transition Metal‐Catalyzed Hydroamidation 二恶唑酮类化合物在过渡金属催化氢酰胺化反应中的应用进展

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2025-09-16 DOI: 10.1002/adsc.70124

Xun Tian, Xueyun Cai, Ying Long, Lin Qi, Lindong Luan, Xiaodong Yang

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Palladium‐Catalyzed Denitrative Decarboxylation of Nitroarenes with Alkynyl Carboxylic Acids 钯催化硝基芳烃与炔基羧酸的脱羧反应