Palladium‐Catalyzed Denitrative Decarboxylation of Nitroarenes with Alkynyl Carboxylic Acids

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-09-15 DOI:10.1002/adsc.70120

Chuan Han, Chau Ming So

引用次数: 0

Abstract

A general approach for the decarboxylation of alkynyl carboxylic acids with nitroarenes via denitrative coupling is reported for the first time. The methodology demonstrates broad substrate generality, accommodating diverse nitroaromatics, including electron‐deficient heteroarenes, to deliver aryl alkynes with high efficiency. Notably, this methodology enables the use of nitroarenes and aryl‐substituted carboxylic acids to access diarylacetylene products. Furthermore, this protocol permits efficient synthesis of 3‐substituted benzofuran or isochromen‐1‐one derivatives, which is a challenging regiochemical outcome unattainable through conventional coupling strategies.

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钯催化硝基芳烃与炔基羧酸的脱羧反应

本文首次报道了烷基羧酸与硝基芳烃通过反硝化偶联脱羧的一般方法。该方法显示了广泛的底物普遍性，适用于各种硝基芳烃，包括缺乏电子的杂芳烃，以高效地传递芳基炔。值得注意的是，这种方法可以使用硝基芳烃和芳基取代的羧酸来获得二芳基乙炔产品。此外，该方案允许有效合成3 -取代苯并呋喃或等色胺- 1 -酮衍生物，这是一个具有挑战性的区域化学结果，无法通过传统的偶联策略实现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.