Advanced Synthesis & Catalysis最新文献

Nickel‐Catalyzed Regio‐ and Stereoselective Three‐Component Difunctionalization of Alkynes 镍催化炔的区域和立体选择性三组分双官能化

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2026-10-30 DOI: 10.1002/adsc.70850

Fu Ye, Juhua Li, Peiwen Liu, Gaoyu Zhao, Ye Meng, Xiaoxiang Xi, Weiming Yuan

{"title":"Nickel‐Catalyzed Regio‐ and Stereoselective Three‐Component Difunctionalization of Alkynes","authors":"Fu Ye, Juhua Li, Peiwen Liu, Gaoyu Zhao, Ye Meng, Xiaoxiang Xi, Weiming Yuan","doi":"10.1002/adsc.70850","DOIUrl":"https://doi.org/10.1002/adsc.70850","url":null,"abstract":"Nickel‐catalyzed three‐component difunctionalization of alkynes has emerged as a powerful strategy for the rapid construction of complex molecular architectures with high step and atom economy. This review systematically summarizes recent advances in alkyne difunctionalizations and categorizes them into two sections based on different catalytic modes: single nickel catalysis and photoredox/nickel dual catalysis. The single nickel catalysis exploits the intrinsic redox versatility of nickel in combination with judicious ligand design to afford high levels of regio‐ and stereocontrol and broad functional‐group tolerance. In contrast, the photoredox/nickel dual catalytic system merges visible‐light‐driven single‐electron transfer with nickel–mediated bond formation, enabling otherwise challenging radical‐type difunctionalizations under mild, room‐temperature conditions and without external reductants. The mechanistic features, substrate scope, and representative examples of each paradigm are critically discussed, with emphasis on their distinct advantages and complementarity. Finally, current limitations and prospects for future development are outlined.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"3 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149292625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photocascade Catalysis: Access to Arene Endoperoxides as Singlet Oxygen Batteries Through Oxyfluoroalkylation and Photooxygenation 光级催化：通过氟氧烷基化和光氧合获得芳烃内过氧化物作为单线态氧电池

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2026-10-30 DOI: 10.1002/adsc.70852

Hoang Vu Minh Trinh, Pierrick Nun, Guillaume Dagousset, Elsa Anselmi, Emmanuel Magnier, Vincent Coeffard

引用次数: 0

Multienzyme Cascade Reactions: Compatibility, Cooperativity, and Control 多酶级联反应：相容性、协同性和控制

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2026-10-30 DOI: 10.1002/adsc.70829

Isabella E. E. Kroschel, Wolfgang Kroutil, Joerg H. Schrittwieser

引用次数: 0

A General Red‐Light Photocatalytic Platform for the Synthesis of Perfluoroalkyl Tellanes 合成全氟烷基碲烷的通用红光光催化平台

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2026-10-30 DOI: 10.1002/adsc.70833

Sheila G. Perez Edighill, Damian E. Yerien, Sebastian Barata‐Vallejo, Al Postigo

{"title":"A General Red‐Light Photocatalytic Platform for the Synthesis of Perfluoroalkyl Tellanes","authors":"Sheila G. Perez Edighill, Damian E. Yerien, Sebastian Barata‐Vallejo, Al Postigo","doi":"10.1002/adsc.70833","DOIUrl":"https://doi.org/10.1002/adsc.70833","url":null,"abstract":"Perfluoroalkyl tellanes (R F –Te–R) constitute a synthetically valuable yet underdeveloped class of organotellurium compounds, despite their potential in fluoroorganic chemistry and materials science. Herein, we disclose a general, efficient, and operationally simple photocatalytic strategy for their synthesis from readily available ditellanes and perfluoroalkyl iodides. The transformation is enabled by red‐light irradiation in the presence of zinc phthalocyanine as an inexpensive and readily accessible photocatalyst, allowing the generation of perfluoroalkyl radicals under exceptionally mild conditions. This protocol exhibits broad substrate scope, accommodating a wide range of diaryl, heteroaryl, and dialkyl ditellanes, including sterically congested and biologically relevant scaffolds, and consistently delivers the corresponding perfluoroalkyl tellanes in high yields. Mechanistic studies, including radical trapping experiments, Stern–Volmer analysis, and quantum yield determination ( Φ = 2.4), reveal a photoinitiated radical chain mechanism in which the inherent lability of the Te─Te bond plays a key role in facilitating efficient radical capture and propagation. By combining low‐energy photochemical activation with the unique reactivity of tellurium‐centered species, this work establishes a practical and scalable platform for C─Te bond formation and significantly expands the synthetic toolbox for accessing perfluoroalkyl tellanes.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"61 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149292645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Para ‐Selective C─H Amination of Benzenepropanamides via Photocatalytic N ‐Centered Radical‐Mediated Dearomatization 通过光催化N中心自由基介导的对选择性C─H胺化苯丙酰胺

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2026-10-29 DOI: 10.1002/adsc.70851

Di‐Jing Luo, Dan‐Na Chen, Li‐Ning Chen, Lu‐Lu Qin, Yu Lv, Zhi‐Peng Ye, Yu Zheng, Shu‐Hui Li, Peng‐Ju Xia

引用次数: 0

Photoelectrochemically Driven Hydrophosphorylation of Alkynes to Access ( E )‐Alkenylphosphine Oxides 光电驱动的炔氢磷酸化反应获得(E)‐烯基膦氧化物

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2026-10-29 DOI: 10.1002/adsc.70837

Zhe Huang, Shangyong Wu, Zhaojun Ding, Xiyu Luo, Zihao Lin, Shi Zang, Na Wu, Jiayu Mo

{"title":"Photoelectrochemically Driven Hydrophosphorylation of Alkynes to Access ( E )‐Alkenylphosphine Oxides","authors":"Zhe Huang, Shangyong Wu, Zhaojun Ding, Xiyu Luo, Zihao Lin, Shi Zang, Na Wu, Jiayu Mo","doi":"10.1002/adsc.70837","DOIUrl":"https://doi.org/10.1002/adsc.70837","url":null,"abstract":"The current metal‐free methods for the hydrophosphorylation of alkynes, encompassing both electrochemical‐driven and photoredox‐catalyzed processes separately, show efficacy only when applied to less hindered terminal alkynes, polarized internal alkynes, or aryl alkyl internal alkynes; diaryl acetylenes are found to be incompatible with these conditions. Both methods involve a radical stepwise addition, yielding a Z / E isomeric mixture with the Z ‐alkenylphosphine oxides as the primary products. Furthermore, electrochemical hydrophosphorylation of alkynes is prone to double reduction of alkynes during extended reaction times. Herein, in sharp contrast to conventional, often separate, electrochemical or photoredox catalytic approaches that typically produce a Z / E isomeric mixture, this photoelectrocatalytic (PEC) process, which combines photocatalysis and electrochemistry, exclusively furnishes stereospecific ( E )‐alkenylphosphine oxides as the sole products. Significantly, this protocol successfully applies efficiently to diaryl acetylenes and bulky terminal alkynes, with no iterative addition of triple bonds observed.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"84 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149292653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Bifunctional Togni’s Reagent in Photoredox‐Catalyzed Oxytrifluoromethylation of Alkenes 双功能Togni试剂在光氧化还原催化烯烃氧三氟甲基化中的应用

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2026-10-29 DOI: 10.1002/adsc.70844

Xiaoyu Wang, Ronghui Zhang, Yuyang Xue, Yichen Tao, Sixu Yang, Lin Tang

引用次数: 0

Multicomponent Reactions Enabled by Photoinduced Formal Alkyl Transfer of Tertiary Amines 光诱导叔胺形式烷基转移的多组分反应

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2026-10-29 DOI: 10.1002/adsc.70846

Yang Zhang, Yating Wang, Conghui Wang, Meizhong Tang, Lan‐Gui Xie

{"title":"Multicomponent Reactions Enabled by Photoinduced Formal Alkyl Transfer of Tertiary Amines","authors":"Yang Zhang, Yating Wang, Conghui Wang, Meizhong Tang, Lan‐Gui Xie","doi":"10.1002/adsc.70846","DOIUrl":"https://doi.org/10.1002/adsc.70846","url":null,"abstract":"Multicomponent reactions (MCRs) provide a powerful and efficient strategy for rapidly accessing structurally diverse compounds under mild conditions. Among MCRs, the Ugi‐type reactions—including the Ugi–azide variant—hold a central role in the synthesis of α‐amino derivatives. Historically, research in this area has largely focused on expanding the scope of nucleophiles to access novel and complex products. However, most reported transformations still rely on imine (or iminium) intermediates generated from primary/secondary amines and aldehydes/ketones. In this work, we disclose a photochemical approach that utilizes photoexcited aromatic amines to trigger the oxidation of tertiary amines, leading to the formation of iminium species. These intermediates undergo a formal alkyl transfer process with aromatic amines to generate new iminium salts, which subsequently engage with various nucleophiles in a multicomponent fashion. This strategy enables the efficient synthesis of three important classes of functional molecules—α‐amino phosphine oxides, tetrazoles, and imides—via a tertiary amine‐involved MCR under light irradiation.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"9 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149292646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Supports on Electrocatalytic Performance of Dual‐Atom Catalysts 载体对双原子催化剂电催化性能的影响

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2026-10-29 DOI: 10.1002/adsc.70840

Pan Zhou, Tieli Zhou, Jingqi Guan

引用次数: 0

Ball‐Milling‐Enabled Pd‐Catalyzed One‐Pot Cross‐Coupling of Aryl Thianthrenium Salts With In Situ Generated Reformatsky Enolates 球磨Pd催化的芳基硫鎓盐与原位生成重整烯醇酯的一罐交叉偶联

IF 5.4 2区化学

Advanced Synthesis & Catalysis Pub Date : 2026-10-29 DOI: 10.1002/adsc.70853

Tomáš Čarný, Barbora Steinhüblová, Maksym Ponedilok, Radovan Šebesta

引用次数: 0