Fe‐Photocatalyzed Decarboxylative Giese‐Type Reaction of α‐N, O or S Carboxylic Acids: Insight into the Mechanism of the Radical Formation

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-09-16 DOI:10.1002/adsc.70114

Fernando Pérez‐Maseda, María Martín, Jorge Labrador‐Santiago, Inés Corral, Diego J. Cárdenas

引用次数: 0

Abstract

Very simple conditions are described for the Fe‐photocatalyzedaddition of α‐amino, α‐alkoxy, and α‐alkylthio radicals to electron‐deficient alkenes. The reactions proceed under smooth ligandless conditions with inexpensive base and in the absence of oxidant. A mechanistic computational TD‐DFT study on the formation and evolution of the electronic excited states supports for the first time that, after Fe(III)‐carboxylate excitation by visible light, homolytic cleavage of the FeO actually takes place, leading to a carboxyl radical.

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铁光催化α - N， O或S羧酸脱羧型反应：自由基形成机制的研究

描述了铁光催化下α -氨基、α -烷氧基和α -烷基硫基自由基加成到缺电子烯烃上的非常简单的条件。该反应在无配体、廉价碱和无氧化剂的条件下进行。一项关于电子激发态形成和演化的机制计算TD - DFT研究首次支持了Fe（III）‐羧酸盐在可见光激发后，Fe（III）‐羧酸盐实际上发生了均裂裂解，导致羧基自由基的产生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.