氮杂环碳催化氮杂七富尔烯与烯醛的高阶化学发散环化

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-09-18 DOI:10.1002/adsc.70127

Yiwen Zhang, Yangjie Yu, Min Xia, Zhen Wang, Manman Sun, Weijun Yao

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引用次数: 0

摘要

通过n -杂环碳催化，在氮杂环呋喃和烯醛之间形成了碱基定向、化学发散、高阶的环。在n -杂环羰基有机催化剂的存在下，DBU以优异的化学选择性和非对映选择性促进[8 + 3]环化，而当碳酸钾作为碱时，反应通过[8 + 2]环化进行。此外，该反应可以在克尺度上进行，产物可以有效地转化为双环衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chemodivergent Higher-Order Annulation of Azaheptafulvenes with Enals Through N-Heterocyclic Carbene Catalysis

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Chemodivergent Higher-Order Annulation of Azaheptafulvenes with Enals Through N-Heterocyclic Carbene Catalysis

A base-directed, chemodivergent, higher-order annulation between azaheptafulvenes and enals has been developed through N-heterocyclic carbene catalysis. In the presence of an N-heterocyclic carbene organocatalyst, DBU promotes an [8 + 3] annulation with excellent chemo- and diastereoselectivities, whereas the reaction proceeds via an [8 + 2] annulation when potassium carbonate is used as the base. In addition, the reaction can be carried out on a gram scale, and the products are efficiently converted into bicyclic derivatives.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.