European Archives of Psychiatry and Clinical Neuroscience最新文献

{"title":"Relationship between elevated habituation tendencies and impulsivity, compulsivity, and childhood adversity among abstinent patients with methamphetamine use disorders.","authors":"Jiajing Chen, Dong Mei Wang, Zhixuan Yu, Yang Tian, Mengqian Qu, Linjun Jiang, Lianglun Jia, Fabing Fu, Han Chen, Ren Huang, Xiang Yang Zhang","doi":"10.1007/s00406-025-02053-5","DOIUrl":"https://doi.org/10.1007/s00406-025-02053-5","url":null,"abstract":"<p><p>Elevated habituation tendencies have been identified in several subgroups of patients with substance use disorders, however, their intricate relationship with substance use disorders remains unknown. A total of 133 individuals with methamphetamine use disorder (PwMUD) and 131 healthy controls (HC) were initially recruited for this study. After exclusion of outliers, data from 128 PwMUD and 125 HC were included in the analyses. Participants reported their habituation tendencies, drug-use characteristics, impulsivity, compulsivity, and experiences of childhood adversity through self-report scales and structured interviews. The results show that PwMUD had a higher level of automatic habituation tendencies compared to healthy controls. This higher level of automaticity demonstrated a tenuous association with the duration of methamphetamine use and a relatively stronger association with compulsivity, suggesting that the imbalance between the goal-directed and habitual systems in PwMUD may be both a risk factor for and a consequence of methamphetamine use disorder.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deficit of oligodendrocyte family cells in layer 5 of the dorsal anterior cingulate cortex in schizophrenia.","authors":"N S Kolomeets, N A Uranova","doi":"10.1007/s00406-025-02057-1","DOIUrl":"https://doi.org/10.1007/s00406-025-02057-1","url":null,"abstract":"<p><p>The deficit of oligodendrocyte family cells has commonly been implicated in the dysfunction of neuronal networks in schizophrenia. Previously we reported a significant deficit of oligodendrocytes (Ol) and oligodendrocyte clusters (OlC), containing differentiating oligodendrocyte progenitors, in the cortical hubs of fronto-parietal cognitive (FPN) and default mode (DMN) networks, and in the striatum which is a central relay of the numerous networks. Anterior cingulate cortex (ACC) is crucial for integration of cognitive and emotional processes in support of goal-directed behavior and it's connections with FPN, DMN and basal ganglia are altered in schizophrenia. Few studies have examined changes in Ol family cell numbers in the ACC in schizophrenia, however, decreased expression of myelin- and oligodendrocyte-related genes in the ACC are characteristic of schizophrenia. We used optical disector method to estimate the numerical density (Nv) of oligodendrocytes and oligodendrocyte clusters in layer 5 of dorsal ACC (dACC) in schizophrenia (18 cases per group) as compared to healthy controls (13 cases per group). A significant reduction in the Nv of oligodendrocytes (- 23%; p < 0.01) and NvOlC (- 28%, p = 0.012) was found in schizophrenia as compared to the control group. We found significant correlations between the NvOl and the NvOlC in both control (R = 0.9; p < 0.001) and schizophrenia groups (R = 0.77; p = 0.014). The deficits in the number of OL and OlC in layer 5 of dACC may be tightly linked with reduced reciprocal ACC-thalamic connectivity in patients brain which were reported strongly correlate with positive symptoms fundamental for schizophrenia.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between emotion regulation skills, resilience, depression and anxiety symptom severity in patients with mood disorders and non-clinical participants: a mediation model.","authors":"Hyun Seok Do, Jakyung Lee, Hyeona Yu, Chan Woo Lee, Hyun Jung Hur, Jongwook Lim, Hyo Shin Kang, Jungkyu Park, Tae Hyon Ha, Woojae Myung","doi":"10.1007/s00406-025-02050-8","DOIUrl":"https://doi.org/10.1007/s00406-025-02050-8","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic reconfigurations of brain subnetworks in female patients with alcohol use disorder or bulimia nervosa: a resting-state functional magnetic resonance imaging study.","authors":"N Leenaerts, T A A Broeders, J Ceccarini, S Sunaert, M M Schoonheim, C H Vinkers, E Vrieze","doi":"10.1007/s00406-025-02055-3","DOIUrl":"https://doi.org/10.1007/s00406-025-02055-3","url":null,"abstract":"<p><strong>Introduction: </strong>The brain forms a complex functional brain network. This network is dynamically reconfigured to support various cognitive processes. Research on brain network dynamics in patients with alcohol use disorder (AUD) or bulimia nervosa (BN), two highly comorbid psychiatric disorders, remains limited. Previous studies showed altered static network patterns, highlighting that the network is disturbed, but implicitly ignoring network dynamics. This study investigates dynamic network reconfigurations in female patients with AUD or BN and healthy controls (HC).</p><p><strong>Methods: </strong>Resting-state functional MRI data were acquired of 102 female participants (AUD:27, BN:24, HC:51). A sliding-window approach assigned brain regions iteratively to one of seven literature-based subnetworks for each window. Then, previously validated parameters of network reconfiguration were assessed: promiscuity (number of subnetworks switched to) and flexibility (number of switches). These measures were compared between groups and related to behavioral and clinical measures.</p><p><strong>Results: </strong>Compared to HC, patients with BN displayed a higher promiscuity of all brain subnetworks combined, and regionally for the dorsal attention network, with no change in flexibility. Patients with AUD showed no difference in either promiscuity or flexibility. Global and dorsal attention network promiscuity were negatively correlated with subjective stress.</p><p><strong>Conclusion: </strong>Regions typically assigned to the dorsal attention network changed their association with a higher number of other subnetworks in BN compared to HC, which was not seen in AUD. This suggests a less focused dynamic integration of information in patients with BN, which could play a role in their vulnerability to stress, attentional biases and impulsivity.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: A multimodal approach to depression diagnosis: insights from machine learning algorithm development in primary care.","authors":"Julia Eder, Mark Sen Dong, Melanie Wöhler, Maria S Simon, Catherine Glocker, Lisa Pfeiffer, Richard Gaus, Johannes Wolf, Kadir Mestan, Helmut Krcmar, Nikolaos Koutsouleris, Antonius Schneider, Jochen Gensichen, Richard Musil, Peter Falkai","doi":"10.1007/s00406-025-02058-0","DOIUrl":"https://doi.org/10.1007/s00406-025-02058-0","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing mental health care: a problem, resources and goals oriented multidimensional framework (PRoGO).","authors":"Stefan Leucht, Bernhard König, Antonio di Francesco, Alessandro Rodolico, Josef Priller, Kerem Böge, Wolfgang Strube, Jochen Gensichen, Peter Bechmann, Amr ElDeeb, Alkomiet Hasan, Steffen Moritz, Markus Jäger, Claudia Leucht, Jim van Os, John M Davis","doi":"10.1007/s00406-025-02045-5","DOIUrl":"https://doi.org/10.1007/s00406-025-02045-5","url":null,"abstract":"<p><strong>Background: </strong>Lawrence Weed introduced the \"Problem-Oriented Medical Records\" (POMR) approach to medicine. Its core principle is that treatment should be organised around patients' specific problems. This approach gained widespread adoption in the United States during the 1970s. However, few studies have compared POMR with the traditional \"source-based\" method, and evidence supporting its application in mental health remains particularly limited.</p><p><strong>Methods: </strong>We carried out a narrative review to examine whether POMR is appropriate for mental health care and which modifications are necessary for this purpose.</p><p><strong>Findings: </strong>Psychiatry and psychotherapy address brain-mediated disorders that lack clear biological markers. Diagnoses rely on the assessment of psychopathological symptoms, which are grouped into syndromes. These symptoms and syndromes can be effectively categorized as \"problems\". Given that psychiatric treatment is often symptomatic in that it focuses on symptoms rather than diagnoses, POMR provides an ideal framework for organizing care. Furthermore, mental health is inherently multidimensional, encompassing biological, psychological, social, and existential domains. This complexity necessitates interdisciplinary collaboration. However, under the conventional source-based approach, professional groups often operate in parallel rather than jointly together. POMR, by contrast, facilitates seamless collaboration by aligning teams around patient-centred problems. A special aspect of mental health care is the emphasis on considering patients' individual goals and resources, rather than focusing only on their deficits.</p><p><strong>Interpretation: </strong>By systematically applying POMR to psychiatric care-particularly through tightly coordinated interdisciplinary treatment-clinicians could enhance both clinical and functional outcomes, improve both patient and team satisfaction, and better align treatment with patients' unique needs. To support this approach, we propose a practical grid which we refer to as the Problem-Resources-Goals Oriented framework (PRoGO), reflecting the necessary adaptations for mental health. Clinical trials are warranted to assess the effectiveness of POMR/PRoGO in psychiatric practice and its potential to advance the field.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal esketamine significantly alleviates depression severity and suicidal ideations in electroconvulsive therapy (ECT) non-responders.","authors":"Erhan Kavakbasi, Kevin Rosemann, Mert Yilmaz, Helmut Berndt, Bernhard T Baune","doi":"10.1007/s00406-025-02041-9","DOIUrl":"https://doi.org/10.1007/s00406-025-02041-9","url":null,"abstract":"<p><strong>Introduction: </strong>Intranasal esketamine (ESK) is a novel therapy option in patients with treatment-resistant depression (TRD). Patients with a history of electroconvulsive therapy (ECT) non-response (ECT+) in the current episode have usually been excluded from previous studies. Data on the effectiveness of ESK in ECT non-responders are sparse.</p><p><strong>Methods: </strong>In this retrospective study, we investigated the effectiveness of intranasal ESK in real-world inpatients with (ECT+, n = 39) history of ECT non-response compared to patients who have not received an adequate course of ECT in their current episode (ECT-, n = 57). A factorial analysis of variance (ANOVA) has been used to determine the impact of ECT non-response on treatment outcome.</p><p><strong>Results: </strong>A total of n = 96 patients (mean age 47.0; 52.1% women) with TRD were included in this study. There was a significant main effect of history of ECT non-response on MADRS score in the ANOVA (F = 10.386, p = 0.002). However, there was no significant interaction effect of time (pre-treatment, post-treatment)*history of ECT non-response in current episode (F = 2.166, p = 0.143). The response (34.9% vs. 21.9%, χ2 = 1.498, p = 0.167) and remission rates (24.4% vs. 12.1%, χ2 = 1.861, p = 0.141) were none significantly lower in the ECT + group than in the ECT- group. There was significant improvement in MADRS and BDI-II in the ECT + group. No major safety concerns occurred during the study.</p><p><strong>Conclusion: </strong>There was no significant impact of ECT non-response on esketamine treatment outcome. Our results support the approach to offer esketamine to ECT non-responders given that the array of treatment alternatives is limited for these patients.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactive effect of BDNF rs10835210 polymorphism and childhood maltreatment on cognitive functioning in Chinese male patients with methamphetamine use disorder.","authors":"Linjun Jiang, Dongmei Wang, Yang Tian, Jiajing Chen, Mengqian Qu, Han Chen, Ren Huang, Lianglun Jia, Fabing Fu, Shanshan Tang, Xiaotao Wang, Xiang-Yang Zhang","doi":"10.1007/s00406-025-02038-4","DOIUrl":"https://doi.org/10.1007/s00406-025-02038-4","url":null,"abstract":"<p><strong>Background: </strong>Patients with methamphetamine use disorder (MUD) are known to experience cognitive dysfunction. Our previous study was the first to demonstrate the negative impact of childhood maltreatment (CM) on cognitive function in MUD patients. Extensive research has highlighted the crucial role of brain-derived neurotrophic factor (BDNF) gene polymorphisms in cognitive function. However, whether genetic variations in BDNF interact with environmental factors such as CM to influence cognition remains unclear. Therefore, this study aimed to investigate the potential interaction between BDNF gene polymorphism and CM in affecting cognitive function among MUD patients.</p><p><strong>Methods: </strong>We recruited 558 MUD patients and 459 healthy controls, assessed cognitive function using the Repeated Battery for the Assessment of Neuropsychological Status (RBANS) and CM using the Chinese version of the Childhood Trauma Questionnaire-Short Form (CTQ-SF) in all participants, and genotyped all patients and 158 healthy controls for the BDNF rs10835210 polymorphism.</p><p><strong>Results: </strong>CM negatively affected cognitive performance in both MUD patients and healthy controls, especially in visuospatial/constructional abilities (HC: FDR p < 0.001), attention (HC: FDR p = 0.008; MUD: FDR p < 0.001), and RBANS total score (HC: FDR p < 0.001; MUD: FDR p = 0.006). Furthermore, a significant interaction between CM and the BDNF rs10835210 polymorphism on attention (FDR p = 0.006) was observed in MUD patients, but not in healthy controls. Post hoc analyses revealed that among carriers of the BDNF rs10835210 A allele, MUD patients with CM had lower RBANS attention scores (FDR p < 0.001) than those without CM. In contrast, no significant simple main effect of CM on RBANS attention was found among MUD patients carrying BDNF rs10835210 CC genotype.</p><p><strong>Conclusions: </strong>Our findings suggest that CM impairs multiple aspects of cognitive function in MUD patients. Moreover, the BDNF gene rs10835210 polymorphism mediates the effect of CM on cognitive function in this population.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating effect of alexithymia between childhood trauma and negative symptoms in chronic schizophrenia.","authors":"Zhenning Feng, Yuying Qiu, Changyong Jiang, Yao Lu, Yifei Liu, Meijuan Li, Jie Li","doi":"10.1007/s00406-025-02049-1","DOIUrl":"https://doi.org/10.1007/s00406-025-02049-1","url":null,"abstract":"<p><p>Evidence suggests that childhood trauma (CT) increases the risk of schizophrenia (SZ) and influences symptom type and severity. However, the link between CT and negative symptoms (NS) has not been fully explored. This study investigated the relationship between CT and NS in SZ, while considering the mediating effect of alexithymia. We enrolled 94 patients with chronic schizophrenia (CS) and 105 age- and sex-matched healthy controls (HCs) from Tianjin Anding Hospital. CT was assessed using the Childhood Trauma Questionnaire (CTQ), psychopathology with the Positive and Negative Syndrome Scale and alexithymia with the 20-item Toronto Alexithymia Scale. Structural equation modeling was used to test the mediation model. CT was reported by 70.1% of patients versus 32.7% of HCs. In patients with SZ, CTQ scores were positively correlated with NS (r = 0.30, p = 0.003). Alexithymia was observed in 18.1% of patients and 7.6% of HCs, and it was positively correlated with NS (r = 0.35, p = 0.001). Two factors of alexithymia-difficulty identifying feelings (95% CI [0.002, 0.085]) and externally oriented thinking (95% CI [0.002, 0.060])-mediated the relationship between CT and NS. These findings suggest that reducing alexithymia may help alleviate NS in SZ.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering causality between social/physical activity and suicide attempt: evidence from Mendelian randomization.","authors":"Haiqi Li, Feixue Yue, Xuan Gu, Haijing Guan, Kaili Chen, Jiao Zhang, Hengyu Ji, Jinting He","doi":"10.1007/s00406-025-02048-2","DOIUrl":"https://doi.org/10.1007/s00406-025-02048-2","url":null,"abstract":"<p><strong>Background: </strong>Previous research has indicated a link between social or physical activity and suicide attempt (SA), yet the causal relationship remains unclear, and the role of psychiatric disorders has not been elucidated.</p><p><strong>Method: </strong>In this study, we used genetic variants of social or physical activity to examine the causal associations with SA based on iPSYCH database, and then replicate the results using FinnGen database.</p><p><strong>Results: </strong>We found that sports clubs or gyms, walking for pleasure, light DIY and other exercises (e.g. bowling, swimming, cycling, and keep fit) may be protective factors for SA, while leisure/social inactivity may be risk factors. After FDR correction of P value, it was revealed that the OR [95%CI] of SA decreased per SD increase in walking for pleasure (0.23[0.07-0.73]), light DIY (0.21[0.07-0.59]), and other exercise (0.22[0.09-0.58]). Within the replication phase, genetic prediction analyses revealed that walking for pleasure, light DIY, and other exercises were associated with reduced susceptibility to SA (P_FDR < 0.05). Given the high comorbidity between psychiatric disorders and SA, we employed two-step MR and multivariate MR (MVMR) to evaluate the proportions the effect of the mediator. We found that Attention Deficit Hyperactivity Disorder (ADHD) explained 24.48% of the total effect of light DIY on SA, 33.52% of the total effect of other exercises.</p><p><strong>Conclusion: </strong>Our research findings highlight the protective effect of social/physical activity in SA, and elucidated that increasing light DIY and other exercise can be used as a prevention strategy of SA, particularly for individuals who have ADHD.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}