高密度脂蛋白相关炎症指数与抑郁伴睡眠障碍患病率之间的关系

IF 3.7 3区 医学 Q1 CLINICAL NEUROLOGY
Shuo Gao, Pu-Le Liu, Qiang-Li Dong, Xin-Ru Liu, Zhi-Qiang Dong, Ya-Wen Pan
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引用次数: 0

摘要

背景:睡眠障碍对身体健康、心理健康和日常功能都有重大影响,随着当代社会生活节奏的加快和工作压力的增加,这种影响更加严重。睡眠障碍的发病率每年持续上升,已成为一个重大的全球公共卫生问题。白细胞-高密度脂蛋白胆固醇比值(WHR)、淋巴细胞-高密度脂蛋白胆固醇比值(LHR)、单核细胞-高密度脂蛋白胆固醇比值(MHR)、中性粒细胞-高密度脂蛋白胆固醇比值(NHR)和血小板-高密度脂蛋白胆固醇比值(PHR)是反映全身炎症和免疫代谢状态的新兴、方便、经济的生物标志物。鉴于越来越多的证据表明慢性炎症和失调的免疫反应与睡眠障碍的患病率有关,探索这些血脂比与睡眠障碍患病率之间的关系可能为潜在的病理生理机制提供新的见解。方法:该研究包括从2005年至2020年3月进行的国家健康和营养检查调查(NHANES)中选出的43273名参与者的多样化和广泛的样本。采用多变量logistic回归模型加权分析,探讨HDL相关炎症生物标志物与睡眠障碍患病率之间的关系。此外,我们还研究了抑郁水平(PHQ-9)在高密度脂蛋白相关炎症标志物和睡眠障碍患病率之间的中介作用。结果:本研究表明,较高水平的MHR和PHR与睡眠障碍的风险增加有关,在男性吸烟者和有合并症的个体中,MHR和男性和有合并症的个体中,PHR的相关性更为明显。中介分析表明,抑郁水平(PHQ-9)在睡眠障碍患病率与MHR或PHR之间起着显著的中介作用。结论:MHR和PHR水平升高与睡眠障碍风险增加显著相关。MHR的相关性在男性吸烟者和有合并症的个体中尤为明显,而PHR在男性和有合并症的个体中表现出更强的相关性。抑郁水平部分介导了这些关联。MHR和PHR可作为临床有用的生物标志物,用于识别高危个体,支持早期筛查和干预的需要。未来的纵向研究有必要确认因果关系,并评估针对这些指标是否可以改善睡眠结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between high-density lipoprotein-related inflammation index and prevalence of sleep disorders with depression as a mediator.

Background: Sleep disorders have a significant impact on physical health, mental health, and daily functioning, exacerbated by the accelerating pace of life and rising work-related stress in contemporary society. The incidence of sleep disorders continues to rise annually, becoming a significant global public health issue. The white blood cell-to-HDL-cholesterol ratio (WHR), lymphocyte-to-HDL-cholesterol ratio (LHR), monocyte-to-HDL-cholesterol ratio (MHR), neutrophil-to-HDL-cholesterol ratio (NHR), and platelet-to-HDL-cholesterol ratio (PHR) are emerging, convenient, and cost-effective biomarkers that reflect systemic inflammation and immunometabolic status. Given the growing evidence linking chronic inflammation and dysregulated immune responses to prevalence of sleep disorders, exploring the association between these hematologic-lipid ratios and prevalence of sleep disorders may provide novel insights into underlying pathophysiological mechanisms.

Methods: The study included a diverse and extensive sample of 43,273 participants, selected from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and March 2020. The association between HDL- associated inflammatory biomarkers and prevalence of sleep disorders was explored using a multivariate logistic regression model with weighted analysis. In addition, the mediating role of depression levels (PHQ-9) between HDL-associated inflammatory markers and prevalence of sleep disorders was examined.

Results: This study suggests that higher levels of MHR and PHR were associated with an increased risk of sleep disorders, with a more pronounced association observed for MHR among male smokers and individuals with comorbidities, and for PHR among males and those with comorbidities. Mediation analysis demonstrates that depression level (PHQ-9) plays a significant mediating role between prevalence of sleep disorders and MHR or PHR.

Conclusion: Elevated MHR and PHR levels were significantly associated with an increased risk of sleep disorders. The association of MHR was particularly pronounced among male smokers and individuals with comorbidities, while PHR showed stronger associations in males and those with comorbidities. Depression levels partially mediated these associations. MHR and PHR may serve as clinically useful biomarkers for identifying high-risk individuals, supporting the need for early screening and intervention. Future longitudinal studies are warranted to confirm causality and assess whether targeting these indices can improve sleep outcomes.

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来源期刊
CiteScore
8.80
自引率
4.30%
发文量
154
审稿时长
6-12 weeks
期刊介绍: The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.
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