European Archives of Psychiatry and Clinical Neuroscience最新文献

{"title":"Ultrastructural disturbances of pericapillary microglia, perioligodendrocyte microglia, oligodendrocytes and their interactions in postmortem caudate nucleus in schizophrenia.","authors":"Natalya A Uranova, Olga V Vikhreva, Valentina I Rakhmanova","doi":"10.1007/s00406-026-02263-5","DOIUrl":"https://doi.org/10.1007/s00406-026-02263-5","url":null,"abstract":"<p><strong>Objectives: </strong>Previously we reported ultrastructural abnormalities of capillaries, microglia and oligodendrocytes in the prefrontal cortex in schizophrenia. We aimed to estimate the ultrastructural changes of pericapillary microglia (PCapMg), perioligodendrocyte microglia (POlMg) and oligodendrocytes adjacent to microglia in the head of the caudate nucleus (CN) in schizophrenia.</p><p><strong>Method: </strong>Electron microscopy and morphometry of microglia and oligodendrocytes in the head of the CN were performed in 21 schizophrenia cases and 20 normal controls.</p><p><strong>Results: </strong>We found age-related lower volume fraction (Vv) and the number (N) of mitochondria in PCapMg, POlMg and in oligodendrocytes and higher Vv and N of lipofuscin in PCapMg in the schizophrenia group as compared to the control group. Area of lipofuscin granules in PCapMg positively correlated with Vv and N of lipofuscin granules in POlMg in the schizophrenia group but not in the control group. Vv and N of mitochondria in PCapMg positively correlated with Vv of mitochondria in POlMg, and Vv and N of mitochondria in oligodendrocytes positively correlated with Vv of mitochondria in POlMg in the control group but not in the schizophrenia group.</p><p><strong>Conclusions: </strong>These data suggest that disturbed interactions between PCapMg, POlMg and oligodendrocytes in schizophrenia are associated with altered energy and lipid metabolism, mitochondria deficit and accelerated aging of PCapMg in schizophrenia. These changes might contribute to a disturbance of blood-brain barrier in the head of the CN in schizophrenia.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic functional connectivity in borderline personality disorder: associations with trauma, emotion regulation and symptom severity.","authors":"Arshia Rana, Marie-Luise Otte, Giovanni Fazio, Daniele Olivio, Yéléna Le Prieult, Mike M Schmitgen, Yunus Balcik, Mert Koc, Chantal Tech, Nadine D Wolf, Fabio Sambataro, Robert Christian Wolf","doi":"10.1007/s00406-026-02255-5","DOIUrl":"https://doi.org/10.1007/s00406-026-02255-5","url":null,"abstract":"<p><strong>Background: </strong>Altered intrinsic functional connectivity is a well-established marker of borderline personality disorder (BPD). However, recent research suggests that investigating brain dynamics may offer a more detailed perspective on the neural signatures of BPD-related symptoms.</p><p><strong>Methods: </strong>Resting-state fMRI data were analyzed in female patients with BPD (n = 47) and healthy controls (n = 28) to derive dynamic functional network connectivity (dFNC) indices using both meta-state and cluster-state approaches. Between-group comparisons assessed BPD-related dFNC alterations, while dimensional analyses explored associations between network dynamics and distinct symptom dimensions.</p><p><strong>Results: </strong>Both meta-state and cluster-state analyses revealed strong associations between symptom dimensions and dynamic range and fluidity. Meta-state analysis indicated that greater emotion regulation difficulties corresponded to an expanded state repertoire, reflecting increased variability in large-scale network configurations. Cluster-state analysis showed that fewer state transitions were associated with heightened borderline symptom severity, greater childhood trauma exposure, and increased dissociative symptoms. Furthermore, childhood trauma and emotion regulation difficulties moderated the relationship between time spent in specific cluster-states and borderline symptom severity.</p><p><strong>Conclusion: </strong>These findings suggest that reduced dynamic flexibility but increased dynamic range in large-scale brain networks may contribute to core BPD symptoms, particularly in early trauma, emotion dysregulation as well as borderline symptom severity. The results highlight the association between aberrant dFNC and BPD and contribute to a more detailed characterization of neural dynamics relevant to the disorder.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes of borderline symptoms, personality functioning, and dysfunctional personality traits after dialectical-behavioral therapy in borderline personality disorder.","authors":"Julia I Kunz, Antonia Zwick, Jennifer J Boll, Johannes Wolf, Judith Meinhardt, Sandrina Hüttner, Rafael Grigo, Richard Musil, Stephan Goerigk, Andrea Jobst, Frank Padberg, Matthias A Reinhard","doi":"10.1007/s00406-026-02215-z","DOIUrl":"https://doi.org/10.1007/s00406-026-02215-z","url":null,"abstract":"<p><p>Borderline Personality Disorder (BPD) is a complex and debilitating condition characterized by limited treatment response and high dropout rates across treatments, even in leading therapeutic approaches, such as Dialectical-Behavioral Therapy (DBT). Given the heterogeneity of BPD symptomatology and the current shift toward dimensional assessments of personality disorders, this study investigates whether dimensional measures according to the DSM-5's Alternative Model for Personality Disorders (AMPD) may serve as additional markers of treatment outcome and dropout. Eighty-five participants with BPD were recruited from a naturalistic inpatient DBT program. Associations between BPD symptoms (Borderline Symptom List, Borderline Personality Disorder Severity Index), personality functioning (Level of Personality Functioning Scale - Brief Form 2.0), and dysfunctional personality traits (Personality Inventory for DSM-5 and ICD-11 - Brief Form Plus) were examined at baseline, as well as their sensitivity to change after DBT. At baseline, both personality functioning and dysfunctional personality traits, except antagonism, were associated with BPD symptoms (all r ≥ 0.4). After 10 weeks of DBT, parallel improvements were observed in personality functioning and dysfunctional personality traits, with significant reductions in negative affectivity and detachment. Elevated baseline levels of negative affectivity and psychoticism were associated with less BPD symptom change. DBT dropout was linked to higher impairment in negative affectivity and anankastia at admission. Personality functioning showed greater sensitivity to change throughout DBT compared to dysfunctional personality traits. These findings emphasize how AMPD may yield benefits beyond categorical BPD diagnoses, potentially contributing to more personalized and effective treatment planning and preventing dropouts.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct neural responses to punishment anticipation in violent and non-violent individuals with schizophrenia.","authors":"Alexandra Fortier, Alexandre Dumais, Maria Athanassiou, Olivier Lipp, Luigi de Benedictis, Inès Zouaoui, Andràs Tikàsz, Stéphane Potvin","doi":"10.1007/s00406-026-02252-8","DOIUrl":"https://doi.org/10.1007/s00406-026-02252-8","url":null,"abstract":"<p><p>Evidence suggests an increased risk of violence in individuals with schizophrenia. While violent behavior in non-psychotic populations has been associated with reduced sensitivity to punishment, the neural mechanisms underlying reward and punishment processing in violent individuals with schizophrenia have yet to be investigated. Thus, this study aims to examine the neural responses to reward and punishment processing in this population. Ninety-four participants were divided into three groups: schizophrenia with violent behaviors (SZ + V, n = 31), schizophrenia without violent behavior (SZ-V, n = 31), and healthy controls (HC, n = 32). All participants performed a monetary incentive delay task during a functional magnetic resonance imaging session. Compared to SZ-V and HC groups, the SZ + V group showed alterations in the lingual gyrus, the dorsal anterior cingulate cortex, and the supplementary motor area during punishment anticipation. The SZ + V group also demonstrated alterations in the fusiform gyrus during reward anticipation, as well as in the inferior temporal gyrus during punishment avoidance. Both SZ + V and SZ-V groups exhibited alterations in the ventrolateral prefrontal cortex during reward outcome, in the dorsolateral prefrontal cortex during no reward outcome, and in the lateral and dorsolateral prefrontal cortex during punishment outcome, compared to the HC group. Mainly, we found that violence in schizophrenia is associated with increased activation in brain regions involved in salience and attentional processing, as well as in motor preparation during punishment processing.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High- and low-frequency accelerated repetitive transcranial magnetic stimulation for major depressive disorder.","authors":"Chaeyeon Yang, Yun Ji Kim, Jihye Ahn, Sehyun Jeon, Jooyoung Lee, Su-Young Song, Seog Ju Kim","doi":"10.1007/s00406-026-02262-6","DOIUrl":"https://doi.org/10.1007/s00406-026-02262-6","url":null,"abstract":"<p><strong>Aim: </strong>This study examined the effects of two accelerated repetitive transcranial magnetic stimulation (rTMS) protocols in patients with major depressive disorder (MDD).</p><p><strong>Methods: </strong>Twenty-two patients received accelerated high-frequency rTMS (HF-rTMS; 10 Hz, left prefrontal cortex), and 18 received accelerated low-frequency rTMS (LF-rTMS; 1 Hz, right prefrontal cortex). Each participant underwent 10 sessions over 2 consecutive days (5 sessions per day). Depression, anxiety, and sleep quality were assessed using the Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), and Pittsburgh Sleep Quality Index (PSQI), respectively. Clinical outcomes were evaluated at baseline and at 1 day, 2 weeks, and 4 weeks after treatment.</p><p><strong>Results: </strong>HAM-D scores significantly decreased from baseline after accelerated rTMS and remained improved over 4 weeks. Both HF-rTMS and LF-rTMS produced comparable early reductions in depression severity, with LF-rTMS showing a greater HAM-D reduction at 4 weeks. HAM-A and PSQI scores also improved at 2 and 4 weeks in both groups, with no significant between-group differences.</p><p><strong>Conclusions: </strong>Both accelerated HF- and LF-rTMS protocols were associated with improvements in depressive, anxiety and sleep symptoms in patients with MDD, and LF-rTMS may confer more sustained antidepressant effects.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered microRNA expression profiles in the postmortem prefrontal cortex of individuals with alcohol use disorder: a case-control study.","authors":"Burcu Çaykara Peran, Hani Alsaadoni, Mehmet Zahit Çıracı, Sibel Kuraş, Halime Hanım Pençe, Yalçın Büyük, Bekir Erdoğan, Sadrettin Pençe","doi":"10.1007/s00406-026-02261-7","DOIUrl":"https://doi.org/10.1007/s00406-026-02261-7","url":null,"abstract":"<p><strong>Background: </strong>MicroRNAs are critical regulators of neuronal plasticity, synaptic signaling, and stress response, and their dysregulation has been implicated in substance use disorders. However, postmortem evidence on their involvement in Alcohol Use Disorder (AUD) remains limited. We aimed to investigate the expression patterns of miR-132, miR-133b, miR-140, miR-181a, miR-190, and miR-212 in the prefrontal cortex of individuals with AUD.</p><p><strong>Methods: </strong>Prefrontal cortex tissues were obtained postmortem from 30 individuals with documented AUD and 30 age- and sex-matched non-alcohol users. Total RNA was isolated, reverse-transcribed into cDNA, and analyzed by quantitative real-time PCR. Relative expression levels were calculated using the 2^-ΔΔCT method, with U6 RNA as endogenous control.</p><p><strong>Results: </strong>Individuals with AUD exhibited increased expression of miR-133b (fold change: 4.4, p = 0.035), and miR-212 (fold change: 1.57, p = 0.006), while miR-132 (fold change: 3, p < 0.001) and miR-190 (fold change: 2.63, p = 0.003) were markedly downregulated compared with controls.</p><p><strong>Conclusions: </strong>The differential expression of these miRNAs suggests their involvement in neuronal signaling pathways underlying AUD, particularly those linked to synaptic plasticity and stress-related transcriptional regulation.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision non-invasive transcranial electromagnetic stimulation: a thematic review of optimizing spatial, temporal, and dose dimensions.","authors":"Ruixuan Lin, Weijia He, Usman Jawed Shaikh, Lukas Lorentz, Roy Rongyue Zeng, Patrick W H Kwong, Tiev Miller, Pablo Cruz Gonzalez, Ananda Sidarta, Ferdinand Binkofski, David M A Mehler, Jack Jiaqi Zhang","doi":"10.1007/s00406-026-02256-4","DOIUrl":"https://doi.org/10.1007/s00406-026-02256-4","url":null,"abstract":"<p><p>Transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (TES) have been extensively used in experimental and clinical research in psychiatry, neurology, and rehabilitation. Several advanced approaches for delivering transcranial electromagnetic stimulation have been proposed to maximize the temporal and spatial precision of conventional stimulation protocols or to optimize stimulation parameters for enhanced efficacy during neuromodulation. Here, we thematically reviewed several advanced neuromodulatory approaches: (1) using prior or real-time brain states to guide the delivery of stimulation through priming protocols or brain-state-dependent stimulation interfaces (temporal precision); (2) facilitating the stimulation target engagement, either from a single brain region to an interregional brain connection using cortico-cortical paired associative stimulation or dual-site in/anti-phase transcranial alternating current stimulation, or from a superficial brain target to a deep brain region using temporal interference stimulation (spatial precision); and (3) strengthening or accelerating the plasticity modulation outcomes using high-dose protocols (dose optimization). While results from these efforts are promising, challenges exist in terms of the optimal timing of brain states and stimulation parameters, treatment durability, as well as the complexity in aggregating different advanced approaches. Future research should focus on exploring the underlying mechanisms, optimizing parameters, and assessing the efficacy in well-designed proof-of-concept experiments and clinical trials.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disturbances in time perception in patients with obsessive-compulsive disorder.","authors":"Paraskevi Mavrogiorgou, Homan Amanpour, Thomas Jedamzik, Georg Juckel","doi":"10.1007/s00406-026-02260-8","DOIUrl":"https://doi.org/10.1007/s00406-026-02260-8","url":null,"abstract":"<p><strong>Background: </strong>The experience of time and the temporal order of external and internal events is essential for humans. Impairments in the experience of time have long been discussed in relation to main psychiatric disorders, but rarely in relation to obsessive-compulsive disorder. This pilot study therefore investigated impairments in the experience of time in terms of time perception and time awareness in patients with obsessive-compulsive disorder, as well as possible neurobiological correlates.</p><p><strong>Method: </strong>Twenty patients (11 men and 9 women, mean age 43.3, SD = 14.3) with an ICD-10 diagnosis of obsessive-compulsive disorder (F42.X) and 20 healthy subjects matched by age and gender (13 men and 7 women, mean age 40.2, SD = 15.4) were examined using time experience questionnaires, time estimation tasks, and flicker fusion frequency.</p><p><strong>Results: </strong>Significant differences were found in the experience of time between patients with obsessive-compulsive disorder and healthy control subjects. The patient group scored lower on time knowledge, time perception, and time management. It is worth mentioning the positive significant correlation (r = 0.641; p = 0.002) between the severity of compulsive behavior and impaired time management.</p><p><strong>Discussion: </strong>Disturbances in the experience of time appear to play an important role in psychiatric disorders, also in OCD. It is suggested that the process changes in the experience of time should be given greater consideration in current psychopathological findings.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between the novel endothelial activation and stress index and mortality in depressed adults: mediation analysis of systemic inflammation in a large NHANES sample.","authors":"Fuad A Abdu, Hengji Hu, Peiyuan Lu","doi":"10.1007/s00406-026-02243-9","DOIUrl":"https://doi.org/10.1007/s00406-026-02243-9","url":null,"abstract":"<p><strong>Background: </strong>Endothelial dysfunction contributes to poor outcomes in depression. However, the prognostic significance of the endothelial activation and stress index (EASIX), a novel marker for endothelial dysfunction, for mortality risk in depression remains unknown. This study aimed to: (1) evaluate the prognostic value of EASIX for mortality risk in US adults with clinically significant depressive symptoms, and (2) explore the potential mediating role of systemic inflammation using multiple hematologic indices.</p><p><strong>Methods: </strong>We included 1717 adults with clinically significant depressive symptoms (PHQ-9 ≥ 10) from NHANES 2005-2018 after applying predefined exclusion criteria, with mortality follow-up through December 2019. Nonlinear associations were assessed using RCS, and survival differences were evaluated with Kaplan-Meier curves. Cox proportional hazards models estimated hazard ratios (HRs). We additionally performed supplementary weighted analyses. Exploratory mediation analyses examined the neutrophil-to-lymphocyte ratio (NLR), eosinophil-to-lymphocyte ratio (ELR), monocyte-to-lymphocyte ratio (MLR), and the systemic inflammation response index (SIRI). Additionally, we conducted sensitivity analyses excluding early deaths (≤ 2 years) and participants with CKD, abnormal platelet counts, or extreme LDH levels.</p><p><strong>Results: </strong>Over a median follow-up of 83 months (IQR, 46-125 months), 251 all-cause and 56 cardiovascular mortalities occurred. Participants in the highest EASIX quartile showed higher mortality rates. RCS analyses indicated a mostly linear association for all-cause mortality and a nonlinear relationship for cardiovascular mortality. In fully adjusted Cox analyses, participants in the highest EASIX quartile had a 1.82-fold higher risk of all-cause mortality (95% CI: 1.13-2.95). For cardiovascular mortality, the point estimate indicated an increased risk (HR = 1.26); however, it was not statistically significant (95% CI: 0.47-3.41). Sensitivity analyses confirmed robustness, with significant associations persisting after excluding early deaths (HR 2.25, 95% CI 1.34-3.78) and after excluding participants with conditions affecting EASIX components (HR 1.93, 95% CI 1.12-3.34). Exploratory mediation analyses showed that systemic inflammation explained a significant portion of the EASIX-mortality link, with mediated proportions ranging from 7.3% (SIRI) to 29.2% (MLR) for all-cause mortality and from 6.3% (SIRI) to 26.8% (MLR) for cardiovascular mortality.</p><p><strong>Conclusion: </strong>Elevated EASIX is strongly associated with increased all-cause mortality in individuals with clinically significant depressive symptoms, with systemic inflammation mediating a substantial portion of this risk.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabidiol for the treatment of positive and negative symptoms in schizophrenia spectrum disorders: a systematic review and meta-analysis.","authors":"Antonio Di Francesco, Pierfelice Cutrufelli, Cecilia Chiarenza, Luca Zambuto, Carmen Concerto, Ludovico Mineo, Antonino Petralia, Marco Catalfo, Alessandro Rodolico, Myrto Samara, Stefan Leucht, Filippo Caraci, Maria Salvina Signorelli","doi":"10.1007/s00406-026-02249-3","DOIUrl":"https://doi.org/10.1007/s00406-026-02249-3","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}