European Archives of Psychiatry and Clinical Neuroscience最新文献

{"title":"Interpersonal sensitivity as a central hub: a network analysis of childhood trauma and psychological symptoms in adolescents with major depressive disorder.","authors":"Dandan Wang, Wei Wang, Yanlong Liao, Hanrui Zhang, Yuanxin Lu, Hongyang Liu, Yaoyao Zhang, Lingling Yuan, Mingxing Wu, Ying Gao, Xinyu Fang, Xiangrong Zhang","doi":"10.1007/s00406-025-02124-7","DOIUrl":"https://doi.org/10.1007/s00406-025-02124-7","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a fully automated assay for the measurement of plasma pTau217 and a composite score integrating the ratio Aβ1-42/1-40 as biomarkers of Alzheimer's disease.","authors":"Barbara Morgado, Hans-Wolfgang Klafki, Chris Bauer, Annik Steiert, Katharina Waniek, Ingolf Lachmann, Dirk Osterloh, Hermann Esselmann, Niels Hansen, Johannes Schuchhardt, Jens Wiltfang","doi":"10.1007/s00406-025-02123-8","DOIUrl":"https://doi.org/10.1007/s00406-025-02123-8","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of tight junction proteins in the pathogenesis of schizophrenia.","authors":"Sukhorukova Yulia, Zorkina Yana, Andryushchenko Alisa, Kostyuk Georgy","doi":"10.1007/s00406-025-02060-6","DOIUrl":"https://doi.org/10.1007/s00406-025-02060-6","url":null,"abstract":"<p><p>The blood-brain barrier (BBB) integrity is important for central nervous system homeostasis, and dysfunction of its components may contribute to the pathogenesis of various neuropsychiatric disorders, including schizophrenia. An additional factor supporting this hypothesis is the association of schizophrenia with DiGeorge syndrome, in which a deletion of a part of one copy of chromosome 22 (22q11DS) leads to haplonephrenia in the Claudin-5 gene (a tight junction protein that forms the BBB). Individuals with 22q11DS have a 25-fold greater risk of schizophrenia than the population average. The aim of our review was to establish the role of tight junction proteins in the pathogenesis of schizophrenia. For this purpose, a systematic literature search was performed. The first part describes genetic polymorphisms of tight junction proteins and studies of patients with DiGeorge syndrome. The second and third parts of the review focus on the expression of tight junction proteins in postmortem samples and serum. The fourth part of the review describes in vitro studies. The fifth part includes animal studies. Mice models with incomplete absence of the Claudin-5 gene have shown specific behavioral and memory impairments. The final part describes the effects of antipsychotics on tight junction proteins and BBB function. The discussed studies support the role of tight junction proteins in the pathogenesis of schizophrenia and the increased permeability of the BBB. However, the number of studies on this topic is extremely small. This review shows the prospects of studying tight junction proteins in psychiatric diseases.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal effect of Helicobacter pylori infection on brain health and potential mediation by immune cells.","authors":"Qibo Wu, Junshuan Cui, Niya Long, Ming Yang, Zhiheng Guo, Liangzhao Chu, Xingwang Zhou","doi":"10.1007/s00406-025-02121-w","DOIUrl":"https://doi.org/10.1007/s00406-025-02121-w","url":null,"abstract":"<p><strong>Objective: </strong>Increasing evidence suggests an association between Helicobacter pylori(HP) infection and brain health and its clinical manifestations. A growing body of evidence underscored the profound influence of immune cells on brain health. However, the existing evidence is equivocal, and the causal link remains uncertain. This study aims to determine if there is a causal connection between Hp infections and 42 brain-related diseases, as well as 1,325 distinct brain structures, and to explore the potential role of immune cells in mediating these associations.</p><p><strong>Methods: </strong>Both univariable and multivariable mendelian randomization (UVMR and MVMR) was applied to evaluate the causal relationships between Hp protein antibodies and 1325 brain structure, as well as various brain-related diseases. Finally, we assessed the relationship between immune cells and HP protein antibodies and brain health, and then calculated the mediating effect of immune cells on the significant causal associations.</p><p><strong>Results: </strong>Hp antibodies exhibited disease-specific effects: CagA conferred protection against anorexia nervosa(OR = 0.94, p = 0.015) and schizophrenia(OR = 0.91, p = 0.038).Conversely, catalase antibodies increased risks for frontotemporal dementia(OR = 1.47, p = 0.002) and juvenile absence epilepsy(OR = 1.01, p = 0.007). MVMR confirmed persistent associations with 61 brain structural alterations, such as IgG's impact on anterior cingulate morphology(OR = 1.06, p = 6.09E-05).Immune cells mediated 8.6-47.4% of Hp-brain effects: CD27⁺IgD⁺CD24⁺ B cells linked IgG to depression(18.2% mediation), while HLA-DR⁺ dendritic cells mediated UreA-associated white matter changes (10.9%).</p><p><strong>Conclusion: </strong>Hp infection may exert dual neuroprotective and pathogenic effects via antibody-specific mechanisms, modulated by immune cell phenotypes.This study underscores the gut-brain-immune axis as a pivotal frontier in neuropsychiatric research, with implications for precision interventions targeting Hp-related immune dysregulation.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping cerebellar subregional volumes and heterogeneity in schizophrenia spectrum disorders and violence.","authors":"Thomas Fischer-Vieler, Jaroslav Rokicki, Milin Kim, Esten Leonardsen, Thomas Wolfers, Christina Bell, Gabriela Hjell, Natalia Tesli, Nina Bang, Ingrid Melle, Ole A Andreassen, Christine Friestad, Petter Andreas Ringen, Unn K Haukvik","doi":"10.1007/s00406-025-02081-1","DOIUrl":"https://doi.org/10.1007/s00406-025-02081-1","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional causal association between frailty and six psychiatric disorders.","authors":"Fangfang Qian, Guoqiang Zheng, Zhuoming Chen","doi":"10.1007/s00406-025-02098-6","DOIUrl":"https://doi.org/10.1007/s00406-025-02098-6","url":null,"abstract":"<p><strong>Background: </strong>This study employs bidirectional Mendelian randomization (MR) analysis to explore the causal relationship between frailty and common psychiatric disorders.</p><p><strong>Methods: </strong>Depression, anxiety disorder, bipolar disorder, schizophrenia, sleep disorders, and eating disorders were considered as outcomes, with frailty index as the exposure variable. The main method employed was inverse variance weighting. Two-step MR was used to evaluate the mediation proportions of body mass index (BMI) between frailty and psychiatric disorders. Additionally, reverse MR analysis was conducted using the same testing methods.</p><p><strong>Results: </strong>Frailty index was positively associated with depression, anxiety disorder, bipolar disorder, sleep disorders, and eating disorders. Schizophrenia indicated no significant causal association. The effect of frailty index on the risk of sleep disorders, eating disorders, depression were all partially mediated by BMI, with mediation proportion of 24.40%, 14.23% and 5.22%. Reverse MR analysis revealed that depression increased the risk of frailty.</p><p><strong>Conclusion: </strong>This study has supported the causal association of frailty with depression, anxiety disorder, bipolar disorder, sleep disorders, and eating disorders. Additionally, individuals diagnosed with depression exhibit a heightened susceptibility to frailty. This sheds new light on the causal relationship between frailty and psychiatric disorders.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early life stress modulates social behavior via oxytocin and arginine vasopressin in males.","authors":"Congcong Liu, Yuru Du, Ye Zhao, Xueyi Wang, Yun Shi, Xi Yin, Youdong Li, Haishui Shi","doi":"10.1007/s00406-025-02119-4","DOIUrl":"https://doi.org/10.1007/s00406-025-02119-4","url":null,"abstract":"<p><p>Social behaviors are essential for both reproduction and survival. Human and animals exhibit distinct patterns of social interaction following trauma experienced during puberty, which are shaped by the complex interplay between environmental and biological factors. Although neuropeptides and early life stress (ELS) influence social behavior, it remains unclear whether the regulation of neuropeptides in response to ELS further modulates social behavior. Two sex neuropeptides, oxytocin (OT) and arginine vasopressin (AVP), exert profound effects on social behaviors. Therefore, we investigate the involvement of OT and AVP in modulating the alterations in social behavior resulting from ELS. The 89 adult men participants were divided into heterosexual (n=32) and gay/bisexual (n=57) groups. Mental health and the serum levels of OT and AVP were evaluated. Our clinical samples reveal significant variations in ELS exposure across sexual orientation groups, which correlate with neuroendocrine alterations, including altered OT and AVP levels. Animal study further substantiates the critical role of OT and AVP in mediating these changes, highlighting their involvement in shaping social behavior. These findings uncover potential underlying mechanisms through which the OT and AVP systems contribute to stress-induced alterations in social behavior.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"There is no sufficient evidence to support the use of probiotics supplementation in schizophrenia treatment.","authors":"Caio Lucca Oliveira Leite, Emilly Sampaio de Lima, Fabio Gomes de Matos E Souza, Luísa Weber Bisol","doi":"10.1007/s00406-025-02110-z","DOIUrl":"https://doi.org/10.1007/s00406-025-02110-z","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autism spectrum traits in adults with attention-deficit/hyperactivity disorder (ADHD): a hidden multifaceted phenotype marked by affective comorbidity, emotional dysregulation, and chronobiological disturbances.","authors":"Giulio Emilio Brancati, Ugo De Rosa, Anna Magnesa, Irene Cocciaro, Elena Costagli, Anna Iriti, Berenice Rimoldi, Matteo Vedovelli, Pierpaolo Medda, Elisa Schiavi, Giulio Perugi","doi":"10.1007/s00406-025-02114-9","DOIUrl":"https://doi.org/10.1007/s00406-025-02114-9","url":null,"abstract":"<p><strong>Background: </strong>Autism spectrum disorder (ASD) is a commonly observed comorbidity in children with attention-deficit/hyperactivity disorder (ADHD). Nevertheless, the impact of autism spectrum traits on clinical presentation and comorbidities in adults with ADHD remains largely underexplored.</p><p><strong>Methods: </strong>105 adults with ADHD were recruited at the outpatient service of the Psychiatry Unit 2 at Pisa University Hospital and subdivided according to screening for ASD based on the Autism-Spectrum Quotient (AQ). Comparative analyses were performed for sociodemographic and clinical variables.</p><p><strong>Results: </strong>Participants with a positive screening for ASD (N = 23, 21.9%) were more frequently females, had a higher age at first clinical referral, higher comorbidity rates with mood and anxiety disorders, particularly social anxiety, and a lower rate of cannabis use disorder. They showed significantly greater severity of ADHD and emotional dysregulation, worse personality and interpersonal functioning, more depressive, cyclothymic and anxious temperamental dispositions, more pathological personality traits, increased biological rhythm disturbances and evening chronotype.</p><p><strong>Conclusions: </strong>Autism spectrum traits are commonly reported in adults with ADHD and may be associated with female sex and a complex clinical presentation characterized by affective comorbidity, more severe emotional dysregulation and chronobiological disturbances.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive and negative falls short: why any attempt to rename schizophrenia must include careful consideration of the sensori-/psychomotor domain.","authors":"Dusan Hirjak, Sebastian Walther, Vijay A Mittal","doi":"10.1007/s00406-025-02108-7","DOIUrl":"https://doi.org/10.1007/s00406-025-02108-7","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}