European Archives of Psychiatry and Clinical Neuroscience最新文献

{"title":"Comment on \"Atypical antipsychotic drugs cause abnormal glucose and lipid metabolism independent of weight gain\".","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1007/s00406-025-01995-0","DOIUrl":"https://doi.org/10.1007/s00406-025-01995-0","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Before stress symptoms, anxiety and depression can be attributed to a SARS-CoV-2 infection, alternative causes must be ruled out.","authors":"Josef Finsterer","doi":"10.1007/s00406-025-01996-z","DOIUrl":"https://doi.org/10.1007/s00406-025-01996-z","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disorganisation and depression: a re-examination of how we think and speak when depressed.","authors":"Lena Palaniyappan, Yingqi Laetitia Wang, Fiona Meister","doi":"10.1007/s00406-025-01994-1","DOIUrl":"https://doi.org/10.1007/s00406-025-01994-1","url":null,"abstract":"<p><p>Disorganised thinking in severe mental illness seriously cripples social functions. Historically, the study of disorganisation has primarily concentrated on schizophrenia, utilizing tools designed to assess formal thought disorder (FTD). This review examines the characteristics, prevalence, and possible neural correlates of FTD within the framework of depressive disorders. Our focus is on disturbances in thought, language, and communication associated with depression, alongside the relevant subjective experiences. We also discuss the challenges and opportunities in using FTD as a predictor of future illness trajectory and advocate for using the broader construct of depressive disorganisation. We review the disruption of brain networks associated with FTD, such as the salience, language, and default mode networks, within the context of depression. In conclusion, we advocate for increased focus on personal narratives, computational psychopathology, and a broader emphasis on thought dynamics to enhance the identification of disorganisation in depression. Renewed emphasis on this neglected area of psychopathology could provide insights on improving employment and social functioning for individuals affected by mood disorders.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum BDNF, depressive symptoms, sleep quality, and cognitive function: a study on their impact and predictive value for suicidal ideation in bipolar depressive disorder patients.","authors":"Dongxia Li, Li Ma, Yingying Feng","doi":"10.1007/s00406-025-01997-y","DOIUrl":"https://doi.org/10.1007/s00406-025-01997-y","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the factors influencing suicidal ideation in patients with bipolar depressive disorder (BDD), focusing primarily on cognitive function, brain-derived neurotrophic factor (BDNF), sleep quality, and depressive symptoms.</p><p><strong>Methods: </strong>A total of 126 patients with depressive episodes of bipolar disorder and 38 healthy controls were recruited for this study. Participants were divided into suicidal ideation and non-suicidal ideation groups based on the Beck Scale for Suicide Ideation-Chinese Version (BSI-CV). Depressive symptoms were assessed using the 24-item Hamilton Rating Scale for Depression (HAMD-24), and sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI). Cognitive function was measured using the Chinese version of the MATRICS Consensus Cognitive Battery (MCCB), and serum BDNF levels were determined.</p><p><strong>Results: </strong>24.6% of the patients exhibited suicidal ideation. High depression scores and poor sleep quality were identified as risk factors, whereas good cognitive function and higher levels of BDNF served as protective factors. Receiver Operating Characteristic (ROC) analysis revealed that serum BDNF, depressive symptoms, sleep quality, and cognitive function have significant predictive value, with a combined use of these four indicators yielding even better predictive results.</p><p><strong>Conclusion: </strong>Serum BDNF levels, depression scores, sleep quality scores, and cognitive function scores can be used as predictive indicators for suicidal ideation in BDD patients. The combined use of these four indicators provides optimal predictive efficacy.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state functional connectivity correlates of brain structural aging in schizophrenia.","authors":"Yana R Panikratova, Alexander S Tomyshev, Ekaterina G Abdullina, Georgiy I Rodionov, Andrey Yu Arkhipov, Denis V Tikhonov, Olga V Bozhko, Vasily G Kaleda, Valeria B Strelets, Irina S Lebedeva","doi":"10.1007/s00406-024-01837-5","DOIUrl":"10.1007/s00406-024-01837-5","url":null,"abstract":"<p><p>A large body of research has shown that schizophrenia patients demonstrate increased brain structural aging. Although this process may be coupled with aberrant changes in intrinsic functional architecture of the brain, they remain understudied. We hypothesized that there are brain regions whose whole-brain functional connectivity at rest is differently associated with brain structural aging in schizophrenia patients compared to healthy controls. Eighty-four male schizophrenia patients and eighty-six male healthy controls underwent structural MRI and resting-state fMRI. The brain-predicted age difference (b-PAD) was a measure of brain structural aging. Resting-state fMRI was applied to obtain global correlation (GCOR) maps comprising voxelwise values of the strength and sign of functional connectivity of a given voxel with the rest of the brain. Schizophrenia patients had higher b-PAD compared to controls (mean between-group difference + 2.9 years). Greater b-PAD in schizophrenia patients, compared to controls, was associated with lower whole-brain functional connectivity of a region in frontal orbital cortex, inferior frontal gyrus, Heschl's Gyrus, plana temporale and polare, insula, and opercular cortices of the right hemisphere (rFTI). According to post hoc seed-based correlation analysis, decrease of functional connectivity with the posterior cingulate gyrus, left superior temporal cortices, as well as right angular gyrus/superior lateral occipital cortex has mainly driven the results. Lower functional connectivity of the rFTI was related to worse verbal working memory and language production. Our findings demonstrate that well-established frontotemporal functional abnormalities in schizophrenia are related to increased brain structural aging.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"755-766"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related variations in heart rate variability profiles among patients with schizophrenia and major depressive disorder.","authors":"YuQing Gao, LinLin Zhou, HaiSu Wu, YanYan Wei, XiaoChen Tang, LiHua Xu, YeGang Hu, Qiang Hu, HaiChun Liu, ZiXuan Wang, Tao Chen, ChunBo Li, YanLi Luo, JiJun Wang, TianHong Zhang","doi":"10.1007/s00406-024-01942-5","DOIUrl":"10.1007/s00406-024-01942-5","url":null,"abstract":"<p><p>Patients with psychiatric disorders exhibit general autonomic dysregulation and elevated cardiovascular risks, which could be indexed by heart rate variability (HRV). However, HRV is susceptible to age and other patient-specific factors. This study aimed to investigate the HRV profile and age-related variations, as well as the potential influence of sex, BMI, and HR on HRV in psychiatric populations. There were 571 consecutive patients diagnosed with schizophrenia (SZ) (N = 282) or major depressive disorder (MDD) (N = 289) recruited and classified as adolescent (11-21 years) and adult (> 21 years) groups. HRV indices were measured with 3-minute resting ECG recordings. Compared to adolescent subjects, all time-domain and nonlinear HRV indices were notably reduced in adults, while frequency-domain HRV was comparable. Between SZ and MDD groups, only HTI differed significantly. Age and psychiatric disorders exhibited complex interaction effects on HRV. Stratified by age stage, MDD patients exhibited slightly higher HRV in adolescence but slightly lower HRV in adulthood. In logistic regression analysis, HTI and SD2 were significantly distinctive between adolescents and adults in MDD group, while pNN50 was distinctive in SZ group. Moreover, female subjects demonstrated lower time-domain HRV, LF/HF and SD2 than males. HR exhibited inverse relationship with three domain HRV. No significant effect of BMI was observed. In psychiatric populations, compared to adolescents, adults decreased in time-domain and nonlinear HRV, but not in frequency-domain HRV. Age and psychotic disorders exhibited complex interaction effects on HRV. Sex and HR also emerged as important influencing factors of HRV.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"607-618"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handedness in schizophrenia and affective disorders: a large-scale cross-disorder study.","authors":"Annakarina Mundorf, Alexander Lischke, Jutta Peterburs, Nina Alexander, Linda M Bonnekoh, Katharina Brosch, Kira Flinkenflügel, Janik Goltermann, Tim Hahn, Andreas Jansen, Susanne Meinert, Igor Nenadić, Navid Nico Schürmeyer, Frederike Stein, Benjamin Straube, Katharina Thiel, Lea Teutenberg, Florian Thomas-Odenthal, Paula Usemann, Alexandra Winter, Udo Dannlowski, Tilo Kircher, Sebastian Ocklenburg","doi":"10.1007/s00406-024-01833-9","DOIUrl":"10.1007/s00406-024-01833-9","url":null,"abstract":"<p><p>While most people are right-handed, a minority are left-handed or mixed-handed. It has been suggested that mental and developmental disorders are associated with increased prevalence of left-handedness and mixed-handedness. However, substantial heterogeneity exists across disorders, indicating that not all disorders are associated with a considerable shift away from right-handedness. Increased frequencies in left- and mixed-handedness have also been associated with more severe clinical symptoms, indicating that symptom severity rather than diagnosis explains the high prevalence of non-right-handedness in mental disorders. To address this issue, the present study investigated the association between handedness and measures of stress reactivity, depression, mania, anxiety, and positive and negative symptoms in a large sample of 994 healthy controls and 1213 patients with DSM IV affective disorders, schizoaffective disorders, or schizophrenia. A series of complementary analyses revealed lower lateralization and a higher percentage of mixed-handedness in patients with major depression (14.9%) and schizophrenia (24.0%) compared to healthy controls (12%). For patients with schizophrenia, higher symptom severity was associated with an increasing tendency towards left-handedness. No associations were found for patients diagnosed with major depression, bipolar disorder, or schizoaffective disorder. In healthy controls, no association between hand preference and symptoms was evident. Taken together, these findings suggest that both diagnosis and symptom severity are relevant for the shift away from right-handedness in mental disorders like schizophrenia and major depression.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"767-783"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11946993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Borderline personality disorder vs. schizophrenia spectrum disorders in young people recruited within an \"Early Intervention in Psychosis\" service: clinical and outcome comparisons.","authors":"Lorenzo Pelizza, Emanuela Leuci, Emanuela Quattrone, Silvia Azzali, Giuseppina Paulillo, Simona Pupo, Pietro Pellegrini, Lorenzo Gammino, Arianna Biancalani, Marco Menchetti","doi":"10.1007/s00406-024-01772-5","DOIUrl":"10.1007/s00406-024-01772-5","url":null,"abstract":"<p><p>Borderline Personality Disorder (BPD) is under-recognized in First-Episode Psychosis (FEP) and its psychotic manifestations are difficult to differentiate from Schizophrenia Spectrum Disorders (SSD). The aim of this investigation was to compare clinical, sociodemographic, and outcome characteristics between FEP patients with BPD vs. FEP subjects with SSD both at baseline and across a 2-year follow-up period. Participants completed the Health of the Nation Outcome Scale (HoNOS), the Positive And Negative Syndrome Scale (PANSS), and the Global Assessment of Functioning (GAF) scale both at entry and every 12 months during the follow-up. A mixed-design ANOVA model was conducted to investigate the temporal stability of clinical scores within and between the two subgroups. Among 356 FEP participants, 49 had a BPD diagnosis. Compared to FEP/SSD (n = 307), FEP/BPD patients showed higher prevalence of employment, current substance use, and past attempted suicide. They had a lower equivalent dose of antipsychotic medication at entry and lower levels of negative symptoms. Finally, they had a higher 2-year drop-out rate and a significant improvement in psychopathological scores limited to the first year of treatment. BPD as categorical entity represents a FEP subgroup with specific clinical challenges. Appropriate treatment guidelines for this FEP subgroup are thus needed.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"893-905"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11946946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of resting cerebral perfusion between methamphetamine-associated psychosis and schizophrenia through arterial spin labeling MRI.","authors":"Zhen-An Hwang, Chia-Wei Li, Ai-Ling Hsu, Changwei W Wu, Wing P Chan, Ming-Chyi Huang","doi":"10.1007/s00406-024-01857-1","DOIUrl":"10.1007/s00406-024-01857-1","url":null,"abstract":"<p><strong>Objective: </strong>The clinical manifestations of methamphetamine (METH)-associated psychosis (MAP) and acute paranoid schizophrenia (SCZ) are similar. This study aims to assess regional cerebral blood flow (rCBF) in individuals who use METH and in those with SCZ using the MRI arterial spin labeling (ASL) technique.</p><p><strong>Methods: </strong>We prospectively recruited 68 participants and divided them into four groups: MAP (N = 15), SCZ (N = 13), METH users with no psychosis (MNP; N = 22), and normal healthy controls (CRL; N = 18). We measured rCBF using an MRI three-dimensional pseudo-continuous ASL sequence. Clinical variables were assessed using the Positive and Negative Syndrome Scale (PANSS) and Brief Assessment of Cognition in Schizophrenia (BACS). Group-level rCBF differences were analyzed using a two-sample t-test.</p><p><strong>Results: </strong>Decreased rCBF was found in the precuneus, premotor cortex, caudate nucleus, dorsolateral prefrontal cortex, and thalamus in the MNP group compared with the CRL group. The MAP group had significantly decreased rCBF in the precuneus, hippocampus, anterior insula, inferior temporal gyrus, inferior orbitofrontal gyrus, and superior occipital gyrus compared with the MNP group. Increased rCBF in the precuneus and premotor cortex was seen in the MAP group compared with the SCZ group. rCBF in the precuneus and premotor cortex significantly correlated negatively with the PANSS but correlated positively with BACS scores in the MAP and SCZ groups.</p><p><strong>Conclusion: </strong>METH exposure was associated with decreased rCBF in the precuneus and premotor cortex. Patients with MAP exhibited higher rCBF than those with SCZ, implying preserved insight and favorable outcomes. rCBF can therefore potentially serve as a diagnostic approach to differentiate patients with MAP from those with SCZ.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"873-883"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygenic risk for psychotic disorders in relation to cardiac autonomic dysfunction in unmedicated patients with schizophrenia.","authors":"Alexander Refisch, Sergi Papiol, Andy Schumann, Berend Malchow, Karl-Jürgen Bär","doi":"10.1007/s00406-024-01933-6","DOIUrl":"10.1007/s00406-024-01933-6","url":null,"abstract":"<p><p>Cardiac autonomic dysfunction (CADF), mainly characterized by increased heart rate, decreased heart rate variability, and loss of vagal modulation, has been extensively described in patients with schizophrenia (SCZ) and their healthy first-degree relatives. As such, it represents an apparent physiological link that contributes to the increased cardiovascular mortality in these patients. Common genetic variation is a putative underlying mechanism, along with lifestyle factors and antipsychotic medications. However, the extent to which CADF is associated with genetic factors for SCZ is unknown. A sample of 83 drug-naive SCZ patients and 96 healthy controls, all of European origin, underwent a 30-minute autonomic assessment under resting conditions. We incorporated parameters from several domains into our model, including time and frequency domains (mean heart rate, low/high frequency ratio) and compression entropy, each of which provides different insights into the dynamics of cardiac autonomic function. These parameters were used as outcome variables in linear regression models with polygenic risk scores (PRS) for SCZ as predictors and age, sex, BMI, smoking status, principal components of ancestry and diagnosis as covariates. Of the three CADF parameters, SCZ PRS was significantly associated with mean heart rate in the combined case/control sample. However, this association was was no longer significant after including diagnosis as a covariate (p = 0.29). In contrast, diagnostic status is statistically significant for all three CADF parameters, accounting for a significantly greater proportion of the variance in mean heart rate compared to SCZ PRS (approximately 16% vs. 4%). Despite evidence for a common genetic basis of CADF and SCZ, we were unable to provide further support for an association between the polygenic burden of SCZ and cardiac autonomic function beyond the diagnostic state. This suggests that there are other important characteristics associated with SCZ that lead to CADF that are not captured by SCZ PRS.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"863-871"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}