European Archives of Psychiatry and Clinical Neuroscience最新文献

Neurobiological and psychosocial mechanisms underlying ADHD and related disorders. ADHD及相关疾病的神经生物学和社会心理机制。

IF 3.7 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-10-24 DOI: 10.1007/s00406-025-02122-9

Kristina Adorjan

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Addressing mental health challenges in clinical practice: a qualitative study to investigate perspectives of international mental health experts. 解决心理健康挑战在临床实践：定性研究调查国际心理健康专家的观点。

IF 3.7 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-10-23 DOI: 10.1007/s00406-025-02064-2

Melissa G Halil, Anissa Abi-Dargham, John H Krystal, David M Clark, Adrian P Mundt, Helen Herrman, Solomon Rataemane, Fritzi Weitzenegger, Isabel Dziobek, Andreas Heinz, Irina Baskow

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Association of the endosomal sorting processes cargo selection and membrane tubulation with human reward system reactivity. 内体分选过程货物选择和膜管与人类奖励系统反应的关联。

IF 3.7 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-10-13 DOI: 10.1007/s00406-025-02102-z

Jens Treutlein, Bernd Krämer, Monika Rex-Haffner, Swapnil Awasthi, Stephan Ripke, Elisabeth Binder, Oliver Gruber

{"title":"Association of the endosomal sorting processes cargo selection and membrane tubulation with human reward system reactivity.","authors":"Jens Treutlein, Bernd Krämer, Monika Rex-Haffner, Swapnil Awasthi, Stephan Ripke, Elisabeth Binder, Oliver Gruber","doi":"10.1007/s00406-025-02102-z","DOIUrl":"https://doi.org/10.1007/s00406-025-02102-z","url":null,"abstract":"Dysfunction of the dopaminergic reward system has been implicated in the pathophysiology of several neuropsychiatric disorders. The endosomal network encompasses important processes related to neurotransmission in dopamine neurons, e.g., endocytosis, sorting, recycling and degradation of receptors. We investigated whether genetic variation influencing the endosomal sorting machinery, in particular cargo selection and membrane tubulation, may impact on the activation strength in key regions of the mesolimbic reward system, i.e. the ventral tegmental area (VTA) and the nucleus accumbens (NAcc). To test our hypothesis, VTA and NAcc responses to conditioned reward stimuli were investigated using the 'desire-reason-dilemma' paradigm during functional magnetic resonance imaging in humans. Association of these neural responses with a set of genetic variants related to endosomal sorting processes (SNX1, SNX6, WASHC2C, WASHC3, WASHC4, DNAJC13) were tested in two independent cohorts (N = 182; N = 214). In the first cohort, the gene set was associated with both VTA and NAcc responses to conditioned reward stimuli [empirical P-values: R-VTA: 0.0036; R-NAcc: 0.0016; L-NAcc: 0.0094]. At the level of the gene set, the effect in the R-VTA could be replicated in the second cohort [empirical P-value: R-VTA: 0.0443]. For the NAcc, an additional exploratory analysis of a patient-only subcohort of the first cohort (N = 64) suggested that the gene set may express its effect in this brain region predominantly in patients. These findings provide first evidence that the endosomal sorting processes cargo selection and membrane tubulation may influence neural responses of the reward system to conditioned stimuli.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Sleep-related metacognitions in inpatients with mental disorders. 修正：住院精神障碍患者睡眠相关元认知。

IF 3.7 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-10-10 DOI: 10.1007/s00406-025-02118-5

Elisabeth Anzenberger, Michael Schredl, Claudia Schilling

引用次数: 0

Correction: All eyes on PCS: analysis of the retinal microvasculature in patients with post-COVID syndrome-study protocol of a 1 year prospective case-control study. 纠正：全眼注视PCS: covid后综合征患者视网膜微血管分析- 1年前瞻性病例对照研究的研究方案。

IF 3.7 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-10-08 DOI: 10.1007/s00406-025-02125-6

Timon Kuchler, Renate Hausinger, Matthias C Braunisch, Roman Günthner, Rebecca Wicklein, Benjamin Knier, Nathalie Bleidißel, Matthias Maier, Andrea Ribero, Maciej Lech, Kristina Adorjan, Hans Stubbe, Konstantin Kotliar, Uwe Heemann, Christoph Schmaderer

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Anthropomorphic technology in everyday life: focus on chatbots and impacts on mental health. 日常生活中的拟人技术：关注聊天机器人及其对心理健康的影响。

IF 3.7 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-10-08 DOI: 10.1007/s00406-025-02088-8

Scott Monteith, Tasha Glenn, John R Geddes, Peter C Whybrow, Eric Achtyes, Michael Bauer

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Obsessive-compulsive and catatonic symptoms in the early stages of psychosis: Are they related? 精神病早期阶段的强迫症和紧张性症状：它们是否相关？

IF 3.7 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-10-06 DOI: 10.1007/s00406-025-02080-2

Sergio Sanchez-Alonso, Manuel Canal-Rivero, Nathalia Garrido-Torres, Enrique Baca-Garcia, Benedicto Crespo-Facorro, Maria Luisa Barrigon, Miguel Ruiz-Veguilla

引用次数: 0

Interpersonal sensitivity as a central hub: a network analysis of childhood trauma and psychological symptoms in adolescents with major depressive disorder. 人际敏感性作为中心枢纽：儿童创伤和青少年重度抑郁症心理症状的网络分析。

IF 3.7 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-09-27 DOI: 10.1007/s00406-025-02124-7

Dandan Wang, Wei Wang, Yanlong Liao, Hanrui Zhang, Yuanxin Lu, Hongyang Liu, Yaoyao Zhang, Lingling Yuan, Mingxing Wu, Ying Gao, Xinyu Fang, Xiangrong Zhang

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Evaluation of a fully automated assay for the measurement of plasma pTau217 and a composite score integrating the ratio Aβ1-42/1-40 as biomarkers of Alzheimer's disease. 评价血浆pTau217全自动测定法和a β1-42/1-40比值综合评分作为阿尔茨海默病的生物标志物。

IF 3.7 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-09-27 DOI: 10.1007/s00406-025-02123-8

Barbara Morgado, Hans-Wolfgang Klafki, Chris Bauer, Annik Steiert, Katharina Waniek, Ingolf Lachmann, Dirk Osterloh, Hermann Esselmann, Niels Hansen, Johannes Schuchhardt, Jens Wiltfang

引用次数: 0

The role of tight junction proteins in the pathogenesis of schizophrenia. 紧密连接蛋白在精神分裂症发病机制中的作用。

IF 3.7 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-09-27 DOI: 10.1007/s00406-025-02060-6

Sukhorukova Yulia, Zorkina Yana, Andryushchenko Alisa, Kostyuk Georgy

{"title":"The role of tight junction proteins in the pathogenesis of schizophrenia.","authors":"Sukhorukova Yulia, Zorkina Yana, Andryushchenko Alisa, Kostyuk Georgy","doi":"10.1007/s00406-025-02060-6","DOIUrl":"https://doi.org/10.1007/s00406-025-02060-6","url":null,"abstract":"The blood-brain barrier (BBB) integrity is important for central nervous system homeostasis, and dysfunction of its components may contribute to the pathogenesis of various neuropsychiatric disorders, including schizophrenia. An additional factor supporting this hypothesis is the association of schizophrenia with DiGeorge syndrome, in which a deletion of a part of one copy of chromosome 22 (22q11DS) leads to haplonephrenia in the Claudin-5 gene (a tight junction protein that forms the BBB). Individuals with 22q11DS have a 25-fold greater risk of schizophrenia than the population average. The aim of our review was to establish the role of tight junction proteins in the pathogenesis of schizophrenia. For this purpose, a systematic literature search was performed. The first part describes genetic polymorphisms of tight junction proteins and studies of patients with DiGeorge syndrome. The second and third parts of the review focus on the expression of tight junction proteins in postmortem samples and serum. The fourth part of the review describes in vitro studies. The fifth part includes animal studies. Mice models with incomplete absence of the Claudin-5 gene have shown specific behavioral and memory impairments. The final part describes the effects of antipsychotics on tight junction proteins and BBB function. The discussed studies support the role of tight junction proteins in the pathogenesis of schizophrenia and the increased permeability of the BBB. However, the number of studies on this topic is extremely small. This review shows the prospects of studying tight junction proteins in psychiatric diseases.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0