{"title":"Neurobiological and psychosocial mechanisms underlying ADHD and related disorders.","authors":"Kristina Adorjan","doi":"10.1007/s00406-025-02122-9","DOIUrl":"https://doi.org/10.1007/s00406-025-02122-9","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145354171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melissa G Halil, Anissa Abi-Dargham, John H Krystal, David M Clark, Adrian P Mundt, Helen Herrman, Solomon Rataemane, Fritzi Weitzenegger, Isabel Dziobek, Andreas Heinz, Irina Baskow
{"title":"Addressing mental health challenges in clinical practice: a qualitative study to investigate perspectives of international mental health experts.","authors":"Melissa G Halil, Anissa Abi-Dargham, John H Krystal, David M Clark, Adrian P Mundt, Helen Herrman, Solomon Rataemane, Fritzi Weitzenegger, Isabel Dziobek, Andreas Heinz, Irina Baskow","doi":"10.1007/s00406-025-02064-2","DOIUrl":"https://doi.org/10.1007/s00406-025-02064-2","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145344418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jens Treutlein, Bernd Krämer, Monika Rex-Haffner, Swapnil Awasthi, Stephan Ripke, Elisabeth Binder, Oliver Gruber
{"title":"Association of the endosomal sorting processes cargo selection and membrane tubulation with human reward system reactivity.","authors":"Jens Treutlein, Bernd Krämer, Monika Rex-Haffner, Swapnil Awasthi, Stephan Ripke, Elisabeth Binder, Oliver Gruber","doi":"10.1007/s00406-025-02102-z","DOIUrl":"https://doi.org/10.1007/s00406-025-02102-z","url":null,"abstract":"<p><p>Dysfunction of the dopaminergic reward system has been implicated in the pathophysiology of several neuropsychiatric disorders. The endosomal network encompasses important processes related to neurotransmission in dopamine neurons, e.g., endocytosis, sorting, recycling and degradation of receptors. We investigated whether genetic variation influencing the endosomal sorting machinery, in particular cargo selection and membrane tubulation, may impact on the activation strength in key regions of the mesolimbic reward system, i.e. the ventral tegmental area (VTA) and the nucleus accumbens (NAcc). To test our hypothesis, VTA and NAcc responses to conditioned reward stimuli were investigated using the 'desire-reason-dilemma' paradigm during functional magnetic resonance imaging in humans. Association of these neural responses with a set of genetic variants related to endosomal sorting processes (SNX1, SNX6, WASHC2C, WASHC3, WASHC4, DNAJC13) were tested in two independent cohorts (N = 182; N = 214). In the first cohort, the gene set was associated with both VTA and NAcc responses to conditioned reward stimuli [empirical P-values: R-VTA: 0.0036; R-NAcc: 0.0016; L-NAcc: 0.0094]. At the level of the gene set, the effect in the R-VTA could be replicated in the second cohort [empirical P-value: R-VTA: 0.0443]. For the NAcc, an additional exploratory analysis of a patient-only subcohort of the first cohort (N = 64) suggested that the gene set may express its effect in this brain region predominantly in patients. These findings provide first evidence that the endosomal sorting processes cargo selection and membrane tubulation may influence neural responses of the reward system to conditioned stimuli.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elisabeth Anzenberger, Michael Schredl, Claudia Schilling
{"title":"Correction: Sleep-related metacognitions in inpatients with mental disorders.","authors":"Elisabeth Anzenberger, Michael Schredl, Claudia Schilling","doi":"10.1007/s00406-025-02118-5","DOIUrl":"https://doi.org/10.1007/s00406-025-02118-5","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Timon Kuchler, Renate Hausinger, Matthias C Braunisch, Roman Günthner, Rebecca Wicklein, Benjamin Knier, Nathalie Bleidißel, Matthias Maier, Andrea Ribero, Maciej Lech, Kristina Adorjan, Hans Stubbe, Konstantin Kotliar, Uwe Heemann, Christoph Schmaderer
{"title":"Correction: All eyes on PCS: analysis of the retinal microvasculature in patients with post-COVID syndrome-study protocol of a 1 year prospective case-control study.","authors":"Timon Kuchler, Renate Hausinger, Matthias C Braunisch, Roman Günthner, Rebecca Wicklein, Benjamin Knier, Nathalie Bleidißel, Matthias Maier, Andrea Ribero, Maciej Lech, Kristina Adorjan, Hans Stubbe, Konstantin Kotliar, Uwe Heemann, Christoph Schmaderer","doi":"10.1007/s00406-025-02125-6","DOIUrl":"https://doi.org/10.1007/s00406-025-02125-6","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Scott Monteith, Tasha Glenn, John R Geddes, Peter C Whybrow, Eric Achtyes, Michael Bauer
{"title":"Anthropomorphic technology in everyday life: focus on chatbots and impacts on mental health.","authors":"Scott Monteith, Tasha Glenn, John R Geddes, Peter C Whybrow, Eric Achtyes, Michael Bauer","doi":"10.1007/s00406-025-02088-8","DOIUrl":"https://doi.org/10.1007/s00406-025-02088-8","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sergio Sanchez-Alonso, Manuel Canal-Rivero, Nathalia Garrido-Torres, Enrique Baca-Garcia, Benedicto Crespo-Facorro, Maria Luisa Barrigon, Miguel Ruiz-Veguilla
{"title":"Obsessive-compulsive and catatonic symptoms in the early stages of psychosis: Are they related?","authors":"Sergio Sanchez-Alonso, Manuel Canal-Rivero, Nathalia Garrido-Torres, Enrique Baca-Garcia, Benedicto Crespo-Facorro, Maria Luisa Barrigon, Miguel Ruiz-Veguilla","doi":"10.1007/s00406-025-02080-2","DOIUrl":"https://doi.org/10.1007/s00406-025-02080-2","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interpersonal sensitivity as a central hub: a network analysis of childhood trauma and psychological symptoms in adolescents with major depressive disorder.","authors":"Dandan Wang, Wei Wang, Yanlong Liao, Hanrui Zhang, Yuanxin Lu, Hongyang Liu, Yaoyao Zhang, Lingling Yuan, Mingxing Wu, Ying Gao, Xinyu Fang, Xiangrong Zhang","doi":"10.1007/s00406-025-02124-7","DOIUrl":"https://doi.org/10.1007/s00406-025-02124-7","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Barbara Morgado, Hans-Wolfgang Klafki, Chris Bauer, Annik Steiert, Katharina Waniek, Ingolf Lachmann, Dirk Osterloh, Hermann Esselmann, Niels Hansen, Johannes Schuchhardt, Jens Wiltfang
{"title":"Evaluation of a fully automated assay for the measurement of plasma pTau217 and a composite score integrating the ratio Aβ1-42/1-40 as biomarkers of Alzheimer's disease.","authors":"Barbara Morgado, Hans-Wolfgang Klafki, Chris Bauer, Annik Steiert, Katharina Waniek, Ingolf Lachmann, Dirk Osterloh, Hermann Esselmann, Niels Hansen, Johannes Schuchhardt, Jens Wiltfang","doi":"10.1007/s00406-025-02123-8","DOIUrl":"https://doi.org/10.1007/s00406-025-02123-8","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of tight junction proteins in the pathogenesis of schizophrenia.","authors":"Sukhorukova Yulia, Zorkina Yana, Andryushchenko Alisa, Kostyuk Georgy","doi":"10.1007/s00406-025-02060-6","DOIUrl":"https://doi.org/10.1007/s00406-025-02060-6","url":null,"abstract":"<p><p>The blood-brain barrier (BBB) integrity is important for central nervous system homeostasis, and dysfunction of its components may contribute to the pathogenesis of various neuropsychiatric disorders, including schizophrenia. An additional factor supporting this hypothesis is the association of schizophrenia with DiGeorge syndrome, in which a deletion of a part of one copy of chromosome 22 (22q11DS) leads to haplonephrenia in the Claudin-5 gene (a tight junction protein that forms the BBB). Individuals with 22q11DS have a 25-fold greater risk of schizophrenia than the population average. The aim of our review was to establish the role of tight junction proteins in the pathogenesis of schizophrenia. For this purpose, a systematic literature search was performed. The first part describes genetic polymorphisms of tight junction proteins and studies of patients with DiGeorge syndrome. The second and third parts of the review focus on the expression of tight junction proteins in postmortem samples and serum. The fourth part of the review describes in vitro studies. The fifth part includes animal studies. Mice models with incomplete absence of the Claudin-5 gene have shown specific behavioral and memory impairments. The final part describes the effects of antipsychotics on tight junction proteins and BBB function. The discussed studies support the role of tight junction proteins in the pathogenesis of schizophrenia and the increased permeability of the BBB. However, the number of studies on this topic is extremely small. This review shows the prospects of studying tight junction proteins in psychiatric diseases.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}