European Archives of Psychiatry and Clinical Neuroscience最新文献

{"title":"Psychopathological, neuropsychological and sociodemographic description of the population using a post-COVID outpatient clinic: results from the 2Long4COVID BLOOD study.","authors":"Katharina Dünnwald, Yannik Adam, Donata von Freymann, Alexia Synetou, Stefan Kruse, Elisabeth Pracht, Dominic Rauschning, Clara Lehmann, Joseph Kambeitz, Theresa Katharina Lichtenstein","doi":"10.1007/s00406-025-02065-1","DOIUrl":"https://doi.org/10.1007/s00406-025-02065-1","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of post-COVID syndrome (PCS) is estimated to be below 1%, with notable variation across different SARS-CoV-2 variants. The syndrome is characterized by a broad spectrum of clinical manifestations affecting multiple organ systems. Cognitive impairments and psychological distress are frequently observed; however, their underlying pathophysiological mechanisms remain poorly understood.</p><p><strong>Objective: </strong>This study examines the sociodemographic, psychopathological, and neuropsychological characteristics of patients treated at our psychiatric post-COVID outpatient clinic (PPCO-clinic).</p><p><strong>Method: </strong>Patients were recruited from the post-COVID outpatient clinic of the Department of Infectious Diseases at Cologne University Hospital. Assessments included observer-rated evaluations, neuropsychological testing, and psychopathological examinations. Data from 41 patients were analyzed and compared with normative data from healthy controls reported in the literature.</p><p><strong>Results: </strong>Between April and November 2022, 42 patients attended the PPCO-clinic, with 41 included in the analysis (58.5% female; mean age: 45 years). Patients exhibited significantly poorer performance across all neuropsychological tests compared to healthy controls, with pronounced deficits in visual memory, phonematic fluency, visuomotor function, and global cognitive screening. Additionally, they reported significantly higher levels of depression, anxiety, daytime sleepiness, fatigue, and reduced quality of life. Personality assessments revealed increased neuroticism and lower extraversion, conscientiousness, and agreeableness.</p><p><strong>Conclusion: </strong>These findings underscore the importance of comprehensive neuropsychological and psychopathological assessments in individuals with PCS-particularly in cases where symptoms persist beyond the scope of routine primary care-to ensure accurate evaluation and effective management.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grouping motivational interviewing for alcohol craving in individuals with alcohol use disorder: the influence of drinking history on its efficacy.","authors":"Jing Yao, Bailing Wang, Shuwen Liu, Zhiwei Wu, Meihong Xiu, Jie Sun, Fengchun Wu","doi":"10.1007/s00406-025-02054-4","DOIUrl":"https://doi.org/10.1007/s00406-025-02054-4","url":null,"abstract":"<p><strong>Background: </strong>Motivational interviewing (MI) is a psychological intervention for patients with alcohol use disorder (AUD). This study examined the role of the history of drinking alcohol in the efficacy of group MI (GMI) on alcohol craving in AUD. The sample (N = 108) consisted of patients with AUD.</p><p><strong>Methods: </strong>A total of 108 patients with AUD received a 6-week GMI or treat-as-usual (TAU) intervention and were interviewed at baseline, weeks 2, 4, and 6. The severity of alcohol craving was evaluated by the Penn Alcohol Craving Scale (PACS), and the depressive symptoms were assessed by the Hamilton Depression Rating Scale (HAMD). Repeated measures ANOVA showed improved alcohol craving and depressive symptoms in the GMI group compared with the TAU group.</p><p><strong>Results: </strong>According to the history of AUD, all patients were divided into two groups: the short-term group (< 20) (n = 38) or the long-term group ( > = 20) (n = 70). The GMI interventions showed a positive effect on alcohol craving (p = 0.01) and depressive symptoms (p < 0.001) only in patients with a long history of AUD rather than in those with a short AUD history (all p > 0.05). There were no significant associations of the improvements in alcohol craving with depressive symptoms following a 6-week GMI intervention in the long-term AUD history group.</p><p><strong>Discussion: </strong>This result suggests that GMI showed greater positive effects on alcohol craving and symptoms of depression in patients with long-term AUD compared with those with a short history of this disorder. Further interventions should emphasize the importance of considering patients' drinking history in alcohol dependence treatment to foster the intervention efficacy of GMI.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between elevated habituation tendencies and impulsivity, compulsivity, and childhood adversity among abstinent patients with methamphetamine use disorders.","authors":"Jiajing Chen, Dong Mei Wang, Zhixuan Yu, Yang Tian, Mengqian Qu, Linjun Jiang, Lianglun Jia, Fabing Fu, Han Chen, Ren Huang, Xiang Yang Zhang","doi":"10.1007/s00406-025-02053-5","DOIUrl":"https://doi.org/10.1007/s00406-025-02053-5","url":null,"abstract":"<p><p>Elevated habituation tendencies have been identified in several subgroups of patients with substance use disorders, however, their intricate relationship with substance use disorders remains unknown. A total of 133 individuals with methamphetamine use disorder (PwMUD) and 131 healthy controls (HC) were initially recruited for this study. After exclusion of outliers, data from 128 PwMUD and 125 HC were included in the analyses. Participants reported their habituation tendencies, drug-use characteristics, impulsivity, compulsivity, and experiences of childhood adversity through self-report scales and structured interviews. The results show that PwMUD had a higher level of automatic habituation tendencies compared to healthy controls. This higher level of automaticity demonstrated a tenuous association with the duration of methamphetamine use and a relatively stronger association with compulsivity, suggesting that the imbalance between the goal-directed and habitual systems in PwMUD may be both a risk factor for and a consequence of methamphetamine use disorder.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketamine and its enantiomers in treatment-resistant depression: promise, pitfalls, and personalized psychiatry.","authors":"Ming-Ming Zhao, Jian-Jun Yang, Kenji Hashimoto","doi":"10.1007/s00406-025-02066-0","DOIUrl":"https://doi.org/10.1007/s00406-025-02066-0","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deficit of oligodendrocyte family cells in layer 5 of the dorsal anterior cingulate cortex in schizophrenia.","authors":"N S Kolomeets, N A Uranova","doi":"10.1007/s00406-025-02057-1","DOIUrl":"https://doi.org/10.1007/s00406-025-02057-1","url":null,"abstract":"<p><p>The deficit of oligodendrocyte family cells has commonly been implicated in the dysfunction of neuronal networks in schizophrenia. Previously we reported a significant deficit of oligodendrocytes (Ol) and oligodendrocyte clusters (OlC), containing differentiating oligodendrocyte progenitors, in the cortical hubs of fronto-parietal cognitive (FPN) and default mode (DMN) networks, and in the striatum which is a central relay of the numerous networks. Anterior cingulate cortex (ACC) is crucial for integration of cognitive and emotional processes in support of goal-directed behavior and it's connections with FPN, DMN and basal ganglia are altered in schizophrenia. Few studies have examined changes in Ol family cell numbers in the ACC in schizophrenia, however, decreased expression of myelin- and oligodendrocyte-related genes in the ACC are characteristic of schizophrenia. We used optical disector method to estimate the numerical density (Nv) of oligodendrocytes and oligodendrocyte clusters in layer 5 of dorsal ACC (dACC) in schizophrenia (18 cases per group) as compared to healthy controls (13 cases per group). A significant reduction in the Nv of oligodendrocytes (- 23%; p < 0.01) and NvOlC (- 28%, p = 0.012) was found in schizophrenia as compared to the control group. We found significant correlations between the NvOl and the NvOlC in both control (R = 0.9; p < 0.001) and schizophrenia groups (R = 0.77; p = 0.014). The deficits in the number of OL and OlC in layer 5 of dACC may be tightly linked with reduced reciprocal ACC-thalamic connectivity in patients brain which were reported strongly correlate with positive symptoms fundamental for schizophrenia.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between emotion regulation skills, resilience, depression and anxiety symptom severity in patients with mood disorders and non-clinical participants: a mediation model.","authors":"Hyun Seok Do, Jakyung Lee, Hyeona Yu, Chan Woo Lee, Hyun Jung Hur, Jongwook Lim, Hyo Shin Kang, Jungkyu Park, Tae Hyon Ha, Woojae Myung","doi":"10.1007/s00406-025-02050-8","DOIUrl":"https://doi.org/10.1007/s00406-025-02050-8","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic reconfigurations of brain subnetworks in female patients with alcohol use disorder or bulimia nervosa: a resting-state functional magnetic resonance imaging study.","authors":"N Leenaerts, T A A Broeders, J Ceccarini, S Sunaert, M M Schoonheim, C H Vinkers, E Vrieze","doi":"10.1007/s00406-025-02055-3","DOIUrl":"https://doi.org/10.1007/s00406-025-02055-3","url":null,"abstract":"<p><strong>Introduction: </strong>The brain forms a complex functional brain network. This network is dynamically reconfigured to support various cognitive processes. Research on brain network dynamics in patients with alcohol use disorder (AUD) or bulimia nervosa (BN), two highly comorbid psychiatric disorders, remains limited. Previous studies showed altered static network patterns, highlighting that the network is disturbed, but implicitly ignoring network dynamics. This study investigates dynamic network reconfigurations in female patients with AUD or BN and healthy controls (HC).</p><p><strong>Methods: </strong>Resting-state functional MRI data were acquired of 102 female participants (AUD:27, BN:24, HC:51). A sliding-window approach assigned brain regions iteratively to one of seven literature-based subnetworks for each window. Then, previously validated parameters of network reconfiguration were assessed: promiscuity (number of subnetworks switched to) and flexibility (number of switches). These measures were compared between groups and related to behavioral and clinical measures.</p><p><strong>Results: </strong>Compared to HC, patients with BN displayed a higher promiscuity of all brain subnetworks combined, and regionally for the dorsal attention network, with no change in flexibility. Patients with AUD showed no difference in either promiscuity or flexibility. Global and dorsal attention network promiscuity were negatively correlated with subjective stress.</p><p><strong>Conclusion: </strong>Regions typically assigned to the dorsal attention network changed their association with a higher number of other subnetworks in BN compared to HC, which was not seen in AUD. This suggests a less focused dynamic integration of information in patients with BN, which could play a role in their vulnerability to stress, attentional biases and impulsivity.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: A multimodal approach to depression diagnosis: insights from machine learning algorithm development in primary care.","authors":"Julia Eder, Mark Sen Dong, Melanie Wöhler, Maria S Simon, Catherine Glocker, Lisa Pfeiffer, Richard Gaus, Johannes Wolf, Kadir Mestan, Helmut Krcmar, Nikolaos Koutsouleris, Antonius Schneider, Jochen Gensichen, Richard Musil, Peter Falkai","doi":"10.1007/s00406-025-02058-0","DOIUrl":"https://doi.org/10.1007/s00406-025-02058-0","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing mental health care: a problem, resources and goals oriented multidimensional framework (PRoGO).","authors":"Stefan Leucht, Bernhard König, Antonio di Francesco, Alessandro Rodolico, Josef Priller, Kerem Böge, Wolfgang Strube, Jochen Gensichen, Peter Bechmann, Amr ElDeeb, Alkomiet Hasan, Steffen Moritz, Markus Jäger, Claudia Leucht, Jim van Os, John M Davis","doi":"10.1007/s00406-025-02045-5","DOIUrl":"https://doi.org/10.1007/s00406-025-02045-5","url":null,"abstract":"<p><strong>Background: </strong>Lawrence Weed introduced the \"Problem-Oriented Medical Records\" (POMR) approach to medicine. Its core principle is that treatment should be organised around patients' specific problems. This approach gained widespread adoption in the United States during the 1970s. However, few studies have compared POMR with the traditional \"source-based\" method, and evidence supporting its application in mental health remains particularly limited.</p><p><strong>Methods: </strong>We carried out a narrative review to examine whether POMR is appropriate for mental health care and which modifications are necessary for this purpose.</p><p><strong>Findings: </strong>Psychiatry and psychotherapy address brain-mediated disorders that lack clear biological markers. Diagnoses rely on the assessment of psychopathological symptoms, which are grouped into syndromes. These symptoms and syndromes can be effectively categorized as \"problems\". Given that psychiatric treatment is often symptomatic in that it focuses on symptoms rather than diagnoses, POMR provides an ideal framework for organizing care. Furthermore, mental health is inherently multidimensional, encompassing biological, psychological, social, and existential domains. This complexity necessitates interdisciplinary collaboration. However, under the conventional source-based approach, professional groups often operate in parallel rather than jointly together. POMR, by contrast, facilitates seamless collaboration by aligning teams around patient-centred problems. A special aspect of mental health care is the emphasis on considering patients' individual goals and resources, rather than focusing only on their deficits.</p><p><strong>Interpretation: </strong>By systematically applying POMR to psychiatric care-particularly through tightly coordinated interdisciplinary treatment-clinicians could enhance both clinical and functional outcomes, improve both patient and team satisfaction, and better align treatment with patients' unique needs. To support this approach, we propose a practical grid which we refer to as the Problem-Resources-Goals Oriented framework (PRoGO), reflecting the necessary adaptations for mental health. Clinical trials are warranted to assess the effectiveness of POMR/PRoGO in psychiatric practice and its potential to advance the field.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal esketamine significantly alleviates depression severity and suicidal ideations in electroconvulsive therapy (ECT) non-responders.","authors":"Erhan Kavakbasi, Kevin Rosemann, Mert Yilmaz, Helmut Berndt, Bernhard T Baune","doi":"10.1007/s00406-025-02041-9","DOIUrl":"https://doi.org/10.1007/s00406-025-02041-9","url":null,"abstract":"<p><strong>Introduction: </strong>Intranasal esketamine (ESK) is a novel therapy option in patients with treatment-resistant depression (TRD). Patients with a history of electroconvulsive therapy (ECT) non-response (ECT+) in the current episode have usually been excluded from previous studies. Data on the effectiveness of ESK in ECT non-responders are sparse.</p><p><strong>Methods: </strong>In this retrospective study, we investigated the effectiveness of intranasal ESK in real-world inpatients with (ECT+, n = 39) history of ECT non-response compared to patients who have not received an adequate course of ECT in their current episode (ECT-, n = 57). A factorial analysis of variance (ANOVA) has been used to determine the impact of ECT non-response on treatment outcome.</p><p><strong>Results: </strong>A total of n = 96 patients (mean age 47.0; 52.1% women) with TRD were included in this study. There was a significant main effect of history of ECT non-response on MADRS score in the ANOVA (F = 10.386, p = 0.002). However, there was no significant interaction effect of time (pre-treatment, post-treatment)*history of ECT non-response in current episode (F = 2.166, p = 0.143). The response (34.9% vs. 21.9%, χ2 = 1.498, p = 0.167) and remission rates (24.4% vs. 12.1%, χ2 = 1.861, p = 0.141) were none significantly lower in the ECT + group than in the ECT- group. There was significant improvement in MADRS and BDI-II in the ECT + group. No major safety concerns occurred during the study.</p><p><strong>Conclusion: </strong>There was no significant impact of ECT non-response on esketamine treatment outcome. Our results support the approach to offer esketamine to ECT non-responders given that the array of treatment alternatives is limited for these patients.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}