European Archives of Psychiatry and Clinical Neuroscience最新文献

{"title":"Alterations of the endocannabinoid system in autism spectrum disorder: a systematic review and meta-analysis.","authors":"Xinlei Jia, Shumin Gao, Xiaotong Liu, Zhendong Feng, Xingxing Wang, Kunyi Lan, Yan'e Lu, Lei Han, Ya Bin Wei, Jia Jia Liu","doi":"10.1007/s00406-025-02031-x","DOIUrl":"https://doi.org/10.1007/s00406-025-02031-x","url":null,"abstract":"<p><p>Dysregulation of the endocannabinoid system (ECS) might be related to autism spectrum disorder (ASD). This study conducts a meta-analysis on the dysregulation of the ECS across ASD animal models and individuals with ASD and systematically reviews the impact of these alterations in ASD animal models. Out of 47 papers assessed for eligibility, 16 animal studies and five human studies were included for narrative synthesis and seven and three for quantitative analysis, respectively. The results revealed a significant decrease in hippocampus anandamide (AEA) levels (SMD = -1.06, 95% CI [-1.78, -0.33], p < 0.01) among ASD animal models and a decrease in blood AEA levels in individuals with ASD (SMD = -0.79, 95% CI [-1.28, -0.30], p = 0.002) compared to normal controls. In the prefrontal cortex, 2-arachidonoylglycerol (2-AG) levels were significantly decreased, despite high heterogeneity between studies (SMD = -1.00, 95% CI [-1.93, -0.06], p = 0.04). No significant changes compared to normal controls were observed in levels of AEA (SMD = -0.48, 95% CI [-1.20, 0.25], p = 0.20), 2-AG (SMD = -0.62, 95% CI [-1.27, 0.02], p = 0.06) in combined brain regions. The narrative synthesis revealed that elevated AEA and 2-AG levels could ameliorate core and associated autistic-like symptoms with region and sex-dependent variations in ASD animal models. Future research should focus on specific mechanisms of endocannabinoids regional effects while considering sex-related influences.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualizing rTMS in treatment-resistant depression from patient-specific perfusion abnormalities a proof-of-concept randomized trial in comparison to standard rTMS and tDCS.","authors":"Ludovic C Dormegny-Jeanjean, Clément de Crespin de Billy, Camille Pierrat, Olivier Mainberger, Benoit Schorr, Alexandre Obrecht, Hippolyte Arcay, Augustin Moreau, Ilia Humbert, Francesco Scarlatti, Gilles Bertschy, Paulo Loureiro de Sousa, Julien Lamy, Sebastien Weibel, Lionel Landré, Jack R Foucher","doi":"10.1007/s00406-025-02027-7","DOIUrl":"https://doi.org/10.1007/s00406-025-02027-7","url":null,"abstract":"<p><strong>Background: </strong>Studies examining treatment-resistant depression (TRD) as a group implicitly assume that these conditions share similar pathophysiological features, like left prefrontal hypoactivity, and should respond to standardized treatments like repetitive transcranial magnetic stimulation (S-rTMS) or transcranial direct current stimulation (tDCS). Recent advances in arterial spin labeling functional MRI (ASL-fMRI) revealed that subject-specific perfusion abnormalities may be more heterogeneous than expected. Individualized rTMS protocols (I-rTMS) could alleviate such abnormalities and establish their relevance.</p><p><strong>Methods: </strong>iADAPT was a randomized, cross-over trial comparing I-rTMS with active comparators (S-rTMS and tDCS) on brain perfusion, assessed with ASL-fMRI, and single blind clinical evaluation. Patient-specific abnormalities were determined from three ASL-fMRI sessions. I-rTMS multi-target interventions targeted all reachable bi-frontal abnormalities, upregulating hypoperfusions and downregulating hyperperfusions. S-rTMS and tDCS were placed on F3. rTMS interventions used neuronavigation and a robotic targeting device. Each arm included 20 sessions over two weeks.</p><p><strong>Results: </strong>Twenty-two patients with TRD were included and analyzed. While at the group level they presented subgenual cingulate hyperperfusion, they presented heterogeneous prefrontal perfusion abnormalities individually. I-rTMS was the only intervention to have specific effects on brain perfusion, showing perfusion reductions compatible with the disengagement of negative emotional systems, e.g. subgenual cingulate, anterior insula.</p><p><strong>Conclusions: </strong>Paradoxically, I-rTMS induced more reproducible remote effects on cerebral perfusion than S-rTMS, while the I-rTMS protocol differed considerably between participants. These results suggest that the heterogeneities observed in ASL-MRI at the individual level are significant and may have the potential to inform individualized treatment.</p><p><strong>Clinicaltrials: </strong>gov no NCT02863380, registered on 2016-08-05.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putamen subregion dysfunction mediates the relationship between childhood maltreatment and major depressive disorder.","authors":"Qianyi Luo, Huiwen Yu, Tong Yu, Jinrou Xia, Yurong Zou, Yuhong Li, Juran Chen, Xiaohui Lin, Hongjun Peng","doi":"10.1007/s00406-025-02034-8","DOIUrl":"https://doi.org/10.1007/s00406-025-02034-8","url":null,"abstract":"<p><p>Childhood maltreatment is a significant risk factor for the development of major depressive disorder (MDD) and is closely linked to abnormalities in the brain's reward circuitry. Previous studies have observed reward circuitry abnormalities centered around the putamen in MDD patients, treating it as a single core nucleus. However, the putamen is a heterogeneous nucleus composed of different functional subregions, and there is limited research focused on the abnormal functional connectivity (FC) of putamen subregions in MDD with childhood maltreatment. To explore putamen-centered reward circuitry abnormalities in MDD with childhood maltreatment, we conducted static and dynamic functional connectivity (FC) analyses with putamen subregions (including the ventral anterior putamen, dorsal anterior putamen, ventral posterior putamen, and dorsal posterior putamen) as regions of interest. Four groups were included: MDD with childhood maltreatment (n = 48), MDD without childhood maltreatment (n = 30), healthy controls with childhood maltreatment (n = 57), and healthy controls without childhood maltreatment (n = 46). Compared to MDD without childhood maltreatment, MDD with childhood maltreatment exhibited higher dynamic FC between the right dorsal putamen and the right prefrontal gyrus, as well as lower static FC between the right ventral anterior putamen and the left middle frontal gyrus and left anterior cingulate gyrus. A positive correlation was found between these aberrant dynamic FC patterns and childhood maltreatment. Additionally, the abnormal dynamic FC mediated the relationship between childhood neglect and the depression severity. These findings suggest that dysfunctional connectivity within the putamen subregions may serve as a neurobiological marker for MDD in individuals with childhood maltreatment. This study contributes to a better understanding of the underlying neurobiological mechanisms of MDD, with implications for more targeted interventions that take into account the specific brain alterations associated with a history of childhood maltreatment.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of internet addiction and its association with quality of life among inflight security officers based on a national survey: a network analysis perspective.","authors":"Zhen Gui, He-Li Sun, Yuan Feng, Qinge Zhang, Zhaohui Su, Teris Cheung, Gabor S Ungvari, Erliang Zhang, Minzhi Chen, Jie Zhang, Lin Zhang, Bin Ren, Qingqing Jin, Chee H Ng, Mi Xiang, Yu-Tao Xiang","doi":"10.1007/s00406-025-02030-y","DOIUrl":"https://doi.org/10.1007/s00406-025-02030-y","url":null,"abstract":"<p><strong>Background: </strong>Given the heavy responsibilities placed on inflight security officers (IFSO) to ensure passenger safety and eliminate inflight hazards, they often turn to Internet use to cope with their work pressure. This study examined the prevalence of internet addiction (IA) among IFSO in China, and its associated factors, relationship with quality of life (QOL), and network structure.</p><p><strong>Methods: </strong>This was a cross-sectional study based on a national survey. Expected influence (EI) was used to identify the most central nodes within the network model.</p><p><strong>Results: </strong>Among 3,475 IFSO included in this study across 10 airlines, the prevalence of IA (IAT-20 total score of ≥ 50) was 13.1% (n = 454; 95% CI: 11.9-14.2%). Further, there was an association between lower annual income, more severe depressive symptoms and anxiety symptoms with IA among IFSOs. Network analysis found that \"Job performance or productivity suffer because of the Internet\" (IAT8) was the most central symptom with the highest EI value, followed by \"Preoccupation with the Internet\" (IAT15) and \"Depressed/moody/nervous only while being offline\" (IAT20). Moreover, \"Sleep loss due to late-night logins\" (IAT14) and \"Spend more time online over going out with others\" (IAT19) had the most negative associations with QOL, while \"Form new relationships with online users\" (IAT4) showed the strongest positive correlation with QOL.</p><p><strong>Conclusion: </strong>IA was common among IFSO. To reduce the adverse impact of IA among IFSO, appropriate interventions targeting central symptoms and those closely associated with QOL found in the network models should be developed.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between proton pump inhibitors and dementia risk: evidence from a Mendelian randomization study.","authors":"Mengmeng Ou, Zhiqiang Du, Rongrong Lu, Ying Jiang, Haohao Zhu","doi":"10.1007/s00406-025-02036-6","DOIUrl":"https://doi.org/10.1007/s00406-025-02036-6","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to analyze the causal relationship between Proton Pump Inhibitors (PPI) and the risk of Dementia (DEM) using Mendelian Randomization (MR) analysis, providing a reference for clinical medication decisions.</p><p><strong>Methods: </strong>Based on summary data from Genome-Wide Association Studies (GWAS), this study uses two common PPI drugs, Lansoprazole (LAN) and Omeprazole (OME), as exposure factors. DEM and its five subtypes: Dementia in Alzheimer Disease (DAD), Vascular Dementia (VD), Dementia due to Parkinson Disease (DPD), Dementia with Lewy bodies (DLB), and Frontotemporal Dementia (FTD) are used as outcome factors. The main method used to assess causal relationships is the Inverse Variance Weighted (IVW) method; other MR methods and sensitivity analyses are also conducted as supplements.</p><p><strong>Results: </strong>There is a significant positive causal relationship between LAN and DEM (IVW: OR = 1.29E + 05, 95% CI: 1.60E + 00 to 1.04E + 10; P = 0.041), and DAD (IVW: OR = 2.39E + 04, 95% CI: 1.09E + 00 to 5.23E + 08; P = 0.048); no significant causal relationship was found between LAN and VD, DPD, DLB, FTD (P > 0.05). There is a significant positive causal relationship between OME and FTD (IVW: OR = 2.95E + 11, 95% CI: 2.13E + 02 to 4.09E + 20; P = 0.014), and a significant negative causal relationship with VD (IVW: OR = 9.56E-07, 95% CI: 1.69E-12 to 5.40E-01; P = 0.040); no significant causal relationship was found between OME and DEM, DAD, DPD, DLB (P > 0.05).</p><p><strong>Conclusion: </strong>This study reveals that LAN may increase the risk of DEM and DAD; OME may increase the risk of FTD and may reduce the risk of VD. This provides a reference for the rational clinical use of PPI.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of cardiorespiratory fitness and muscular fitness with plasma levels of endocannabinoids and their analogues in adults with diagnosed depression: SONRIE study.","authors":"Manuel Ruiz-Muñoz, Sonia Ortega-Gómez, Maria Del Mar Espinosa-Nogales, Eulalio Valmisa-Gómez de Lara, Miguel Ángel Rosety-Rodríguez, Vanesa España-Romero","doi":"10.1007/s00406-025-02032-w","DOIUrl":"https://doi.org/10.1007/s00406-025-02032-w","url":null,"abstract":"<p><strong>Background: </strong>Depression is a leading cause of global disability, affecting approximately 280 million individuals worldwide. Emerging evidence suggests that both physical fitness and endocannabinoids system play significant roles in the pathophysiology and management of depressive disorders.</p><p><strong>Purpose: </strong>To examine the associations between physical fitness, in terms of cardiorespiratory fitness (CRF) and muscular fitness (MF), with plasma levels of endocannabinoids (eCBs) and their analogues, in adults diagnosed with depression.</p><p><strong>Methods: </strong>The study involved 80 adults (ages 25-65) with a psychiatric diagnosis of mild-to-moderate depression based on the International Classification of Diseases 10th Revision (ICD-10) criteria. Physical fitness was assessed through tests measuring CRF (6-Minute Walk Test) and MF (Handgrip, Arm Curl, Chair Stand, Standing Long Jump Test). Fasting plasma levels of eCBs, such as anandamide (AEA) and 2-arachidonoyl glycerol (2-AG), and their analogues were measured using liquid chromatography-tandem mass spectrometry. Linear regression analyses were conducted or the associations between fitness variables and plasma levels of eCBs and their analogues using three models.</p><p><strong>Results: </strong>CRF and jump performance were inversely associated with plasma levels of the eCBs AEA (β range: - 0.302 to - 0.237 for CRF, - 0.315 to - 0.370 for jump; All p < 0.05) and 2-AG (β range: - 0.308 to - 0.326 across all models). eCBs analogues correlated negatively with CRF [2-linoleoylglycerol, 2-oleoylglycerol, docosatetraenoylethanolamide (DEA)] and jump (linoleylethanolamine, stearoylethanolamine, DEA); findings persisted after lean mass normalization.</p><p><strong>Conclusion: </strong>Our findings indicated that higher physical fitness was associated with lower plasma levels of eCBs and their analogues.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory ratios as predictors of length of hospitalization in psychiatric patients: A multicenter study.","authors":"Ayse Kurtulmus, Fatma Busra Parlakkaya Yildiz, Rabia Kevser Sancili Boyraz, Zulal Celik, Aynur Gormez","doi":"10.1007/s00406-025-02033-9","DOIUrl":"https://doi.org/10.1007/s00406-025-02033-9","url":null,"abstract":"<p><strong>Introduction: </strong>Burgeoning evidence underscores the role of inflammation in psychiatric disorders where inflammation is linked to some clinical parameters such as disease severity and treatment resistance. However, the relationship between inflammation and the length of hospitalization remains poorly understood.</p><p><strong>Objectives: </strong>This study aimed to investigate whether elevated inflammation at the time of admission, as indicated by blood cell ratios which are easily accessible markers of peripheral inflammation, predicts the length of stay (LOS) in acutely ill psychiatric patients.</p><p><strong>Methods: </strong>This multi-centre study was conducted at two state hospitals using retrospective data. A total of 497 inpatients were screened, and clinical records at admission were carefully reviewed to exclude any intervening infections or inflammatory conditions. Patients were excluded if they had significantly elevated acute-phase reactants, symptoms of infection, received treatment for suspected infections, used anti-inflammatory drugs, or had physical examination findings suggestive of infection. Additionally, patients with alcohol/substance use disorders and those hospitalized after a suicide attempt were not included. Ultimately, the final sample comprised 167 individuals. CRP levels and NLR, MLR and PLR ratios derived from routine laboratory tests.</p><p><strong>Results: </strong>The length of hospitalization ranged from 10 to 85 days, with a mean of 30.43 ± 14.45 days. A significant positive correlation was found between LOS and NLR (r = 0.453, p <.001), PLR (r = 0.351, p <.001), and MLR (r = 0.292, p <.001), even after controlling for age, gender, diagnosis, comorbid medical conditions, and study site. However, CRP levels did not correlate with LOS (r = 0.025, p =.762). Hierarchical regression analysis revealed that adding the set of immune ratios significantly improved the model's predictive value (p <.001), with immune ratios explaining an additional 10.8% of the variance in LOS, even after controlling for other factors. No significant differences in NLR, PLR, or MLR were observed across diagnostic groups (p =.47, p =.52, and p =.15, respectively). No significant difference was observed between diagnostic groups in terms of inflammatory ratios.</p><p><strong>Conclusions: </strong>Our findings indicate that an elevated inflammatory response, as reflected by blood cell ratios, is associated with prolonged hospitalization in all patients, regardless of their diagnosis. These results emphasize the importance of addressing inflammatory processes in psychiatric care. Targeting inflammation as a modifiable risk factor may offer a new therapeutic avenue to reduce LOS. Future studies should focus on prospective designs and randomized controlled trials to determine whether targeting inflammation can directly reduce LOS and improve recovery in psychiatric populations.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor insight and self-disorders in schizophrenia: an empirical study.","authors":"Lars Siersbæk Nilsson, Julie Nordgaard, Mads Gram Henriksen, Josef Parnas, Andreas Rosén Rasmussen","doi":"10.1007/s00406-025-02035-7","DOIUrl":"https://doi.org/10.1007/s00406-025-02035-7","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the potential of the 3-hydroxykynurenine/kynurenic acid ratio: a promising biomarker in adolescent major depressive disorder.","authors":"Zhihan Ye, Shuran Yang, Liu Lu, Ming Zong, Lieying Fan, Chuanyuan Kang","doi":"10.1007/s00406-024-01815-x","DOIUrl":"10.1007/s00406-024-01815-x","url":null,"abstract":"<p><p>Metabolites disruptions in tryptophan (TRP) and kynurenine pathway (KP) are believed to disturb neurotransmitter homeostasis and contribute to depressive symptoms. This study aims to investigate serum levels of KP metabolites in adolescent major depressive disorder (AMDD), and examine their relationship with depression severities. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to analyze serum levels of TRP, kynurenic acid (KYNA), kynurenine (KYN), and 3-hydroxy-kynurenine (3-HK) in 143 AMDD participants and 98 healthy controls (HC). Clinical data, including Children's Depression Inventory (CDI) scores, were collected and analyzed using statistical methods, such as ANOVA, logistic regression, Receiver operating characteristic curve analysis and a significance level of p < 0.05 was used for all analyses. AMDD showed significantly decreased serum levels of KYNA (-25.5%), KYN (-14.2%), TRP (-11.0%) and the KYNA/KYN ratio (-11.9%) compared to HC (p < 0.01). Conversely, significant increases were observed in 3-HK levels (+50.4%), the 3-HK/KYNA ratio (+104.3%) and the 3-HK/KYN ratio (+93.0%) (p < 0.01). Logistic regression analysis identified increased level of 3-HK as a contributing factor to AMDD, while increased level of KYNA acted as a protective factor against AMDD. The 3-HK/KYNA ratio demonstrated an area under the curve (AUC) of 0.952. This study didn't explore AMDD's inflammatory status and its metabolites relationship explicitly. These findings indicate that metabolites of TRP and KP may play a crucial role in the pathogenesis of AMDD, emphasizing the potential of the 3-HK/KYNA ratio as a laboratory biomarker for early detection and diagnosis of AMDD.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"1049-1061"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobiological similarities and clinical differences between Post-COVID and depression; response to Bonnet and Kuhn 2024.","authors":"Carla P Rus","doi":"10.1007/s00406-024-01849-1","DOIUrl":"10.1007/s00406-024-01849-1","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"1265-1266"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}