European Archives of Psychiatry and Clinical Neuroscience最新文献

{"title":"Association between neuroticism, genetic susceptibility, and peripheral artery disease risk: a prospective study in UK Biobank.","authors":"Guoying Wang, Qi Rao, Fang Lei, Yu Tian, Li Mao, Jinxing He, Lijin Lin, Chuhua Huang","doi":"10.1007/s00406-025-02111-y","DOIUrl":"https://doi.org/10.1007/s00406-025-02111-y","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations of insomnia symptoms and clinical features as well as blood metabolic parameters in adolescents with major depressive disorders.","authors":"Xi Zhang, Lewei Liu, Yun Zhang, Lili Zhao, Jiawei Wang, Changhao Chen, Zhiwei Liu, Feng Geng, Daming Mo, Xiangfen Luo, Xiangwang Wen, Ling Zhang, Huanzhong Liu","doi":"10.1007/s00406-025-02113-w","DOIUrl":"https://doi.org/10.1007/s00406-025-02113-w","url":null,"abstract":"<p><strong>Background: </strong>Adolescents with major depressive disorder (MDD) frequently experience insomnia (difficulty initiating, maintaining sleep or early awakening). This prevalent symptom may associate with depression, negative life events, childhood maltreatment (CM), and blood metabolic parameters. We investigated associations between insomnia, clinical features, and blood metabolic parameters in adolescents with MDD .</p><p><strong>Methods: </strong>From January 2021 to December 2022, 361 adolescents with MDD aged 12-18 were included in this cross-sectional study. We used the Center for Epidemiological Studies Depression Scale (CES-D), the Insomnia Severity Index Scale (ISI), the Adolescent Self-rating Life Events Checklist (ASLEC), and the Childhood Trauma Questionnaire (CTQ) to assess depression, insomnia, negative Life events, and CM. Additionally, we measured blood metabolic parameters Levels in 150 subjects. Finally, logistic regression analyses and receiver operating characteristic (ROC) curve analyses were conducted.</p><p><strong>Results: </strong>Among adolescents with MDD, the prevalence of insomnia was 37.4%. Compared with the non-insomnia, patients in the insomnia had a greater propensity to live in families with abnormal parental marital status, to have attempted suicide, and to exhibite higher scores on a series of scales. Further logistic regression analyses revealed that abnormal parental marital status (OR = 2.012, 95% CI = 1.127-3.592), CES-D score (OR = 1.093, 95% CI = 1.063-1.124), healthy adaptation (OR = 1.130, 95% CI = 1.402-1.226), and emotional neglect (OR = 0.941, 95% CI = 0.889-0.996) were independently associated with insomnia. When metabolic parameters were included, thyroid-stimulating hormone (TSH) (OR = 1.730, 95% CI = 1.170-2.558) and 25-hydroxyvitamin D [25(OH)D] (OR = 0.851, 95% CI = 0.758-0.954) were also identified as independent factors influencing insomnia. Additionally, ROC curve analyses showed that the model based solely on clinical features had good predictive performance for insomnia (AUC = 0.777, 95% CI = 0.730-0.825, P < 0.001). When metabolic parameters were included, the predictive performance of the model was further improved (AUC = 0.777, 95% CI = 0.730-0.825, P < 0.001).</p><p><strong>Conclusion: </strong>Among adolescents with MDD, insomnia are widespread and may correlate with depression, negative Life events, CM, TSH, and 25(OH)D. Therefore, it is necessary to consider these factors comprehensively in clinical interventions.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential role of ANXA11/ANXA3 protein level ratio in predicting antidepressant treatment outcomes.","authors":"Xiangjun Zhou, Yucai Qu, Lingyi Shi, Zhiqiang Du, Qin Zhou, Zhenhe Zhou, Ying Jiang, Haohao Zhu","doi":"10.1007/s00406-025-02117-6","DOIUrl":"https://doi.org/10.1007/s00406-025-02117-6","url":null,"abstract":"<p><strong>Objective: </strong>To explore the causal relationship between 2,821 plasma protein level ratios and antidepressant treatment response to uncover the potential molecular mechanisms.</p><p><strong>Methods: </strong>We utilized the protein level ratio dataset from the UK Biobank Pharma Proteomics Project (UKB PPP) and the antidepressant treatment dataset from the Psychiatric Genomics Consortium. We employed Mendelian Randomization (MR) analysis to explore the causal relationships between 2,821 protein level ratios and antidepressant treatment. Additionally, we conducted GO/KEGG analysis to uncover associated biological processes, cellular components, molecular functions, and signaling pathways.</p><p><strong>Results: </strong>We found that the protein level ratio of ANXA11/ANXA3 was significantly positively associated with the positive effects of antidepressant treatment(IVW method(FEM): OR = 1.537, 95%CI = 1.263-1.869, p = 1.730E-05, pFDR = 0.049), suggesting its potential as a biomarker for predicting antidepressant efficacy. Moreover, the GO/KEGG analysis provided new insights into the genetic architecture and molecular mechanisms underlying antidepressant efficacy.</p><p><strong>Conclusion: </strong>Our results highlight the significance of protein level ratios in the pathophysiological processes of depression and offer novel strategies for the development of personalized treatment approaches. Future studies are warranted to further validate these findings and explore their clinical implications.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota: contributing to high CVD prevalence in people living with schizophrenia?","authors":"Chuanwen Fu, Xuehui Zhang, Ying Qian, Ximei Wang, Xinqiang Chen, Jia Zeng, Nichang Zhang, Liming Wang, Mingsong Li, Zhengxu Li, Teng Zhang, Yuemei Feng, Jianzhong Yin","doi":"10.1007/s00406-025-02103-y","DOIUrl":"https://doi.org/10.1007/s00406-025-02103-y","url":null,"abstract":"<p><p>People living with schizophrenia (PLWS) have a reduced life expectancy with cardiovascular disease (CVD) as a major contributor. This article reviews the existing populations and animal studies and summarizes that reduced abundance of Lachnospiraceae, Bacteroides, Faecalibacterium, Ruminococcus, Roseburia, Bifidobacterium, Lactobacillus, Akkermansia, Rikenellaceae and increased abundance of Prevotella, Clostridium, Escherichia in PLWS is one of the probable reasons for the increased risk of CVD prevalence in PLWS by affecting the metabolism of substances related to the development of Schizophrenia (SCZ) and CVD.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145052063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating substance-induced psychosis (SIP) into the positive and negative symptoms disorder (PND) spectrum.","authors":"Albert Batalla, Jørgen G Bramness","doi":"10.1007/s00406-025-02104-x","DOIUrl":"https://doi.org/10.1007/s00406-025-02104-x","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent olfactory dysfunction as an indicator of cognitive impairment in long COVID-19 syndrome: implications for monitoring and rehabilitation.","authors":"Alna Carolina Mendes Paranhos, Apio Ricardo Nazareth Dias, Erick Antonio Rodrigues Mendes, Emily Vitória Almeida Paixão, Samuel Franco Viana Santos Silva, Lidiane Palheta Miranda Dos Santos, Gisele Vieira Hennemann Koury, Mariângela Moreno Domingues, Juarez Antônio Simões Quaresma, Givago da Silva Souza, Luiz Fábio Magno Falcão","doi":"10.1007/s00406-025-02116-7","DOIUrl":"https://doi.org/10.1007/s00406-025-02116-7","url":null,"abstract":"<p><strong>Background: </strong>Persistent olfactory dysfunction (OD) and cognitive impairment are among the most frequently reported sequelae of long term infection with SARS-CoV-2 (long COVID-19). However, the association between these conditions remains unclear. This study investigated the correlation between OD and cognitive impairment in patients recovering from COVID-19 to identify the implications for therapeutic and rehabilitation strategies.</p><p><strong>Materials and methods: </strong>A cross-sectional study of adult patients diagnosed with long COVID was conducted at a healthcare centre in Brazil. Olfactory function was assessed using the Connecticut Chemosensory Clinical Research Centre (CCCRC) test, and cognitive performance was evaluated using the Montreal Cognitive Assessment (MoCA). Statistical analyses included odds ratios (OR) and linear regression to explore the association between OD severity and cognitive scores, adjusting for potential confounders such as age, sex, and comorbidities.</p><p><strong>Results: </strong>A total of 241 patients (age: 48.60 ± 12.68 years; 73% female) were included. Cognitive impairment (MoCA < 23) was present in 64% of the participants. OD was identified in 92% of the patients and ranged from mild to anosmia. Linear regression analysis showed a weak yet statistically significant correlation between the CCCRC and MoCA scores (R = 0.14, p = 0.02). An OR of 2.87 (95% CI: 1.57-5.25, p = 0.00) indicated higher odds of cognitive impairment in patients with severe OD.</p><p><strong>Discussion: </strong>This study supports the hypothesis that there is a weak yet significant association between OD and cognitive impairment in patients with long COVID. These findings underscore the importance of early screening for olfactory dysfunction as a potential marker of cognitive monitoring and the need for intervention in this population.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Group-activity cognitive remediation therapy on cognitive impairment in patients with chronic schizophrenia: a randomized controlled follow-up study.","authors":"Xiaomei Xu, Yuhong Wang, Xinfu Wang, Lida Shi, Huijing Yu, Zhanmin Li, Lijun Liu","doi":"10.1007/s00406-025-02076-y","DOIUrl":"https://doi.org/10.1007/s00406-025-02076-y","url":null,"abstract":"<p><strong>Background: </strong>Schizophrenia (SZ) is a severe chronic mental disorder characterized by pervasive impairments in cognition, emotion, perception, and behavior. We developed a novel group activity intervention aimed at improving cognitive function. The objective of this study was to investigate the effects of group activity therapy on cognitive functioning in patients with chronic schizophrenia.</p><p><strong>Methods: </strong>In this 8-week, randomized, single-blind, controlled study, 100 schizophrenia patients with residual negative symptoms were randomly assigned to either the group activity or control group. Both groups continued their original antipsychotic treatments; however, the intervention group participated in an additional group activity program while the control group received standard rehabilitation programs. Assessment of psychotic symptoms and cognitive performance was conducted at baseline, week 4, and week 8 using the Positive and Negative Syndrome Scale (PANSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).</p><p><strong>Results: </strong>There were no significant changes in PANSS scores between the control and intervention groups at baseline, 4 weeks, and 8 weeks (p > 0.05). After 8 weeks of treatment, the intervention group exhibited significant improvements in Immediate Memory (IM), Visuospatial/Constructional (VC), Language, Attention, Delayed Memory (DM), and total RBANS scores compared to baseline (p < 0.05). These cognitive gains were significantly greater than those observed in the control group (p < 0.05).</p><p><strong>Conclusions: </strong>Our findings indicate that group activity therapy can effectively improve cognitive impairment in schizophrenia patients with residual negative symptoms. Additionally, both age and duration of illness were found to negatively impact cognitive function recovery.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary: towards a name change of schizophrenia: positive and negative symptoms disorder (PND).","authors":"Alexandre Andrade Loch","doi":"10.1007/s00406-025-02109-6","DOIUrl":"https://doi.org/10.1007/s00406-025-02109-6","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional and national burdens of mental disorders, substance use disorders and self-harm among adolescents and young adults, 1990-2021: a systematic analysis for the Global Burden of Diseases Study 2021.","authors":"Siwei Sun, Qiqi Chen, Guoping Li, Hui Yang, Wenqing Cai, Yunning Hu, Yuxi Zhang, Xin Yang, Yan Liu, Le Zhang, Kai Yuan, Yang Deng","doi":"10.1007/s00406-025-02115-8","DOIUrl":"https://doi.org/10.1007/s00406-025-02115-8","url":null,"abstract":"<p><p>Concerns over the mental health among young people have been increasing recently. We aimed to estimate the burdens of mental disorders, substance use disorders (SUDs), and self-harm at global, regional and national levels among adolescents and young adults aged 10-24 years from 1990 to 2021. Incidence, prevalence, and disability-adjusted life years (DALYs) of mental disorders, SUDs, and self-harm among young people were examined by age, sex, region, and country/territory. Average annual percentage changes (AAPCs) were utilized to assess the temporal trends of age-standardized rates during 1990-2021. Spearman rank-correlation analysis was used to analyze the correlation between age-standardized rates for incidence, prevalence, and DALYs and Socio-demographic Index (SDI). In 2021, there were 36.32 million DALYs due to mental disorders, 4.37 million DALYs due to SUDs, and 8.00 million DALYs due to self-harm among adolescents and young adults aged 10-24 years globally. Age-standardized DALY rate of mental disorders exhibited a slightly increasing trend, whereas DALY rates of SUDs and self-harm decreased from 1990 to 2021. Age-standardized incidence, prevalence, and DALY rates for depressive and anxiety disorders in 2020 and 2021 were approximately 20% higher than those observed in the pre-pandemic period. The burdens of mental disorders, SUDs, and self-harm were higher in high SDI countries such as New Zealand, Australia, Greenland, United States of America, and Canada. Global burdens due to mental disorders, mainly included anxiety and depressive disorders among adolescents and young adults markedly increased from 1990 to 2021, with a significant increase coinciding with the COVID-19 pandemic.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor regarding: \"Towards a name change of schizophrenia: positive and negative symptoms disorder (PND)\".","authors":"Carlos De Las Cuevas","doi":"10.1007/s00406-025-02107-8","DOIUrl":"https://doi.org/10.1007/s00406-025-02107-8","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}