European Archives of Psychiatry and Clinical Neuroscience最新文献

{"title":"There is no sufficient evidence to support the use of probiotics supplementation in schizophrenia treatment.","authors":"Caio Lucca Oliveira Leite, Emilly Sampaio de Lima, Fabio Gomes de Matos E Souza, Luísa Weber Bisol","doi":"10.1007/s00406-025-02110-z","DOIUrl":"https://doi.org/10.1007/s00406-025-02110-z","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autism spectrum traits in adults with attention-deficit/hyperactivity disorder (ADHD): a hidden multifaceted phenotype marked by affective comorbidity, emotional dysregulation, and chronobiological disturbances.","authors":"Giulio Emilio Brancati, Ugo De Rosa, Anna Magnesa, Irene Cocciaro, Elena Costagli, Anna Iriti, Berenice Rimoldi, Matteo Vedovelli, Pierpaolo Medda, Elisa Schiavi, Giulio Perugi","doi":"10.1007/s00406-025-02114-9","DOIUrl":"https://doi.org/10.1007/s00406-025-02114-9","url":null,"abstract":"<p><strong>Background: </strong>Autism spectrum disorder (ASD) is a commonly observed comorbidity in children with attention-deficit/hyperactivity disorder (ADHD). Nevertheless, the impact of autism spectrum traits on clinical presentation and comorbidities in adults with ADHD remains largely underexplored.</p><p><strong>Methods: </strong>105 adults with ADHD were recruited at the outpatient service of the Psychiatry Unit 2 at Pisa University Hospital and subdivided according to screening for ASD based on the Autism-Spectrum Quotient (AQ). Comparative analyses were performed for sociodemographic and clinical variables.</p><p><strong>Results: </strong>Participants with a positive screening for ASD (N = 23, 21.9%) were more frequently females, had a higher age at first clinical referral, higher comorbidity rates with mood and anxiety disorders, particularly social anxiety, and a lower rate of cannabis use disorder. They showed significantly greater severity of ADHD and emotional dysregulation, worse personality and interpersonal functioning, more depressive, cyclothymic and anxious temperamental dispositions, more pathological personality traits, increased biological rhythm disturbances and evening chronotype.</p><p><strong>Conclusions: </strong>Autism spectrum traits are commonly reported in adults with ADHD and may be associated with female sex and a complex clinical presentation characterized by affective comorbidity, more severe emotional dysregulation and chronobiological disturbances.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive and negative falls short: why any attempt to rename schizophrenia must include careful consideration of the sensori-/psychomotor domain.","authors":"Dusan Hirjak, Sebastian Walther, Vijay A Mittal","doi":"10.1007/s00406-025-02108-7","DOIUrl":"https://doi.org/10.1007/s00406-025-02108-7","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between neuroticism, genetic susceptibility, and peripheral artery disease risk: a prospective study in UK Biobank.","authors":"Guoying Wang, Qi Rao, Fang Lei, Yu Tian, Li Mao, Jinxing He, Lijin Lin, Chuhua Huang","doi":"10.1007/s00406-025-02111-y","DOIUrl":"https://doi.org/10.1007/s00406-025-02111-y","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations of insomnia symptoms and clinical features as well as blood metabolic parameters in adolescents with major depressive disorders.","authors":"Xi Zhang, Lewei Liu, Yun Zhang, Lili Zhao, Jiawei Wang, Changhao Chen, Zhiwei Liu, Feng Geng, Daming Mo, Xiangfen Luo, Xiangwang Wen, Ling Zhang, Huanzhong Liu","doi":"10.1007/s00406-025-02113-w","DOIUrl":"https://doi.org/10.1007/s00406-025-02113-w","url":null,"abstract":"<p><strong>Background: </strong>Adolescents with major depressive disorder (MDD) frequently experience insomnia (difficulty initiating, maintaining sleep or early awakening). This prevalent symptom may associate with depression, negative life events, childhood maltreatment (CM), and blood metabolic parameters. We investigated associations between insomnia, clinical features, and blood metabolic parameters in adolescents with MDD .</p><p><strong>Methods: </strong>From January 2021 to December 2022, 361 adolescents with MDD aged 12-18 were included in this cross-sectional study. We used the Center for Epidemiological Studies Depression Scale (CES-D), the Insomnia Severity Index Scale (ISI), the Adolescent Self-rating Life Events Checklist (ASLEC), and the Childhood Trauma Questionnaire (CTQ) to assess depression, insomnia, negative Life events, and CM. Additionally, we measured blood metabolic parameters Levels in 150 subjects. Finally, logistic regression analyses and receiver operating characteristic (ROC) curve analyses were conducted.</p><p><strong>Results: </strong>Among adolescents with MDD, the prevalence of insomnia was 37.4%. Compared with the non-insomnia, patients in the insomnia had a greater propensity to live in families with abnormal parental marital status, to have attempted suicide, and to exhibite higher scores on a series of scales. Further logistic regression analyses revealed that abnormal parental marital status (OR = 2.012, 95% CI = 1.127-3.592), CES-D score (OR = 1.093, 95% CI = 1.063-1.124), healthy adaptation (OR = 1.130, 95% CI = 1.402-1.226), and emotional neglect (OR = 0.941, 95% CI = 0.889-0.996) were independently associated with insomnia. When metabolic parameters were included, thyroid-stimulating hormone (TSH) (OR = 1.730, 95% CI = 1.170-2.558) and 25-hydroxyvitamin D [25(OH)D] (OR = 0.851, 95% CI = 0.758-0.954) were also identified as independent factors influencing insomnia. Additionally, ROC curve analyses showed that the model based solely on clinical features had good predictive performance for insomnia (AUC = 0.777, 95% CI = 0.730-0.825, P < 0.001). When metabolic parameters were included, the predictive performance of the model was further improved (AUC = 0.777, 95% CI = 0.730-0.825, P < 0.001).</p><p><strong>Conclusion: </strong>Among adolescents with MDD, insomnia are widespread and may correlate with depression, negative Life events, CM, TSH, and 25(OH)D. Therefore, it is necessary to consider these factors comprehensively in clinical interventions.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential role of ANXA11/ANXA3 protein level ratio in predicting antidepressant treatment outcomes.","authors":"Xiangjun Zhou, Yucai Qu, Lingyi Shi, Zhiqiang Du, Qin Zhou, Zhenhe Zhou, Ying Jiang, Haohao Zhu","doi":"10.1007/s00406-025-02117-6","DOIUrl":"https://doi.org/10.1007/s00406-025-02117-6","url":null,"abstract":"<p><strong>Objective: </strong>To explore the causal relationship between 2,821 plasma protein level ratios and antidepressant treatment response to uncover the potential molecular mechanisms.</p><p><strong>Methods: </strong>We utilized the protein level ratio dataset from the UK Biobank Pharma Proteomics Project (UKB PPP) and the antidepressant treatment dataset from the Psychiatric Genomics Consortium. We employed Mendelian Randomization (MR) analysis to explore the causal relationships between 2,821 protein level ratios and antidepressant treatment. Additionally, we conducted GO/KEGG analysis to uncover associated biological processes, cellular components, molecular functions, and signaling pathways.</p><p><strong>Results: </strong>We found that the protein level ratio of ANXA11/ANXA3 was significantly positively associated with the positive effects of antidepressant treatment(IVW method(FEM): OR = 1.537, 95%CI = 1.263-1.869, p = 1.730E-05, pFDR = 0.049), suggesting its potential as a biomarker for predicting antidepressant efficacy. Moreover, the GO/KEGG analysis provided new insights into the genetic architecture and molecular mechanisms underlying antidepressant efficacy.</p><p><strong>Conclusion: </strong>Our results highlight the significance of protein level ratios in the pathophysiological processes of depression and offer novel strategies for the development of personalized treatment approaches. Future studies are warranted to further validate these findings and explore their clinical implications.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating substance-induced psychosis (SIP) into the positive and negative symptoms disorder (PND) spectrum.","authors":"Albert Batalla, Jørgen G Bramness","doi":"10.1007/s00406-025-02104-x","DOIUrl":"https://doi.org/10.1007/s00406-025-02104-x","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent olfactory dysfunction as an indicator of cognitive impairment in long COVID-19 syndrome: implications for monitoring and rehabilitation.","authors":"Alna Carolina Mendes Paranhos, Apio Ricardo Nazareth Dias, Erick Antonio Rodrigues Mendes, Emily Vitória Almeida Paixão, Samuel Franco Viana Santos Silva, Lidiane Palheta Miranda Dos Santos, Gisele Vieira Hennemann Koury, Mariângela Moreno Domingues, Juarez Antônio Simões Quaresma, Givago da Silva Souza, Luiz Fábio Magno Falcão","doi":"10.1007/s00406-025-02116-7","DOIUrl":"https://doi.org/10.1007/s00406-025-02116-7","url":null,"abstract":"<p><strong>Background: </strong>Persistent olfactory dysfunction (OD) and cognitive impairment are among the most frequently reported sequelae of long term infection with SARS-CoV-2 (long COVID-19). However, the association between these conditions remains unclear. This study investigated the correlation between OD and cognitive impairment in patients recovering from COVID-19 to identify the implications for therapeutic and rehabilitation strategies.</p><p><strong>Materials and methods: </strong>A cross-sectional study of adult patients diagnosed with long COVID was conducted at a healthcare centre in Brazil. Olfactory function was assessed using the Connecticut Chemosensory Clinical Research Centre (CCCRC) test, and cognitive performance was evaluated using the Montreal Cognitive Assessment (MoCA). Statistical analyses included odds ratios (OR) and linear regression to explore the association between OD severity and cognitive scores, adjusting for potential confounders such as age, sex, and comorbidities.</p><p><strong>Results: </strong>A total of 241 patients (age: 48.60 ± 12.68 years; 73% female) were included. Cognitive impairment (MoCA < 23) was present in 64% of the participants. OD was identified in 92% of the patients and ranged from mild to anosmia. Linear regression analysis showed a weak yet statistically significant correlation between the CCCRC and MoCA scores (R = 0.14, p = 0.02). An OR of 2.87 (95% CI: 1.57-5.25, p = 0.00) indicated higher odds of cognitive impairment in patients with severe OD.</p><p><strong>Discussion: </strong>This study supports the hypothesis that there is a weak yet significant association between OD and cognitive impairment in patients with long COVID. These findings underscore the importance of early screening for olfactory dysfunction as a potential marker of cognitive monitoring and the need for intervention in this population.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary: towards a name change of schizophrenia: positive and negative symptoms disorder (PND).","authors":"Alexandre Andrade Loch","doi":"10.1007/s00406-025-02109-6","DOIUrl":"https://doi.org/10.1007/s00406-025-02109-6","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards a name change of schizophrenia: is it really necessary?","authors":"Lorenzo Pelizza, Simona Pupo","doi":"10.1007/s00406-025-02105-w","DOIUrl":"https://doi.org/10.1007/s00406-025-02105-w","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}