European Archives of Psychiatry and Clinical Neuroscience最新文献

{"title":"Secondary analysis of GenRED data (Genetics of Recurrent Early-Onset major Depression) using MERLIN.","authors":"Mutaz Amin, Claudia Gragnoli","doi":"10.1007/s00406-025-02014-y","DOIUrl":"https://doi.org/10.1007/s00406-025-02014-y","url":null,"abstract":"<p><p>The familial relevance of depression is a critical aspect, with evidence suggesting a substantial hereditary component. Investigating the inheritance patterns within families can provide valuable insights into the genetic underpinnings of depression. To gain a new perspective on the genetics underpinning of depression, we conducted a novel analysis of the Genetics of Recurrent Early-onset Depression (GenRED) dataset including 683 U.S. Caucasian families, each with one proband with recurrent early-onset major depression and at least one sibling with depression. Using the MERLIN tool, we identified 37 genomic markers with nominal significance linkage to early-onset recurrent depression. The findings differ from prior analyses of GenRED using a different analytical tool. Our findings highlight the variability and potential discrepancies that can arise from using different analytical tools on the same dataset. Given the chance of microsatellites undergoing duplication, mutations, and amplification errors, our two-point analysis can be more robust compared to the previous multipoint analysis. Also, one limitation is genetic admixture; studies with more homogenous ethnic groups are warranted.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between suicidal ideation and childhood maltreatment as well as inflammatory cytokines in adolescents with major depressive disorder.","authors":"Lewei Liu, Xin Zhao, Xi Zhang, Mingru Hao, Haojie Fan, Yinghan Tian, Cheng Yang, Jiawei Wang, Feng Geng, Daming Mo, Ling Zhang, Huanzhong Liu","doi":"10.1007/s00406-025-02002-2","DOIUrl":"https://doi.org/10.1007/s00406-025-02002-2","url":null,"abstract":"<p><strong>Background: </strong>Suicidal ideation (SI) is thought to be associated with childhood maltreatment (CM) and inflammatory processes. Yet, these links are not thoroughly studied in adolescents with major depressive disorder (MDD). So, this study focused on investigating the predictive value of CM and inflammatory cytokines for SI in this population.</p><p><strong>Methods: </strong>This study included 156 depressed adolescents. The Center for Epidemiological Studies Depression Scale (CES-D), the Childhood Trauma Questionnaire (CTQ) and the Positive and Negative Suicidal Ideation Scale (PANSI) were used to assess depression, CM and SI, respectively. Additionally, plasma inflammatory cytokines levels were measured, including interleukin (IL)-1β, IL-6, IL-10, IL-17A and tumor necrosis factor-α (TNF-α).</p><p><strong>Results: </strong>Univariate analyses showed that females had higher levels of SI in adolescents with MDD. Moreover, the level of SI was negatively correlated with age and age at onset, and positively correlated with duration of illness, CES-D score, CTQ score, as well as levels of IL-1β, IL-6 and TNF-α (all p < 0.05). Furthermore, regression analyses revealed that SI was independently associated with age at onset, CES-D score, CTQ score, and Log IL-1β (all p < 0.05). Finally, receiver operating characteristic (ROC) curve analyses revealed that the combination of the CES-D score, CTQ score, and IL-1β (AUC = 0.910, 95% CI = 0.864-0.956, p < 0.001) had a better ability to identify SI in adolescents with MDD, exhibiting higher sensitivity and specificity.</p><p><strong>Conclusion: </strong>SI is associated with depressive symptoms, CM and elevated levels of inflammatory cytokines (especially IL-1β) in adolescents with MDD. In the future, interventions such as cognitive behavioural therapy and the administration of anti-inflammatory drugs, targeting the modulation of CM and inflammatory cytokine levels, may play important roles in preventing suicidal behaviors in depressed adolescents.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiological evidence for emotion regulation abnormalities in individuals at clinical high-risk for psychosis.","authors":"Gregory P Strauss, Lisa A Bartolomeo, Gifty Ayawvi","doi":"10.1007/s00406-025-02006-y","DOIUrl":"https://doi.org/10.1007/s00406-025-02006-y","url":null,"abstract":"<p><p>Past studies indicate that individuals at clinical high-risk for psychosis (CHR) display emotion regulation abnormalities that predict increased symptom severity and poor functional outcome. However, it is unclear which neurophysiological processes contribute to impairments in implementing various strategies to down-regulate negative emotion. The current study used electroencephalography (EEG) to determine whether individuals at CHR have difficulty implementing reappraisal and distraction. Participants included individuals at CHR (n = 25) and healthy controls (CN: n = 36) who completed an EEG task while unpleasant or neutral stimuli were presented and they were required to either passively view or down-regulate negative emotion using reappraisal or distraction. The late positive potential (LPP) event related potential component was calculated from the EEG data and used as an objective neurophysiological indicator of emotion regulation effectiveness. CN effectively decreased the amplitude of the LPP for both reappraisal and distraction compared with unpleasant passive viewing; however, CHR did not differ in LPP amplitude for unpleasant passive viewing, reappraisal, and distraction, suggesting an implementation abnormality. Difficulty implementing distraction was associated with greater severity of attenuated positive symptoms. Collectively, these findings suggest that CHR display neurophysiological patterns of emotion regulation impairment that are similar to those that have been identified among individuals with schizophrenia in past studies. Interventions have been developed to target these mechanisms. It may be beneficial to apply these interventions to psychosis-spectrum populations where they would have relevance for both treatment of established symptoms and prevention of illness among those at CHR.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between telomere length and psychiatric disorders: a bidirectional Mendelian randomization study.","authors":"Han Zhang, Jing Zhou, Yuan Cao, Xiaoan Zhang, Hui Chang, Yan Zhao, Yacong Bo, Huanhuan Zhang, Zengli Yu, Xin Zhao","doi":"10.1007/s00406-025-02008-w","DOIUrl":"https://doi.org/10.1007/s00406-025-02008-w","url":null,"abstract":"<p><p>Observational studies have suggested that shorter telomere length (TL) may be a risk factor for psychiatric disorders. However, whether this association underlie causal effects remains unknown. This study aims to investigate the potential association between TL and psychiatric disorders by conducting a bidirectional Mendelian randomization (MR) study. Summary statistics for TL were obtained from the UK Biobank (n = 472,174), while summary statistics for ten psychiatric disorders were acquired from the Psychiatric Genomics Consortium (PGC). The inverse-variance weighted (IVW) method was used as primary analysis, with the MR-Egger, weighted median, MR-PRESSO, simple mode, and weighted mode approaches were utilized as sensitivity analyses. Our findings indicated a potential association between genetic predisposition to attention deficit hyperactivity disorder (ADHD) and shortened TL (Beta = - 0.039, SE = 0.011, P = 4.00E-04). Additionally, posttraumatic stress disorder (PTSD) may be was potentially associated with TL (Beta = - 0.014, SE = 0.006, P = 0.019). Our findings suggest a potential correlation between ADHD and TL, yet no significant association exists between TL and other psychiatric disorders. Nevertheless, considering the small effect size and the fact that it might have limited practical clinical significance, TL may not function as a biomarker for psychiatric disorders.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mild motor signs and depression: more than just medication side effects?","authors":"Antonina Luca, Maria Luca, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Raffaella Zanardi, Raffaella Ferri, Bartolo Lanuzza, Basilio Pecorino, Bernhard T Baune, Giuseppe Fanelli, Chiara Fabbri, Alessandro Serretti","doi":"10.1007/s00406-025-02015-x","DOIUrl":"https://doi.org/10.1007/s00406-025-02015-x","url":null,"abstract":"<p><p>The relationship between major depressive disorder (MDD) and mild motor signs (MMS) remains to be elucidated. The present study aims to assess the association between neurological symptoms and medications and treatment response. Neurological signs in 790 patients with MDD were correlated with treatment outcome. Three hundred ten (39.2%) were responders and 480 (60.8%) were non-responders. 342 (43.3%) presented neurological signs. In the whole sample negative associations between dystonia and rigidity and various medications was observed. Non-response was associated with dystonia, rigidity, and hypokinesia independent from age and medications. This study highlighted an association between MMS and specific medications. Moreover, MMS were associated with non-response to treatment, regardless of medication use. This may suggest that a subgroup of patients with MDD may respond less to therapy because of an underlying still undetected neurological disorder.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison between rTMS and antidepressant medication on depressive symptom clusters in treatment-resistant depression.","authors":"Iris Dalhuisen, Tom Biemans, Cornelis F Vos, Sophie Ter Hark, Iris van Oostrom, Jan Spijker, Ben Wijnen, Eric van Exel, Hans van Mierlo, Dieuwertje de Waardt, Martijn Arns, Indira Tendolkar, Joost Janzing, Philip van Eijndhoven","doi":"10.1007/s00406-025-02012-0","DOIUrl":"https://doi.org/10.1007/s00406-025-02012-0","url":null,"abstract":"<p><strong>Background: </strong>Antidepressive treatment outcomes can be assessed using sum scores from measurement scales, but symptom clusters may better capture the multidimensional structure of depression. Little is known about the comparative effectiveness of different treatment modalities on these clusters. We sought to evaluate the effects of rTMS and antidepressant medication on four symptom clusters and the extent to which these differ between treatments. In addition, we assessed whether baseline cluster scores predicted (non)response.</p><p><strong>Methods: </strong>Data were obtained from two clinical trials (DETECT: rTMS vs. medication; PITA: tricyclic antidepressants). Primary outcomes were symptom cluster scores: 'General Depression', 'Anxiety', 'Somatic Symptoms' and 'Insomnia'. In the primary analysis based on DETECT, a MANCOVA comparing rTMS with medication was performed. For validation, a MANCOVA was performed replacing medication data from DETECT with data from PITA. Baseline symptom cluster scores were compared between responders and non-responders, as well as treatment groups.</p><p><strong>Results: </strong>In both the primary and validation analyses, no difference was seen between rTMS and medication on the symptom clusters. Similar patterns of response were observed in all groups, with 'Insomnia' showing the greatest effect of treatment. Baseline cluster scores did not predict treatment response.</p><p><strong>Conclusions: </strong>We did not find a differential effect of rTMS or antidepressant medication on depressive symptom clusters. Both treatments demonstrated comparable response patterns for all clusters, and baseline cluster scores did not differ between responders and non-responders. Future studies with larger samples or more homogeneous treatments may elucidate the role of symptom clusters as a tool for more individualized treatment.</p><p><strong>Trial registration: </strong>PITA NCT03548675 DETECT The Netherlands Trial Register NL7628.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the complex relationships between anxiety, depression, and quality of life in schizophrenia: a network analysis study.","authors":"Peiyi Wu, Yucheng Wang, Yang Zhou, Yixiao Xu, Huanrui Zhang, Zijia Li, Yanqing Tang","doi":"10.1007/s00406-025-02011-1","DOIUrl":"https://doi.org/10.1007/s00406-025-02011-1","url":null,"abstract":"<p><p>This study utilized network analysis to explore the intricate relationships between anxiety, depression, and quality of life in a cohort of hospitalized schizophrenia patients. Through a cross-sectional design, the investigation aimed to identify key symptoms and bridge connections to inform tailored clinical interventions and improve patient well-being. Symptom severity was measured using the Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, and Schizophrenia Quality of Life Scale, with network analysis elucidating central nodes and bridging symptoms within the patient sample of 1328 individuals. Findings revealed psychic anxiety, insomnia, and depressed mood as pivotal within the network, significantly impacting overall symptomatology and quality of life. Furthermore, symptoms such as tension and fears were identified as essential connectors among different symptom domains, highlighting potential intervention targets. The study underscores the complex dynamics between anxiety, depression, and quality of life in schizophrenia, advocating for an integrated treatment approach that focuses on critical symptoms to enhance overall well-being. This approach suggests a paradigm shift towards personalized care in schizophrenia management, aiming to optimize outcomes by addressing the root of symptom networks.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between anhedonia and prefrontal cortex activation in patients with major depression: a functional near-infrared spectroscopy study.","authors":"Li-Fen Chen, Ching-En Lin, Chi-Hsiang Chung, Yong-An Chung, Sonya Youngju Park, Wei-Chou Chang, Chuan-Chia Chang, Hsin-An Chang","doi":"10.1007/s00406-025-02010-2","DOIUrl":"https://doi.org/10.1007/s00406-025-02010-2","url":null,"abstract":"<p><p>This study investigated cerebral blood flow characteristics using functional nearinfrared spectroscopy (fNIRS) in agomelatine-treated depressed patients with anhedonia. The level of anhedonia was assessed by the Snaith Hamilton Rating Scale (SHAPS) and Montgomery Åsberg Depression Rating Scale 5-item (MADRS 5-item) score. All 84 patients were evaluated on the day of the study initiation and followed at week 1, 4 and 8 after the study initiation. Graph theory-based network analysis showed 2-back task-modulated global efficiency (adjusted B = 0.055, 95% CI = 0.043 - 0.066) and local efficiency (adjusted B = 0.066, 95% CI = 0.050 - 0.081) were significantly increased 1 week after treatment compared with the baseline. Furthermore, the increased oxy-hemoglobin (oxy-Hb) values from the baseline to the one week after treatment was positively related to the total MADRAS 5-item score reductions in the left-hemispheric orbitofrontal cortex (r = - 0.307, p = 0.005). Our findings suggest that abnormal functional connectivity over OFC may reflect the pathophysiological characteristics of anhedonia and serve as a clinical biomarker for anhedonia.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do withdrawal symptoms predict depression relapse after antidepressant cessation?","authors":"Constantin Volkmann, Subati Abulikemu, Isabel M Berwian, Quentin J M Huys, Henrik Walter","doi":"10.1007/s00406-025-02005-z","DOIUrl":"https://doi.org/10.1007/s00406-025-02005-z","url":null,"abstract":"<p><p>Discontinuing antidepressants after remission poses risks of withdrawal symptoms and relapse. This study addressed four questions: Can withdrawal symptoms be differentiated from relapse? What are their risk factors? Are withdrawal symptoms associated with relapse? Can discontinuation be optimized? 103 patients with a remitted major depressive disorder were randomized to continue or discontinue antidepressants. Withdrawal symptoms were assessed using the Discontinuation Emergent Signs and Symptoms scale (DESS). Withdrawal syndrome was defined as experiencing at least four new or worsened DESS symptoms. Associations between clinical factors and symptom count were examined using linear regressions. After the randomization phase, all patients discontinued treatment and were monitored for six months. The relationship between withdrawal symptoms, clinical factors, and relapse risk was analyzed via logistic regression and a Cox proportional hazards model. Ten symptoms were reported exclusively in the discontinuation group and may aid in distinguishing withdrawal syndrome from relapse. Withdrawal syndrome occurred in 29% (95% PI [8.3%, 72%]) of patients. Women reported more withdrawal symptoms than men (factor 1.67 (95% PI [1.06, 2.56])). None of the other predictors were associated with symptom count. Of 83 patients with outcome data, 54 (65%) remained well and 29 (35%) relapsed. Withdrawal symptoms (0.58, 95% PI [0.07, 1.16]) and early depressive symptoms (0.63, 95% PI [0.16, 1.17]) were associated with a higher relapse risk. Tapering duration was not associated with either withdrawal symptoms or relapse rate. Withdrawal symptoms were common and more frequent in women. Experiencing withdrawal symptoms may increase relapse risk.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis: multigenerational and food chain impacts.","authors":"Albert Stuart Reece, Gary Kenneth Hulse","doi":"10.1007/s00406-025-02003-1","DOIUrl":"https://doi.org/10.1007/s00406-025-02003-1","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}