European Archives of Psychiatry and Clinical Neuroscience最新文献

{"title":"Gut microbiota: contributing to high CVD prevalence in people living with schizophrenia?","authors":"Chuanwen Fu, Xuehui Zhang, Ying Qian, Ximei Wang, Xinqiang Chen, Jia Zeng, Nichang Zhang, Liming Wang, Mingsong Li, Zhengxu Li, Teng Zhang, Yuemei Feng, Jianzhong Yin","doi":"10.1007/s00406-025-02103-y","DOIUrl":"https://doi.org/10.1007/s00406-025-02103-y","url":null,"abstract":"<p><p>People living with schizophrenia (PLWS) have a reduced life expectancy with cardiovascular disease (CVD) as a major contributor. This article reviews the existing populations and animal studies and summarizes that reduced abundance of Lachnospiraceae, Bacteroides, Faecalibacterium, Ruminococcus, Roseburia, Bifidobacterium, Lactobacillus, Akkermansia, Rikenellaceae and increased abundance of Prevotella, Clostridium, Escherichia in PLWS is one of the probable reasons for the increased risk of CVD prevalence in PLWS by affecting the metabolism of substances related to the development of Schizophrenia (SCZ) and CVD.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145052063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating substance-induced psychosis (SIP) into the positive and negative symptoms disorder (PND) spectrum.","authors":"Albert Batalla, Jørgen G Bramness","doi":"10.1007/s00406-025-02104-x","DOIUrl":"https://doi.org/10.1007/s00406-025-02104-x","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent olfactory dysfunction as an indicator of cognitive impairment in long COVID-19 syndrome: implications for monitoring and rehabilitation.","authors":"Alna Carolina Mendes Paranhos, Apio Ricardo Nazareth Dias, Erick Antonio Rodrigues Mendes, Emily Vitória Almeida Paixão, Samuel Franco Viana Santos Silva, Lidiane Palheta Miranda Dos Santos, Gisele Vieira Hennemann Koury, Mariângela Moreno Domingues, Juarez Antônio Simões Quaresma, Givago da Silva Souza, Luiz Fábio Magno Falcão","doi":"10.1007/s00406-025-02116-7","DOIUrl":"https://doi.org/10.1007/s00406-025-02116-7","url":null,"abstract":"<p><strong>Background: </strong>Persistent olfactory dysfunction (OD) and cognitive impairment are among the most frequently reported sequelae of long term infection with SARS-CoV-2 (long COVID-19). However, the association between these conditions remains unclear. This study investigated the correlation between OD and cognitive impairment in patients recovering from COVID-19 to identify the implications for therapeutic and rehabilitation strategies.</p><p><strong>Materials and methods: </strong>A cross-sectional study of adult patients diagnosed with long COVID was conducted at a healthcare centre in Brazil. Olfactory function was assessed using the Connecticut Chemosensory Clinical Research Centre (CCCRC) test, and cognitive performance was evaluated using the Montreal Cognitive Assessment (MoCA). Statistical analyses included odds ratios (OR) and linear regression to explore the association between OD severity and cognitive scores, adjusting for potential confounders such as age, sex, and comorbidities.</p><p><strong>Results: </strong>A total of 241 patients (age: 48.60 ± 12.68 years; 73% female) were included. Cognitive impairment (MoCA < 23) was present in 64% of the participants. OD was identified in 92% of the patients and ranged from mild to anosmia. Linear regression analysis showed a weak yet statistically significant correlation between the CCCRC and MoCA scores (R = 0.14, p = 0.02). An OR of 2.87 (95% CI: 1.57-5.25, p = 0.00) indicated higher odds of cognitive impairment in patients with severe OD.</p><p><strong>Discussion: </strong>This study supports the hypothesis that there is a weak yet significant association between OD and cognitive impairment in patients with long COVID. These findings underscore the importance of early screening for olfactory dysfunction as a potential marker of cognitive monitoring and the need for intervention in this population.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Group-activity cognitive remediation therapy on cognitive impairment in patients with chronic schizophrenia: a randomized controlled follow-up study.","authors":"Xiaomei Xu, Yuhong Wang, Xinfu Wang, Lida Shi, Huijing Yu, Zhanmin Li, Lijun Liu","doi":"10.1007/s00406-025-02076-y","DOIUrl":"https://doi.org/10.1007/s00406-025-02076-y","url":null,"abstract":"<p><strong>Background: </strong>Schizophrenia (SZ) is a severe chronic mental disorder characterized by pervasive impairments in cognition, emotion, perception, and behavior. We developed a novel group activity intervention aimed at improving cognitive function. The objective of this study was to investigate the effects of group activity therapy on cognitive functioning in patients with chronic schizophrenia.</p><p><strong>Methods: </strong>In this 8-week, randomized, single-blind, controlled study, 100 schizophrenia patients with residual negative symptoms were randomly assigned to either the group activity or control group. Both groups continued their original antipsychotic treatments; however, the intervention group participated in an additional group activity program while the control group received standard rehabilitation programs. Assessment of psychotic symptoms and cognitive performance was conducted at baseline, week 4, and week 8 using the Positive and Negative Syndrome Scale (PANSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).</p><p><strong>Results: </strong>There were no significant changes in PANSS scores between the control and intervention groups at baseline, 4 weeks, and 8 weeks (p > 0.05). After 8 weeks of treatment, the intervention group exhibited significant improvements in Immediate Memory (IM), Visuospatial/Constructional (VC), Language, Attention, Delayed Memory (DM), and total RBANS scores compared to baseline (p < 0.05). These cognitive gains were significantly greater than those observed in the control group (p < 0.05).</p><p><strong>Conclusions: </strong>Our findings indicate that group activity therapy can effectively improve cognitive impairment in schizophrenia patients with residual negative symptoms. Additionally, both age and duration of illness were found to negatively impact cognitive function recovery.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary: towards a name change of schizophrenia: positive and negative symptoms disorder (PND).","authors":"Alexandre Andrade Loch","doi":"10.1007/s00406-025-02109-6","DOIUrl":"https://doi.org/10.1007/s00406-025-02109-6","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional and national burdens of mental disorders, substance use disorders and self-harm among adolescents and young adults, 1990-2021: a systematic analysis for the Global Burden of Diseases Study 2021.","authors":"Siwei Sun, Qiqi Chen, Guoping Li, Hui Yang, Wenqing Cai, Yunning Hu, Yuxi Zhang, Xin Yang, Yan Liu, Le Zhang, Kai Yuan, Yang Deng","doi":"10.1007/s00406-025-02115-8","DOIUrl":"https://doi.org/10.1007/s00406-025-02115-8","url":null,"abstract":"<p><p>Concerns over the mental health among young people have been increasing recently. We aimed to estimate the burdens of mental disorders, substance use disorders (SUDs), and self-harm at global, regional and national levels among adolescents and young adults aged 10-24 years from 1990 to 2021. Incidence, prevalence, and disability-adjusted life years (DALYs) of mental disorders, SUDs, and self-harm among young people were examined by age, sex, region, and country/territory. Average annual percentage changes (AAPCs) were utilized to assess the temporal trends of age-standardized rates during 1990-2021. Spearman rank-correlation analysis was used to analyze the correlation between age-standardized rates for incidence, prevalence, and DALYs and Socio-demographic Index (SDI). In 2021, there were 36.32 million DALYs due to mental disorders, 4.37 million DALYs due to SUDs, and 8.00 million DALYs due to self-harm among adolescents and young adults aged 10-24 years globally. Age-standardized DALY rate of mental disorders exhibited a slightly increasing trend, whereas DALY rates of SUDs and self-harm decreased from 1990 to 2021. Age-standardized incidence, prevalence, and DALY rates for depressive and anxiety disorders in 2020 and 2021 were approximately 20% higher than those observed in the pre-pandemic period. The burdens of mental disorders, SUDs, and self-harm were higher in high SDI countries such as New Zealand, Australia, Greenland, United States of America, and Canada. Global burdens due to mental disorders, mainly included anxiety and depressive disorders among adolescents and young adults markedly increased from 1990 to 2021, with a significant increase coinciding with the COVID-19 pandemic.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor regarding: \"Towards a name change of schizophrenia: positive and negative symptoms disorder (PND)\".","authors":"Carlos De Las Cuevas","doi":"10.1007/s00406-025-02107-8","DOIUrl":"https://doi.org/10.1007/s00406-025-02107-8","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards a name change of schizophrenia: is it really necessary?","authors":"Lorenzo Pelizza, Simona Pupo","doi":"10.1007/s00406-025-02105-w","DOIUrl":"https://doi.org/10.1007/s00406-025-02105-w","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperhomocysteinemia in chronic schizophrenia: prevalence, clinical correlates, and paradoxical associations with symptom severity.","authors":"Jianyan Du, Rui Jiang, Yuanyuan Liu, Jianan Zhou, Guoshuai Luo, Xiangyang Zhang","doi":"10.1007/s00406-025-02106-9","DOIUrl":"https://doi.org/10.1007/s00406-025-02106-9","url":null,"abstract":"<p><strong>Background: </strong>Elevated homocysteine levels, known as hyperhomocysteinemia (HHcy), have been implicated in the pathophysiology of schizophrenia. Most prior studies focused on first-episode or acute-phase schizophrenia patients, leaving the prevalence, determinants, and clinical correlates of HHcy in chronic schizophrenia understudied. This study aims to investigate the prevalence and determinants of HHcy in patients with chronic schizophrenia, as well as its clinical correlates. ​​METHODS: A cross-sectional study was conducted involving 509 patients diagnosed with chronic schizophrenia, recruited from multiple psychiatric hospitals in China. Demographic, clinical, and lifestyle data were collected through structured interviews and medical record reviews. Blood samples were analyzed for homocysteine levels and other biochemical parameters. The Positive and Negative Syndrome Scale (PANSS), Hamilton Depression Rating Scale (HAMD), Insomnia Severity Index (ISI), and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were used to assess clinical symptoms and cognitive function. Binary logistic regression analysis was performed to identify independent predictors of HHcy. RESULTS​​: ​​The prevalence of HHcy in the study population was 56.2%. Patients with HHcy were significantly older (mean age: 52.1 ± 12.2 years) and had a higher proportion of males (67.1%) compared to those without HHcy. The HHcy group exhibited milder positive and general psychopathology symptoms, as indicated by lower PANSS scores, revealing unexpected inverse associations with symptom severity. Elevated levels of C-reactive protein (CRP), total bilirubin (TBIL), and creatine phosphokinase (CPK) were observed in the HHcy group. Binary logistic regression analysis identified female gender and older age as independent predictors of HHcy.</p><p><strong>Conclusions: </strong>​​This study highlights a high prevalence of HHcy in patients with chronic schizophrenia, associated with older age and male gender. Contrary to expectations, HHcy was linked to milder symptom severity, suggesting a potential paradoxical relationship.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical deep phenotyping of treatment response in schizophrenia (CDP-STAR): design and methodology of a prospective multimodal observational study.","authors":"Vladislav Yakimov, Lara Neuwinger, Madeleine M Weber, Maximilian Brantl, Isabel Maurus, Jana Sautner, Miriam John, Berkhan Karslı, Genc Hasanaj, Anne Bungard, Alkomiet Hasan, Elias Wagner, Laura Fischer, Paula Steiner, Benedikt Schworm, Siegfried Priglinger, Sergi Papiol, Peter Falkai, Andrea Schmitt, Florian J Raabe, Daniel Keeser, Lukas Roell, Joanna Moussiopoulou, Emanuel Boudriot","doi":"10.1007/s00406-025-02100-1","DOIUrl":"https://doi.org/10.1007/s00406-025-02100-1","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}