Group-activity cognitive remediation therapy on cognitive impairment in patients with chronic schizophrenia: a randomized controlled follow-up study.

IF 3.7 3区 医学 Q1 CLINICAL NEUROLOGY
Xiaomei Xu, Yuhong Wang, Xinfu Wang, Lida Shi, Huijing Yu, Zhanmin Li, Lijun Liu
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引用次数: 0

Abstract

Background: Schizophrenia (SZ) is a severe chronic mental disorder characterized by pervasive impairments in cognition, emotion, perception, and behavior. We developed a novel group activity intervention aimed at improving cognitive function. The objective of this study was to investigate the effects of group activity therapy on cognitive functioning in patients with chronic schizophrenia.

Methods: In this 8-week, randomized, single-blind, controlled study, 100 schizophrenia patients with residual negative symptoms were randomly assigned to either the group activity or control group. Both groups continued their original antipsychotic treatments; however, the intervention group participated in an additional group activity program while the control group received standard rehabilitation programs. Assessment of psychotic symptoms and cognitive performance was conducted at baseline, week 4, and week 8 using the Positive and Negative Syndrome Scale (PANSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).

Results: There were no significant changes in PANSS scores between the control and intervention groups at baseline, 4 weeks, and 8 weeks (p > 0.05). After 8 weeks of treatment, the intervention group exhibited significant improvements in Immediate Memory (IM), Visuospatial/Constructional (VC), Language, Attention, Delayed Memory (DM), and total RBANS scores compared to baseline (p < 0.05). These cognitive gains were significantly greater than those observed in the control group (p < 0.05).

Conclusions: Our findings indicate that group activity therapy can effectively improve cognitive impairment in schizophrenia patients with residual negative symptoms. Additionally, both age and duration of illness were found to negatively impact cognitive function recovery.

群体活动认知修复疗法对慢性精神分裂症患者认知功能障碍的治疗:一项随机对照随访研究。
背景:精神分裂症(Schizophrenia, SZ)是一种严重的慢性精神障碍,以认知、情绪、知觉和行为方面的普遍障碍为特征。我们开发了一种新的团体活动干预,旨在改善认知功能。本研究的目的是探讨团体活动治疗对慢性精神分裂症患者认知功能的影响。方法:在这项为期8周的随机、单盲、对照研究中,将100例残余阴性症状的精神分裂症患者随机分为组活动组和对照组。两组都继续原来的抗精神病药物治疗;然而,干预组参加了一个额外的团体活动项目,而对照组则接受了标准的康复项目。在基线、第4周和第8周使用阳性和阴性症状量表(PANSS)和神经心理状态评估可重复电池(rban)评估精神病症状和认知表现。结果:对照组与干预组在基线、4周、8周时PANSS评分差异无统计学意义(p < 0.05)。治疗8周后,干预组在即时记忆(IM)、视觉空间/结构(VC)、语言、注意力、延迟记忆(DM)和rban总分方面与基线相比有显著改善(p)。结论:我们的研究结果表明,团体活动治疗可以有效改善残余阴性症状的精神分裂症患者的认知功能障碍。此外,年龄和疾病持续时间都对认知功能的恢复产生负面影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.80
自引率
4.30%
发文量
154
审稿时长
6-12 weeks
期刊介绍: The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.
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