European Archives of Psychiatry and Clinical Neuroscience最新文献

{"title":"Deciphering causality between social/physical activity and suicide attempt: evidence from Mendelian randomization.","authors":"Haiqi Li, Feixue Yue, Xuan Gu, Haijing Guan, Kaili Chen, Jiao Zhang, Hengyu Ji, Jinting He","doi":"10.1007/s00406-025-02048-2","DOIUrl":"https://doi.org/10.1007/s00406-025-02048-2","url":null,"abstract":"<p><strong>Background: </strong>Previous research has indicated a link between social or physical activity and suicide attempt (SA), yet the causal relationship remains unclear, and the role of psychiatric disorders has not been elucidated.</p><p><strong>Method: </strong>In this study, we used genetic variants of social or physical activity to examine the causal associations with SA based on iPSYCH database, and then replicate the results using FinnGen database.</p><p><strong>Results: </strong>We found that sports clubs or gyms, walking for pleasure, light DIY and other exercises (e.g. bowling, swimming, cycling, and keep fit) may be protective factors for SA, while leisure/social inactivity may be risk factors. After FDR correction of P value, it was revealed that the OR [95%CI] of SA decreased per SD increase in walking for pleasure (0.23[0.07-0.73]), light DIY (0.21[0.07-0.59]), and other exercise (0.22[0.09-0.58]). Within the replication phase, genetic prediction analyses revealed that walking for pleasure, light DIY, and other exercises were associated with reduced susceptibility to SA (P_FDR < 0.05). Given the high comorbidity between psychiatric disorders and SA, we employed two-step MR and multivariate MR (MVMR) to evaluate the proportions the effect of the mediator. We found that Attention Deficit Hyperactivity Disorder (ADHD) explained 24.48% of the total effect of light DIY on SA, 33.52% of the total effect of other exercises.</p><p><strong>Conclusion: </strong>Our research findings highlight the protective effect of social/physical activity in SA, and elucidated that increasing light DIY and other exercise can be used as a prevention strategy of SA, particularly for individuals who have ADHD.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding Huntington's disease: a global survey on symptoms and genetic testing practices.","authors":"C A M Koriath, C Kurz, S Mead, E J Wild, S J Tabrizi","doi":"10.1007/s00406-025-02042-8","DOIUrl":"https://doi.org/10.1007/s00406-025-02042-8","url":null,"abstract":"<p><strong>Background: </strong>Huntington's disease (HD) is a fatal, autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the HTT gene. While chorea is the hallmark motor symptom, HD presents with diverse psychiatric and cognitive manifestations that usually precede motor onset.</p><p><strong>Methods: </strong>A 10-question online survey was distributed to 130 neurologists and neuro-geneticists from the European Huntington's Disease Network (EHDN) to identify clinical symptoms considered pathognonomic of HD and criteria for genetic testing. Responses from 52 specialists were anonymized and analysed using Microsoft Excel and SPSS 26.</p><p><strong>Results: </strong>Respondents, averaging 18.4 years of experience, universally identified chorea as indicative of HD, alongside cognitive slowing, irritability, and gait abnormalities. Symptoms like neuropathy, limb weakness, and tremor were deemed inconsistent with HD. Notably, 19% of experts reported that ancillary symptoms would not deter them from recommending testing if a primary HD symptom was present. Without a family history, only chorea with or without additional symptoms was deemed sufficient for testing.</p><p><strong>Discussion: </strong>The findings highlight the complexity of diagnosing HD, the importance of considering subtle psychiatric and cognitive symptoms, and the need for comprehensive patient counselling. Advances in genetic testing and therapeutic trials targeting the molecular root of HD offer hope for curative treatments.</p><p><strong>Conclusion: </strong>This study underscores the growing recognition of HD's pleiotropy, the ethical considerations in testing, and the importance of clinical vigilance as patients may often first present in a non-neurological setting.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of prolonged grief disorder according to the international classification of diseases 11: a scoping review.","authors":"Kiana Nafarieh, Sophia Krüger, Karl Deutscher, Stefanie Schreiter, Adrian P Mundt, Andreas Jung, Seena Fazel, Andreas Heinz, Stefan Gutwinski","doi":"10.1007/s00406-025-02046-4","DOIUrl":"https://doi.org/10.1007/s00406-025-02046-4","url":null,"abstract":"<p><strong>Background: </strong>The eleventh revision of the International Classification of Diseases (ICD-11) introduces Prolonged Grief Disorder (PGD) as a new diagnostic category. This paper summarizes methodological approaches and prevalence estimates of studies on PGD in ICD-11.</p><p><strong>Methods: </strong>This review follows the JBI Manual of Evidence Synthesis and PRISMA-ScR guidelines. We searched MEDLINE, Embase, Web of Science, and PsycINFO (2011-2024), along with grey literature sources (Web of Science, Science.gov, NDLTD Global ETD Search). Included studies were cross-sectional or longitudinal, evaluating PGD prevalence using ICD-11 criteria. Two reviewers (KN, SK) independently screened studies, with a third (SG) resolving disagreements. Methodological quality was not assessed. Data extraction covered bibliographic details, study period, location, sample characteristics, diagnostic tools, algorithms, and prevalence.</p><p><strong>Results: </strong>Of 124 screened records, 35 studies were included in a qualitative synthesis. Seven main study categories emerged, primarily bereaved adults and representative national samples. Of 46 study samples, 24 were from Europe, followed by North America (n = 10) and Asia (n = 5), with none from South America. The PG-13 was the most commonly used tool, often omitting and raising ICD-11 PGD criteria simultaneously. ICD-11 PGD prevalence ranged from 1.5 to 15.3% in bereaved adults and 9.9-11.4% in national samples.</p><p><strong>Conclusions: </strong>Findings reveal heterogeneous study populations but limited geographic diversity. Standardized PGD assessments aligned with ICD-11 criteria, using tools specifically designed for ICD-11, along with detailed sample reporting, are needed to improve study comparability and consistency of prevalence. Important gaps by geographical and demographic groups remain.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of recent cannabis use on altered spectral entropy modulation and connectivity strength in patients with psychosis.","authors":"Vicente Molina, Álvaro Díez, Inés Fernández-Linsenbarth, Emma Osorio-Iriarte, Rosa Beño-Ruiz de la Sierra, Oscar Martín-Santiago, Claudia Rodríguez-Valbuena, Juan Carlos Fiorini-Talavera, Antonio Arjona","doi":"10.1007/s00406-025-02004-0","DOIUrl":"https://doi.org/10.1007/s00406-025-02004-0","url":null,"abstract":"<p><p>Cannabis use is highly prevalent in individuals with psychosis, raising concerns about its influence on brain function. Electroencephalography (EEG) studies have identified alterations in brain activity in psychosis, including changes in spectral entropy (SE) modulation and connectivity strength (CS). However, the degree to which cannabis use contributes to these alterations remains unclear. This study investigated the effects of recent cannabis use on specific EEG measures previously found to be altered in psychosis: (i) SE modulation, (ii) pre-stimulus theta and broadband CS, and (iii) baseline CS in the gamma band. We focused specifically on the immediate effects of recent cannabis use, without considering factors like tetrahydrocannabinol content, frequency of use, or age of onset. We included 93 patients with psychosis (32 recent cannabis users, 61 non-users) and 86 age- and sex-matched healthy controls (HC; all non-users). Recent cannabis use was defined as any consumption within the past week, assessed through a clinical interview and confirmed by urinalysis. Patients had diagnosis of schizophrenia or bipolar disorder. EEG data were recorded during a P300 task, and SE modulation and baseline CS were calculated. Both patient groups (cannabis users and non-users) exhibited significantly impaired SE modulation and elevated gamma and broadband CS, compared to HC. Crucially, no significant differences were found between the two patient groups in any of the EEG measures. Recent cannabis use does not appear to be the primary driver of the observed electrophysiological alterations in psychosis. Impaired SE modulation and increased CS are likely core features of psychosis itself, independent of recent cannabis exposure. This suggests that these EEG abnormalities may represent underlying vulnerability markers for psychosis. However, further research is needed to explore the potential long-term and early-onset effects of cannabis use on brain function in individuals with psychosis.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of, access to and need for electroconvulsive therapy in forensic psychiatric hospitals: a survey in Germany and Switzerland.","authors":"Matthias Besse, Michael Belz, Henning Hachtel, Alfred Simon, Dirk Hesse, Jürgen Müller, Aniela Friese, David Zilles-Wegner","doi":"10.1007/s00406-025-02044-6","DOIUrl":"https://doi.org/10.1007/s00406-025-02044-6","url":null,"abstract":"<p><strong>Objective: </strong>Patients with treatment resistant schizophrenia (TRS) may benefit from electroconvulsive therapy (ECT). Although TRS is a frequent problem in forensic hospitals, ECT is rarely used in this setting. This study investigates the availability and implementation of ECT in forensic hospitals in Germany and Switzerland. Moreover, we collected anonymized clinical data of patients treated with ECT.</p><p><strong>Methods: </strong>A digital survey was sent to all forensic psychiatric hospitals in Germany and Switzerland. The questionnaire comprised general information (hospital structure, use of ECT) and an optional second part for patients treated with ECT during the last 12 months.</p><p><strong>Results: </strong>41 German and 4 Suisse hospitals responded, of which the majority stated to have the possibility to offer ECT. The estimated percentage of patients with ECT indication was 7.35% (360 patients) and 7.5% (13 patients), respectively. However, only 38 patients were actually treated with ECT over a period of 12 months. Slightly over 50% of the patients were responders according to the Clinical Global Impression Improvement Scale.</p><p><strong>Conclusion: </strong>Our study presents the largest population of patients with TRS treated with ECT in forensic hospitals to date. Compared to 2018, there was a marked increase in the proportion of patients for whom ECT was considered indicated. Patients treated with ECT experienced a reduction in both symptom severity and the need for restraints. The response rate aligns with matching data from non-forensic populations. In view of these promising results, prospective controlled observational studies are needed to further strengthen the evidence regarding the effectiveness of ECT in forensic populations.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of overlapping genetic loci between inflammatory bowel disease and major depressive disorder.","authors":"Shuangqing Chang, Qinghua Luo","doi":"10.1007/s00406-025-02047-3","DOIUrl":"10.1007/s00406-025-02047-3","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormalities of gray matter volume and structural covariance in children with attention-deficit/hyperactivity disorder subtypes: implications for clinical correlations.","authors":"Qiao-Ru Chen, Yi Wang, Bin-Rang Yang, Yu-Feng Wang, Raymond C K Chan","doi":"10.1007/s00406-025-02029-5","DOIUrl":"10.1007/s00406-025-02029-5","url":null,"abstract":"<p><p>Attention deficit and hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder characterized by attention deficits, hyperactivity, and impulsivity. This study investigated brain structural differences in children with ADHD compared to typically developing children. Our sample included 199 ADHD children (114 ADHD-predominantly inattentive; 85 ADHD-combined presentation subtypes) and 94 typically developing controls. All participants completed clinical assessments and MRI scans. We conducted whole-brain voxel-based morphometry (VBM) analysis, structural covariance analysis, and clinical correlation. We used Analysis of Covariance (ANCOVA) and Multivariate Analysis of Covariance (MANCOVA) to compare gray matter volume (GMV) and structural covariance between the ADHD subgroups and typically developing children. We also analyzed correlations between structural covariance and clinical symptoms. The results showed significant GMV differences, particularly in the frontal cortex and basal ganglia, among ADHD subtypes and typically developing children. Compared to controls, children with ADHD combined presentation (ADHD-C) exhibited significantly larger GMV in the right precentral gyrus, right inferior frontal gyrus, right superior frontal gyrus, and left cingulate gyrus, while children with ADHD-predominantly inattentive (ADHD-I) exhibited larger GMV in the right cingulate gyrus. Within the ADHD subtypes, ADHD-C children displayed larger GMV in the left caudate nucleus compared to ADHD-I children. Structural covariance analysis highlighted the altered connectivity patterns, involving the striatum and regions within the default mode network. Correlation analysis indicated associations between altered brain structures and symptoms, cognitive abilities, and social functioning. Our findings suggested that specific brain regions are implicated in ADHD pathology and associated with clinical symptoms, paving ways for developing diagnostic markers and future interventions.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the bidirectional causal association between allergic diseases and neuropsychiatric disorders.","authors":"Guo Zhen Fan, Li Xin Hu, Jie Guan, Ren Zheng Guan, Zheng Hai Qu","doi":"10.1007/s00406-025-02051-7","DOIUrl":"10.1007/s00406-025-02051-7","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to explore the causal associations between allergic diseases and neuropsychiatric disorders via bidirectional Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>This study employed three methodologies for MR analysis, primarily utilizing the inverse variance weighted approach, while supplementing with MR-Egger regression and the weighted median method. Sensitivity analyses encompassed Cochran's Q test, MR-PRESSO test, MR-Egger regression intercept and leave-one-out analysis, all serving to validate the reliability of the reported findings.</p><p><strong>Results: </strong>The forward MR analysis results indicated that bipolar disorder (BD) was positively correlated with allergic asthma (AA) (OR = 1.204) and allergic rhinitis (AR) (OR = 4.647), and depression was positively correlated with AA (OR = 1.141) and atopic dermatitis (AD) (OR = 1.103). The reverse MR analysis outcomes unveiled a negative association between allergic urticaria (AU) and autism spectrum disorder (ASD) (OR = 0.780), a positive correlation between allergic conjunctivitis (AC) and tic disorder (TD) (OR = 1.020). Sensitivity analysis indicated an absence of significant heterogeneity or potential horizontal pleiotropy.</p><p><strong>Conclusions: </strong>AA and AD acted as risk factors for depression; AA and AR increased the risk of BD; ASD served as a protective factor for AU; TD was a risk factor for AC.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schizophrenia and schizoaffective are useful terms of essential concepts in medicine: what we need is a general consideration and more research regarding the causes of secondary psychotic syndromes.","authors":"João Gama-Marques, Martin M Schumacher, Josef Finsterer","doi":"10.1007/s00406-025-02052-6","DOIUrl":"https://doi.org/10.1007/s00406-025-02052-6","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased DTI-APLS correlated with cognitive impairment in veterans with post-traumatic stress disorder.","authors":"Ming-Liang Wang, Zheng Sun, Jun-Jie Zhang, Jing-Kun Zhang, Xue Wu, Yue-Hua Li, Xiao-Er Wei","doi":"10.1007/s00406-025-02037-5","DOIUrl":"https://doi.org/10.1007/s00406-025-02037-5","url":null,"abstract":"<p><p>Post-traumatic stress disorder (PTSD) is a risk for cognitive impairment with underlying mechanism unresolved. Our study aimed to evaluate the glymphatic function in veterans with post-traumatic stress disorder (PTSD), and to explore associations between glymphatic function, sleep patterns, cerebrospinal fluid (CSF) biomarkers (Aβ, t-tau, p-tau), and cognitive impairment. In our study, we included 43 Vietnam War veterans with PTSD and 43 controls. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) was calculated to reflect glymphatic function. Multiple linear regressions and mediation analyses were employed to examine the relationships between the clinician-administered PTSD scale (CAPS) scores, Pittsburgh Sleep Quality Index (PSQI), DTI-ALPS and cognitive impairment. Our study revealed that PTSD group exhibited lower DTI-ALPS (p = 0.001), higher CAPS (p < 0.001), higher PSQI (p < 0.001), and poorer cognitive performance in CDR-SoB (p = 0.019) and ADAS-Cog total 13 (p = 0.009). CAPS was significantly associated with DTI-ALPS (β = -0.0018, 95% CI: -0.0029, -0.0006, p = 0.0028). PSQI demonstrated an indirect effect (β = -0.0005, 95% CI: -0.0011, -0.0001) and mediated 21.74% effect for the relationship between CAPS and DTI-ALPS. CAPS was significantly associated with CDR-SoB and ADAS-Cog total 13 (β = 0.0067, 95% CI: 0.00087, 0.0124, p = 0.024; β = 0.058, 95% CI: 0.013, 0.103, p = 0.012). DTI-ALPS had an indirect effect (β = 0.0024, 95% CI: 0.0006, 0.0069) and mediated all effect for the relationship between CAPS and CDR-SoB. In conclusion, glymphatic system was impaired in PTSD veterans revealed by DTI-ALPS, and poor sleep quality partially mediated the relationship between PTSD severity and impaired glymphatic function. DTI-ALPS mediated the relationship between PTSD severity and cognitive impairment.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}