European Archives of Psychiatry and Clinical Neuroscience最新文献

{"title":"Putamen subregion dysfunction mediates the relationship between childhood maltreatment and major depressive disorder.","authors":"Qianyi Luo, Huiwen Yu, Tong Yu, Jinrou Xia, Yurong Zou, Yuhong Li, Juran Chen, Xiaohui Lin, Hongjun Peng","doi":"10.1007/s00406-025-02034-8","DOIUrl":"https://doi.org/10.1007/s00406-025-02034-8","url":null,"abstract":"<p><p>Childhood maltreatment is a significant risk factor for the development of major depressive disorder (MDD) and is closely linked to abnormalities in the brain's reward circuitry. Previous studies have observed reward circuitry abnormalities centered around the putamen in MDD patients, treating it as a single core nucleus. However, the putamen is a heterogeneous nucleus composed of different functional subregions, and there is limited research focused on the abnormal functional connectivity (FC) of putamen subregions in MDD with childhood maltreatment. To explore putamen-centered reward circuitry abnormalities in MDD with childhood maltreatment, we conducted static and dynamic functional connectivity (FC) analyses with putamen subregions (including the ventral anterior putamen, dorsal anterior putamen, ventral posterior putamen, and dorsal posterior putamen) as regions of interest. Four groups were included: MDD with childhood maltreatment (n = 48), MDD without childhood maltreatment (n = 30), healthy controls with childhood maltreatment (n = 57), and healthy controls without childhood maltreatment (n = 46). Compared to MDD without childhood maltreatment, MDD with childhood maltreatment exhibited higher dynamic FC between the right dorsal putamen and the right prefrontal gyrus, as well as lower static FC between the right ventral anterior putamen and the left middle frontal gyrus and left anterior cingulate gyrus. A positive correlation was found between these aberrant dynamic FC patterns and childhood maltreatment. Additionally, the abnormal dynamic FC mediated the relationship between childhood neglect and the depression severity. These findings suggest that dysfunctional connectivity within the putamen subregions may serve as a neurobiological marker for MDD in individuals with childhood maltreatment. This study contributes to a better understanding of the underlying neurobiological mechanisms of MDD, with implications for more targeted interventions that take into account the specific brain alterations associated with a history of childhood maltreatment.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of internet addiction and its association with quality of life among inflight security officers based on a national survey: a network analysis perspective.","authors":"Zhen Gui, He-Li Sun, Yuan Feng, Qinge Zhang, Zhaohui Su, Teris Cheung, Gabor S Ungvari, Erliang Zhang, Minzhi Chen, Jie Zhang, Lin Zhang, Bin Ren, Qingqing Jin, Chee H Ng, Mi Xiang, Yu-Tao Xiang","doi":"10.1007/s00406-025-02030-y","DOIUrl":"https://doi.org/10.1007/s00406-025-02030-y","url":null,"abstract":"<p><strong>Background: </strong>Given the heavy responsibilities placed on inflight security officers (IFSO) to ensure passenger safety and eliminate inflight hazards, they often turn to Internet use to cope with their work pressure. This study examined the prevalence of internet addiction (IA) among IFSO in China, and its associated factors, relationship with quality of life (QOL), and network structure.</p><p><strong>Methods: </strong>This was a cross-sectional study based on a national survey. Expected influence (EI) was used to identify the most central nodes within the network model.</p><p><strong>Results: </strong>Among 3,475 IFSO included in this study across 10 airlines, the prevalence of IA (IAT-20 total score of ≥ 50) was 13.1% (n = 454; 95% CI: 11.9-14.2%). Further, there was an association between lower annual income, more severe depressive symptoms and anxiety symptoms with IA among IFSOs. Network analysis found that \"Job performance or productivity suffer because of the Internet\" (IAT8) was the most central symptom with the highest EI value, followed by \"Preoccupation with the Internet\" (IAT15) and \"Depressed/moody/nervous only while being offline\" (IAT20). Moreover, \"Sleep loss due to late-night logins\" (IAT14) and \"Spend more time online over going out with others\" (IAT19) had the most negative associations with QOL, while \"Form new relationships with online users\" (IAT4) showed the strongest positive correlation with QOL.</p><p><strong>Conclusion: </strong>IA was common among IFSO. To reduce the adverse impact of IA among IFSO, appropriate interventions targeting central symptoms and those closely associated with QOL found in the network models should be developed.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of cardiorespiratory fitness and muscular fitness with plasma levels of endocannabinoids and their analogues in adults with diagnosed depression: SONRIE study.","authors":"Manuel Ruiz-Muñoz, Sonia Ortega-Gómez, Maria Del Mar Espinosa-Nogales, Eulalio Valmisa-Gómez de Lara, Miguel Ángel Rosety-Rodríguez, Vanesa España-Romero","doi":"10.1007/s00406-025-02032-w","DOIUrl":"https://doi.org/10.1007/s00406-025-02032-w","url":null,"abstract":"<p><strong>Background: </strong>Depression is a leading cause of global disability, affecting approximately 280 million individuals worldwide. Emerging evidence suggests that both physical fitness and endocannabinoids system play significant roles in the pathophysiology and management of depressive disorders.</p><p><strong>Purpose: </strong>To examine the associations between physical fitness, in terms of cardiorespiratory fitness (CRF) and muscular fitness (MF), with plasma levels of endocannabinoids (eCBs) and their analogues, in adults diagnosed with depression.</p><p><strong>Methods: </strong>The study involved 80 adults (ages 25-65) with a psychiatric diagnosis of mild-to-moderate depression based on the International Classification of Diseases 10th Revision (ICD-10) criteria. Physical fitness was assessed through tests measuring CRF (6-Minute Walk Test) and MF (Handgrip, Arm Curl, Chair Stand, Standing Long Jump Test). Fasting plasma levels of eCBs, such as anandamide (AEA) and 2-arachidonoyl glycerol (2-AG), and their analogues were measured using liquid chromatography-tandem mass spectrometry. Linear regression analyses were conducted or the associations between fitness variables and plasma levels of eCBs and their analogues using three models.</p><p><strong>Results: </strong>CRF and jump performance were inversely associated with plasma levels of the eCBs AEA (β range: - 0.302 to - 0.237 for CRF, - 0.315 to - 0.370 for jump; All p < 0.05) and 2-AG (β range: - 0.308 to - 0.326 across all models). eCBs analogues correlated negatively with CRF [2-linoleoylglycerol, 2-oleoylglycerol, docosatetraenoylethanolamide (DEA)] and jump (linoleylethanolamine, stearoylethanolamine, DEA); findings persisted after lean mass normalization.</p><p><strong>Conclusion: </strong>Our findings indicated that higher physical fitness was associated with lower plasma levels of eCBs and their analogues.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory ratios as predictors of length of hospitalization in psychiatric patients: A multicenter study.","authors":"Ayse Kurtulmus, Fatma Busra Parlakkaya Yildiz, Rabia Kevser Sancili Boyraz, Zulal Celik, Aynur Gormez","doi":"10.1007/s00406-025-02033-9","DOIUrl":"https://doi.org/10.1007/s00406-025-02033-9","url":null,"abstract":"<p><strong>Introduction: </strong>Burgeoning evidence underscores the role of inflammation in psychiatric disorders where inflammation is linked to some clinical parameters such as disease severity and treatment resistance. However, the relationship between inflammation and the length of hospitalization remains poorly understood.</p><p><strong>Objectives: </strong>This study aimed to investigate whether elevated inflammation at the time of admission, as indicated by blood cell ratios which are easily accessible markers of peripheral inflammation, predicts the length of stay (LOS) in acutely ill psychiatric patients.</p><p><strong>Methods: </strong>This multi-centre study was conducted at two state hospitals using retrospective data. A total of 497 inpatients were screened, and clinical records at admission were carefully reviewed to exclude any intervening infections or inflammatory conditions. Patients were excluded if they had significantly elevated acute-phase reactants, symptoms of infection, received treatment for suspected infections, used anti-inflammatory drugs, or had physical examination findings suggestive of infection. Additionally, patients with alcohol/substance use disorders and those hospitalized after a suicide attempt were not included. Ultimately, the final sample comprised 167 individuals. CRP levels and NLR, MLR and PLR ratios derived from routine laboratory tests.</p><p><strong>Results: </strong>The length of hospitalization ranged from 10 to 85 days, with a mean of 30.43 ± 14.45 days. A significant positive correlation was found between LOS and NLR (r = 0.453, p <.001), PLR (r = 0.351, p <.001), and MLR (r = 0.292, p <.001), even after controlling for age, gender, diagnosis, comorbid medical conditions, and study site. However, CRP levels did not correlate with LOS (r = 0.025, p =.762). Hierarchical regression analysis revealed that adding the set of immune ratios significantly improved the model's predictive value (p <.001), with immune ratios explaining an additional 10.8% of the variance in LOS, even after controlling for other factors. No significant differences in NLR, PLR, or MLR were observed across diagnostic groups (p =.47, p =.52, and p =.15, respectively). No significant difference was observed between diagnostic groups in terms of inflammatory ratios.</p><p><strong>Conclusions: </strong>Our findings indicate that an elevated inflammatory response, as reflected by blood cell ratios, is associated with prolonged hospitalization in all patients, regardless of their diagnosis. These results emphasize the importance of addressing inflammatory processes in psychiatric care. Targeting inflammation as a modifiable risk factor may offer a new therapeutic avenue to reduce LOS. Future studies should focus on prospective designs and randomized controlled trials to determine whether targeting inflammation can directly reduce LOS and improve recovery in psychiatric populations.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor insight and self-disorders in schizophrenia: an empirical study.","authors":"Lars Siersbæk Nilsson, Julie Nordgaard, Mads Gram Henriksen, Josef Parnas, Andreas Rosén Rasmussen","doi":"10.1007/s00406-025-02035-7","DOIUrl":"https://doi.org/10.1007/s00406-025-02035-7","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the potential of the 3-hydroxykynurenine/kynurenic acid ratio: a promising biomarker in adolescent major depressive disorder.","authors":"Zhihan Ye, Shuran Yang, Liu Lu, Ming Zong, Lieying Fan, Chuanyuan Kang","doi":"10.1007/s00406-024-01815-x","DOIUrl":"10.1007/s00406-024-01815-x","url":null,"abstract":"<p><p>Metabolites disruptions in tryptophan (TRP) and kynurenine pathway (KP) are believed to disturb neurotransmitter homeostasis and contribute to depressive symptoms. This study aims to investigate serum levels of KP metabolites in adolescent major depressive disorder (AMDD), and examine their relationship with depression severities. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to analyze serum levels of TRP, kynurenic acid (KYNA), kynurenine (KYN), and 3-hydroxy-kynurenine (3-HK) in 143 AMDD participants and 98 healthy controls (HC). Clinical data, including Children's Depression Inventory (CDI) scores, were collected and analyzed using statistical methods, such as ANOVA, logistic regression, Receiver operating characteristic curve analysis and a significance level of p < 0.05 was used for all analyses. AMDD showed significantly decreased serum levels of KYNA (-25.5%), KYN (-14.2%), TRP (-11.0%) and the KYNA/KYN ratio (-11.9%) compared to HC (p < 0.01). Conversely, significant increases were observed in 3-HK levels (+50.4%), the 3-HK/KYNA ratio (+104.3%) and the 3-HK/KYN ratio (+93.0%) (p < 0.01). Logistic regression analysis identified increased level of 3-HK as a contributing factor to AMDD, while increased level of KYNA acted as a protective factor against AMDD. The 3-HK/KYNA ratio demonstrated an area under the curve (AUC) of 0.952. This study didn't explore AMDD's inflammatory status and its metabolites relationship explicitly. These findings indicate that metabolites of TRP and KP may play a crucial role in the pathogenesis of AMDD, emphasizing the potential of the 3-HK/KYNA ratio as a laboratory biomarker for early detection and diagnosis of AMDD.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"1049-1061"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypharmacy in psychiatry and weight gain: longitudinal study of 832 patients hospitalized for depression or schizophrenia, along with data of 3180 students from Europe, the U.S., South America, and China.","authors":"H H Stassen, S Bachmann, R Bridler, K Cattapan, E Seifritz","doi":"10.1007/s00406-024-01767-2","DOIUrl":"10.1007/s00406-024-01767-2","url":null,"abstract":"<p><p>Epidemiologic data indicate that overweight and obesity are on the rise worldwide. Psychiatric patients are particularly vulnerable in this respect as they have an increased prevalence of overweight and obesity, and often experience rapid, highly undesirable weight gain under psychotropic drug treatment. Current treatment strategies in psychiatry are oriented towards polypharmacy, so that the information on drug-induced weight gain from earlier monotherapy studies is of very limited validity. We have analyzed the longitudinal data of 832 inpatients with ICD-10 diagnoses of either F2 (schizophrenia; n = 282) or F3 (major depression; n = 550) with the goal of ranking treatment regimens in terms of weight gain, side effects, and response to treatment. The patient data were complemented by the data of 3180 students aged 18-22 years, with which we aimed to identify factors that enable the early detection and prevention of obesity and mental health problems. After 3 weeks of treatment, 47.7% of F2 patients and 54.9% of F3 patients showed a weight gain of 2 kg and more. Major predictive factors were \"starting weight\" (r = 0.115), \"concurrent medications\" (r = 0.176), and \"increased appetite\"(r = 0.275). Between 11 and 30% of the observed variance in weight gain could be explained by these factors, complemented by sex and age. The comparison between monotherapy (n = 409) and polypharmacy (n = 399) revealed significant drawbacks for polypharmacy: higher weight gain (p = 0.0005), more severe side effects (p = 0.0011), and lower response rates (F2: p = 0.0008); F3: p = 0.0101). The data of 3180 students made it clear that overweight and obesity often begin early in life among those affected, and are interconnected with personality traits, while increasing the risk of developing psychosomatic disturbances, mental health problems, or somatic illnesses. Although the available data did not readily lead to a comprehensive, clinically applicable model of unwanted weight gain, our results have nevertheless demonstrated that there are ways to successfully counteract such weight gain at early stages of treatment.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"1001-1014"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of obesity in patients with major depressive disorder at different ages of onset.","authors":"Xiaoen Liu, Xue Tian, Lina Wang, Xiangyang Zhang","doi":"10.1007/s00406-024-01766-3","DOIUrl":"10.1007/s00406-024-01766-3","url":null,"abstract":"<p><p>Major depressive disorder (MDD) and obesity are two serious public health problems. Although there have been some research on both, there have few studies on differences in obesity among MDD patients at different ages of onset. The study aims to evaluate the prevalence and factors associated with obesity in MDD patients at different ages of onset. This study totally recruited 1718 first-episode drug-naive MDD patients aged from 18 to 60 years. All subjects were divided into two subgroups: early adulthood onset (EAO, 18-45 years) and mid-adulthood onset (MAO, 45-60 years). Clinical symptoms of patients were evaluated using the 17-item Hamilton Depression Rating Scale (HAMD-17), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) positive subscale. Baseline parameters including body mass index (BMI), blood pressure, and hematological biochemical parameters were assessed to investigate the association between these parameters and weight gain risk. The percentages of overweight and obesity patients with MDD in EAO group were 54.4% and 4.1%, respectively, and the percentages of overweight and obesity patients with MDD in MAO group were 60.4% and 2.8%, respectively. MDD patients in the MAO group had a longer duration of illness and higher scores in HAMD, HAMA, and PANSS positive subscale. They also had higher levels of thyroid stimulating hormone (TSH), anti-thyroglobulin (TgAb), fasting blood glucose (FBG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), systolic and diastolic blood pressures (SBP and DBP) levels. BMI did not differ significantly between the two groups. In the EAO group, statistically significant differences were found among normal weight, overweight and obese group in duration of illness, age of onset, TSH, TgAb, thyroid peroxidase antibody (TPOAb), free thyroxine (FT4), TC, triglycerides (TG), SBP and DBP. The TSH, TgTb and SBP were identified as risk factors for weight gain. In the MAO group, statistically significant differences were found among normal weight, overweight and obese group in TSH and FBG. The two indicators were identified as risk factors for weight gain. There were no significant differences in the weight of MDD patients at different ages of onset, while the factors that could potentially lead to obesity did show some differences.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"991-1000"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying latent subtypes of symptom trajectories in major depressive disorder patients and their predictors.","authors":"Fanyu Meng, Wenwen Ou, Xiaotian Zhao, Mi Wang, Xiaowen Lu, Qiangli Dong, Liang Zhang, Jinrong Sun, Hua Guo, Futao Zhao, Mei Huang, Mohan Ma, Guanyi Lv, Yaqi Qin, Weihui Li, Zexuan Li, Mei Liao, Li Zhang, Jin Liu, Bangshan Liu, Yumeng Ju, Yan Zhang, Lingjiang Li","doi":"10.1007/s00406-024-01883-z","DOIUrl":"10.1007/s00406-024-01883-z","url":null,"abstract":"<p><p>This study aimed to identify different symptom trajectories based on the severity of depression symptoms within a 2-month follow-up, and to explore predictive factors for different symptom trajectories. Three hundred and ninety-two adults diagnosed with major depressive disorder (MDD) were recruited from two longitudinal cohorts. Patients received antidepressant treatment as usual, and the depression symptoms were evaluated by the 17-item Hamilton depression rating scale (HAMD-17) at baseline, two weeks, and eight weeks. Based on the HAMD-17 scores, different trajectories of symptom change were distinguished by applying Growth Mixture Modeling (GMM). Furthermore, the baseline sociodemographic, clinical, and cognitive characteristics were compared to identify potential predictors for different trajectories. Through GMM, three unique depressive symptom trajectories of MDD patients were identified: (1) mild-severity class with significant improvement (Mild, n = 255); (2) high-severity class with significant improvement (High, n = 39); (3) moderate-severity class with limited improvement (Limited, n = 98). Among the three trajectories, the Mild class had a relatively low level of anxiety symptoms at baseline, whereas the High class had the lowest education level and the worst cognitive performance. Additionally, participants in the Limited class exhibited an early age of onset and experienced a higher level of emotional abuse. MDD patients could be categorised into three distinct latent subtypes through different symptom trajectories in this study, and the characteristics of these subtype patients may inform identifications for trajectory-specific intervention targets.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"1177-1187"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive use of mindfulness-based mobile application in depression: randomized controlled study.","authors":"Jan Sarlon, Else Schneider, Annette B Brühl, Sarah Ulrich, Timur Liwinski, Jessica P Doll, Markus Muehlauser, Undine E Lang","doi":"10.1007/s00406-024-01884-y","DOIUrl":"10.1007/s00406-024-01884-y","url":null,"abstract":"<p><p>Mindfulness-based interventions (MBI) are effective in relapse prevention in Major Depressive Disorder (MDD). Internet-based interventions have been demonstrated to be effective in the treatment of MDD. Consequently, the integration of MBI through mobile applications emerges as a promising supplementary intervention for MDD, contributing to the augmentation of mental health services, particularly within ambulatory care contexts. The current randomized controlled study is designed to evaluate the efficacy of adjunctive MBI delivered via a mobile app in mitigating symptom severity and stress levels. This assessment involves a comparison with standard treatment practices in an ambulatory setting among individuals diagnosed with MDD. A total of 83 patients diagnosed with MDD (depressive episode, recurrent depression or depressive phase of bipolar disorder) were randomly allocated to the intervention (41 patients) or control condition (42 patients). The intervention consisted of the daily use of the mindfulness mobile application \"Headspace\" for thirty days. The control condition was treatment as usual (TAU) only. The symptom severity has been assessed by the Beck Depression Inventory (BDI-II) as well as the Hamilton Depression Rating Scale (HDRS-17). Blood pressure and resting heart rate have been assessed as secondary outcome. Upon hospital discharge, the mean scores on the Beck Depression Inventory (BDI) and Hamilton Depression Rating Scale (HDRS) signaled partial remission of MDD in both treatment arms. In both groups, a subsequent decrease in both self-reported and expert-rated scores was evident after a 30-day period. However, the decrease in depression severity as measured by HDRS was significantly higher in the MBI group compared to the control group after 30 days. For secondary outcomes, systolic blood pressure was lower in the intervention group compared to control group. The total drop-out rate was 29%. Short term mindfulness intervention via mobile application (30 days) can be beneficial as adjunctive therapy to treatment as usual in patients with MDD.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"1243-1251"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}