肠道菌群：精神分裂症患者心血管疾病患病率高的原因？

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-09-13 DOI:10.1007/s00406-025-02103-y

Chuanwen Fu, Xuehui Zhang, Ying Qian, Ximei Wang, Xinqiang Chen, Jia Zeng, Nichang Zhang, Liming Wang, Mingsong Li, Zhengxu Li, Teng Zhang, Yuemei Feng, Jianzhong Yin

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引用次数: 0

摘要

精神分裂症（PLWS）患者预期寿命缩短，心血管疾病（CVD）是主要诱因。本文通过对现有人群和动物研究的回顾，总结出PLWS中毛杆菌科、拟杆菌科、粪杆菌科、鲁米诺球菌科、玫瑰杆菌科、双歧杆菌科、乳杆菌科、Akkermansia、Rikenellaceae丰度的降低和普雷沃菌科、梭状芽孢杆菌科、埃希氏菌科丰度的增加可能是PLWS中CVD患病率增加的原因之一，可能是通过影响与精神分裂症（SCZ）和CVD发展相关物质的代谢而导致的。

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Gut microbiota: contributing to high CVD prevalence in people living with schizophrenia?

People living with schizophrenia (PLWS) have a reduced life expectancy with cardiovascular disease (CVD) as a major contributor. This article reviews the existing populations and animal studies and summarizes that reduced abundance of Lachnospiraceae, Bacteroides, Faecalibacterium, Ruminococcus, Roseburia, Bifidobacterium, Lactobacillus, Akkermansia, Rikenellaceae and increased abundance of Prevotella, Clostridium, Escherichia in PLWS is one of the probable reasons for the increased risk of CVD prevalence in PLWS by affecting the metabolism of substances related to the development of Schizophrenia (SCZ) and CVD.

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来源期刊

European Archives of Psychiatry and Clinical Neuroscience 医学-精神病学

CiteScore

8.80

自引率

4.30%

发文量

154

审稿时长

6-12 weeks

期刊介绍： The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.