European Archives of Psychiatry and Clinical Neuroscience最新文献

{"title":"Altered functional connectivity of the hippocampus in cortico-subcortical networks in early-stage and emerging psychosis.","authors":"Gina Brunner, Ruchika Gajwani, Joachim Gross, Andrew Gumley, Rajeev Krishnadas, Stephen M Lawrie, Matthias Schwannauer, Frauke Schultze-Lutter, Peter J Uhlhaas, Alessio Fracasso","doi":"10.1007/s00406-025-02079-9","DOIUrl":"10.1007/s00406-025-02079-9","url":null,"abstract":"<p><strong>Background: </strong>Deficits in the hippocampus are a consistent finding in schizophrenia and have also been demonstrated in early-stage psychosis. Moreover, alterations in hippocampal anatomy and connectivity have been implicated in aberrant functional interactions in subcortical and cortical networks. However, the nature and extent of these alterations and their association with frontal and subcortical regions remain unclear.</p><p><strong>Methods: </strong>To address these questions, we analysed resting state fMRI functional connectivity and graph properties in n = 93 individuals at clinical high-risk for psychosis (CHR-P), n = 26 patients with first-episode psychosis (FEP), n = 31 individuals with affective disorders and substance abuse as well as n = 58 healthy controls. We used novel denoising techniques and individually optimised functional connectivity matrices, which were compared across clinical groups. Finally, the centrality of the hippocampus as well as network segregation and integration were assessed using graph-based analysis.</p><p><strong>Results: </strong>Both the FEP and CHR-P groups were characterised by reduced functional connectivity between the hippocampus and inferior frontal cortex albeit the differences in CHR-P individuals did not survive corrections for multiple comparisons. Compared to CHR-P, FEP show lower centrality of the hippocampus but increased network segregation.</p><p><strong>Conclusions: </strong>Our findings show lower connectivity between the hippocampus and frontal cortex in early-stage psychosis, with FEP patients showing stronger decreases in connectivity compared to CHR-Ps. Furthermore, network-based analyses highlight reduced centrality in FEPs compared to CHR-Ps, indicating reduced influence on the wider network. Thus, altered connectivity along the hippocampal-frontal axis could be a potential marker of illness stage in early-stage psychosis.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in the interactions and inferred causal relationships between risk factors and gaming disorder: a network and structural equation modeling approach.","authors":"Fei Cheng, Lei Guo, Yawen Shi, Shujun Pan, Lei Zhang, Shiyan Qu, Chenxin Yuan, Ying Jiang, Dawei Huang, Tianzhen Chen, Jiang Du, Min Zhao","doi":"10.1007/s00406-025-02075-z","DOIUrl":"https://doi.org/10.1007/s00406-025-02075-z","url":null,"abstract":"<p><strong>Objective: </strong>Gaming Disorder (GD) is linked to severe psychological distress and functional impairment, substantially affecting individuals' daily lives. Current researches have not fully clarified the complex, gender-specific risk factors that contribute to GD development. This study aims to uncover key risk factors, such as negative emotions, childhood trauma, social anxiety, personality traits, and GD symptoms, by utilizing network analysis and structural equation modeling to explore differences between genders.</p><p><strong>Methods: </strong>An online survey was conducted with 1,073 Chinese participants aged 18 to 35. The research assessed GD symptoms, childhood trauma, personality traits, impulsivity, social anxiety, depression, and anxiety through validated scales. The EBICglasso network model was employed to identify core factors and symptoms. Directed Acyclic Graphs (DAGs) were used to infer potential causal pathways among these variables, with results further validated using Structural Equation Modeling (SEM).</p><p><strong>Results: </strong>The EBICglasso network analysis revealed distinct gender-specific core factors across variable clusters. DAGs and SEM identified stable causal pathways to GD symptoms that differed by gender. Among males, GD symptoms were predominantly driven by negative emotions, with \"suicidal ideation\" and \"low energy\" emerging as primary contributors. For females, the pathway to GD symptoms was influenced by childhood trauma, which affected personality traits and negative emotions, ultimately contributing to the development of GD.</p><p><strong>Conclusion: </strong>This study emphasize the critical need for gender-specific intervention strategies in preventing and addressing GD. For males, interventions should prioritize emotional regulation and the reduction of suicidal ideation. For females, it is essential to target anxiety and depressive symptoms associated with childhood trauma.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Sarcopenia-related traits and depression: an observational and Mendelian randomization analysis.","authors":"Shitu Zhuo, Biyue Zhang, Xinxia Yang","doi":"10.1007/s00406-025-02091-z","DOIUrl":"https://doi.org/10.1007/s00406-025-02091-z","url":null,"abstract":"<p><strong>Objectives: </strong>Sarcopenia and depression are common among older people. However, the association between the two remains unclear. This study aimed to explore the relationship between sarcopenia-related traits and depression.</p><p><strong>Methods: </strong>This observational study included 5,466 participants from the 2011-2014 National Health and Nutrition Examination Survey. We performed logistic regression, subgroup, and restricted cubic spline analyses to examine the relationship between sarcopenia and depression. Bidirectional two-sample and multivariable Mendelian randomization (MR) analyses were performed to examine the causal relationship between sarcopenia and depression.</p><p><strong>Results: </strong>We noted that body mass index (BMI)-adjusted appendicular lean mass (ALM) (ALM/BMI) and grip strength were negatively correlated with depression. Restricted cubic spline analysis confirmed a negative linear relationship between these traits and depression. Subgroup analyses revealed sex-related differences in the association of ALM/BMI and grip strength with depression. In the MR analyses, genetically predicted ALM, grip strength, and walking speed were causally associated with depression. These findings remained robust in the sensitivity analysis. In the multivariable MR analysis, ALM and grip strength retained this robust relationship.</p><p><strong>Conclusion: </strong>Our findings suggest that ALM and grip strength are negatively correlated with depression and have a bidirectional causal relationship. This finding underscores the importance of timely identification and intervention for depression as a means of preventing sarcopenia.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy and acceptability of anxiolytic drugs for the treatment of anxiety disorders: a systematic review and network meta-analysis.","authors":"Thomas J Müller, Arnaud Künzi, Ellen Heitlinger, Bernd Krämer, Roland von Känel, Josef Hättenschwiler, Matthias Hilpert, Christian Imboden, Edith Holsboer-Trachsler, Martin Hatzinger, Siegfried Kasper, Borwin Bandelow, Erich Seifritz","doi":"10.1007/s00406-025-02082-0","DOIUrl":"https://doi.org/10.1007/s00406-025-02082-0","url":null,"abstract":"<p><strong>Background: </strong>Anti-anxiety medications' side effects and dependency risks necessitate thorough consideration of their efficacy and acceptability when making treatment decisions.</p><p><strong>Methods: </strong>A systematic review and Network Meta-Analysis (NMA) was conducted using three databases from 1980 to 2020, focusing on adults diagnosed with generalized anxiety disorder (GAD) or any relevant diagnostic classification of anxiety disorder or those for whom Hamilton Anxiety (HAM-A) data is available, and including any comparator (placebo and/or active comparator treatments). The primary outcomes were efficacy (mean difference in change from baseline in HAM-A total score) and acceptability (study discontinuations for any cause). This study is registered with Open Science Framework (OSF) database.</p><p><strong>Findings: </strong>Analysis of 100 trials involving 28,637 participants showed that most active drugs were more effective than placebo in reducing anxiety. Notably, silexan was the only phytopharmaceutical included in the NMA. Clomipramine had the highest efficacy and vortioxetine the least. However, in terms of acceptability, clomipramine led to the most study discontinuations, while clobazam had the lowest discontinuation rate, indicating that efficacy and acceptability do not always align. Notably, silexan was both highly effective and as acceptable as a placebo. Only four treatments showed fewer adverse events than placebo (diazepam, agomelatine, clobazam, and silexan).</p><p><strong>Conclusion: </strong>This network meta-analysis provides a unique comparison of the efficacy and acceptability of anxiolytics. It represents one of the most comprehensive evidence bases available to guide the first choice of treatment for anxiety disorders in adults.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiological features in women with antenatal depressive symptoms: a resting-state quantitative electroencephalography study.","authors":"Hyeon Ji Kim, Daseul Lee, Jinuk Kim, Na Young Kim, Subeen Hong, Woojae Myung, Hyukjun Lee, Jee Yoon Park","doi":"10.1007/s00406-025-02078-w","DOIUrl":"https://doi.org/10.1007/s00406-025-02078-w","url":null,"abstract":"<p><strong>Background: </strong>Antenatal depression, which is prevalent during pregnancy, frequently continues into the postpartum period. We aimed to investigate the potential neurophysiological brain changes in women exhibiting antenatal depressive symptoms, using resting-state quantitative electroencephalography (qEEG) patterns as an objective indicator.</p><p><strong>Methods: </strong>Pregnant women with high-risk conditions were included and evaluated for antenatal depressive symptoms using the Edinburgh Postnatal Depression Scale (EPDS), then divided into groups based on an EPDS score of 10. Resting-state qEEG recordings were then obtained to assess relative power topography within classical frequency bands, comparing these measures across the two groups and examining their correlation with EPDS scores.</p><p><strong>Results: </strong>Among 36 participants, 12 scored ≥ 10 on the EPDS, indicative of significant depressive symptoms, while 24 scored < 10. Those with scores ≥ 10 exhibited heightened beta power in frontal areas (Fz and F4; p < 0.05), along with significant alpha and theta band asymmetry at the T3/T4 (r = 0.383, p = 0.021) and P3/P4 (r = 0.369, p = 0.027) sites respectively, positively correlating with EPDS scores.</p><p><strong>Limitations: </strong>Depressive symptoms were solely evaluated according to the EPDS, which is a screening tool. Additional limitations include the cross-sectional study design and the relatively small sample size, necessitating cautious interpretation of the results.</p><p><strong>Conclusion: </strong>The distinct qEEG patterns observed in women with EPDS scores ≥ 10 highlight the potential of qEEG as an objective indicator for assessing antenatal depression.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alexithymia as a mechanistic bridge: validating the mediating role of emotion processing deficits between childhood trauma and negative symptoms in schizophrenia.","authors":"Kui Zhang, Shan Tao, Chengqiang Jin","doi":"10.1007/s00406-025-02070-4","DOIUrl":"https://doi.org/10.1007/s00406-025-02070-4","url":null,"abstract":"<p><p>This pioneering study published in European Archives of Psychiatry and Clinical Neuroscience elucidates the mediating role of alexithymia-specifically difficulty identifying feelings (DIF) and externally oriented thinking (EOT)-in the pathway linking childhood trauma (CT) to negative symptoms (NS) in chronic schizophrenia (β < sub > DIF</sub > = 0.04, 95% CI [0.002, 0.085]; β < sub > EOT</sub > = 0.03, 95% CI [0.002, 0.060]). Using Hayes' PROCESS macro with bootstrapping in 94 patients, the authors establish alexithymia as a mechanistically actionable target for trauma-informed interventions. Methodological refinements are proposed to address antipsychotic class effects on emotion processing, neurobiological mediators (e.g., amygdala volume), and positive symptom confounding. This work redefines therapeutic paradigms for trauma-associated schizophrenia, underscoring the journal's leadership in transformative clinical neuroscience.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PACIC: patient activation and problem solving not related to age in patients with depressive symptoms.","authors":"Karoline Lukaschek, H Schillok, L Junker, C Jung-Sievers, P Falkai, P Henningsen, T Dreischulte, G Pitschel-Walz, H Krcmar, A Schneider, P Schoenweger, C Haas, V Brisnik, F Gökce, J Eder, L Pfeiffer, V von Schrottenberg, C Teusen, M Bühner, J Gensichen","doi":"10.1007/s00406-025-02061-5","DOIUrl":"https://doi.org/10.1007/s00406-025-02061-5","url":null,"abstract":"<p><p>The Patient Assessment of Chronic Illness Care (PACIC) assesses alignment of chronic care with the Chronic Care Model (CCM). We analysed PACIC subscales in patients with depressive symptoms to identify gaps in patient-centred care. A total of N = 2741 patients (59.5% women, mean age 45.3 ± 16.9) were assessed for depression (PHQ-9), anxiety (GAD-7) and socioeconomic data. PACIC data from 1210 patients (62.7% women, mean age 47.2 years ± 16.8) revealed low scores in subscales patient activation, goal setting, problem-solving, and follow-up. Patient activation and problem-solving were age-independent. Overall, the low PACIC scores highlight poor CCM alignment in German depression care.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep-related metacognitions in inpatients with mental disorders.","authors":"Elisabeth Anzenberger, Michael Schredl, Claudia Schilling","doi":"10.1007/s00406-025-02073-1","DOIUrl":"10.1007/s00406-025-02073-1","url":null,"abstract":"<p><strong>Background: </strong>Sleep difficulties are a well-known issue among patients with mental disorders. Sleep related metacognitions often play a role in the etiology of sleep disturbances. This study examined the role of sleep-related metacognitions in a sample of psychiatric inpatients.</p><p><strong>Methods: </strong>A total of 75 patients admitted to the psychiatric clinic of the Central Institute of Mental Health (CIMH) in Mannheim, Germany, were included in the study. The participants completed a series of psychometric questionnaires, including the Metacognitive Questionnaire for Insomnia (MCQ-I 20), the Patient Health Questionnaire (PHQ-9) and the Insomnia Severity Index (ISI).</p><p><strong>Results: </strong>The psychiatric patient sample exhibited significantly elevated scores on the MCQ-I 20 when compared to a healthy control group and demonstrated comparable scores to a group of insomnia patients. Sleep-related metacognitions in the psychiatric patient sample correlated significantly with increased depression levels and insomnia symptoms.</p><p><strong>Conclusions: </strong>The findings of this study provide evidence that sleep-related metacognitions play a role in the etiology of sleep problems in patients with mental disorders.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional connectivity of the nucleus accumbens and the amygdala in offspring of parents with bipolar or major depressive disorder.","authors":"Mélanie Boisvert, Jules Roger Dugré, Stéphane Potvin","doi":"10.1007/s00406-025-02056-2","DOIUrl":"https://doi.org/10.1007/s00406-025-02056-2","url":null,"abstract":"","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic insights into the effect of Metformin on psychiatry disorders.","authors":"Qin Zhou, Zhiqiang Du, Rongrong Lu, Yuan Shen, Ying Jiang, Haohao Zhu","doi":"10.1007/s00406-025-02039-3","DOIUrl":"10.1007/s00406-025-02039-3","url":null,"abstract":"<p><strong>Objective: </strong>This study employs Mendelian Randomization (MR) to explore the causal relationships between Metformin and 20 mental illnesses. The aim is to provide new pharmacological treatment bases for the treatment and intervention of mental illnesses, thereby reducing incidence rates and alleviating the disease burden.</p><p><strong>Methods: </strong>This study uses summarized data from Genome Wide Association Studies (GWAS) to identify genetic instrumental variables (IVs) that are significantly associated with Metformin and are mutually independent. The primary method used to evaluate causal relationships is the Inverse Variance Weighted (IVW) approach, complemented by other MR methods for sensitivity analysis.</p><p><strong>Results: </strong>MR analysis results indicate a significant negative causal relationship between genetically predicted Metformin and Neuroticism(NEU) (OR = 0.700, 95% CI: 0.505-0.970, P = 0.032) and Bipolar Disorder(BID) (OR = 0.0374, 95% CI: 0.00266-0.525, P = 0.015). Additionally, a significant positive causal relationship was found with Attention deficit hyperactivity disorder(ADHD) (OR = 15.4, 95% CI: 1.95-122, P = 0.010) and Insomnia(INS) (OR = 1.96E + 06, 95% CI: 351-1.10E + 10, P = 0.001). There were no significant causal relationships with the remaining mental illnesses (P>0.05). Sensitivity analyses indicate that the results are robust.</p><p><strong>Conclusion: </strong>From a genetic perspective, this study finds that Metformin may reduce the risk of NEU and BID while increasing the risk of ADHD and INS. These findings not only provide theoretical support for further research into the etiological mechanisms but also offer valuable reference points for the clinical use of Metformin in treating NEU and BID, and for exercising caution in its use among patients with ADHD and INS.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"1465-1476"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}