European Archives of Psychiatry and Clinical Neuroscience最新文献_第5页

Association between overt aggression and suicidal ideation in patients with major depressive disorder: the mediational role of cognitive symptoms.

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-03-04 DOI: 10.1007/s00406-025-01979-0

Ningning Chen, Meiti Wang, Yiming Chen, Fan Wang, Qinte Huang, Dongbin Lyu, Chenglin Wu, Vivien Yang, Shuang He, Xirui Liu, Yixia Xie, Qinting Zhang, Wu Hong

{"title":"Association between overt aggression and suicidal ideation in patients with major depressive disorder: the mediational role of cognitive symptoms.","authors":"Ningning Chen, Meiti Wang, Yiming Chen, Fan Wang, Qinte Huang, Dongbin Lyu, Chenglin Wu, Vivien Yang, Shuang He, Xirui Liu, Yixia Xie, Qinting Zhang, Wu Hong","doi":"10.1007/s00406-025-01979-0","DOIUrl":"https://doi.org/10.1007/s00406-025-01979-0","url":null,"abstract":"Suicidal ideation, under the dominion of suicidal behavior, represents the most severe consequence of depressive disorders. Overt aggressive behaviors leading to agitated symptoms, coupled with cognitive symptoms during a depressive episode, both impact suicidal ideation and behavior. However, the precise mechanisms by which cognitive symptoms and overt aggressive behaviors influence suicidal ideation in patients with depressive disorders remain unclear. This cross-sectional study analyzed 301 MDD patients from the Shanghai Mental Health Centre between May 2017 and July 2020. Depression severity and cognitive symptoms were assessed using the 17-item Hamilton Depression Rating Scale (HAMD-17), overt aggression with the Modified Overt Aggression Scale (MOAS), and suicidal ideation with the Beck Scale for Suicide Ideation (BSSI). A multivariate logistic regression was conducted to identify risk factors for suicidal ideation. Patients with suicidal ideation had higher levels of cognitive impairment and overt aggression (Z = - 5.527, P < 0.01; Z = - 3.482, P < 0.01). Overt aggressive symptoms positively correlated with suicide ideation (r = 0.177, P = 0.006) and cognitive performance scores (r = 0.173, P = 0.035). And cognitive performance scores also positively correlated with suicide ideation (r = 0.308, P < 0.001). Logistic regression identified cognitive symptoms (OR 1.47) and overt aggression (OR 1.40) as predictors of suicidal ideation in MDD patients (P < 0.05). Mediation analysis revealed that cognitive symptoms mediated the relationship between overt aggression and suicidal ideation (indirect effect: 0.1903). In MDD, cognitive symptoms and overt aggression are significant predictors of suicidal ideation, with cognitive symptoms playing a mediating role. These findings suggest potential targets for therapeutic intervention.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive function and social cognition in adolescents with bipolar disorder: comparison between manic episode and remission period.

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-03-03 DOI: 10.1007/s00406-025-01987-0

Celal Yeşilkaya, Sezen Alarslan, Mustafa Tuncturk, Cagatay Ermis, Serkan Turan, Gul Karacetin

{"title":"Cognitive function and social cognition in adolescents with bipolar disorder: comparison between manic episode and remission period.","authors":"Celal Yeşilkaya, Sezen Alarslan, Mustafa Tuncturk, Cagatay Ermis, Serkan Turan, Gul Karacetin","doi":"10.1007/s00406-025-01987-0","DOIUrl":"https://doi.org/10.1007/s00406-025-01987-0","url":null,"abstract":"Background: We aimed to investigate the extent of cognitive impairments in early-onset bipolar disorder (EBD) during manic episode in comparison to remission period.Method: 30 healthy controls (HC) and 95 patients with EBD, with manic episode (n = 55) and remission period (n = 40) were included. Additionally, 31 (%56.4) of 55 patients with manic episode were re-evaluated during remission. A comprehensive cognitive battery was implemented to asses verbal and visual learning/memory, attention, inhibition, problem-solving, working memory, processing speed, and verbal fluency skills and global cognitive factor was calculated to estimate overall cognitive ability. Theory of mind (ToM) was evaluated using the Reading the Mind in the Eyes and Faux-Pas tests.Findings: Individuals in patient groups and HC were matched for gender and education. Patients in remission had a significantly older mean age than the other groups. Antipsychotic dosage was also higher in cases with mania. Patients with manic episode had moderate impairments in processing speed (Cohen's d: 0.51-0.78), attention (d: 0.57), inhibition (d: 0.56-0.63) and global cognitive function (d: 0.54) compared to patients in remission period. Individuals in remission period had poorer performance in verbal memory (d: 1.03-1.32), working memory (d: 0.88-1.13), ToM (d: 0.60-0.87), processing speed (d: 1.21-1.27), problem solving (d: 0.56-0.67), attention (d: 0.58), inhibition (d: 0.89-1.00) and visual memory (d: 1.28-1.37) in comparison with HC.Conclusion: Our findings indicated that impairments in social cognition, processing speed, inhibition, and attention were more prominent in the manic episode. Future studies should focus on pharmaco- and psychotherapeutic interventions aimed to treat neurocognitive impairments.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstructive sleep apnea's causal links to depression, well-being, and negative moods: a bidirectional mendelian randomized study.

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-03-02 DOI: 10.1007/s00406-025-01969-2

Jianhong Liao, Xiang Gao, Ting Fang, Yanru Li, Demin Han

{"title":"Obstructive sleep apnea's causal links to depression, well-being, and negative moods: a bidirectional mendelian randomized study.","authors":"Jianhong Liao, Xiang Gao, Ting Fang, Yanru Li, Demin Han","doi":"10.1007/s00406-025-01969-2","DOIUrl":"https://doi.org/10.1007/s00406-025-01969-2","url":null,"abstract":"Previous observational studies showed associations between obstructive sleep apnea (OSA) and depression and other negative moods. However, the causality has not been determined. Single nucleotide polymorphisms were identified as instrumental variables by screening from genome-wide association studies. Bidirectional two-sample mendelian randomization (MR) was applied to assess the potential causal relationship between OSA and depression, subjective well-being, negative moods. Inverse variance weighting (IVW) method and weight median were chosen as the main methods to estimate possible causal effects. MR-Egger, MR pleiotropy residual sum and outlier and leave-one-out analysis methods, were used as sensitivity analysis methods to ensure robust results. MR analyses indicated significantly causal association of OSA on depression (OR = 1.22, P = .010) and major depressive disorder (OR = 1.02, P = .006). Furthermore, genetically predicted OSA was negatively associated with subjective well-being (βIVW = -0.06, P = .009), and was positively associated with negative moods including depressed affect (OR = 1.04, P = .012), irritable mood (P = .006), feeling lonely (P = .011), feeling fed-up (P = .005) and mood swings (P = .017). There is no reverse effect of the above psychiatric traits on OSA. Genetic predisposition to OSA causally increased depression and major depressive disorder. Consistently, OSA has causal impacts on both subjective well-being, representing positive emotions, and negative moods.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naturalistic comparison of clomethiazole and Diazepam treatment in alcohol withdrawal: effects on oxidative stress, inflammatory cytokines and hepatic biomarkers. 氯美噻唑和地西泮治疗酒精戒断的自然比较：对氧化应激、炎症细胞因子和肝脏生物标志物的影响。

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-06-08 DOI: 10.1007/s00406-024-01835-7

David Strischewski, Amira Kalmar, Paul C Guest, Henrik Dobrowolny, Gabriela Meyer-Lotz, Conrad J Schiffner, Wolfgang Jordan, Ulf J Müller, Katrin Borucki, Michael Böttcher, Borna Relja, Johann Steiner

引用次数: 0

Cannabis use in Europe.

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-03-01 DOI: 10.1007/s00406-025-01972-7

Eva Hoch, Wayne Hall, Daniel Feingold

引用次数: 0

DNAJC13 influences responses of the extended reward system to conditioned stimuli: a genome-wide association study. DNAJC13影响扩展奖赏系统对条件刺激的反应：一项全基因组关联研究。

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-10-17 DOI: 10.1007/s00406-024-01905-w

Jens Treutlein, Karolin E Einenkel, Bernd Krämer, Swapnil Awasthi, Oliver Gruber

{"title":"DNAJC13 influences responses of the extended reward system to conditioned stimuli: a genome-wide association study.","authors":"Jens Treutlein, Karolin E Einenkel, Bernd Krämer, Swapnil Awasthi, Oliver Gruber","doi":"10.1007/s00406-024-01905-w","DOIUrl":"10.1007/s00406-024-01905-w","url":null,"abstract":"Reward system dysfunction is implicated in the pathogenesis of major psychiatric disorders. We conducted a genome-wide association study (GWAS) to identify genes that influence activation strength of brain regions within the extended reward system in humans. A homogeneous sample of 214 participants was genotyped and underwent functional magnetic resonance imaging (fMRI). All subjects performed the 'desire-reason dilemma' (DRD) paradigm allowing systematic investigation of systems-level mechanisms of reward processing in humans. As a main finding, we identified the single nucleotide variant rs113408797 in the DnaJ Heat Shock Protein Family Member C13 gene [DNAJC13], alias Receptor-Mediated Endocytosis 8 [RME-8], that was associated with the activation strength of the ventral tegmental area (VTA; p = 2.50E-07) and the nucleus accumbens (NAcc; p = 5.31E-05) in response to conditioned reward stimuli. Moreover, haplotype analysis assessing the information across the entire DNAJC13 locus demonstrated an impact of a five-marker haplotype on VTA activation (p = 3.21E-07), which further corroborates a link between this gene and reward processing. The present findings provide first direct empirical evidence that genetic variation of DNAJC13 influences neural responses within the extended reward system to conditioned stimuli. Further studies are required to investigate the role of this gene in the pathogenesis and pathophysiology of neuropsychiatric disorders.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"499-510"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of effective therapy among individuals with Cannabis Use Disorder: a review of the literature. 大麻使用障碍患者有效治疗的预测因素：文献综述。

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-03-16 DOI: 10.1007/s00406-024-01781-4

Daniel Feingold, Dana Tzur Bitan, Marica Ferri, Eva Hoch

{"title":"Predictors of effective therapy among individuals with Cannabis Use Disorder: a review of the literature.","authors":"Daniel Feingold, Dana Tzur Bitan, Marica Ferri, Eva Hoch","doi":"10.1007/s00406-024-01781-4","DOIUrl":"10.1007/s00406-024-01781-4","url":null,"abstract":"Treatment demand for Cannabis Use Disorder (CUD) has increased in the past decade in almost all European countries, and CUD is currently the most common reason for first-time drug-related treatment admission in the European Union. Even though several therapeutic approaches have been shown to benefit individuals with CUD, there is a lack of knowledge regarding factors associated with effective therapy and the underlying mechanisms of change among individuals with CUD presenting for treatment. The aim of the present paper was to review current knowledge on factors that have been shown to contribute to positive outcomes in CUD treatment. A scoping methodology was used, focusing on empirically evaluated studies that used defined, cannabis-related outcome measures. In eligible studies, factors of investigation were categorized as either 'mediators', i.e., treatment-related factors associated with the processes or mechanisms through which patients benefit from therapy, or 'moderators' which are patient-related characteristics that predict his/her odds to benefit from treatment or patient-related (i.e., moderators). Factors categorized as mediators were then classified 'specific factors' if they were related to a certain technique or treatment modality or 'common factors' if they were assessed beyond treatment modalities. Findings suggest that in CUD treatment, specific mediators include treatment duration, addressing motivation to change, acquiring coping skills, enhancing self-efficacy, and integrating several therapeutic components. Common mediators include therapeutic alliance, empathy, expectations and cultural adaptation. Moderators in CUD treatment include sex, ethnicity, age-related factors and comorbid disorders.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"341-353"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crime rates in Wernicke-Korsakoff syndrome and alcohol-related dementia may not depend solely on these disorders. Wernicke-Korsakoff 综合症和酒精相关痴呆症的犯罪率可能并不完全取决于这些疾病。

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-06-25 DOI: 10.1007/s00406-024-01845-5

Josef Finsterer

引用次数: 0

Predictors of changes in marijuana consumption in Germany during the covid-19 pandemic. covid-19大流行期间德国大麻消费变化的预测因素。

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-03-01 Epub Date: 2024-07-06 DOI: 10.1007/s00406-024-01861-5

Sally Olderbak, Justin Möckl, Christian Rauschert, Evita Schäfer, Stefanie Helmer, Nicki-Nils Seitz, Eva Hoch

{"title":"Predictors of changes in marijuana consumption in Germany during the covid-19 pandemic.","authors":"Sally Olderbak, Justin Möckl, Christian Rauschert, Evita Schäfer, Stefanie Helmer, Nicki-Nils Seitz, Eva Hoch","doi":"10.1007/s00406-024-01861-5","DOIUrl":"10.1007/s00406-024-01861-5","url":null,"abstract":"During the Covid-19 pandemic Germany experienced its first increase in the proportion of heavy cannabis users since 1995. With the expected nationwide decriminalization of cannabis before 2025, we investigate the potential causes for that increase. Data were from the 2021 European Web Survey on Drugs (EWSD) including 762 12-month marijuana users from Germany (72.9% male, mean age = 29.5 years). Both heavy and regular cannabis consumers reported an increase in marijuana consumption during the pandemic, with infrequent users reporting a decrease. Using multinomial logistic regression, we found younger individuals (OR = 0.95 [95% CI = 0.92, 0.98]) and those not pursuing or completing higher education (OR = 1.86 [1.23, 2.81]) had increased use. Additionally, using cannabis to self-medicate (OR = 2.79 [1.56, 4.99]) and purchasing marijuana (OR = 2.26 [1.35, 3.77]) was associated with increased use. We found, relative to infrequent users, both regular (OR = 4.00 [2.39, 6.72]) and notably heavy users (OR = 31.17 [12.10, 80.32]) were more likely to use cannabis to self-medicate. Both regular (OR = 4.09 [2.47, 6.77]) and especially heavy users (OR = 13.53 [6.74, 27.16]) were also more likely to purchase marijuana. Heavy users were also more likely to be past 30-day tobacco users (OR = 5.92 [2.81, 12.45]). We identified the self-reported motivation of using cannabis to self-medicate as well as act of purchasing marijuana as having the strongest relation to being a heavy user and increasing marijuana use during the Covid-19 pandemic.","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":"389-396"},"PeriodicalIF":3.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: The association between childhood trauma and tobacco smoking in patients with psychosis, unaffected siblings, and healthy controls. 更正：精神病患者、未受影响的兄弟姐妹和健康对照组的童年创伤与吸烟之间的关系。

IF 3.5 3区医学

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-03-01 DOI: 10.1007/s00406-024-01823-x

Justine de With, Heleen S van der Heijden, Therese van Amelsvoort, Maud Daemen, Claudia Simons, Behrooz Alizadeh, Daphne van Aalst, Lieuwe de Haan, Jentien Vermeulen, Frederike Schirmbeck

引用次数: 0