Predictors of Methylphenidate response in children and adolescents with ADHD: the role of sleep disturbances.

IF 3.5 3区医学 Q1 CLINICAL NEUROLOGY

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2024-11-15 DOI:10.1007/s00406-024-01932-7

Barbara D'Aiello, Deny Menghini, Silvia Di Vara, Pietro De Rossi, Stefano Vicari

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引用次数: 0

Abstract

Sleep Disturbances (SD) have been linked to children and adolescents with ADHD, impacting its progression and outcomes. Methylphenidate (MPH), a commonly used stimulant medication for ADHD treatment, has been observed to potentially influence SD as a side effect, while SD can in turn potentially affect the response to MPH. This study aimed to explore the potential role of SD on MPH response in children and adolescents with ADHD. At this aim, 43 children and adolescents with ADHD received a single dose of MPH and were assessed for attention before and after medication administration. As expected, the administration of MPH resulted in improved attention levels. Our data indicate that patients with higher SD experienced greater benefits from the medication, stabilizing Reaction Times Variability (VRTs). This suggests that SD might influence the response to MPH, with individuals exhibiting higher SD deriving more advantages from the treatment. In addition, we found that other factors, such as externalizing problems and IQ, interact with each other and with SD, influencing the response to stimulant medication. Early detection of SD, along with the study of cognitive and emotional-behavioral characteristics, could assist clinicians in predicting the effectiveness of MPH therapy in children and adolescents with ADHD. However, further research is necessary to gain a deeper understanding of the role of SD and other factors in the long-term effects of MPH.

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多动症儿童和青少年对哌醋甲酯反应的预测因素：睡眠障碍的作用。

睡眠障碍（SD）与患有多动症（ADHD）的儿童和青少年有关，会影响其病情发展和治疗效果。哌醋甲酯（MPH）是治疗多动症的常用兴奋剂药物，据观察，它的副作用可能会影响睡眠障碍，而睡眠障碍反过来又可能影响对 MPH 的反应。本研究旨在探讨 SD 对患有多动症的儿童和青少年对 MPH 反应的潜在作用。为此，43 名患有多动症的儿童和青少年接受了单剂量的 MPH，并在用药前后接受了注意力评估。不出所料，服用 MPH 后注意力得到了改善。我们的数据表明，SD值越高的患者从药物中获益越大，反应时变异性（VRTs）趋于稳定。这表明，SD 可能会影响对 MPH 的反应，SD 越高的人从治疗中获益越多。此外，我们还发现其他因素，如外化问题和智商，也会与自闭症相互作用，影响对兴奋剂药物的反应。早期发现SD，同时研究认知和情绪行为特征，可以帮助临床医生预测MPH疗法对多动症儿童和青少年的疗效。然而，要更深入地了解 SD 和其他因素在 MPH 长期疗效中的作用，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Archives of Psychiatry and Clinical Neuroscience 医学-精神病学

CiteScore

8.80

自引率

4.30%

发文量

154

审稿时长

6-12 weeks

期刊介绍： The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.