Xiaoying Dong, Tina Gupta, Gretchen Haas, Kristen L Eckstrand, Jennifer S Silk, Neal D Ryan, Erika E Forbes
{"title":"发展为严重精神疾病高风险的青少年的类精神病经历:两年以上的变化以及与神经奖励加工和情感症状的关联","authors":"Xiaoying Dong, Tina Gupta, Gretchen Haas, Kristen L Eckstrand, Jennifer S Silk, Neal D Ryan, Erika E Forbes","doi":"10.1007/s00406-025-02095-9","DOIUrl":null,"url":null,"abstract":"<p><p>Psychotic-like experiences (PLEs) -subclinical experiences or symptoms that resemble psychosis, such as hallucinations and delusional thoughts-often emerge during adolescence and are predictive of serious psychopathology. Understanding PLEs during adolescence is crucial due to co-occurring developmental changes in neural reward systems that heighten the risk for psychotic-related and affective psychopathology, especially in those with a family history of severe mental illness (SMI). We examined associations among PLEs, clinical symptoms, and neural reward function during this critical developmental period. Over two-years, 117 adolescents (aged 13-19 years at baseline) at high-risk (n = 74) or low-risk (n = 43) for SMI based on family history of affective or psychotic disorder completed symptom questionnaires annually and fMRI scanning at study entry during a guessing reward task. We assessed changes in PLEs over two-years and evaluated whether clinical symptoms (anxiety, depression, anhedonia) and response to rewards of the dorsal medial prefrontal cortex (dmPFC) and ventral striatum (VS) predicted PLEs two-years later. PLEs total scores and distress increased over time, with the high-risk group showing a greater rise in PLEs than the low-risk group. Heightened right VS neural activation and higher anxiety at baseline (but not left VS or dmPFC neural activation, depression, or anhedonia) predicted more PLEs at 24-months. Heightened vigilance and sensitivity to external stimuli may be important precursors to the development of PLEs for adolescents.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493122/pdf/","citationCount":"0","resultStr":"{\"title\":\"Psychotic-like experiences in adolescents enriched for high-risk for developing severe mental illness: change over two-years and associations with neural reward processing and affective symptoms.\",\"authors\":\"Xiaoying Dong, Tina Gupta, Gretchen Haas, Kristen L Eckstrand, Jennifer S Silk, Neal D Ryan, Erika E Forbes\",\"doi\":\"10.1007/s00406-025-02095-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Psychotic-like experiences (PLEs) -subclinical experiences or symptoms that resemble psychosis, such as hallucinations and delusional thoughts-often emerge during adolescence and are predictive of serious psychopathology. Understanding PLEs during adolescence is crucial due to co-occurring developmental changes in neural reward systems that heighten the risk for psychotic-related and affective psychopathology, especially in those with a family history of severe mental illness (SMI). We examined associations among PLEs, clinical symptoms, and neural reward function during this critical developmental period. Over two-years, 117 adolescents (aged 13-19 years at baseline) at high-risk (n = 74) or low-risk (n = 43) for SMI based on family history of affective or psychotic disorder completed symptom questionnaires annually and fMRI scanning at study entry during a guessing reward task. We assessed changes in PLEs over two-years and evaluated whether clinical symptoms (anxiety, depression, anhedonia) and response to rewards of the dorsal medial prefrontal cortex (dmPFC) and ventral striatum (VS) predicted PLEs two-years later. PLEs total scores and distress increased over time, with the high-risk group showing a greater rise in PLEs than the low-risk group. Heightened right VS neural activation and higher anxiety at baseline (but not left VS or dmPFC neural activation, depression, or anhedonia) predicted more PLEs at 24-months. Heightened vigilance and sensitivity to external stimuli may be important precursors to the development of PLEs for adolescents.</p>\",\"PeriodicalId\":11822,\"journal\":{\"name\":\"European Archives of Psychiatry and Clinical Neuroscience\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493122/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Archives of Psychiatry and Clinical Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00406-025-02095-9\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Archives of Psychiatry and Clinical Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00406-025-02095-9","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Psychotic-like experiences in adolescents enriched for high-risk for developing severe mental illness: change over two-years and associations with neural reward processing and affective symptoms.
Psychotic-like experiences (PLEs) -subclinical experiences or symptoms that resemble psychosis, such as hallucinations and delusional thoughts-often emerge during adolescence and are predictive of serious psychopathology. Understanding PLEs during adolescence is crucial due to co-occurring developmental changes in neural reward systems that heighten the risk for psychotic-related and affective psychopathology, especially in those with a family history of severe mental illness (SMI). We examined associations among PLEs, clinical symptoms, and neural reward function during this critical developmental period. Over two-years, 117 adolescents (aged 13-19 years at baseline) at high-risk (n = 74) or low-risk (n = 43) for SMI based on family history of affective or psychotic disorder completed symptom questionnaires annually and fMRI scanning at study entry during a guessing reward task. We assessed changes in PLEs over two-years and evaluated whether clinical symptoms (anxiety, depression, anhedonia) and response to rewards of the dorsal medial prefrontal cortex (dmPFC) and ventral striatum (VS) predicted PLEs two-years later. PLEs total scores and distress increased over time, with the high-risk group showing a greater rise in PLEs than the low-risk group. Heightened right VS neural activation and higher anxiety at baseline (but not left VS or dmPFC neural activation, depression, or anhedonia) predicted more PLEs at 24-months. Heightened vigilance and sensitivity to external stimuli may be important precursors to the development of PLEs for adolescents.
期刊介绍:
The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience.
Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered.
Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.