Environmental toxicology and pharmacology最新文献_第5页

Multiple biochemical responses, osmoregulation, fatty acid composition, and vitamin E level in crayfish as biomarkers of exposure to thiacloprid and trifloxystrobin pesticides 小龙虾暴露于噻虫啉和三氯虫酯农药后的多种生化反应、渗透调节、脂肪酸组成和维生素E水平

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-09 DOI: 10.1016/j.etap.2025.104788

Miraç Uçkun , Aysel Alkan Uçkun , Özden Barım Öz , Ertan Yoloğlu

{"title":"Multiple biochemical responses, osmoregulation, fatty acid composition, and vitamin E level in crayfish as biomarkers of exposure to thiacloprid and trifloxystrobin pesticides","authors":"Miraç Uçkun , Aysel Alkan Uçkun , Özden Barım Öz , Ertan Yoloğlu","doi":"10.1016/j.etap.2025.104788","DOIUrl":"10.1016/j.etap.2025.104788","url":null,"abstract":"<div><div>Neonicotinoids and strobilurins are commonly used pesticides in agriculture, posing significant risks to aquatic animals. In this study, the toxic effects of thiacloprid and trifloxystrobin on <em>Astacus leptodactylus</em> were evaluated using various biomarkers, including acetylcholinesterase, carboxylesterase, glutathione S-transferase, glutathione reductase, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, total antioxidant content, total oxidant scavenging capacity, adenosine 5’-TriPhospahatases, fatty acid composition, and vitamin E level. Both pesticides significantly affected the biomarkers compared to the control, activating and inhibiting them. Exposure to the pesticides led to an increase in monounsaturated and saturated fatty acids and a significant decrease in polyunsaturated fatty acids and vitamin E. The study’s findings suggest that thiacloprid and trifloxystrobin have harmful effects on <em>A. leptodactylus</em> through oxidative stress, detoxification, cholinergic, osmoregulation, and food quality systems. It is possible to conclude that these pesticides pose a major risk to public health as well as the aquatic ecology.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104788"},"PeriodicalIF":4.2,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-term effects of acetamiprid on common carp: Genotoxic, biochemical, and histopathological responses 对乙酰氨脒对鲤鱼的短期影响：基因毒性、生化和组织病理学反应。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-09 DOI: 10.1016/j.etap.2025.104787

Göktuğ Gül , Pınar Arslan Yüce , Aysel Çağlan Günal , Caterina Faggio

引用次数: 0

Acute toxic effects of an imidacloprid-based commercial insecticide in Caenorhabditis elegans 吡虫啉类商业杀虫剂对秀丽隐杆线虫的急性毒性作用。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-09 DOI: 10.1016/j.etap.2025.104783

Julia Machado Menezes , Belisa Avila Rodrigues , Dora de Athayde Saul , Ariane da Silva Goulart , Matteus Teixeira Guerra , Daiana Silva Ávila , Karine Rigon Zimmer , Eliane Dallegrave

{"title":"Acute toxic effects of an imidacloprid-based commercial insecticide in Caenorhabditis elegans","authors":"Julia Machado Menezes , Belisa Avila Rodrigues , Dora de Athayde Saul , Ariane da Silva Goulart , Matteus Teixeira Guerra , Daiana Silva Ávila , Karine Rigon Zimmer , Eliane Dallegrave","doi":"10.1016/j.etap.2025.104783","DOIUrl":"10.1016/j.etap.2025.104783","url":null,"abstract":"<div><div>Imidacloprid (IMI), a neonicotinoid insecticide, targets postsynaptic nicotinic acetylcholine receptors, resulting in neurotoxicity in insects. Although selective for insects, IMI may have adverse effects on non-target species. This study investigated the acute toxicity of the commercial IMI formulation, Much 600 FS®, in <em>Caenorhabditis elegans</em>. L1-stage nematodes were acutely exposed to IMI at 2.4, 4.8, 7.2, 9.6, and 14.4 g/L concentrations. Developmental inhibition was observed at all concentrations, while significant mortality and reduced brood size occurred at 14.4 g/L. Behavioral assays revealed concentration-dependent decreases in pharyngeal pumping and locomotion. Cholinergic neuronal damage was evident at 7.2 g/L and above, indicating neurotoxicity. Our findings demonstrate that Much 600 FS® exerts toxic effects on <em>C. elegans</em> across developmental, behavioral, reproductive, and neuronal parameters, highlighting its potential risk to non-target organisms, even at sublethal levels.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104783"},"PeriodicalIF":4.2,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How are host-parasite interactions affected by veterinary anti-parasitic treatment? An experimental approach 兽医抗寄生虫治疗如何影响宿主-寄生虫相互作用？实验方法。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-08 DOI: 10.1016/j.etap.2025.104782

Léa Lorrain-Soligon , Simon Agostini , Clotilde Biard , Beatriz Decencière , Baptiste Lemaire , Alexis Millot , Sandrine Meylan , Eliott Salles , Aurélie Goutte

{"title":"How are host-parasite interactions affected by veterinary anti-parasitic treatment? An experimental approach","authors":"Léa Lorrain-Soligon , Simon Agostini , Clotilde Biard , Beatriz Decencière , Baptiste Lemaire , Alexis Millot , Sandrine Meylan , Eliott Salles , Aurélie Goutte","doi":"10.1016/j.etap.2025.104782","DOIUrl":"10.1016/j.etap.2025.104782","url":null,"abstract":"<div><div>The effects of veterinary anti-parasitic compounds on wild fish species and their parasites are poorly investigated. Bithionol, an antibacterial, anthelmintic, and algaecide, is commonly used in aquaculture to control parasitic infections, particularly acanthocephalan (spiny-headed worm) infestations. This study aims to evaluate the impacts of bithionol exposure on European chub (<em>Squalius cephalus</em>) originating from natural populations, and its naturally occurring acanthocephalans. We assessed fish behavioral responses, alongside physiological markers, in addition with response of their parasites (number, size, reproductive outputs). Our results indicate that bithionol exposure induces behavioral alterations (increased opercular movements, altered spatial positioning), but does not significantly affect key physiological markers. Furthermore, acanthocephalan parasites influence host immunity and behavior, but their presence does not mitigate (decrease or increase) the effects of bithionol on fish. Contrary to expectations, bithionol treatment does not affect parasites, suggesting potential resistance or environmental factors affecting its efficacy.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104782"},"PeriodicalIF":4.2,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biochemical, behavioural and mitochondria respiratory responses to neurotoxicity associated with nickel chloride exposure in lobster cockroach Nauphoeta cinerea 氯化镍暴露对龙虾蟑螂神经毒性的生化、行为和线粒体呼吸反应。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-08 DOI: 10.1016/j.etap.2025.104779

Stanley U. Nwawuba , Blessing A. Obafemi , Alessandro S. Prestes , Isaac A. Adedara , Michael Aschner , Joao B.T. Rocha

{"title":"Biochemical, behavioural and mitochondria respiratory responses to neurotoxicity associated with nickel chloride exposure in lobster cockroach Nauphoeta cinerea","authors":"Stanley U. Nwawuba , Blessing A. Obafemi , Alessandro S. Prestes , Isaac A. Adedara , Michael Aschner , Joao B.T. Rocha","doi":"10.1016/j.etap.2025.104779","DOIUrl":"10.1016/j.etap.2025.104779","url":null,"abstract":"<div><div>Nickel (II) chloride (NiCl₂) is an environmental toxicant that may cause neurotoxicity. This study investigated the effects of 30-day dietary exposure to NiCl₂ (0.01, 0.1, and 1 mg/g) in <em>Nauphoeta cinerea</em>, focusing on body weight, oxidative stress, behavior, and mitochondrial function. Exposure to 1 mg/g reduced body weight and food intake. All concentrations impaired some exploratory behavioral parameters (e.g., distance travelled and average speed). Oxidative stress markers, including TBARS and ROS, increased, along with GST and SOD activity. Neurotransmitter metabolism was affected, with elevated acetylcholinesterase and reduced monoamine oxidase activity. Mitochondrial respiration showed impaired oxidative phosphorylation, altered proton leakage, and decreased complex II activity, indicating mitochondrial dysfunction. These findings demonstrate that NiCl₂ (1 mg/g) disrupts mitochondrial neuroenergetics and redox balance. Notably, behavioral impairments occurred even at the lowest concentrations, suggesting that subtle changes in activity may serve as early indicators of NiCl₂-induced neurotoxicity.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104779"},"PeriodicalIF":4.2,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of phthalate metabolites in urine and follicular fluid with endometrial thickness in the TREE cohort TREE队列中尿和卵泡液中邻苯二甲酸酯代谢物与子宫内膜厚度的关系

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-07 DOI: 10.1016/j.etap.2025.104781

Xiu-Ting Li , Chong Liu , Yan-Ling Deng , Yu Miao , Min Zhang , Jia-Yue Zeng , Peng-Hui Liu , A.-Xue Liu , Yang-Juan Li , Jin-Qin Zhu , Ning Zhang , Juan Li , Yu-Feng Li , Tao-Ran Deng , Qiang Zeng

{"title":"Associations of phthalate metabolites in urine and follicular fluid with endometrial thickness in the TREE cohort","authors":"Xiu-Ting Li , Chong Liu , Yan-Ling Deng , Yu Miao , Min Zhang , Jia-Yue Zeng , Peng-Hui Liu , A.-Xue Liu , Yang-Juan Li , Jin-Qin Zhu , Ning Zhang , Juan Li , Yu-Feng Li , Tao-Ran Deng , Qiang Zeng","doi":"10.1016/j.etap.2025.104781","DOIUrl":"10.1016/j.etap.2025.104781","url":null,"abstract":"<div><div>Endometrial thickness (EMT) is a crucial indicator of female fecundity and pregnancy success. Experimental studies have suggested that phthalates can disrupt EMT by exerting estrogenic effects or affecting the expression of related receptors, but human evidence is scarce. We aimed to explore the relationships of phthalate metabolites in paired urine and follicular fluid (FF) with EMT among 548 women undergoing assisted reproductive technology (ART). In single-pollutant analyses, all urinary di(2-ethylhexyl) phthalate (DEHP) metabolites were positively linked with follicular phase EMT (all <em>p</em> for trends ≤ 0.01) and higher risks of thick EMT (all <em>p</em> for trends ≤ 0.10). Meanwhile, mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) in FF showed similar positive associations (both <em>p</em> for trends ≤ 0.01). Bayesian kernel machine regression (BKMR) models revealed that phthalate mixtures in urine and FF were positively associated with follicular phase EMT or the risk of thick EMT. Our results indicated that DEHP exposure may increase EMT among women undergoing ART.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104781"},"PeriodicalIF":4.2,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concentration-dependent biphasic toxicity and steroidogenic stimulation by aminocarb in murine Leydig cells 氨基威对小鼠间质细胞的浓度依赖性双相毒性和甾体性刺激。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-07-30 DOI: 10.1016/j.etap.2025.104777

Sílvia Moreira , Ana D. Martins , Raquel L. Bernardino , Marisa Pinho , Inês M.S. Guerra , M. Rosário Domingues , Marco G. Alves , Luis Miguel Pastor , Vicente Seco-Rovira , Maria de Lourdes Pereira , Pedro F. Oliveira

{"title":"Concentration-dependent biphasic toxicity and steroidogenic stimulation by aminocarb in murine Leydig cells","authors":"Sílvia Moreira , Ana D. Martins , Raquel L. Bernardino , Marisa Pinho , Inês M.S. Guerra , M. Rosário Domingues , Marco G. Alves , Luis Miguel Pastor , Vicente Seco-Rovira , Maria de Lourdes Pereira , Pedro F. Oliveira","doi":"10.1016/j.etap.2025.104777","DOIUrl":"10.1016/j.etap.2025.104777","url":null,"abstract":"<div><div>Exposure to environmental chemicals, like pesticides, can impair male reproductive health by affecting Leydig cell (LC) function. This study investigated aminocarb, a widely used carbamate pesticide, and its impact on murine LCs (BLTK1 cell line). We observed a concentration-dependent biphasic toxicity, where higher aminocarb concentrations (500 μM) reduced LC viability, while lower doses (5 and 50 μM) unexpectedly increased it. Aminocarb selectively disrupted mitochondrial complexes I and III without altering overall mitochondrial respiration or reactive oxygen species (ROS) production. Notably, 50 μM aminocarb enhanced androstenedione production, a key androgen precursor. This research highlights the nuanced impact of aminocarb on LCs, suggesting targeted mitochondrial effects and steroidogenic stimulation, with implications for male reproductive health and environmental toxicology.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104777"},"PeriodicalIF":4.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human neurons are susceptible to the internalization of small-sized nanoplastics 人类神经元容易受到小尺寸纳米塑料内在化的影响。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-07-29 DOI: 10.1016/j.etap.2025.104776

Tomohiro Ito , Yudai Ikuno , Osamu Udagawa , Kosuke Tanaka , Yoshika Kurokawa , Masaki Kakeyama , Fumihiko Maekawa

{"title":"Human neurons are susceptible to the internalization of small-sized nanoplastics","authors":"Tomohiro Ito , Yudai Ikuno , Osamu Udagawa , Kosuke Tanaka , Yoshika Kurokawa , Masaki Kakeyama , Fumihiko Maekawa","doi":"10.1016/j.etap.2025.104776","DOIUrl":"10.1016/j.etap.2025.104776","url":null,"abstract":"<div><div>Environmental pollution caused by small plastics has become a social concern due to growing awareness of their adverse impacts on organisms, including humans. While the brain has been identified as a major site of small plastic accumulation, fundamental information about their impacts at the cellular level remains limited. In this study, we investigated the neuronal uptake and toxicity of nanoplastics using the human neurons (LUHMES). LUHMES cells internalized polystyrene (PS) nanoplastics with a preference for 50 nm particles, mainly through clathrin-mediated endocytosis and macropinocytosis. However, PS uptake by LUHMES cells was lower than that by other neural cell types. PS nanoparticles were predominantly localized in lysosomes and minimally in mitochondria. On the other hand, PS nanoparticles had no obvious effects on acute cytotoxicity, neurite outgrowth, and oxidative stress. This study provides essential data on the neuronal responses to nanoplastics and highlights the need for further evaluation of their neurodevelopmental impact.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104776"},"PeriodicalIF":4.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual environmental stressors: How pH modulates antibiotic toxicity in Danio rerio? 双重环境应激源：pH值如何调节达尼奥鱼的抗生素毒性？

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-07-25 DOI: 10.1016/j.etap.2025.104774

Bárbara S. Diogo , Sara Rodrigues , Oksana Golovko , Sara C. Antunes

{"title":"Dual environmental stressors: How pH modulates antibiotic toxicity in Danio rerio?","authors":"Bárbara S. Diogo , Sara Rodrigues , Oksana Golovko , Sara C. Antunes","doi":"10.1016/j.etap.2025.104774","DOIUrl":"10.1016/j.etap.2025.104774","url":null,"abstract":"<div><div>Aquatic ecosystems are increasingly subjected to environmental stressors, including pH fluctuations, and antibiotic contamination, which can disrupt essential biological functions such as metabolism, respiration, and reproduction. The interaction between these stressors presents significant ecological risks, as pH affects the toxicity, pharmacodynamics/kinetics of antibiotics by altering their ionization state and membrane permeability. This study assessed the toxicity of environmentally relevant concentrations of sulfamethoxazole (150 µg SMX/L), trimethoprim (30 µg TRIM/L), and their mixture (MIX: 150 µg SMX/L + 30 µg TRIM/L) under different pH conditions (6.5, 7.5, and 9.0) on <em>Danio rerio</em> juveniles. A multi-biomarker approach was used to assess <em>D. rerio</em> biological health status, including oxidative stress responses, lipid peroxidation, cholinergic neurotransmission, energetic metabolism, and DNA damage. Results revealed that SMX was marginally toxic across all pH scenarios, but caused more severe effects such as oxidative stress, lipid peroxidation, and DNA damage, under acidic pH. In contrast, TRIM toxicity increased at neutral and alkaline pH, causing severe alterations in antioxidant defenses and cellular integrity. The MIX treatment exhibited marginal toxicity at acidic and alkaline pH but was moderately toxic at neutral pH, leading to oxidative stress, lipid peroxidation, and DNA damage. These physiological and metabolic disruptions highlight how antibiotic mixtures, under varying pH conditions, can impair critical biological functions in aquatic organisms. These findings emphasize the urgent need for integrated research addressing multiple environmental stressors, particularly chemical contamination and climate change-driven abiotic factors. Ignoring these threats could lead to irreversible damage to aquatic ecosystems and biodiversity.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104774"},"PeriodicalIF":4.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the effects of Glyphosate and Roundup on Sertoli cell proliferation 草甘膦和农达对支持细胞增殖影响的分析。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-07-24 DOI: 10.1016/j.etap.2025.104775

Cecilia Lucia Centola, Marina Ercilia Dasso, Agostina Gorga, Gustavo Marcelo Rindone, Maria Noel Galardo, Maria Fernanda Riera, Silvina Beatriz Meroni

引用次数: 0