Environmental toxicology and pharmacology最新文献_第5页

Comparative toxicities of commonly used agricultural insecticides to four honey bee species (Hymenoptera: Apidae) in Vietnam 越南常用农业杀虫剂对四种蜜蜂（膜翅目：蜂科）的毒性比较。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104605

Thai H. Pham , Ngoc T. Phan , Duy D. Trinh , Ha N. Duong , Phuong T. Tran , Khanh D. Nguyen , Gadi V.P. Reddy , Chuleui Jung , Neelendra K. Joshi

{"title":"Comparative toxicities of commonly used agricultural insecticides to four honey bee species (Hymenoptera: Apidae) in Vietnam","authors":"Thai H. Pham , Ngoc T. Phan , Duy D. Trinh , Ha N. Duong , Phuong T. Tran , Khanh D. Nguyen , Gadi V.P. Reddy , Chuleui Jung , Neelendra K. Joshi","doi":"10.1016/j.etap.2024.104605","DOIUrl":"10.1016/j.etap.2024.104605","url":null,"abstract":"<div><div>Beekeeping for honey production is a vital economic activity in Vietnam, significantly contributing to the nation's agricultural exports and poverty alleviation. However, the widespread use of pesticides, compounded by insufficient regulations, poses serious challenges to the industry and threatens bee health. This study examined the oral toxicities of five commonly used agricultural insecticides including bifenthrin, imidacloprid, thiacloprid, thiamethoxam, and chlorantraniliprole, on four honey bee species prevalent in Vietnam: the Asian honey bee (<em>Apis cerana</em>), the European honey bee (<em>A. mellifera</em>), the giant honey bee (<em>A. dorsata</em>), and the red dwarf honey bee (<em>A. florea</em>). Our results indicated significant variability in toxicity among the pesticides and honey bee species, with the managed species <em>A. cerana</em> showing the highest tolerance across all tested insecticides. In contrast, the wild species <em>A. dorsata</em> and <em>A. florea</em> were significantly more sensitive. These findings highlight the need to develop a pesticide risk assessment and improve pesticide regulations that consider the impacts on a broader range of honey bee species beyond <em>A. mellifera</em>.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104605"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive tetracycline, ciprofloxacin and sulfamethoxazole toxicity evaluation to earthworm Dendrobaena veneta through life-cycle, behavioral and biochemical parameters 四环素、环丙沙星、磺胺甲恶唑对蚯蚓生命周期、行为及生化指标的综合毒性评价

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104609

Jūratė Žaltauskaitė , Diana Miškelytė, Gintarė Sujetovienė, Austra Dikšaitytė, Giedrė Kacienė, Irena Januškaitienė, Renata Dagiliūtė

{"title":"Comprehensive tetracycline, ciprofloxacin and sulfamethoxazole toxicity evaluation to earthworm Dendrobaena veneta through life-cycle, behavioral and biochemical parameters","authors":"Jūratė Žaltauskaitė , Diana Miškelytė, Gintarė Sujetovienė, Austra Dikšaitytė, Giedrė Kacienė, Irena Januškaitienė, Renata Dagiliūtė","doi":"10.1016/j.etap.2024.104609","DOIUrl":"10.1016/j.etap.2024.104609","url":null,"abstract":"<div><div>Veterinary antibiotics are widely spread in the environment, however, the knowledge about their impact on soil key species is still limited. This study evaluated the short-term and long-term effects of tetracycline (TC), ciprofloxacin (CIP) and sulfamethoxazole (SMX) (1–500 mg kg) on earthworm <em>Dendrobaena veneta</em> by measuring multiple parameters (survival, growth, reproduction, behavior and biochemical responses). Neither antibiotic induced acute toxicity and low mortality was observed after chronic exposure. TC and CIP had a negligible effect on the earthworm’s weight from the 6th week of exposure, SMX inhibited the earthworm growth when was present in the range of 50–500 mg kg<sup>−1</sup>. In parallel, SMX reduced earthworm reproduction at environmentally relevant concentrations. Antibiotics altered superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) and gluthathione-S-transferase (GST) activities and induced lipid peroxidation. Overall, earthworms showed no apparent acute response at environmentally relevant concentrations except for avoidance behavior; after long-term exposure earthworms experienced biochemical, physiological, and reproductive impairments and reduced survival at high soil contamination.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104609"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicity assessment of effluent from a potato-processing industry in Cyprinus carpio 鲤鱼马铃薯加工业废水的毒性评价。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104616

Carine Baggiotto , Marciano Friedrich , Vania Lucia Loro , Tiele Medianeira Rizzetti , Renato Zanella , Jossiele Wesz Leitemperger , Bárbara Estevao Clasen , Rosana de Cassia De Souza Schneider , Francisco Rossarolla Forgiarini

{"title":"Toxicity assessment of effluent from a potato-processing industry in Cyprinus carpio","authors":"Carine Baggiotto , Marciano Friedrich , Vania Lucia Loro , Tiele Medianeira Rizzetti , Renato Zanella , Jossiele Wesz Leitemperger , Bárbara Estevao Clasen , Rosana de Cassia De Souza Schneider , Francisco Rossarolla Forgiarini","doi":"10.1016/j.etap.2024.104616","DOIUrl":"10.1016/j.etap.2024.104616","url":null,"abstract":"<div><div>Potato (<em>Solanum tuberosum)</em> cultivation faces the challenge of excessive pesticide use. During processing, the disposal of large volumes of contaminated water into water bodies can result in severe environmental damage, such as fish deaths. This study aimed to evaluate the toxicological effects of chemical compounds present in the effluent from a potato-processing industry using the test organism <em>Cyprinus carpio</em>. The liver, gills, muscles, and brain were analyzed for biochemical parameters such as catalase (CAT), superoxide dismutase (SOD), acetylcholinesterase (AChE), and lipid peroxidation (TBARS). The highest quantities of pesticides found in the effluent were atrazine, azoxystrobin, fipronil, flutolanil, imidacloprid, tebuconazole, and thiamethoxam. Fish were exposed to the effluent for 7, 14, and 28 days in the laboratory. The CAT enzyme increased activity in the gills at 7 (p-value=0.000) and 14 days (p-value=0.003). Lipid peroxidation showed an increase in the gills at seven days (p-value=0.0281) and in the liver at 7 (p-value=0.000) and 14 days (p-value=0.000). There was also a significant increase (p-value=0.000) in AChE activity in the muscle at all periods. This result highlights the environmental risk and toxicity of potato effluent containing pesticide residues, which can cause biochemical damage to <em>C. carpio</em> and other living organisms.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104616"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing azithromycin's ecological toll: Unveiling multifaceted impacts on Poecilia reticulata THROUGH biomarker analysis 评估阿奇霉素的生态代价：通过生物标志物分析揭示对网状水蛭的多方面影响。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104617

Gabriela Pustiglione Marinsek , Manuela Agullo Tagliamento , Isabelly Cristina Correia dos Santos Oliveira , Anna Capaldo , Paloma Kachel Gusso-Choueri , Caio César Ribeiro , Ana Carolina Cruz Feitosa , Denis Moledo de Souza Abessa , Marcos Antônio Oliveira , Renata de Britto Mari

{"title":"Assessing azithromycin's ecological toll: Unveiling multifaceted impacts on Poecilia reticulata THROUGH biomarker analysis","authors":"Gabriela Pustiglione Marinsek , Manuela Agullo Tagliamento , Isabelly Cristina Correia dos Santos Oliveira , Anna Capaldo , Paloma Kachel Gusso-Choueri , Caio César Ribeiro , Ana Carolina Cruz Feitosa , Denis Moledo de Souza Abessa , Marcos Antônio Oliveira , Renata de Britto Mari","doi":"10.1016/j.etap.2024.104617","DOIUrl":"10.1016/j.etap.2024.104617","url":null,"abstract":"<div><div>This study investigates the impact of environmentally relevant concentrations of azithromycin on <em>Poecilia reticulata</em>, through biomarkers at different levels. To this end, the somatic indexes of <em>P. reticulata</em> were evaluated, and liver and gill samples were collected and analyzed for biochemical and histopathological alterations. Azithromycin caused significant effects in <em>P. reticulata</em>, such as increased hepatosomatic index, altered redox responses, particularly in gills, indicating oxidative stress, and notable tissue damage in the liver and gills in a dose-dependent response manner. Principal Component Analysis highlighted differences between control and exposed groups, demonstrating the azithromycin's influence on organismal homeostasis. This research underscores the importance of understanding azithromycin action in nontarget organisms of aquatic environments.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104617"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engraftment after pediatric hematopoietic stem cell transplantation and its association with recipient and donor phthalate and bisphenol A exposure levels: A cohort study 儿童造血干细胞移植后的植入及其与受体和供体邻苯二甲酸盐和双酚A暴露水平的关系：一项队列研究。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-12-27 DOI: 10.1016/j.etap.2024.104625

Sıddika Songül Yalçın , Esin Okman , Bülent Barış Kuşkonmaz , Suzan Yalçın , Osman Aykut , Duygu Uçkan Çeti̇nkaya

{"title":"Engraftment after pediatric hematopoietic stem cell transplantation and its association with recipient and donor phthalate and bisphenol A exposure levels: A cohort study","authors":"Sıddika Songül Yalçın , Esin Okman , Bülent Barış Kuşkonmaz , Suzan Yalçın , Osman Aykut , Duygu Uçkan Çeti̇nkaya","doi":"10.1016/j.etap.2024.104625","DOIUrl":"10.1016/j.etap.2024.104625","url":null,"abstract":"<div><div>Phthalates and bisphenols, ubiquitous compounds found in various everyday products, have garnered attention due to their potential health-disrupting effects. This study aimed to (1) investigate urinary phthalate metabolites and bisphenol A (BPA) levels in donors and recipients prior to allogeneic hematopoietic stem cell transplantation (HSCT) and monitor changes in these compounds in pediatric recipients at different time points (day-9, day 0, day+7, day+28, day+90), and (2) assess their association with engraftment success. Urine samples from pediatric recipients and donors were collected for analysis of phthalate metabolites and BPA in 34 donor-recipient pairs. Monomethyl phthalate metabolite was not detectable in any of the urine samples. A notable increase in phthalate metabolites and BPA levels was observed in recipients starting from day+28. Granulocyte engraftment time showed a positive correlation with donor urinary levels of mono-n-butyl phthalate (MBP), mono-2-ethylhexyl phthalate (MEHP), and monobenzyl phthalate metabolites with recipient MBP levels measured on day-9. Moreover, donor urinary MBP and MEHP levels were also linked to delayed platelet engraftment. No relationship was observed between engraftment timing and the urine levels of monoethyl phthalate metabolite or BPA in donor-recipient pairs. In cases of mucositis, MEHP and MEP levels on day 0 were higher compared to the non-mucositis group. No relationship was identified between hemorrhagic cystitis and the levels of urine phthalate metabolites or BPA. These findings highlight the potential role of plasticizer exposure in influencing engraftment outcomes, although no significant associations were found between MEP or BPA levels and engraftment.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"114 ","pages":"Article 104625"},"PeriodicalIF":4.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of detoxification of xenobiotic aromatic amine dyes by N-acetyltransferase 1 (NAT1) enzyme on human keratinocytes cells through structural modification N-acetyltransferase 1（NAT1）酶通过结构修饰增强人类角朊细胞对异生物芳香胺染料的解毒作用。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-12-25 DOI: 10.1016/j.etap.2024.104622

Gopalakrishnan Venkatesan , Huan-Qing Yang , Hong Chen , Paul Bigliardi , Giorgia Pastorin

{"title":"Enhancement of detoxification of xenobiotic aromatic amine dyes by N-acetyltransferase 1 (NAT1) enzyme on human keratinocytes cells through structural modification","authors":"Gopalakrishnan Venkatesan , Huan-Qing Yang , Hong Chen , Paul Bigliardi , Giorgia Pastorin","doi":"10.1016/j.etap.2024.104622","DOIUrl":"10.1016/j.etap.2024.104622","url":null,"abstract":"<div><div>The metabolic conversion of aromatic amines to N-acetylated forms in skin and keratinocytes depends on N-acetyltransferase-1 (NAT1). Common hair color ingredient such as para-phenylenediamine (PPD) causes allergic contact dermatitis. We explored how different electronic substituents on PPD aided NAT1 enzyme biotransform oxidative arylamine (AA) compounds G1-G13 by N-acetylation, NAT-1 activity assays, metabolism, and in vitro clearance investigations in human keratinocytes, while identifying NAT-1 protein levels by Western blot and qRT-PCR. Electron-donating groups (EDG) compounds G2,G3,and G8, N-acetylate at a higher rate (58–62 nmol/mg/min), increase NAT1 activity by 20–25 %, and showed 3.4–3.8 times faster elimination and clearance rates than electron withdrawing groups (EWG) compounds G6 and G11. We found that chemicals substituted with EDG at ortho position increase aromatic system electron density, improving N-acetylation and detoxification on HaCaT cells. Our research facilitates the effective identification of aromatic amine hair dyes characterized by rapid metabolism, detoxification, and environmental safety.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"114 ","pages":"Article 104622"},"PeriodicalIF":4.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-disciplinary investigation identifies increased potency of ethyl-parathion inhaled within a soil-dust matrix to cause acetylcholinesterase-dependent molecular impacts 多学科研究发现在土壤-粉尘基质中吸入乙基对硫磷的效力增加，导致乙酰胆碱酯酶依赖的分子影响。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-12-20 DOI: 10.1016/j.etap.2024.104615

Kurt A. Gust , Saroj K. Amar , Chet P. Gut , Renee M. Styles , Ranju R. Karna , R. Arden James , David M. Holtzapple , Joshua.L. Stricker , Shawn M. McInturf , Elizabeth A. Phillips , Cary Honnold , Xiao Luo , Karen L. Mumy , David R. Mattie , Mark A. Chappell , Michael L. Mayo

{"title":"Multi-disciplinary investigation identifies increased potency of ethyl-parathion inhaled within a soil-dust matrix to cause acetylcholinesterase-dependent molecular impacts","authors":"Kurt A. Gust , Saroj K. Amar , Chet P. Gut , Renee M. Styles , Ranju R. Karna , R. Arden James , David M. Holtzapple , Joshua.L. Stricker , Shawn M. McInturf , Elizabeth A. Phillips , Cary Honnold , Xiao Luo , Karen L. Mumy , David R. Mattie , Mark A. Chappell , Michael L. Mayo","doi":"10.1016/j.etap.2024.104615","DOIUrl":"10.1016/j.etap.2024.104615","url":null,"abstract":"<div><div>Neurotoxicity investigations of inhaled organophosphorus pesticide (OP), ethyl-parathion (EP), were conducted in Sprague Dawley rats comparing exposures to EP volatilized at 0, 1, 10, and 20 mg/m<sup>3</sup> versus EP incorporated into soil dust (5 mg/m<sup>3</sup>) at 0, 0.0095, 0.09, and 0.185 mg/mg<sup>3</sup>. All exposures were sublethal, caused no respiratory effects, and no effects on balance and coordination behavior. Both volatilized and dust-incorporated EP exposures significantly decreased acetylcholinesterase (AChE) activity in plasma and hippocampus tissue. Correspondingly, plasma and hippocampal dopamine levels spiked in these exposures suggesting compensatory cholinergic / dopaminergic signal balancing. The EP exposures significantly increased expression of pro-inflammatory genes, including MAPK-14, IL6, IL1β, and TNF-α, while global RNA-seq results identified significant enrichment of inflammation, oxidative stress, and apoptosis pathways. Remarkably, dust-incorporated EP impacted similar molecular endpoints as volatilized EP but at concentrations two orders of magnitude lower highlighting potentially increased potency of EP incorporated into soil dust.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"114 ","pages":"Article 104615"},"PeriodicalIF":4.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mechanism of all-trans retinoic acid-induced cleft palate may be related to the novel ENSMUST00000159153-miR-137–5p-Wnt7a and ENSMUST000000236086-miR-34b-3p-EphA10/TRPM2 ceRNA crosstalk 全反式维甲酸诱发腭裂的机制可能与新型ENSMUST00000159153-miR-137-5p-Wnt7a和ENSMUST000000236086-miR-34b-3p-EphA10/TRPM2 ceRNA串扰有关。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-12-20 DOI: 10.1016/j.etap.2024.104623

Zengli Yu , Yaxin Zhang , Guoxu Wang , Shuaixing Song , Hexin Su , Yang Wu , Yuwei Zhang , Pengfei Liu , Xiaozhuan Liu

{"title":"The mechanism of all-trans retinoic acid-induced cleft palate may be related to the novel ENSMUST00000159153-miR-137–5p-Wnt7a and ENSMUST000000236086-miR-34b-3p-EphA10/TRPM2 ceRNA crosstalk","authors":"Zengli Yu , Yaxin Zhang , Guoxu Wang , Shuaixing Song , Hexin Su , Yang Wu , Yuwei Zhang , Pengfei Liu , Xiaozhuan Liu","doi":"10.1016/j.etap.2024.104623","DOIUrl":"10.1016/j.etap.2024.104623","url":null,"abstract":"<div><div>Cleft palate is the most prevalent congenital condition. Cleft palate is brought on by an exogenous chemical called all-trans retinoic acid (atRA). In order to indirectly control gene expression, long chain non-coding RNAs (lncRNAs) act as competitive endogenous RNA (ceRNA) sponges. Its exact mode of action in cleft palate has not yet been determined. The purpose of this study was to determine whether lncRNAs and miRNAs regulated palatal fusion genes during the formation of cleft palate and to offer a possible course for cleft palate target gene therapy. In this work, we created a cleft palate model using atRA, conducted RNA sequencing (RNA-seq) to identify the genes that differed between the atRA-treated group and the control group, and built the lncRNA-miRNA-mRNA ceRNA network based on the projected ceRNA. The results were confirmed using a quantitative real-time polymerase chain reaction (qRT-PCR). ENSMUST00000159153-miR-137–5p-Wnt7a and ENSMUST000000236086-miR-34b-3p-EphA10/TRPM2 may be the main causes of atRA-induced cleft palate, according to the results.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"114 ","pages":"Article 104623"},"PeriodicalIF":4.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compound-dependent fetal toxicity after in utero exposure to chemotherapy in a pregnant mouse model 妊娠小鼠模型在子宫内暴露于化疗后的化合物依赖性胎儿毒性

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-12-01 DOI: 10.1016/j.etap.2024.104594

Ilana Struys , Ji-Ying Song , Carolina Velázquez , Terry Boadum , Marloes J. Posch , Marieke van de Ven , Liesbeth Lenaerts , Frédéric Amant

{"title":"Compound-dependent fetal toxicity after in utero exposure to chemotherapy in a pregnant mouse model","authors":"Ilana Struys , Ji-Ying Song , Carolina Velázquez , Terry Boadum , Marloes J. Posch , Marieke van de Ven , Liesbeth Lenaerts , Frédéric Amant","doi":"10.1016/j.etap.2024.104594","DOIUrl":"10.1016/j.etap.2024.104594","url":null,"abstract":"<div><div>Although chemotherapy is integrated in the treatment of second-trimester pregnant cancer patients, its potential cyto- and genotoxicity to fetal tissue remains unknown. To investigate any causal relation between <em>in utero</em> chemotherapy exposure and fetal toxicity, late-gestation pregnant BL6 mice were exposed to vehicle, or one of six chemotherapeutic compounds, used to treat pregnant cases: cyclophosphamide, carboplatin, cisplatin (alkylating agents), epirubicin, doxorubicin (anthracyclines) or paclitaxel (taxane). fetuses were euthanized at gestational day 18.5, after 48 hours of <em>in utero</em> exposure. Fetuses <em>in utero</em> exposed to alkylating agents presented with morphological changes in liver, bone marrow and thymus. Furthermore, decreased expression of Ki67, and increased expression of caspase-3 and P-H2AX markers, pointed to inhibited proliferation and increased apoptosis and DNA-double stranded breaks respectively, in several fetal tissues. Moderate toxicity was seen after <em>in utero</em> exposure to anthracyclines and taxanes. These findings emphasize the importance of investigating fetal toxicity in the clinical setting.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104594"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal, predictive or observational? Different understandings of key event relationships for adverse outcome pathways and their implications on practice 因果关系，预测还是观察？对不良结果通路关键事件关系的不同理解及其对实践的影响

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-30 DOI: 10.1016/j.etap.2024.104597

Zheng Zhou , Jeroen L.A. Pennings , Ullrika Sahlin

{"title":"Causal, predictive or observational? Different understandings of key event relationships for adverse outcome pathways and their implications on practice","authors":"Zheng Zhou , Jeroen L.A. Pennings , Ullrika Sahlin","doi":"10.1016/j.etap.2024.104597","DOIUrl":"10.1016/j.etap.2024.104597","url":null,"abstract":"<div><div>The Adverse Outcome Pathways (AOPs) framework is pivotal in toxicology, but the, terminology describing Key Event Relationships (KERs) varies within AOP guidelines.This study examined the usage of causal, observational and predictive terms in AOP, documentation and their adaptation in AOP development. A literature search and text, analysis of key AOP guidance documents revealed nuanced usage of these terms, with KERs often described as both causal and predictive. The adaptation of, terminology varies across AOP development stages. Evaluation of KER causality often, relies targeted blocking experiments and weight-of-evidence assessments in the, putative and qualitative stages. Our findings highlight a potential mismatch between,terminology in guidelines and methodologies in practice, particularly in inferring,causality from predictive models. We argue for careful consideration of terms like, causal and essential to facilitate interdisciplinary communication. Furthermore, integrating known causality into quantitative AOP models remains a challenge.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104597"},"PeriodicalIF":4.2,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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