Associations of phthalate metabolites in urine and follicular fluid with endometrial thickness in the TREE cohort

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-08-07 DOI:10.1016/j.etap.2025.104781

Xiu-Ting Li , Chong Liu , Yan-Ling Deng , Yu Miao , Min Zhang , Jia-Yue Zeng , Peng-Hui Liu , A.-Xue Liu , Yang-Juan Li , Jin-Qin Zhu , Ning Zhang , Juan Li , Yu-Feng Li , Tao-Ran Deng , Qiang Zeng

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引用次数: 0

Abstract

Endometrial thickness (EMT) is a crucial indicator of female fecundity and pregnancy success. Experimental studies have suggested that phthalates can disrupt EMT by exerting estrogenic effects or affecting the expression of related receptors, but human evidence is scarce. We aimed to explore the relationships of phthalate metabolites in paired urine and follicular fluid (FF) with EMT among 548 women undergoing assisted reproductive technology (ART). In single-pollutant analyses, all urinary di(2-ethylhexyl) phthalate (DEHP) metabolites were positively linked with follicular phase EMT (all p for trends ≤ 0.01) and higher risks of thick EMT (all p for trends ≤ 0.10). Meanwhile, mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) in FF showed similar positive associations (both p for trends ≤ 0.01). Bayesian kernel machine regression (BKMR) models revealed that phthalate mixtures in urine and FF were positively associated with follicular phase EMT or the risk of thick EMT. Our results indicated that DEHP exposure may increase EMT among women undergoing ART.

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TREE队列中尿和卵泡液中邻苯二甲酸酯代谢物与子宫内膜厚度的关系

子宫内膜厚度（EMT）是衡量女性生育能力和妊娠成功率的重要指标。实验研究表明邻苯二甲酸酯可以通过施加雌激素效应或影响相关受体的表达来破坏EMT，但人体证据很少。我们旨在探讨548名接受辅助生殖技术（ART）的女性尿液和卵泡液（FF）配对中邻苯二甲酸酯代谢物与EMT的关系。在单污染物分析中，所有尿邻苯二甲酸二（2-乙基己基）（DEHP）代谢物与卵泡期EMT（趋势均为p≤0.01）和厚EMT的高风险（趋势均为p≤0.10）呈正相关。邻苯二甲酸单（2-乙基-5-氧己基）酯（MEOHP）与FF呈相似的正相关（趋势p均≤0.01）。贝叶斯核机回归（BKMR）模型显示，尿液和FF中的邻苯二甲酸盐混合物与卵泡期EMT或厚EMT的风险呈正相关。我们的研究结果表明，DEHP暴露可能会增加接受抗逆转录病毒治疗的妇女的EMT。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.