Environmental toxicology and pharmacology最新文献

Mother-child exposure to polychlorinated biphenyls and organochlorine pesticides in the Northern Finland cohort (NUGEN)

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-03-23 DOI: 10.1016/j.etap.2025.104679

Saranya Palaniswamy , Soha Salah , Petra Přibylová , Petr Kukučka , Liisa Laatio , Elina Sieppi , Maria Kummu , Arja Rautio , Päivi Myllynen , Khaled Abass

{"title":"Mother-child exposure to polychlorinated biphenyls and organochlorine pesticides in the Northern Finland cohort (NUGEN)","authors":"Saranya Palaniswamy , Soha Salah , Petra Přibylová , Petr Kukučka , Liisa Laatio , Elina Sieppi , Maria Kummu , Arja Rautio , Päivi Myllynen , Khaled Abass","doi":"10.1016/j.etap.2025.104679","DOIUrl":"10.1016/j.etap.2025.104679","url":null,"abstract":"<div><div>Limited knowledge exists on persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs), in mother-child pairs from Northern Finland. This study examines plasma PCB and OCP concentrations and their determinants. Blood plasma concentrations of 13 PCBs and 6 OCPs were measured in mothers and in cord samples from the NUGEN birth cohort (N = 102, 2012–2014). Correlations between maternal and cord POPs were assessed using Spearman correlation, and linear regression identified factors influencing lipid-adjusted POPs. Maternal age and alcohol consumption during pregnancy were positively associated with PCBs and OCPs. Pre-pregnancy BMI and weight change during pregnancy were inversely associated with PCBs, but positively with p,p’-DDE in children. Increasing parity and smoking were associated with lower PCBs. Maternal fish consumption was associated with higher PCBs in children. Finnish pregnant women had lower PCBs and OCPs than other European populations. These findings inform exposure risk assessment and prevention strategies.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104679"},"PeriodicalIF":4.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single and mixture effect of cyanobacterial metabolites, cylindrospermopsin, anabaenopeptin-A, microginin-FR1 and aeruginosin 98-A, on behaviour, food uptake, oxygen consumption and muscular F-actin degradation of Thamnocephalus platyurus

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-03-21 DOI: 10.1016/j.etap.2025.104677

Małgorzata Adamczuk, Adam Bownik, Barbara Pawlik-Skowrońska

{"title":"Single and mixture effect of cyanobacterial metabolites, cylindrospermopsin, anabaenopeptin-A, microginin-FR1 and aeruginosin 98-A, on behaviour, food uptake, oxygen consumption and muscular F-actin degradation of Thamnocephalus platyurus","authors":"Małgorzata Adamczuk, Adam Bownik, Barbara Pawlik-Skowrońska","doi":"10.1016/j.etap.2025.104677","DOIUrl":"10.1016/j.etap.2025.104677","url":null,"abstract":"<div><div>This study showed that single cyanobacterial metabolites had various effects on the tested parameters. Among them, only cylindrospermopsin was lethal to the animals; cylindrospermopsin was also the most potent inhibitor of the remaining parameters. Cylindrospermopsin in binary mixtures with the other tested metabolites displayed antagonistic or additive effects for survival, movement, food uptake and oxygen consumption and synergistic effect for F-actin degradation. Aeruginosin 98 A at lower concentrations displayed an enhanced effect on movement, food uptake and oxygen consumption while inhibiting these parameters at higher concentrations. Anabaenopeptin-A at higher concentrations (> 250 µg/L) had a significant inhibitory effect on <em>T. platyurus</em>. Microginin-FR1 had the lowest impact on <em>T. platyurus</em>, but produced mainly synergistic effects in a binary mixture with aeruginosin 98 A and mostly antagonistic or additive effects in a mixture with anabaenopeptin-A. Quaternary mixtures of metabolites had mostly antagonistic effects on the examined parameters.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104677"},"PeriodicalIF":4.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to a widely used mito-toxic fungicide negatively affects hemolymph protein and vitellogenin levels in honey bees (Apis mellifera)

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-03-16 DOI: 10.1016/j.etap.2025.104676

Adrian Fisher II , Keerut Chahal , Gloria DeGrandi-Hoffman , Brian H. Smith , Jennifer H. Fewell , Jon F. Harrison

{"title":"Exposure to a widely used mito-toxic fungicide negatively affects hemolymph protein and vitellogenin levels in honey bees (Apis mellifera)","authors":"Adrian Fisher II , Keerut Chahal , Gloria DeGrandi-Hoffman , Brian H. Smith , Jennifer H. Fewell , Jon F. Harrison","doi":"10.1016/j.etap.2025.104676","DOIUrl":"10.1016/j.etap.2025.104676","url":null,"abstract":"<div><div>Mito-toxic fungicides used in crop protection negatively affect pollinating insects. The fungicide formulation Pristine® (ai: 25.2 % boscalid, 12.8 % pyraclostrobin) induces precocious foraging, reduced lifespan, impaired homing abilities, and reduced body size at field-relevant concentrations. However, the underlying physiological mechanisms for these outcomes are poorly understood. To assess the hypothesis that Pristine® negatively affects the nutritional status of honey bees, we collected workers from colonies that were fed field-relevant concentrations of Pristine® fungicide. Workers were collected concurrently from two experiments in which colonies were subjected to long- or short-term fungicide exposure. Pristine® exposure significantly reduced hemolymph protein concentration in bees from the long-term but not short-term study, and reduced vitellogenin levels during the short-term summer exposure. These findings suggest that mito-toxic fungicides can negatively affect the nutritional status of honey bee workers inducing detrimental behavioral and health outcomes which ultimately impact colony health and growth patterns.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104676"},"PeriodicalIF":4.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reliability of pesticide toxicity evaluation: Effects of pesticides on cellular respiration under conventional versus physiological growth conditions

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-03-15 DOI: 10.1016/j.etap.2025.104675

Kersti Tepp , Giuseppe Leonardo Auditano , Marju Puurand , Tuuli Kaambre

{"title":"Reliability of pesticide toxicity evaluation: Effects of pesticides on cellular respiration under conventional versus physiological growth conditions","authors":"Kersti Tepp , Giuseppe Leonardo Auditano , Marju Puurand , Tuuli Kaambre","doi":"10.1016/j.etap.2025.104675","DOIUrl":"10.1016/j.etap.2025.104675","url":null,"abstract":"<div><div>The use of pesticides to enhance crop yields remains prevalent despite persistent concerns about their potential harmful side effects. Moreover, most cell viability studies are conducted in growth media and oxygen concentrations that do not accurately reflect the <em>in vivo</em> conditions in tissues, and therefore may influence the outcomes of toxicity assessments. The aim of the study was to examine how culture conditions alter the influence of pesticides on mitochondrial energy production. For this purpose, two cell lines - Caco-2 (human colorectal adenocarcinoma cells) and HepG2 (a human hepatoma cell line) - were cultured over an extended period with low doses of three widely used plant protection products: the fungicide boscalid, the herbicide glyphosate, and the insecticide NeemAzal. Cells were grown in conventional DMEM and Plasmax media, the latter resembling blood plasma composition, under normoxic (19 %) and physoxic (5 %) oxygen concentrations. High-resolution respirometry was employed to assess pesticide-induced alterations on mitochondrial metabolism and to evaluate how these effects differed between conventional and physiologically relevant environments. The results revealed minimal alterations with NeemAzal exposure, while boscalid induced the most pronounced effects, including a decreased mitochondrial bioenergetics index, reduced ATP-synthase-linked oxygen consumption, and impaired respiration associated with respiratory chain complexes I and II. Notably, these impairments in mitochondrial energy production were more pronounced in cells cultured in Plasmax media compared to DMEM. These findings highlight the critical importance of mimicking tissue-specific conditions, such as media composition and oxygen tension, in toxicity studies to obtain more accurate and physiologically relevant insights.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104675"},"PeriodicalIF":4.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dimethylmonothioarsinic acid (DMMTAV) induces NQO1 expression through coordinated activation of NRF2 and AHR pathways

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-03-08 DOI: 10.1016/j.etap.2025.104674

Sara R. El-Mahrouk , Ayman O.S. El-Kadi

{"title":"Dimethylmonothioarsinic acid (DMMTAV) induces NQO1 expression through coordinated activation of NRF2 and AHR pathways","authors":"Sara R. El-Mahrouk , Ayman O.S. El-Kadi","doi":"10.1016/j.etap.2025.104674","DOIUrl":"10.1016/j.etap.2025.104674","url":null,"abstract":"<div><div>Dimethylmonothioarsinic acid (DMMTA<sup>V</sup>), a potent toxic metabolite of arsenic, exhibits higher cytotoxicity than other arsenicals. This study investigates its influence on NAD(P)H:quinone oxidoreductase (NQO1) regulation in C57BL/6 mice and Hepa-1c1c7 cells. Mice were administered DMMTA<sup>V</sup> (6 mg/kg, IP) with or without TCDD (15 µg/kg, IP), and hepatic and extrahepatic tissues were analyzed for NQO1 expression. In vitro, Hepa-1c1c7 cells were treated with 0–2 µM DMMTA<sup>V</sup> in the presence and absence of TCDD (1 nM), and NQO1 levels were assessed over time. Western blot, real-time PCR, and ARE-luciferase assays determined protein and transcriptional regulation. DMMTA<sup>V</sup> upregulated NQO1 in liver tissues and induced a time-dependent increase in vitro, peaking at 12 h. It enhanced TCDD-induced NQO1 expression and increased nuclear NRF2 and AHR levels, with peak accumulation at two hours. ARE-luciferase activity confirmed transcriptional activation. These findings reveal DMMTA<sup>V</sup> enhances NQO1 primarily via NRF2/AHR pathway activation, providing insight into cellular responses to thioarsenicals.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104674"},"PeriodicalIF":4.2,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitigating pesticide risk on bee pollinators and angiosperm biodiversity in the Ndop wetlands: A conservation approach

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-03-07 DOI: 10.1016/j.etap.2025.104671

Therese Ncheuveu Nkwatoh , Patricia Bi Asanga Fai , Alvine Larissa Meyabeme Elono , Louis Sevitenyi Nkwatoh , Sali Atanga Ndindeng

{"title":"Mitigating pesticide risk on bee pollinators and angiosperm biodiversity in the Ndop wetlands: A conservation approach","authors":"Therese Ncheuveu Nkwatoh , Patricia Bi Asanga Fai , Alvine Larissa Meyabeme Elono , Louis Sevitenyi Nkwatoh , Sali Atanga Ndindeng","doi":"10.1016/j.etap.2025.104671","DOIUrl":"10.1016/j.etap.2025.104671","url":null,"abstract":"<div><div>This study aimed to assess the risk of pesticides on bee pollinators and propose strategies to conserve entomophilous angiosperm species in the Ndop wetlands. Results showed that the applied pesticide doses were often excessive, increasing the exposure toxicity ratios (ETR). Among the pesticides, insecticides posed the highest risk to bee pollinators, with Emamectin benzoate (ETR=591.4) presenting the highest risk, followed by imidacloprid (ETR=517.5), fipronil (ETR=496.4), chlorpyrifos (ETR=240.7), and cypermethrin (ETR=131). Lambda-cyhalothrin (ETR=50.53) posed a possible risk. The study found that imidacloprid, fipronil, and chlorpyrifos posed definite risks through dietary exposure, while Emamectin benzoate, fipronil, and cypermethrin posed risks through direct contact. Approximately 46.03 % of angiosperms are anemophilous while 53 % are entomophilous with bee pollinators facilitating the pollination of nearly 90 % of the entomophilous species. To mitigate pesticide risks and for conservation purposes, farmers should refrain from applying pesticides during blooming and peak pollinator activity times, particularly midday.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104671"},"PeriodicalIF":4.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the toxicity of gadolinium in freshwater and marine ecosystems: Effects across trophic levels

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-03-06 DOI: 10.1016/j.etap.2025.104673

Camilla Mossotto , Serena Anselmi , Stefania Trevisan , Francesca Provenza , Alessandra Maganza , Alice Gabetti , Giuseppe Esposito , Antonia Concetta Elia , Marino Prearo , Monia Renzi , Paolo Pastorino

{"title":"Assessing the toxicity of gadolinium in freshwater and marine ecosystems: Effects across trophic levels","authors":"Camilla Mossotto , Serena Anselmi , Stefania Trevisan , Francesca Provenza , Alessandra Maganza , Alice Gabetti , Giuseppe Esposito , Antonia Concetta Elia , Marino Prearo , Monia Renzi , Paolo Pastorino","doi":"10.1016/j.etap.2025.104673","DOIUrl":"10.1016/j.etap.2025.104673","url":null,"abstract":"<div><div>Rare Earth Elements, particularly gadolinium (Gd), are increasingly used in industrial and medical applications, leading to their dispersion in aquatic environments. This study examines the ecotoxicological effects of Gd on aquatic organisms across different trophic levels in freshwater and marine ecosystems. Using standardized bioassays, the impact of Gd was assessed on <em>Aliivibrio fischeri</em>, <em>Raphidocelis subcapitata</em>, <em>Phaeodactylum tricornutum</em>, <em>Daphnia magna</em>, and <em>Paracentrotus lividus</em> larvae. Results showed that primary producers exhibited the highest sensitivity, with growth inhibition at low concentrations. In contrast, primary consumers (<em>D. magna</em> and <em>P. lividus</em>) were less affected by Gd, displaying a higher tolerance to its toxic effects even at elevated concentrations. Principal component analysis highlighted distinct responses between freshwater and marine organisms, suggesting a complex relationship between Gd bioavailability and toxicity. Hence, Gd contamination poses ecological risks requiring further research on its environmental impact.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104673"},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of 5-OH-DMT (bufotenine) in the Asian toad Duttyphrynus melanostictus, Hoplobatrachus tigerinus and Haemopis sanguisiga in Madagascar by UHPLC-MS/MS

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-03-06 DOI: 10.1016/j.etap.2025.104672

Christina Ververi , Elisah Rasoanomenjanahary Nahavitatsara , Brigitte Annie Bezandry , Vonimanitra Juliana Rasoma Rahantavololona , Cristina Giacoma , Alberto Salomone

{"title":"Determination of 5-OH-DMT (bufotenine) in the Asian toad Duttyphrynus melanostictus, Hoplobatrachus tigerinus and Haemopis sanguisiga in Madagascar by UHPLC-MS/MS","authors":"Christina Ververi , Elisah Rasoanomenjanahary Nahavitatsara , Brigitte Annie Bezandry , Vonimanitra Juliana Rasoma Rahantavololona , Cristina Giacoma , Alberto Salomone","doi":"10.1016/j.etap.2025.104672","DOIUrl":"10.1016/j.etap.2025.104672","url":null,"abstract":"<div><div>5-hydroxy-N,N-dimethyltryptamine (5-OH-DMT), known as bufotenine, is proven to have psychoactive effects in high concentrations. <em>Duttyphrynus melanostictus</em>, which produces bufotenine, has migrated to the city of Toamasina in Madagascar, thus, the determination bufotenine’s levels in <em>the species’</em> samples is necessary. This study aimed to quantify bufotenine in eggs, tadpoles and toad’s skin samples of the <em>Duttyphrynus melanostictus</em> as well as in its predator <em>Hoplobatrachus tigerinus</em> and <em>Haemopis sanguisiga</em>. Two extraction protocols were applied depending on the sample type both based on liquid liquid extraction. Spiked calibration samples were prepared at six concentration levels (10–1000 ng/mL), and performance parameters were evaluated: linearity, accuracy (bias%), precision (CV%) and limit of detection. The proposed protocol is simple and quick, and the UHPLC-MS/MS system used exhibited adequate sensitivity. The target analyte was detected in all samples except for the eggs of <em>Duttyphrynus melanostictus</em>, with concentrations increasing in line with the animal’s development.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104672"},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contaminant-driven midgut histological damage in bees and other aculeate Hymenoptera: A quantitative review

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-03-04 DOI: 10.1016/j.etap.2025.104670

Carlo Polidori , Chiara Francesca Trisoglio , Andrea Ferrari , Andrea Romano , Francesco Bonasoro

{"title":"Contaminant-driven midgut histological damage in bees and other aculeate Hymenoptera: A quantitative review","authors":"Carlo Polidori , Chiara Francesca Trisoglio , Andrea Ferrari , Andrea Romano , Francesco Bonasoro","doi":"10.1016/j.etap.2025.104670","DOIUrl":"10.1016/j.etap.2025.104670","url":null,"abstract":"<div><div>We present a review about histological sub-lethal effects due to anthropogenic contaminants on the midgut of bees and other aculeate hymenopterans. Contaminant types, damage types, and methodology were extracted and summarized from 74 published articles, and then quantitatively analyzed. We found that the Western honeybee (<em>Apis mellifera</em>) is by far the most widely used model. Contaminants have largely been tested under laboratory conditions, particularly insecticides and fungicides. Tissue-level damage (e.g., degradation of epithelium and of peritrophic membrane) were often detected together with cell-level damage (e.g., cell vacuolisation, karyorrhexis). Descriptive statistics and mixed models suggested that herbicides may cause a specific mix of alterations with an overall lower severity compared with other pesticides, while the combined use of light and electron microscopy seemed to detect more damage types. We claim for efforts to reduce biases in future studies on such histological effects, allowing their clearer use as markers of human activities.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104670"},"PeriodicalIF":4.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexually dimorphic cardiovascular impacts of prenatal exposure to a real-life environmental chemical mixture in adult offspring

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-03-04 DOI: 10.1016/j.etap.2025.104669

Noor Muhammad Khan , Victoria Scott , Mohammad Ghasemzadeh-Hasankolaei , Vasantha Padmanabhan , Arpita Vyas , Neil P. Evans , Michelle Bellingham

{"title":"Sexually dimorphic cardiovascular impacts of prenatal exposure to a real-life environmental chemical mixture in adult offspring","authors":"Noor Muhammad Khan , Victoria Scott , Mohammad Ghasemzadeh-Hasankolaei , Vasantha Padmanabhan , Arpita Vyas , Neil P. Evans , Michelle Bellingham","doi":"10.1016/j.etap.2025.104669","DOIUrl":"10.1016/j.etap.2025.104669","url":null,"abstract":"<div><div>Cardiovascular disease (CVD) is a leading cause of death that is sexually dimorphic. This study used an ovine model to investigate whether maternal exposure to an environmental chemical (EC) mixture (biosolids) prior to and throughout pregnancy, affected offspring cardiovascular (CV) structure and function in adulthood. CV function of male and female offspring from ewes grazed on either conventionally fertilised (control, C) or biosolids-treated pasture (B) was assessed. Males exhibited higher blood pressure compared to females with no significant effect of EC exposure. Heart rate variability in females suggested reduced autonomic regulation in the B group. EC-exposed males, but not females, showed significantly increased left ventricular dimensions, end-diastolic and systolic volumes, and cardiac output. The findings indicate sexually dimorphic effects of maternal EC mixture exposure on adult CV structure and function. Further studies are needed to explore the mechanisms and long-term implications of prenatal exposure to ECs on CV health.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104669"},"PeriodicalIF":4.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0