Environmental toxicology and pharmacology最新文献

Early-life long-term exposure to di(2-ethylhexyl) phthalate (DEHP) impairs pathogenic avoidance behavior associated with dopaminergic pathway in Caenorhabditis elegans 早期长期暴露于邻苯二甲酸二（2-乙基己基）酯（DEHP）会损害秀丽隐杆线虫与多巴胺能途径相关的致病性回避行为

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-05-27 DOI: 10.1016/j.etap.2025.104726

Ting-An Lin, Chun-Han Chang, Tzu-Ting Chang, Vivian Hsiu-Chuan Liao

{"title":"Early-life long-term exposure to di(2-ethylhexyl) phthalate (DEHP) impairs pathogenic avoidance behavior associated with dopaminergic pathway in Caenorhabditis elegans","authors":"Ting-An Lin, Chun-Han Chang, Tzu-Ting Chang, Vivian Hsiu-Chuan Liao","doi":"10.1016/j.etap.2025.104726","DOIUrl":"10.1016/j.etap.2025.104726","url":null,"abstract":"<div><div>The plasticizer di(2-ethylhexyl) phthalate (DEHP) is frequently detected at high environmental concentrations in the environment. <em>Bacillus thuringiensis</em> (Bt), used for insect control, and the soil nematode <em>Caenorhabditis elegans</em> (<em>C. elegans</em>) likely coexist in soil ecosystems. Avoidance behavior is essential for organisms to evade potential hazards and optimize survival in fluctuating environments; however, research regarding the pathogenic avoidance behavior of <em>C. elegans</em> against Bt is still limited. This study investigated whether DEHP exposure impairs Bt avoidance in <em>C. elegans</em> and the mechanisms involved. Results show that Bt adversely affects the growth and survival of <em>C. elegans</em>. In addition, exposure to 5 mg/L of DEHP for 5 days interferes with the avoidance behavior towards Bt, yet it does not impact the food preference between Bt and its food source <em>Escherichia coli</em> OP50. Furthermore, the impaired avoidance behavior correlates with the downregulation of tyrosine hydroxylase homolog <em>cat-2</em> and dopamine D1 receptor homolog <em>dop-1</em>. Moreover, molecular docking analysis reveals that DEHP exhibits a stronger binding affinity with the dopamine D1 receptor than dopamine. As DEHP is a ubiquitous environmental contaminant, the observed impairment in avoidance behavior, a crucial survival mechanism for <em>C. elegans</em>, highlights the potential environmental risks of DEHP exposure to the ecosystems.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"117 ","pages":"Article 104726"},"PeriodicalIF":4.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of aflatoxin B1-exposure on the genotoxic potential of larval extracts of the black soldier fly (Hermetia illucens), housefly (Musca domestica) and lesser mealworm (Alphitobius diaperinus) 黄曲霉毒素b1暴露对黑兵蝇、家蝇和小粉虫幼虫提取物遗传毒性的影响

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-05-22 DOI: 10.1016/j.etap.2025.104724

Winnie C.W. Tao , Kelly Niermans , Yoran B.N. Weide, Katja C.W. van Dongen, Nathan Meijer, Elise F. Hoek - van den Hil, H.J. van der Fels-Klerx

{"title":"Impact of aflatoxin B1-exposure on the genotoxic potential of larval extracts of the black soldier fly (Hermetia illucens), housefly (Musca domestica) and lesser mealworm (Alphitobius diaperinus)","authors":"Winnie C.W. Tao , Kelly Niermans , Yoran B.N. Weide, Katja C.W. van Dongen, Nathan Meijer, Elise F. Hoek - van den Hil, H.J. van der Fels-Klerx","doi":"10.1016/j.etap.2025.104724","DOIUrl":"10.1016/j.etap.2025.104724","url":null,"abstract":"<div><div>Aflatoxin B<sub>1</sub> (AFB<sub>1</sub>)-contaminated crops could serve as insect feed without affecting growth and survival of black soldier fly (BSFL), housefly (HFL), and lesser mealworm (LMW) larvae. However, the genotoxic safety of larvae reared on AFB<sub>1</sub>-contaminated substrate remains uncertain. This study assessed the genotoxic effects of larvae reared on 0, 20, and 200 µg/kg AFB<sub>1</sub> spiked substrate through <em>in vitro</em> testing. AFB<sub>1</sub> and metabolites were analysed in the feed substrate, larvae and residual material using a LC-MS/MS-based method. Cytotoxic and genotoxic potential of larval extracts were assessed using the Ames MPF™ assay (mini-Ames assay), Ames test, and <em>in vitro</em> micronucleus assay.</div></div><div><h3>Results</h3><div>indicated no effect on survival and biomass for all insects and no bioaccumulation of AFB<sub>1</sub>. Species-specific AFB<sub>1</sub> metabolism appeared to occur. HFL exhibited no cytotoxic or genotoxic potential. Further research is required for BSFL and LMW, due to matrix effects and incompatibility with the used <em>in vitro</em> tests.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"117 ","pages":"Article 104724"},"PeriodicalIF":4.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The thiamethoxam-based insecticide Cruiser 350 Fs induced histopathological and oxidative stress in the stingless bee Partamona helleri (Hymenoptera: Apidae: Meliponini) 噻虫胺类杀虫剂Cruiser 350fs诱导无刺蜜蜂的组织病理和氧化应激（膜翅目：蜂科：蜂蜂）

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-05-21 DOI: 10.1016/j.etap.2025.104722

João Victor de Oliveira Motta, Davy Soares Gomes, João Paulo Pimentel de Oliveira Cruz, Laryssa Lemos da Silva, Mateus Soares de Oliveira, Daniel Silva Sena Bastos, Leandro Licursi de Oliveira, José Eduardo Serrão

{"title":"The thiamethoxam-based insecticide Cruiser 350 Fs induced histopathological and oxidative stress in the stingless bee Partamona helleri (Hymenoptera: Apidae: Meliponini)","authors":"João Victor de Oliveira Motta, Davy Soares Gomes, João Paulo Pimentel de Oliveira Cruz, Laryssa Lemos da Silva, Mateus Soares de Oliveira, Daniel Silva Sena Bastos, Leandro Licursi de Oliveira, José Eduardo Serrão","doi":"10.1016/j.etap.2025.104722","DOIUrl":"10.1016/j.etap.2025.104722","url":null,"abstract":"<div><div>The stingless bee <em>Partamona helleri</em> plays a crucial role in pollinating both native and cultivated plants. However, the intensive use of pesticides in agriculture are contributing to the decline of its population. Thiamethoxam, a systemic neonicotinoid insecticide, acts on the nervous system, however, it can also affect other non-target insect organs. This study evaluated the sublethal effects of chronic oral exposure to a thiamethoxam formulation on the fat body and Malpighian tubules in <em>P. helleri</em> workers. Bees were exposed orally for seven days to sublethal concentration of thiamethoxam (0.09 ng g<sup>−1</sup>). The results revealed histopathological alterations in the fat body and Malpighian tubules, including changes in protein and carbohydrate reserves, nuclear pyknosis, cytoplasmic vacuolization, and affect lipid peroxidation in <em>P. helleri</em>. These findings indicate that chronic exposure of <em>P. helleri</em> workers to the residual concentration of thiamethoxam found in the field elicits a detoxification response in the fat body and Malpighian tubules; however, the previously reported high mortality rate suggests that these physiological responses are insufficient to mitigate the toxic effects of thiamethoxam on this pollinator.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"116 ","pages":"Article 104722"},"PeriodicalIF":4.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicity of ametryn and clomazone in zebrafish: Environmentally relevant concentrations induce developmental and enzymatic alterations 阿米丁和氯马酮对斑马鱼的毒性：环境相关浓度诱导发育和酶的改变。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-05-17 DOI: 10.1016/j.etap.2025.104721

Camila A. Miranda , Paloma V.L. Peixoto , Cristina Viriato , Luiza Aggio , Lílian C. Pereira , Fábio E. Mingatto

{"title":"Toxicity of ametryn and clomazone in zebrafish: Environmentally relevant concentrations induce developmental and enzymatic alterations","authors":"Camila A. Miranda , Paloma V.L. Peixoto , Cristina Viriato , Luiza Aggio , Lílian C. Pereira , Fábio E. Mingatto","doi":"10.1016/j.etap.2025.104721","DOIUrl":"10.1016/j.etap.2025.104721","url":null,"abstract":"<div><div>Ametryn (AMT) and clomazone (CLZ) are widely used for weed control, often in combination. This study evaluated the effects of environmentally relevant concentrations of AMT, CLZ, and their mixtures on zebrafish embryonic-larval development and enzyme activity. Exposure to AMT (≥0.1 µg/L) and CLZ (≥36 µg/L) significantly reduced swim bladder inflation, although their mixture showed an antagonistic effect, minimizing damage. Both herbicides reduced acetylcholinesterase (AChE) activity, an effect observed from the lowest concentrations tested, indicating neurotoxicity, while the mixture mitigated this effect. Aspartate aminotransferase (AST) activity increased from 6 µg/L AMT and 20 µg/L CLZ, and alanine aminotransferase (ALT) activity increased from 3.7 µg/L AMT and 6 µg/L CLZ, suggesting hepatotoxicity. Alkaline phosphatase (ALP) activity increased with 3.7 µg/L AMT and 6 µg/L CLZ. The mixture modulated enzyme alterations and increased damage at specific concentrations. Overall, AMT and CLZ exposure impaired development and altered enzyme function, causing neurotoxic and hepatotoxic effects.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"116 ","pages":"Article 104721"},"PeriodicalIF":4.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ecotoxicity of a representative urban mixture of rare earth elements to rainbow trout juveniles 具有代表性的城市稀土混合元素对虹鳟鱼幼鱼的生态毒性

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-05-16 DOI: 10.1016/j.etap.2025.104720

J. Auclair, E. Roubeau-Dumont, C. André, F. Gagné

{"title":"Ecotoxicity of a representative urban mixture of rare earth elements to rainbow trout juveniles","authors":"J. Auclair, E. Roubeau-Dumont, C. André, F. Gagné","doi":"10.1016/j.etap.2025.104720","DOIUrl":"10.1016/j.etap.2025.104720","url":null,"abstract":"<div><div>Municipal wastewaters contain a peculiar mix of rare earth elements (REEs) dominated by gadolinium (Gd). The sublethal and lethal toxicity was examined in rainbow trout exposed to a representative REE mixture (municipal waswaters) composed of Gd (105 ng/L), Ce (9 ng/L), Nd (8 ng/L), Yb (6.2 ng/L) and Dy (4 ng/L) corresponding to total REEs loading of 137 ng/L. Juveniles were exposed to a mixture of REEs (Gd representing 80 % of the loading) at concentrations between 0.5 and 100X for 96 h at 15 °C. The data revealed that the 100X mixture was not acutely lethal but produced a range of sublethal effects at concentrations in the 1–10X range, which could be found in some municipal wastewaters. The sublethal effects involved changes in liver weight, heat stable metal binding proteins, protein aggregation, lipid peroxidation and DNA damage. Hence, these sublethal effects were observed in juvenile fish at environmentally relevant concentrations. This suggests that the REEs found in wastewaters could contribute to long-term negative impacts on fish populations.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"116 ","pages":"Article 104720"},"PeriodicalIF":4.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of chlorpyrifos contamination on oxidative stress status of Lamellidens marginalis: A multibiomarker approach 毒死蜱污染对边缘薄叶草氧化应激状态的影响：一种多生物标志物方法。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-05-16 DOI: 10.1016/j.etap.2025.104723

Sayantan Mahapatra, Biboshwan De, Sritama Baag, Sumit Mandal

{"title":"The influence of chlorpyrifos contamination on oxidative stress status of Lamellidens marginalis: A multibiomarker approach","authors":"Sayantan Mahapatra, Biboshwan De, Sritama Baag, Sumit Mandal","doi":"10.1016/j.etap.2025.104723","DOIUrl":"10.1016/j.etap.2025.104723","url":null,"abstract":"<div><div>The present study aims to investigate the impact of chlorpyrifos on the oxidative stress responses in the freshwater bivalve <em>Lamellidens marginalis</em>. To assess the extent of chlorpyrifos induced stress, physiological parameters including respiration and excretion rates alongside a battery of biomarkers like superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST), and lipid peroxidation (LPO) were evaluated. These parameters were monitored at various time points over 14 days in a mesocosm study. Furthermore, an integrated biomarker response (IBR) approach was employed to coalesce biomarker data. The results showed a significant impact on the physiological activities and biomarker levels of <em>L. marginalis</em>. While most antioxidant and detoxifying enzymes activities were increased, catalase levels decreased significantly, leading to intense lipid peroxidation. Our findings confirm the susceptibility of <em>L. marginalis</em> even under short-term exposure and accentuate the potential threat of chlorpyrifos contamination in freshwater systems.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"116 ","pages":"Article 104723"},"PeriodicalIF":4.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ivermectin induced early developmental damage to the nervous system of zebrafish larvae 伊维菌素诱导斑马鱼幼体神经系统的早期发育损伤。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-05-15 DOI: 10.1016/j.etap.2025.104719

Yixuan Jiang , Lin Su , Bo Peng , Weiguo Wang , Yang Zhang

引用次数: 0

Ammonia-induced testicular tissue damage: Apoptosis and autophagy pathways mediated by regulating Cyt C/Bcl-2 and p62/LC3B pathways 氨诱导睾丸组织损伤：通过调节Cyt C/Bcl-2和p62/LC3B途径介导的凋亡和自噬途径

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-05-15 DOI: 10.1016/j.etap.2025.104716

Mengqi Duan , Shixiong Dong , Kejun Wang , Peng Shang , Chunli Li

{"title":"Ammonia-induced testicular tissue damage: Apoptosis and autophagy pathways mediated by regulating Cyt C/Bcl-2 and p62/LC3B pathways","authors":"Mengqi Duan , Shixiong Dong , Kejun Wang , Peng Shang , Chunli Li","doi":"10.1016/j.etap.2025.104716","DOIUrl":"10.1016/j.etap.2025.104716","url":null,"abstract":"<div><div>Ammonia gas (NH<sub>3</sub>) is a major hazard in animal husbandry that negatively affects animal growth and reproductive activities. Although the adverse effects of ammonia on livestock health and performance have been studied, its specific effects on the male reproductive system and its underlying biological mechanisms remain unclear. The aim of this study was to investigate the effects of ammonia exposure on male reproduction and its potential mechanisms of action. Immunohistochemistry revealed a significant increase in IL-10 expression in mouse testicular tissues under ammonia-induced stress. Ammonia exposure significantly decreased anti-apoptotic factor Bcl-2 and anti-autophagy factor p62 expression, coupled with increased expression of pro-apoptotic factors, including p53, Caspase-8, Bax, and Apaf, as well as the pro-autophagy factors Beclin1, ATG5, LC3B, the ratio of Bax/Bcl-2 and the ratio of P53/Bcl-2. The fluorescence intensity of the Cyt C apoptotic gene and pro-autophagy factor LC3B in immune tissues was significantly higher than that in the normal control group. In summary, ammonia exposure significantly affects the reproductive ability of male mice by inducing inflammation, apoptosis, and autophagic damage in the testes. Our findings provide insights into ammonia-induced reproductive disorders, which will contribute to the management and control of ammonia in animal husbandry, thereby reducing the negative effects of ammonia on the reproductive health of livestock and poultry and improving the quality and yield of livestock products.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"116 ","pages":"Article 104716"},"PeriodicalIF":4.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time dynamics models for oxidative stress markers in honey bees (Apis mellifera) following paraquat-induced stress 百草枯诱导应激后蜜蜂氧化应激标志物的时间动力学模型

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-05-15 DOI: 10.1016/j.etap.2025.104718

Jana Biová , Dalibor Kodrík , Martina Janků , Silvie Dostálková , Michael Simone-Finstrom , Marek Petřivalský , Jiří Danihlík

{"title":"Time dynamics models for oxidative stress markers in honey bees (Apis mellifera) following paraquat-induced stress","authors":"Jana Biová , Dalibor Kodrík , Martina Janků , Silvie Dostálková , Michael Simone-Finstrom , Marek Petřivalský , Jiří Danihlík","doi":"10.1016/j.etap.2025.104718","DOIUrl":"10.1016/j.etap.2025.104718","url":null,"abstract":"<div><div>Many agrochemicals disrupt redox homeostasis, yet the dynamics of oxidative stress responses in honey bees (<em>Apis mellifera</em>) remain insufficiently understood. This study established a controlled model to monitor ROS-related markers over time following paraquat injection, using Bayesian modeling to characterize time-dependent changes. We observed a transient rise in hydroperoxides and early fluctuation in adipokinetic hormone (AKH) levels, which declined and stabilized within 8 hours. No significant differences were detected in secondary lipid peroxidation products (TBARS) among treatments. While injection does not represent natural exposure pathways, it enables precise dosing and timing, avoiding variability from oral intake. This experimental design provides a tractable system to investigate oxidative stress mechanisms under defined conditions. Our findings underscore the importance of time-resolved analysis in redox physiology and offer a mechanistic framework to complement field-relevant toxicological studies in bees and other beneficial insects.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"116 ","pages":"Article 104718"},"PeriodicalIF":4.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The blood response to subway-derived iron nanoparticles 血液对地铁铁纳米颗粒的反应。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-05-14 DOI: 10.1016/j.etap.2025.104717

Kristina N. Ekdahl , Lisa Monie , Ana T. Juárez-Facio , Ulf Olofsson , Alessandro Mancini , Bozhena Tsyupa , Karine Elihn , Bo Nilsson , Karin Fromell

{"title":"The blood response to subway-derived iron nanoparticles","authors":"Kristina N. Ekdahl , Lisa Monie , Ana T. Juárez-Facio , Ulf Olofsson , Alessandro Mancini , Bozhena Tsyupa , Karine Elihn , Bo Nilsson , Karin Fromell","doi":"10.1016/j.etap.2025.104717","DOIUrl":"10.1016/j.etap.2025.104717","url":null,"abstract":"<div><div>In this study, we investigated the impact of iron-rich nanoparticles derived from different locations in the subway on the innate immune system in blood. Nanoparticles were generated from Third Rail, Rail, and Wheel materials and characterized using several techniques. The response in a human whole-blood model was analyzed using ELISA and capillary immunoelectrophoresis. All nanoparticles were iron oxides, but Third Rail nanoparticles also contained Silicon and were highly thrombo-inflammatory, activating Factor XI-induced coagulation and pro-inflammatory kallikrein/kinin pathways. Wheel and Rail nanoparticles were less reactive, mainly activating the kallikrein/kinin pathway, leading to milder inflammatory reactions. The strong thrombo-inflammatory properties of Third Rail nanoparticles are attributed to their high Silicon content. None of the nanoparticles significantly activated the complement system. In conclusion, we found that the elemental composition of nanoparticles is crucial in determining whether activation leads to kallikrein/kinin system activation and bradykinin release or Factor XI activation and thrombosis.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"116 ","pages":"Article 104717"},"PeriodicalIF":4.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0