Environmental toxicology and pharmacology最新文献

Exposure assessment to waste anesthetic isoflurane during large-animal surgery: Environmental, personal and biological monitoring 大型动物手术期间对废麻醉剂异氟醚的暴露评估：环境、个人和生物监测

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-08-15 DOI: 10.1016/j.etap.2026.105132

Mariana G. Braz, Tony F. Grassi, Maria Vitória Destro, Francisco J. Teixeira-Neto, Leandro G. Braz

引用次数: 0

Nephroprotective effects of C60 fullerenes in chronic glyphosate intoxication C60富勒烯对慢性草甘膦中毒的肾保护作用

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-08-15 DOI: 10.1016/j.etap.2026.105124

Olga Abramchuk, Dmytro Nozdrenko, Svitlana Prylutska, Igor Vareniuk, Illia Pronko, Oleksandr Kropyva, Volodymyr Bulda, Uwe Ritter, Yuriy Prylutskyy

引用次数: 0

Molecular mechanisms of podophyllotoxin-induced subacute kidney injury: Oxidative stress-mediated activation of the TRPM2–NOD–NF-κB pathway 鬼叶毒素诱导亚急性肾损伤的分子机制：氧化应激介导的TRPM2-NOD-NF -κB通路的激活

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-08-14 DOI: 10.1016/j.etap.2026.105119

Lulu Chen, Zilong Chen, Xinze Li, Tao Jiang, Hanbing Zhao, Ruifang Wang, Wanying Wang, Song Qi, Mengjia Zhang, Mengyu Zhang, Xiaojing Ke, Guangda Li, Chuanxin Liu

引用次数: 0

Corrigendum to “Lead exposure and poisoning among artisanal kohl manufacturers in Fez, Morocco” [Environ. Toxicol. Pharmacol. 125 (2026) 105053] “摩洛哥非斯手工科尔生产商的铅暴露和中毒”的勘误表[环境]。Toxicol。药理学杂志，25(5):391 - 391。

IF 4.6 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-08-01 Epub Date: 2026-06-17 DOI: 10.1016/j.etap.2026.105076

S. Achour, I. Iken, W. Chellal, Y. Metarfi, Z. Ben Khadda, H. Hoummani, K. Abidi, O. Messouak, F. Belahsen, X. Dumont, A. Bernard

引用次数: 0

Bisphenol A–induced NF-κB activation enhances proliferation and migration of renal cell carcinoma cells via SLC7A11 upregulation and redox remodeling 双酚a诱导的NF-κB活化通过SLC7A11上调和氧化还原重塑促进肾癌细胞的增殖和迁移。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-06-01 Epub Date: 2026-05-19 DOI: 10.1016/j.etap.2026.105045

Qidi Zhai , Zhisheng Guo , Chenbo Ni , Qingsheng Tang , Jie Li

{"title":"Bisphenol A–induced NF-κB activation enhances proliferation and migration of renal cell carcinoma cells via SLC7A11 upregulation and redox remodeling","authors":"Qidi Zhai , Zhisheng Guo , Chenbo Ni , Qingsheng Tang , Jie Li","doi":"10.1016/j.etap.2026.105045","DOIUrl":"10.1016/j.etap.2026.105045","url":null,"abstract":"<div><div>Bisphenol A (BPA) is a ubiquitous endocrine-disrupting chemical, yet its influence on renal cell carcinoma (RCC) remains unclear. We examined whether low-dose BPA alters redox regulation linked to ferroptosis susceptibility in 786-O and ACHN cells. After concentration screening, 100 nM BPA was used for mechanistic experiments. BPA enhanced proliferation and migration, increased the glutathione redox ratio (GSH/GSSG), reduced reactive oxygen species (ROS) signals, and preserved mitochondrial membrane potential. Public cancer dataset analyses prioritized SLC7A11, which was upregulated by BPA at mRNA and protein levels. Under inhibition of the cystine/glutamate antiporter system xc− with erastin, BPA co-treatment partially attenuated cytotoxicity and functional suppression. BPA increased NF-κB p65 phosphorylation, and pyrrolidine dithiocarbamate reduced p-p65 and SLC7A11 expression. These findings suggest that environmentally relevant BPA exposure may promote stress-tolerant phenotypes in RCC cells via an NF-κB–SLC7A11–associated antioxidant response.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"124 ","pages":"Article 105045"},"PeriodicalIF":4.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Microplastics in dialysis effluent: Environmental chemistry insights and metal-organic frameworks-based remediation prospects” [Environ. Toxicol. Pharmacol. 124 (2026) 105033] “透析废水中的微塑料：环境化学见解和基于金属有机框架的修复前景”的更正[环境]。Toxicol。药理学杂志，2004(5):349 - 349。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-06-01 Epub Date: 2026-05-27 DOI: 10.1016/j.etap.2026.105050

Aqsa Kanwal , Jie Han , Jing Xu , Xiaodong Xue , Nilufar Akhmedova , Zhongquan Gao , Rongguo Fu

引用次数: 0

Chemical residues in declining commercial honey bee colonies 下降的商业蜂群中的化学残留物。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-06-01 Epub Date: 2026-05-29 DOI: 10.1016/j.etap.2026.105048

Zachary S. Lamas , Yanping Chen , Elina L. Niño , Dawn Boncristiani , Christopher Mayack , Arathi Seshadri , Julia Fine , Jay D. Evans

{"title":"Chemical residues in declining commercial honey bee colonies","authors":"Zachary S. Lamas , Yanping Chen , Elina L. Niño , Dawn Boncristiani , Christopher Mayack , Arathi Seshadri , Julia Fine , Jay D. Evans","doi":"10.1016/j.etap.2026.105048","DOIUrl":"10.1016/j.etap.2026.105048","url":null,"abstract":"<div><div>Following heightened colony losses, we screened 132 colonies from 23 commercial beekeeping operations in the states of Florida and California. We assessed chemical residues, finding beekeeper-applied miticides, followed by fungicides, were in the highest prevalence and concentration in all colony matrices. Insecticides comprised a minority of detections and concentration. Due to their heightened toxicity, insecticides contributed substantially to hazard quotients with one residue, the neonicotinoid imidacloprid, contributing 99.9% to overall HQ. We found both high prevalence and high levels of imidacloprid in adult bee bodies. Additionally, we preserved a small subsample of dying bees. Our findings highlight a survivorship bias, where dying bees had active ingredients known to have acute toxicity to bees. This result mirrors recent evidence for viral drivers of bee declines that were missed in whole-colony surveys. While bees die from multiple, often interacting, stressors, here we show single contributors at levels capable of causing acute harm.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"124 ","pages":"Article 105048"},"PeriodicalIF":4.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148102155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of skin cancer from hydrochlorothiazide and other diuretics across races: A global cohort study 氢氯噻嗪和其他利尿剂的皮肤癌风险跨种族：一项全球队列研究

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-06-01 Epub Date: 2026-05-20 DOI: 10.1016/j.etap.2026.105043

Chaw-Ning Lee , Shih-Chieh Shao , Chao-Chun Yang , Jia-Horung Hung , Edward Chia-Cheng Lai , Ching-Chi Chi

{"title":"Risk of skin cancer from hydrochlorothiazide and other diuretics across races: A global cohort study","authors":"Chaw-Ning Lee , Shih-Chieh Shao , Chao-Chun Yang , Jia-Horung Hung , Edward Chia-Cheng Lai , Ching-Chi Chi","doi":"10.1016/j.etap.2026.105043","DOIUrl":"10.1016/j.etap.2026.105043","url":null,"abstract":"<div><h3>Background</h3><div>Hydrochlorothiazide (HCTZ) has been linked to increased skin cancer risk. However, comparative evidence across racial groups remains limited. Using TriNetX, a global database, we evaluated the association between thiazide diuretic use and skin cancer risk across whites and other races within a single analytic platform, including both HCTZ and non-HCTZ thiazides.</div></div><div><h3>Objective</h3><div>To determine if the skin cancer risk associated with thiazide diuretics varies by racial group.</div></div><div><h3>Methods</h3><div>Using the TriNetX platform, we analyzed adults with newly treated hypertension, applying propensity score matching for baseline covariates, and calculated adjusted hazard ratios (aHRs) for skin cancers.</div></div><div><h3>Results</h3><div>Comparing to non-diuretic antihypertensive drug (NDAH) use, HCTZ increased the risk of keratinocyte carcinomas (KC) (aHR 1.44), squamous cell carcinoma (aHR 1.67), basal cell carcinoma (aHR 1.43), and malignant melanoma (aHR 1.54) only in the White population. No increased risk was found in the Asian, Hispanic, or Black populations. Chlorthalidone showed a similar pattern for KC, with increased event rates only in the White population.</div></div><div><h3>Conclusion</h3><div>HCTZ is associated with an increased risk of skin cancers only among whites, while similar associations were not observed in other races. These findings may be considered when prescribing thiazide diuretics in this population.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"124 ","pages":"Article 105043"},"PeriodicalIF":4.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147990575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redox-driven mechanisms link pesticide-induced microglial immunotoxicity to neurobehavioural impairment in an invertebrate ecotoxicological model 在无脊椎动物生态毒理学模型中，氧化还原驱动机制将农药诱导的小胶质细胞免疫毒性与神经行为损伤联系起来。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-06-01 Epub Date: 2026-05-22 DOI: 10.1016/j.etap.2026.105049

Ivana Beatrice Mânica da Cruz , Ivo Emílio da Cruz Jung , Nathalia Cardoso de Afonso Bonotto , Débora Felipetto Pulcinelli , Bárbara Osmarin Turra , Maria Eduarda Chelotti , Vitória Farina Azzolin , Verônica Farina Azzolin , Euler Ribeiro- Filho , Fernanda Barbisan

{"title":"Redox-driven mechanisms link pesticide-induced microglial immunotoxicity to neurobehavioural impairment in an invertebrate ecotoxicological model","authors":"Ivana Beatrice Mânica da Cruz , Ivo Emílio da Cruz Jung , Nathalia Cardoso de Afonso Bonotto , Débora Felipetto Pulcinelli , Bárbara Osmarin Turra , Maria Eduarda Chelotti , Vitória Farina Azzolin , Verônica Farina Azzolin , Euler Ribeiro- Filho , Fernanda Barbisan","doi":"10.1016/j.etap.2026.105049","DOIUrl":"10.1016/j.etap.2026.105049","url":null,"abstract":"<div><div>This study aimed to compare the biological consequences of mitochondrial- versus cytoplasmic-driven superoxide dysregulation, with a focus on microglial immunotoxicity and neurobehavioural outcomes. Murine BV-2 microglial cells were exposed to sublethal concentrations of rotenone (ROT) or paraquat (PQT) to assess cytotoxicity, redox imbalance, mitochondrial alterations, oxidative macromolecular damage, inflammatory modulation, and cytomorphological alterations. In parallel, acute toxicity and neurobehavioural responses were evaluated in the invertebrate model <em>Eisenia fetida</em>. Both pesticides reduced microglial viability and induced early increases in intracellular superoxide and nitric oxide levels, followed by oxidative damage. ROT elicited more pronounced mitochondrial alterations and cytotoxicity, whereas PQT promoted a stronger and sustained pro-inflammatory microglial phenotype, characterized by enhanced cytokine release. In vivo, both compounds impaired neurobehavioural responses, with higher lethality following ROT exposure. Mitochondrial- and cytoplasmic-derived superoxide production differentially modulate redox-sensitive neuroinflammatory pathways, converging on functional neurobehavioural impairment.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"124 ","pages":"Article 105049"},"PeriodicalIF":4.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148007741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to “Serum perfluoroalkyl substances and infant measles antibody concentrations before and after vaccination: Results from Burkina Faso” [Environ. Toxicol. Pharmacol. 124 (2026) 104979] 对“接种前后血清全氟烷基物质和婴儿麻疹抗体浓度：布基纳法索的结果”的勘误。Toxicol。药理学杂志，2004(5):349 - 349。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-06-01 Epub Date: 2026-03-19 DOI: 10.1016/j.etap.2026.105000

Sarah Dencker Mikkelsen , Ane Bærent Fisker , Eric Ipyn Nebie , Sidagna Alphonse Zakane , Ali Sie , Boubacar Coulibaly , Katrine Lynggaard Trans , Kristoffer Jarlov Jensen , Marie Pedersen , Janne Tolstrup , Flemming Nielsen , Christine Stabell Benn , Amalie Timmermann

引用次数: 0