Environmental toxicology and pharmacology最新文献

Occupational Genotoxic Risk in Jewelry Workshop Employees: Evidence from Buccal Cytome and Repair Index Analyses 珠宝车间员工的职业遗传毒性风险：来自颊细胞组和修复指数分析的证据

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-10-28 DOI: 10.1016/j.etap.2026.105210

Ayla ÇELİK, Zeliha ÇİLLİBAL, Berfin Gül GÜNEY

引用次数: 0

Do nanoplastics reshape microglial support of neuronal resilience? A study of microglial bioenergetics and microglia–neuron communication in vitro 纳米塑料重塑神经弹性的小胶质支持吗？体外小胶质细胞生物能量学及小胶质-神经元通讯的研究

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-10-27 DOI: 10.1016/j.etap.2026.105214

Electra Brunialti, Alessandro Villa, Clara Meda, Parolini Marco, Paolo Ciana, Lavinia Casati

{"title":"Do nanoplastics reshape microglial support of neuronal resilience? A study of microglial bioenergetics and microglia–neuron communication in vitro","authors":"Electra Brunialti, Alessandro Villa, Clara Meda, Parolini Marco, Paolo Ciana, Lavinia Casati","doi":"10.1016/j.etap.2026.105214","DOIUrl":"https://doi.org/10.1016/j.etap.2026.105214","url":null,"abstract":"Nanoplastics (NPs) are emerging environmental contaminants able to cross biological barriers, disrupt cellular and organelle homeostasis, and alter the brain microenvironment. This study investigated whether NPs affect microglia–neuron communication, a key mechanism underlying neuronal resilience, via the nuclear factor erythroid 2-like 2 (NFE2L2) pathway. Using an <ce:italic>in vitro</ce:italic> model, we evaluated the effects of polystyrene nanoplastics on microglial metabolic fitness and microglia-mediated neuronal stress responses. Increasing NP concentrations induced a dose-dependent biphasic effect. Low- to intermediate-concentration treatments increased intracellular adenosine triphosphate (ATP) levels in microglia and enhanced microglia-mediated activation of neuronal NFE2L2. In contrast, high NP concentrations impaired microglial metabolism, reduced ATP availability, and decreased microglial–neuronal communication. These findings indicate that NPs alter microglial energetic status and modulate neuroprotective signaling, potentially contributing to impaired neuron–microglia interactions and increased susceptibility to neurotoxicity.","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"17 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149290739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recombinogenic potency analysis of a commercial glyphosate-based herbicide formulation on the soil filamentous fungus Aspergillus nidulans 以草甘膦为基础的商品除草剂配方对土壤丝状真菌细粒曲霉的重组效力分析

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-10-27 DOI: 10.1016/j.etap.2026.105213

Nathalie Oestreicher, Christian Vélot

{"title":"Recombinogenic potency analysis of a commercial glyphosate-based herbicide formulation on the soil filamentous fungus Aspergillus nidulans","authors":"Nathalie Oestreicher, Christian Vélot","doi":"10.1016/j.etap.2026.105213","DOIUrl":"https://doi.org/10.1016/j.etap.2026.105213","url":null,"abstract":"A commercial Glyphosate-based-herbicide (GBH) containing 450<ce:hsp sp=\"0.25\"></ce:hsp>g/L of glyphosate (R450) was shown to affect the soil filamentous fungus Aspergillus <ce:italic>nidulans</ce:italic>, with multiple cytotoxic effects. Recently, R450 proved to exert also mutagenic effects on <ce:italic>A. nidulans</ce:italic> but only on dividing cells with active metabolism. The present study investigated further the R450 genotoxic potential by studying its putative recombinogenic effects on this fungus, which is a relevant model for such studies since the G2 phase represents the main period of its cell cycle. While R450 had no impact on sexual and meiotic processes, herbicide exposure resulted in a higher mitotic segregation frequency due to crossing-over and/or gene conversion stimulation. Sexual cycle induction being associated with a slowed metabolism, our results again suggest the prerequisite of active metabolism for the herbicide to exert these recombinogenic effects. The significance of such genotoxic damage in the context of human and animal exposure to GBH is discussed.","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"7 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149291055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid Profile and Liver Enzyme Alterations in HIV-Positive Patients Receiving Highly Active Antiretroviral Therapy in South-Eastern Nigeria: A Cross-Sectional Analysis and Implications for Pharmacogenetic Research 在尼日利亚东南部接受高活性抗逆转录病毒治疗的hiv阳性患者的脂质谱和肝酶改变：横断面分析和药物遗传学研究的意义

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-10-27 DOI: 10.1016/j.etap.2026.105196

Francis O. UGWUENE, Blessing U. ONWUMELU, Innocent O. ORHONIGBE, Amaechi L OGARA, Linus Ogbonnaya AGWU, Isioma Christian OKONTA, Bravo Udochukwu UMEH, Parker Elijah JOSHUA

引用次数: 0

Associations between prenatal mercury exposure from rice consumption and foetal growth: A cross-sectional study 产前大米摄入汞暴露与胎儿生长之间的关系：一项横断面研究。

IF 4.6 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-10-01 Epub Date: 2026-09-25 DOI: 10.1016/j.etap.2026.105174

Yaya Dai, Fuli Wen, Ping Li, Wenjuan Wang

{"title":"Associations between prenatal mercury exposure from rice consumption and foetal growth: A cross-sectional study","authors":"Yaya Dai, Fuli Wen, Ping Li, Wenjuan Wang","doi":"10.1016/j.etap.2026.105174","DOIUrl":"10.1016/j.etap.2026.105174","url":null,"abstract":"<div><div>The effect of prenatal Hg exposure on foetal development remains unclear, and the role of rice consumption as a dietary exposure source warrants further study. This study measured THg concentrations in maternal venous blood, placental tissue, and cord blood from 111 mother-infant pairs. Overall, THg exposure levels in this population were relatively low; however, pregnant women who consumed home-grown rice exhibited higher Hg concentrations than those who consumed market-purchased rice. After adjusting for covariates, Hg exposure was negatively associated with birth weight Z-score (BWz) and biparietal diameter Z-score (BPDz). Restricted cubic spline analysis further revealed a nonlinear relationship between cord blood THg and BWz, as well as a similar pattern between maternal THg and placental 5-methylcytosine (5mC) levels. Our findings suggest that prenatal Hg exposure may be associated with foetal growth outcomes and placental epigenetic alterations in a population where rice represents an important dietary source of MeHg. Given the cross-sectional design, causal inference is limited, and the findings should be interpreted with caution and not be overgeneralized. Further longitudinal studies in diverse populations are warranted to confirm these associations and clarify underlying mechanisms.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"127 ","pages":"Article 105174"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated network toxicology and transcriptomics uncover that the involvement of NF-κB/NLRP3 pyroptosis axis in mediating BaP-induced hepatotoxicity and fibrosis 综合网络毒理学和转录组学揭示NF-κB/NLRP3焦亡轴参与介导bap诱导的肝毒性和纤维化。

IF 4.6 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-10-01 Epub Date: 2026-09-26 DOI: 10.1016/j.etap.2026.105179

Bohe Wang, Xiuxia Dong, Jiayue Li, Xiaojuan Feng, Yongkang Chen, Na Liu, Pengjuan Fu, Junling Wang, Xiangli Li

{"title":"Integrated network toxicology and transcriptomics uncover that the involvement of NF-κB/NLRP3 pyroptosis axis in mediating BaP-induced hepatotoxicity and fibrosis","authors":"Bohe Wang, Xiuxia Dong, Jiayue Li, Xiaojuan Feng, Yongkang Chen, Na Liu, Pengjuan Fu, Junling Wang, Xiangli Li","doi":"10.1016/j.etap.2026.105179","DOIUrl":"10.1016/j.etap.2026.105179","url":null,"abstract":"<div><div>Benzo[<em>a</em>]pyrene (BaP), a ubiquitous environmental pollutant, exerts hepatotoxicity primarily through its metabolite BPDE. This study combined network toxicology and experimental validation to delineate the mechanisms of BaP-induced liver injury and fibrosis. Network analysis identified ICAM-1 as a potential core target, and previous clinical data confirmed its upregulation in liver injury patients. In a rat model, BaP exposure induced dose-dependent hepatic injury and oxidative stress. Mechanistically, BaP activated the NF-κB/TNF-α signaling axis, upregulating ICAM-1 and initiating NLRP3 inflammasome assembly. Activated NLRP3 promoted Caspase-1-dependent cleavage of GSDMD, leading to hepatocyte pyroptosis and the release of IL-1β and IL-18. Concurrently, ICAM-1 facilitated inflammatory cell infiltration. This sustained inflammatory microenvironment ultimately activated the TGF-β/α-SMA/Col-I axis, driving hepatic stellate cell activation and excessive extracellular matrix deposition, thereby promoting liver fibrosis. Our findings elucidate a cascading pathway linking BaP exposure to oxidative stress, NLRP3-mediated pyroptosis, and hepatic fibrogenesis.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"127 ","pages":"Article 105179"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the impact of mixed exposure to 18 PFASs on dyslipidemia risk: An epidemiological study in middle-aged and elderly adults 评估混合暴露于18种PFASs对血脂异常风险的影响：一项针对中老年人的流行病学研究。

IF 4.6 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-10-01 Epub Date: 2026-09-24 DOI: 10.1016/j.etap.2026.105175

Chiqun Shan, Xinhui Qiu, Qinru Xiao, Yiming Ge, Bo Fu, Yuli Lin, Aihua Guo, Mengyan Li, Pan Xu, Jimin Xu, Shaoyou Lu, Haobo Chen

{"title":"Assessing the impact of mixed exposure to 18 PFASs on dyslipidemia risk: An epidemiological study in middle-aged and elderly adults","authors":"Chiqun Shan, Xinhui Qiu, Qinru Xiao, Yiming Ge, Bo Fu, Yuli Lin, Aihua Guo, Mengyan Li, Pan Xu, Jimin Xu, Shaoyou Lu, Haobo Chen","doi":"10.1016/j.etap.2026.105175","DOIUrl":"10.1016/j.etap.2026.105175","url":null,"abstract":"<div><div>Dyslipidemia is a major cardiovascular risk factor, and per- and polyfluoroalkyl substances (PFASs) may disrupt lipid metabolism. This cross-sectional study measured urinary concentrations of 18 PFASs and fasting serum lipids in 214 middle-aged and elderly adults from Guangzhou, China. Associations were assessed using regression models and three mixture approaches: weighted quantile sum regression, quantile g-computation, and Bayesian kernel machine regression, with stratification by sex and age. Twelve PFASs were detected in over 60% of participants, with PFBA and PFPeA showing the highest concentrations. Short-chain PFASs, including PFBA, PFHxA, and PFBS, were positively associated with total cholesterol, triglycerides, and low-density lipoprotein, whereas PFHpA showed inverse associations. 6:2-Cl-PFESA was associated with lower high-density lipoprotein and total cholesterol. Mixture analyses showed no overall association but suggested antagonistic and interactive effects. Associations were stronger in men and adults aged 60–75 years. Prospective studies are needed to clarify causality and mechanisms.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"127 ","pages":"Article 105175"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Metformin alleviates paraquat-induced pulmonary fibrosis by promoting caveolin-1 and inhibiting ferroptosis” [Environ. Toxicol. Pharmacol. 126 (2026) 105113] “二甲双胍通过促进小窝蛋白-1和抑制铁下垂减轻百草枯诱导的肺纤维化”的更正[环境]。Toxicol。药理学杂志，26 (2026):1051 [j]。

IF 4.6 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-10-01 Epub Date: 2026-08-27 DOI: 10.1016/j.etap.2026.105134

Luan Wang, Zhiyu Ma, Tiegang Li

引用次数: 0

Mycotoxins as environmental pollutants: epigenetic modifications in animals and implications for ecosystem health 真菌毒素作为环境污染物：动物的表观遗传修饰及其对生态系统健康的影响。

IF 4.6 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-10-01 Epub Date: 2026-09-24 DOI: 10.1016/j.etap.2026.105176

Hira Sayed, Saber Y. Adam, Syeda Amna Batool, Thobela Louis Tyasi, In Ho Kim, Abdelkareem A. Ahmed, Hao-Yu Liu, Demin Cai

{"title":"Mycotoxins as environmental pollutants: epigenetic modifications in animals and implications for ecosystem health","authors":"Hira Sayed, Saber Y. Adam, Syeda Amna Batool, Thobela Louis Tyasi, In Ho Kim, Abdelkareem A. Ahmed, Hao-Yu Liu, Demin Cai","doi":"10.1016/j.etap.2026.105176","DOIUrl":"10.1016/j.etap.2026.105176","url":null,"abstract":"<div><div>Mycotoxins are widespread environmental contaminants whose global prevalence and ecological impacts are intensifying due to climate change. However, their sublethal effects on wildlife populations and ecosystem stability remain significantly underexplored. Laboratory studies have demonstrated that mycotoxins induce epigenetic toxicity, but the implications of these molecular findings for populations and ecosystems are not yet fully understood. This review synthesizes current knowledge regarding mycotoxin-induced epigenetic modifications and evaluates their effects across multiple levels of biological organization. Mycotoxins can induce intergenerational effects in model organisms, but true transgenerational inheritance remains less established in mammals. These heritable epigenetic modifications could propagate from individuals to populations, potentially affecting food webs, biodiversity, and ecosystem services, although these outcomes remain largely hypothetical. To address these knowledge gaps, we propose an epigenetics-informed risk assessment framework that incorporates early-warning epigenetic biomarkers, accounts for both intergenerational and transgenerational effects, integrates multi-stressor interactions, and evaluates ecosystem-level responses under climate change scenarios. Implementing this framework will depend on field-deployable detection methods, enzyme-based bioremediation strategies, and climate-adaptive management under a One Health approach. This review highlights the urgent need for interdisciplinary collaboration to address mycotoxin-induced epigenetic damage, which poses a potential threat to ecosystem integrity. However, the ecological consequences of these effects remain hypothetical and require further investigation.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"127 ","pages":"Article 105176"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary cadmium exposure and biomarkers of inflammation, lipid peroxidation, and kidney injury in apparently healthy adults from the Central Region of Mexico 墨西哥中部地区健康成人尿镉暴露与炎症、脂质过氧化和肾损伤的生物标志物

IF 4.6 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2026-10-01 Epub Date: 2026-09-30 DOI: 10.1016/j.etap.2026.105182

N. Pérez-Maldonado Iván, De la Trinidad-Chacón Carlos G, Rangel-Ramírez Velia V, C. Ochoa-Martínez Angeles, Varela-Silva José Antonio

{"title":"Urinary cadmium exposure and biomarkers of inflammation, lipid peroxidation, and kidney injury in apparently healthy adults from the Central Region of Mexico","authors":"N. Pérez-Maldonado Iván, De la Trinidad-Chacón Carlos G, Rangel-Ramírez Velia V, C. Ochoa-Martínez Angeles, Varela-Silva José Antonio","doi":"10.1016/j.etap.2026.105182","DOIUrl":"10.1016/j.etap.2026.105182","url":null,"abstract":"<div><div>Human exposure to cadmium remains a major global public health concern because of its potential to induce multiple adverse health effects. This study investigated the associations between cadmium exposure and effect biomarkers of oxidative stress, inflammation, and renal injury in a population from the Central Region of Mexico. The mean urinary cadmium concentration was 0.55 ± 1.15 µg/g creatinine. Higher urinary cadmium concentrations were significantly associated with increased levels of biomarkers of oxidative stress, inflammation, and kidney injury. These findings indicate that cadmium exposure is associated with biological alterations linked to an elevated risk of renal impairment, cardiovascular events, and metabolic syndrome, potentially mediated by oxidative stress and a sustained pro-inflammatory state. Overall, these findings highlight the importance of implementing public health strategies to reduce cadmium exposure and mitigate its potential contribution to the development of non-communicable diseases.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"127 ","pages":"Article 105182"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0