Environmental toxicology and pharmacology最新文献

Exposure to PCB52 (2,2′,5,5′-tetrachlorobiphenyl) blunts induction of the gene for uncoupling protein 1 (UCP1) in white adipose 接触 PCB52（2,2′,5,5′-四氯联苯）会减弱白色脂肪中解偶联蛋白 1（UCP1）基因的诱导作用

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-12-13 DOI: 10.1016/j.etap.2024.104612

Francoise A. Gourronc, Amanda J. Bullert, Brynn Kyleakin Helm-Kwasny, Andrea Adamcakova-Dodd, Hui Wang, Xuefang Jing, Xueshu Li, Peter S. Thorne, Hans-Joachim Lehmler, James A. Ankrum, Aloysius J. Klingelhutz

{"title":"Exposure to PCB52 (2,2′,5,5′-tetrachlorobiphenyl) blunts induction of the gene for uncoupling protein 1 (UCP1) in white adipose","authors":"Francoise A. Gourronc, Amanda J. Bullert, Brynn Kyleakin Helm-Kwasny, Andrea Adamcakova-Dodd, Hui Wang, Xuefang Jing, Xueshu Li, Peter S. Thorne, Hans-Joachim Lehmler, James A. Ankrum, Aloysius J. Klingelhutz","doi":"10.1016/j.etap.2024.104612","DOIUrl":"https://doi.org/10.1016/j.etap.2024.104612","url":null,"abstract":"Polychlorinated biphenyls (PCBs) are linked to cancer, learning disabilities, liver and cardiovascular disease, and diabetes. Older schools often contain high levels of PCBs, and inhalation is a major source of exposure. Technical PCB mixtures, called Aroclors, and individual dioxin-like PCBs impair adipocyte function, which can lead to type II diabetes. To determine how PCB52, a non-dioxin like PCB congener found in school air, affects adipose, adolescent male and female rats were exposed to PCB52 by nose-only inhibition for 4 h per day for 28 consecutive days. Transcriptomic analysis of white adipose revealed sex-specific differences in gene expression between PCB52- and sham-exposed males and females. Exposed females showed mitochondrial gene changes, including downregulation of the thermogenic uncoupling gene, <ce:italic>Ucp1</ce:italic>. Human preadipocytes/adipocytes exposed to PCB52 or its main metabolite, 4-OH-PCB52, also showed reduced norepinephrine-induced <ce:italic>UCP1</ce:italic> expression. These findings suggest that PCB52 inhalation disrupts thermogenesis in adipose tissue, potentially contributing to metabolic syndrome.","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"29 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compound-dependent fetal toxicity after in utero exposure to chemotherapy in a pregnant mouse model

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-12-01 DOI: 10.1016/j.etap.2024.104594

Ilana Struys , Ji-Ying Song , Carolina Velázquez , Terry Boadum , Marloes J. Posch , Marieke van de Ven , Liesbeth Lenaerts , Frédéric Amant

{"title":"Compound-dependent fetal toxicity after in utero exposure to chemotherapy in a pregnant mouse model","authors":"Ilana Struys , Ji-Ying Song , Carolina Velázquez , Terry Boadum , Marloes J. Posch , Marieke van de Ven , Liesbeth Lenaerts , Frédéric Amant","doi":"10.1016/j.etap.2024.104594","DOIUrl":"10.1016/j.etap.2024.104594","url":null,"abstract":"<div><div>Although chemotherapy is integrated in the treatment of second-trimester pregnant cancer patients, its potential cyto- and genotoxicity to fetal tissue remains unknown. To investigate any causal relation between <em>in utero</em> chemotherapy exposure and fetal toxicity, late-gestation pregnant BL6 mice were exposed to vehicle, or one of six chemotherapeutic compounds, used to treat pregnant cases: cyclophosphamide, carboplatin, cisplatin (alkylating agents), epirubicin, doxorubicin (anthracyclines) or paclitaxel (taxane). fetuses were euthanized at gestational day 18.5, after 48 hours of <em>in utero</em> exposure. Fetuses <em>in utero</em> exposed to alkylating agents presented with morphological changes in liver, bone marrow and thymus. Furthermore, decreased expression of Ki67, and increased expression of caspase-3 and P-H2AX markers, pointed to inhibited proliferation and increased apoptosis and DNA-double stranded breaks respectively, in several fetal tissues. Moderate toxicity was seen after <em>in utero</em> exposure to anthracyclines and taxanes. These findings emphasize the importance of investigating fetal toxicity in the clinical setting.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104594"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal, predictive or observational? Different understandings of key event relationships for adverse outcome pathways and their implications on practice

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-30 DOI: 10.1016/j.etap.2024.104597

Zheng Zhou , Jeroen L.A. Pennings , Ullrika Sahlin

{"title":"Causal, predictive or observational? Different understandings of key event relationships for adverse outcome pathways and their implications on practice","authors":"Zheng Zhou , Jeroen L.A. Pennings , Ullrika Sahlin","doi":"10.1016/j.etap.2024.104597","DOIUrl":"10.1016/j.etap.2024.104597","url":null,"abstract":"<div><div>The Adverse Outcome Pathways (AOPs) framework is pivotal in toxicology, but the, terminology describing Key Event Relationships (KERs) varies within AOP guidelines.This study examined the usage of causal, observational and predictive terms in AOP, documentation and their adaptation in AOP development. A literature search and text, analysis of key AOP guidance documents revealed nuanced usage of these terms, with KERs often described as both causal and predictive. The adaptation of, terminology varies across AOP development stages. Evaluation of KER causality often, relies targeted blocking experiments and weight-of-evidence assessments in the, putative and qualitative stages. Our findings highlight a potential mismatch between,terminology in guidelines and methodologies in practice, particularly in inferring,causality from predictive models. We argue for careful consideration of terms like, causal and essential to facilitate interdisciplinary communication. Furthermore, integrating known causality into quantitative AOP models remains a challenge.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104597"},"PeriodicalIF":4.2,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Joint action of six-component mixtures based on concentration response curves morphological parameter in acute and long-term toxicity assay

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-28 DOI: 10.1016/j.etap.2024.104595

Yujiao Zhang , Yajiao Li , Na Wang , Xiaoyan Ma , Jiajing Sun , Xiaochang Wang , Jiaxuan Wang

{"title":"Joint action of six-component mixtures based on concentration response curves morphological parameter in acute and long-term toxicity assay","authors":"Yujiao Zhang , Yajiao Li , Na Wang , Xiaoyan Ma , Jiajing Sun , Xiaochang Wang , Jiaxuan Wang","doi":"10.1016/j.etap.2024.104595","DOIUrl":"10.1016/j.etap.2024.104595","url":null,"abstract":"<div><div>Previous studies found that the multi-component mixtures with hormesis concentration-response curves (CRCs) were divided into three types according to the combined toxicity analysis of the segment-based method and <em>σ</em><sup>2</sup><sub>(<em>k∙ECx</em>)</sub> (the variance of <em>k∙EC</em><sub><em>x</em></sub>). In this study, the acute and long-term toxicity of six pollutants and 12 six-component mixtures were assessed using microplate toxicity analyses (MTA). The functional relationship between <em>σ</em><sup><em>2</em></sup><sub>(<em>k·ECx</em>)</sub> and effect ratio (<em>ER</em><sub><em>x</em></sub>) was determined by means of the independent action (IA) and the ER model to systematically investigate the correlation between mixture types in acute and long-term toxicity. The results indicated that across the entire concentration range, the mixture type of acute toxicity was consistent with short time exposure (0.25 h) measured in the long-term toxicity experiment. In the inhibition effect range, the types of mixtures of acute toxicity remained consistent with the chronic toxicity (exposure for 24 h) in 11 of the 12 mixtures. This study clarified the changes in the joint action of multi-component mixtures on <em>Aliivibrio fischeri</em> in terms of acute and long-term toxicity. The chronic toxicity of the mixtures can be predicted from the acute toxicity results, which provides a theoretical basis for the biological toxicity evaluation of multi-component mixtures.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104595"},"PeriodicalIF":4.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased metabolic demand reveals morpho-functional impacts caused by settleable atmospheric particulate matter on fish gills 新陈代谢需求的增加揭示了可沉降大气颗粒物对鱼鳃造成的形态功能影响

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-26 DOI: 10.1016/j.etap.2024.104593

C.F. De Angelis , M.P. Soares , I.L. Cardoso , E.W. Taylor , H. Sadauskas-Henrique , E.N. Fragoso-Moura , J.A.M. Milan , I.C. Souza , D.A. Wunderlin , M.V. Monferrán , M.N. Fernandes , C.A.C. Leite

{"title":"Increased metabolic demand reveals morpho-functional impacts caused by settleable atmospheric particulate matter on fish gills","authors":"C.F. De Angelis , M.P. Soares , I.L. Cardoso , E.W. Taylor , H. Sadauskas-Henrique , E.N. Fragoso-Moura , J.A.M. Milan , I.C. Souza , D.A. Wunderlin , M.V. Monferrán , M.N. Fernandes , C.A.C. Leite","doi":"10.1016/j.etap.2024.104593","DOIUrl":"10.1016/j.etap.2024.104593","url":null,"abstract":"<div><div>Exposure to environmentally relevant levels of settleable atmospheric particulate matter (SePM) limits the aerobic performance of inactive healthy adult fish. We evaluated the gill morpho-functional impacts (gill structure and ionic balance) caused by SePM exposure (96 h) in Nile tilapia when fish is impelled to maximal aerobic swimming effort. In control fish, swimming reduced epithelial filament thickness (EFT, 25 %), increased the distance between lamellae (DL, 21 %), and reduced the plasma Na<sup>+</sup> (5 %). In resting fish, SePM exposure increased EFT (11 %), reduced DL (30 %), lamellar height (LH, 18 %), and plasma Na<sup>+</sup> (4 %), whereas increased Cl<sup>-</sup> and K<sup>+</sup> (8 % and 20 %). In SePM-exposure fish, swimming reduced EFT (40 %), increased DL (30 %) and LH (30 %), while reduced Na<sup>+</sup> and Cl<sup>-</sup> (9 % and 18 %), and increased K<sup>+</sup> when compared to inactive SePM-exposed fish. These morpho-functional limitations may compromise whole-body maintenance and swimming recovery, affecting the fish ability to perform at higher activity levels.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104593"},"PeriodicalIF":4.2,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term impact of embryonic exposure to ethinylestradiol and clotrimazole on behavior and neuroplasticity in zebrafish (Danio rerio) 胚胎期接触炔雌醇和克霉唑对斑马鱼（Danio rerio）行为和神经可塑性的长期影响。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-22 DOI: 10.1016/j.etap.2024.104592

M. Blanc-Legendre , L. Guillot , L. Chevalier , C. Malleret , K. Le Menach , P. Pardon , H. Budzinski , F. Brion , S. Sire , P. Coumailleau , T.D. Charlier , E. Pellegrini , X. Cousin

{"title":"Long-term impact of embryonic exposure to ethinylestradiol and clotrimazole on behavior and neuroplasticity in zebrafish (Danio rerio)","authors":"M. Blanc-Legendre , L. Guillot , L. Chevalier , C. Malleret , K. Le Menach , P. Pardon , H. Budzinski , F. Brion , S. Sire , P. Coumailleau , T.D. Charlier , E. Pellegrini , X. Cousin","doi":"10.1016/j.etap.2024.104592","DOIUrl":"10.1016/j.etap.2024.104592","url":null,"abstract":"<div><div>Estrogen receptors (ER) are widely expressed in the brain of many species and experimental results highlighted the role of estradiol in neuronal plasticity and behavior. Consequently, the brain is therefore a prime target for endocrine disrupting chemicals (EDCs) interacting with estrogen signaling. Very little is known about the late effects of early disruption of estrogen signaling by EDCs. We focused on: ethinylestradiol (EE2; ER agonist) and clotrimazole (inhibitor of key steroidogenesis enzymes, including aromatases). Zebrafish eleutheroembryos were exposed (0–5 days) and then raised normally until adulthood. Several behavioral tests were performed in adults, then cell proliferation and dopaminergic neurons were quantified in several brain regions using immunostaining. Overall, a developmental exposure to EDCs stimulates cell proliferation in the dorsal telencephalon. At environmentally-relevant concentrations, male fish exposed to EE2 exhibited increased activity levels and decreased social behavior, posing a potential risk to population balance and health.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104592"},"PeriodicalIF":4.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress indicators in conservative tissues of Humboldt penguin under captivity 人工饲养下洪堡企鹅保守组织的压力指标

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-22 DOI: 10.1016/j.etap.2024.104590

Montserrat Solé , Sergi Omedes , Vanessa Almagro , Manel López-Béjar , Annaïs Carbajal

{"title":"Stress indicators in conservative tissues of Humboldt penguin under captivity","authors":"Montserrat Solé , Sergi Omedes , Vanessa Almagro , Manel López-Béjar , Annaïs Carbajal","doi":"10.1016/j.etap.2024.104590","DOIUrl":"10.1016/j.etap.2024.104590","url":null,"abstract":"<div><div>Humboldt penguins (<em>Spheniscus humboldti</em>) from the Barcelona zoo (n=9) were followed to assess their physiological stress status using conservative protocols. Corticosterone levels were measured in feathers and plasma as indicative of chronic and acute physiological stress, respectively. Other markers: B-esterases, potentially indicative of xenobiotic exposure were measured in plasma of these same individuals and reported for the first time in this species. The sensitivity to chemicals of environmental concern, employed as plastic additives, was assessed <em>in vitro</em> with plasma of this species using the inhibition of carboxylesterase (CE) and acetylcholinesterase enzymatic measurements. Among the tested additives, the organophosphorus flame retardants displayed the highest <em>in vitro</em> inhibitory potential on basal CE activity, suggesting their potential utility as biomarkers of this particular chemical class. Additionally, enzymatic measurements in plasma are determined for the first time in Humboldt penguin and can be regarded as baseline values for a potential field monitoring application.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104590"},"PeriodicalIF":4.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synbiotics, a promising approach for alleviating exacerbated allergic airway immune responses in offspring of a preclinical murine pollution model 合成益生菌是缓解临床前小鼠污染模型后代过敏性气道免疫反应加重的有效方法。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-20 DOI: 10.1016/j.etap.2024.104591

Ali Dehghani , Lei Wang , Johan Garssen , Eirini Styla , Thea Leusink-Muis , Ingrid Van Ark , Gert Folkerts , Jeroen Van Bergenhenegouwen , Saskia Braber

{"title":"Synbiotics, a promising approach for alleviating exacerbated allergic airway immune responses in offspring of a preclinical murine pollution model","authors":"Ali Dehghani , Lei Wang , Johan Garssen , Eirini Styla , Thea Leusink-Muis , Ingrid Van Ark , Gert Folkerts , Jeroen Van Bergenhenegouwen , Saskia Braber","doi":"10.1016/j.etap.2024.104591","DOIUrl":"10.1016/j.etap.2024.104591","url":null,"abstract":"<div><div>Exposure to pollutants like environmental cigarette smoke (CS) poses a major global health risk, affecting individuals from an early age. Therefore, this study explores how postnatal synbiotic supplementation affects allergic asthma symptoms in house-dust-mite (HDM)- challenged offspring maternally exposed to CS. In HDM-allergic offspring of CS-exposed dams, lung resistance was elevated, but synbiotic supplementation effectively reduced this resistance. Elevated eosinophil BALF counts following HDM challenge were intensified in pups maternally exposed to CS. Similarly, Th2 cell activation and serum IgE and IgG1 levels were more pronounced in HDM-allergic offspring of CS-exposed mothers. Synbiotics reduced eosinophil numbers and serum IgE and IgG1, and tended to decrease Th2 cell infiltration and activation. Synbiotics promoted beneficial gut bacteria like Bifidobacterium and Akkermansia. In conclusion, early-life synbiotic intervention mitigated allergic asthma associated with maternal air pollution exposure, highlighting the potential of synbiotics for clinical evaluation as a strategy to prevent allergy development in offspring.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104591"},"PeriodicalIF":4.2,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between exposure to per- and polyfluoroalkyl substances and missed miscarriage: A hospital-based case-control study in Shanghai, China 接触全氟和多氟烷基物质与流产漏诊之间的关系：中国上海医院病例对照研究》。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-16 DOI: 10.1016/j.etap.2024.104589

Beiying Wang, Wei Hong, Zhiping Wu, Xiaocui Li

{"title":"Association between exposure to per- and polyfluoroalkyl substances and missed miscarriage: A hospital-based case-control study in Shanghai, China","authors":"Beiying Wang, Wei Hong, Zhiping Wu, Xiaocui Li","doi":"10.1016/j.etap.2024.104589","DOIUrl":"10.1016/j.etap.2024.104589","url":null,"abstract":"<div><div>Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants linked to reproductive disruptions. This study investigated the relationship between PFAS exposure and missed miscarriage in a hospital-based, case-control study in Shanghai, China. There were 393 women in our research, including 198 cases and 195 controls. Concentrations of 30 PFAS in plasma were quantified using HPLC-MS/MS, and 15 PFAS were detected at a rate greater than 90 percent. PFOA, L-PFOS, and PFOS isomers were significantly higher in the cases than those in the controls. 13 PFAS showed significant positive associations with miscarriage risk after adjustment for confounders, particularly PFOA (OR: 2.99, 95 % CI: 1.96–4.68) and various PFOS isomers. BKMR analysis confirmed higher overall PFAS levels were associated with increased miscarriage risk. These findings highlight the potential reproductive toxicity of PFAS and underscore the need for further investigations and regulatory actions to mitigate PFAS exposure in pregnant women.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104589"},"PeriodicalIF":4.2,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of an insecticide, fungicide and plant growth regulator and their mixture on the survival of the springtail Folsomia candida and the potential reduction of toxicity by vitamins 杀虫剂、杀真菌剂和植物生长调节剂及其混合物对念珠绣春蜱存活的影响以及维生素的潜在减毒作用。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-13 DOI: 10.1016/j.etap.2024.104588

Pavla Pabiskova , Bruno Sopko , Elena Shcherbachenko , Tomas Erban

{"title":"Effect of an insecticide, fungicide and plant growth regulator and their mixture on the survival of the springtail Folsomia candida and the potential reduction of toxicity by vitamins","authors":"Pavla Pabiskova , Bruno Sopko , Elena Shcherbachenko , Tomas Erban","doi":"10.1016/j.etap.2024.104588","DOIUrl":"10.1016/j.etap.2024.104588","url":null,"abstract":"<div><div>A pesticide-free model soil was pretreated with field-realistic doses/applications of the insecticide, Biscaya 240 OD; the fungicide Tilmor; the growth regulator, Atonik and their mixture. Because <em>Folsomia candida</em> is eyeless, unpigmented, avoids light, and prefers dark, wet and cold conditions, we grew and tested it in the dark and at 18°C. Survival of springtails added to soil at 50 % moisture was assessed after 28 days. The experiments were repeated three times in order to confirm the validity of the test and results. The mixture decreased the survival most significantly. Bayesian statistics showed that pesticide treatment had a greater effect than repeating the experiment. Further tests revealed that the negative effect of the mixture on springtail survival was effectively suppressed by the application of biotin (vitamin B7), whereas riboflavin (vitamin B2) had little effect. Vitamins can reduce the toxicity of agrochemicals in the soil through potential effects on soil biological activity.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104588"},"PeriodicalIF":4.2,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0