Environmental toxicology and pharmacology最新文献_第10页

Acute exposure and biomarkers assessment in rainbow trout exposed to selected pharmaceuticals 虹鳟鱼接触特定药物后的急性暴露和生物标志物评估

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-17 DOI: 10.1016/j.etap.2024.104472

C. André, J. Auclair, F. Gagné

{"title":"Acute exposure and biomarkers assessment in rainbow trout exposed to selected pharmaceuticals","authors":"C. André, J. Auclair, F. Gagné","doi":"10.1016/j.etap.2024.104472","DOIUrl":"10.1016/j.etap.2024.104472","url":null,"abstract":"<div><p>Pharmaceuticals released from municipal effluents discharges pose a risk to aquatic organisms. The toxicity of 5 pharmaceuticals with distinct therapeutic actions were assessed in rainbow trout: olanzapine (antipsychotic), erythromycin (antibiotic), mycophenoate (immunosuppression), pinaverium (anti-inflammatory) and trazodone (sedative). Juveniles were exposed to these drugs for 96 h at concentrations between 64 µg/L up to 40 mg/L to reach lethality. Survival was determined and a suite of biomarkers was analyzed for drug biotransformation, oxidative stress/damage and metabolic activity at sublethal concentrations. The data revealed the following toxicity: olanzapine >trazodone>mycophenolate>pinaverium∼erythromycin based on mortality. The data also revealed that toxicity was associated to mass, pKa and hydrophobicity and the following sublethal effects: GST, LPO and DNA strand breaks. Pharmaceuticals with lower molecular weight, physiological pKa, moderate hydrophobicity, low biotransformation and DNA strand breaks were generally more toxic to fish. However, this should be considered as a general guide in identifying toxic pharmaceuticals in non-target organisms.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"108 ","pages":"Article 104472"},"PeriodicalIF":4.3,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141048847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral profile alterations and predation susceptibility of Japanese medaka fish exposed to phenytoin, an antiepileptic drug 暴露于苯妥英（一种抗癫痫药物）的日本青鳉的行为特征变化和捕食易感性

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-17 DOI: 10.1016/j.etap.2024.104474

Ayaka Sawada , Uaciquete Dorcas , Yoshifumi Horie

{"title":"Behavioral profile alterations and predation susceptibility of Japanese medaka fish exposed to phenytoin, an antiepileptic drug","authors":"Ayaka Sawada , Uaciquete Dorcas , Yoshifumi Horie","doi":"10.1016/j.etap.2024.104474","DOIUrl":"10.1016/j.etap.2024.104474","url":null,"abstract":"<div><p>Antiepileptic drugs, such as phenytoin, are often leaked into aquatic systems through sewage facilities due to their low metabolic rate. Fish, such as the Japanese medaka (<em>Oryzias latipes</em>), demonstrate abnormal swimming behavior such as equilibrium abnormalities, rotational behavior, and vertical swimming, when exposed to phenytoin. Therefore, it is hypothesized that predator avoidance may be hindered. This study aimed to investigate the effects of phenytoin exposure-induced behavioral abnormalities in predator avoidance in Japanese medaka. The results showed that individuals with behavioral abnormalities had a reduced ability to avoid danger. Furthermore, the fish demonstrated a delayed recognition reaction to approaching predators. Additionally, predatory fish, such as silver pike characin (<em>Ctenolucius hujeta</em>), were more likely to prey upon abnormal individuals. In conclusion, the fish exposed to phenytoin demonstrated behavioral changes that increased its predation risk. This study is the first to determine the effects of behavioral abnormalities in Japanese medaka which was induced after phenytoin exposure on predator risk avoidance.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"108 ","pages":"Article 104474"},"PeriodicalIF":4.3,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141025424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacokinetics and residues of florfenicol in Nile tilapia (Oreochromis niloticus) post-oral gavage 尼罗罗非鱼（Oreochromis niloticus）灌胃后氟苯尼考的药代动力学和残留量

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-17 DOI: 10.1016/j.etap.2024.104471

Avishek Bardhan , Thangapalam Jawahar Abraham , Tapas Kumar Sar , Ravindran Rajisha , Satyen Kumar Panda , Prasanna Kumar Patil

{"title":"Pharmacokinetics and residues of florfenicol in Nile tilapia (Oreochromis niloticus) post-oral gavage","authors":"Avishek Bardhan , Thangapalam Jawahar Abraham , Tapas Kumar Sar , Ravindran Rajisha , Satyen Kumar Panda , Prasanna Kumar Patil","doi":"10.1016/j.etap.2024.104471","DOIUrl":"10.1016/j.etap.2024.104471","url":null,"abstract":"<div><p>In the study on <em>Oreochromis niloticus</em>, singular oral gavage of florfenicol (FFC) at 15 mg/kg biomass/day was conducted, mimicking approved aquaculture dosing. Samples of plasma, bile, muscle, intestine, skin, liver, kidney, gill, and brain tissues were collected at 0, 2, 3, 4, 6, 8, 12, 16, 24, 32, 48, 64, 96, and 128 hours (h) after oral gavage. LC-MS/MS analysis revealed FFC concentrations peaked at 12.15 μg/mL in plasma and 77.92 μg/mL in bile, both at 24 hours. Elimination half-lives were 28.17 h (plasma) and 26.88 h (bile). The residues of FFC ranked muscle>intestine>skin>liver>kidney>gill. In contrast, the residues of florfenicol amine (FFA) ranked kidney>skin>liver>muscle>gill>intestine>brain, particularly notable in tropical summer conditions. The minimum inhibitory concentration of FFC was elucidated against several bacterial pathogens revealing its superior efficacy. Results highlight bile's crucial role in FFC elimination. Further investigation, especially during winter when fish susceptibility to infections rises, is warranted.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"108 ","pages":"Article 104471"},"PeriodicalIF":4.3,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141051811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring novel insights into the molecular mechanisms underlying Bisphenol A-induced toxicity: A persistent threat to human health 探索双酚 A 诱导毒性的分子机制：对人类健康的持久威胁。

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-17 DOI: 10.1016/j.etap.2024.104467

Israel Ahmad , Mandeep Kaur , Devansh Tyagi , Tejinder Bir Singh , Gurpreet Kaur , Shaikh Mohammad Afzal , Mohsin Jauhar

{"title":"Exploring novel insights into the molecular mechanisms underlying Bisphenol A-induced toxicity: A persistent threat to human health","authors":"Israel Ahmad , Mandeep Kaur , Devansh Tyagi , Tejinder Bir Singh , Gurpreet Kaur , Shaikh Mohammad Afzal , Mohsin Jauhar","doi":"10.1016/j.etap.2024.104467","DOIUrl":"10.1016/j.etap.2024.104467","url":null,"abstract":"<div><p>Bisphenol A (BPA) is a ubiquitous industrial chemical used in the production of polycarbonate plastics and epoxy resins, found in numerous consumer products. Despite its widespread use, its potential adverse health effects have raised significant concerns. This review explores the molecular mechanisms and evidence-based literature underlying BPA-induced toxicities and its implications for human health. BPA is an endocrine-disrupting chemical (EDC) which exhibits carcinogenic properties by influencing various receptors, such as ER, AhR, PPARs, LXRs, and RARs. It induces oxidative stress and contributes to cellular dysfunction, inflammation, and DNA damage, ultimately leading to various toxicities including but not limited to reproductive, cardiotoxicity, neurotoxicity, and endocrine toxicity. Moreover, BPA can modify DNA methylation patterns, histone modifications, and non-coding RNA expression, leading to epigenetic changes and contribute to carcinogenesis. Overall, understanding molecular mechanisms of BPA-induced toxicity is crucial for developing effective strategies and policies to mitigate its adverse effects on human health.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"108 ","pages":"Article 104467"},"PeriodicalIF":4.3,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-Acetyl-L-cysteine attenuates titanium dioxide nanoparticle (TiO2 NP)-induced autophagy in male germ cells N-乙酰-L-半胱氨酸可减轻二氧化钛纳米粒子（TiO2 NP）诱导的雄性生殖细胞自噬作用

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-16 DOI: 10.1016/j.etap.2024.104466

Beom-Jin Shin , Bang-Jin Kim , Eun-Ji Paeng , Jack Tyler Rifkin , Sung-Hwan Moon , Seung Hee Shin , Buom-Yong Ryu

引用次数: 0

Gene expression profiles and protein-protein interaction networks in THP-1 cells exposed to metal-based nanomaterials 暴露于金属基纳米材料的 THP-1 细胞的基因表达谱和蛋白质相互作用网络。

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-15 DOI: 10.1016/j.etap.2024.104469

Šíma Michal , Líbalová Helena , Závodná Táňa , Vrbová Kristýna , Kléma Jiří , Rössner Pavel

{"title":"Gene expression profiles and protein-protein interaction networks in THP-1 cells exposed to metal-based nanomaterials","authors":"Šíma Michal , Líbalová Helena , Závodná Táňa , Vrbová Kristýna , Kléma Jiří , Rössner Pavel","doi":"10.1016/j.etap.2024.104469","DOIUrl":"10.1016/j.etap.2024.104469","url":null,"abstract":"<div><p>We analyzed gene expression in THP-1 cells exposed to metal-based nanomaterials (NMs) [TiO<sub>2</sub> (NM-100), ZnO (NM-110), SiO<sub>2</sub> (NM-200), Ag (NM-300 K)]. A functional enrichment analysis of the significant differentially expressed genes (DEGs) identified the key modulated biological processes and pathways. DEGs were used to construct protein–protein interaction networks. NM-110 and NM-300 K induced changes in the expression of genes involved in oxidative and genotoxic stress, immune response, alterations of cell cycle, detoxification of metal ions and regulation of redox-sensitive pathways. Both NMs shared a number of highly connected protein nodes (hubs) including CXCL8, ATF3, HMOX1, and IL1B. NM-200 induced limited transcriptional changes, mostly related to the immune response; however, several hubs (CXCL8, ATF3) were identical with NM-110 and NM-300 K. No effects of NM-100 were observed. Overall, soluble nanomaterials NM-110 and NM-300 K exerted a wide variety of toxic effects, while insoluble NM-200 induced immunotoxicity; NM-100 caused no detectable changes on the gene expression level.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"108 ","pages":"Article 104469"},"PeriodicalIF":4.3,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141044058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathology and changes in the expression of metallothioneins, heat shock proteins and inducible nitric oxide synthase in Prochilodus costatus from a neotropical river contaminated by heavy metals 受重金属污染的新热带河流中鲈鱼的组织病理学以及金属硫蛋白、热休克蛋白和诱导型一氧化氮合酶的表达变化。

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-15 DOI: 10.1016/j.etap.2024.104473

Alessandro Loureiro Paschoalini , Yves Moreira Ribeiro , Breno Thuller , Camila Leandro Gomes Soares , Elizete Rizzo , Nilo Bazzoli

{"title":"Histopathology and changes in the expression of metallothioneins, heat shock proteins and inducible nitric oxide synthase in Prochilodus costatus from a neotropical river contaminated by heavy metals","authors":"Alessandro Loureiro Paschoalini , Yves Moreira Ribeiro , Breno Thuller , Camila Leandro Gomes Soares , Elizete Rizzo , Nilo Bazzoli","doi":"10.1016/j.etap.2024.104473","DOIUrl":"10.1016/j.etap.2024.104473","url":null,"abstract":"<div><p>The most recent dam rupture in Brazil released tons of mining tailings into the upper course of the Paraopeba River, affecting this river in an unprecedented way. The present study aimed to evaluate the influence of heavy metals on <em>Prochilodus costatus</em>, an important commercial species in Brazil, four years after the dam colapse. To this end, biomarkers of heavy metals, oxidative stress, and environmental stress were analyzed, and histological analyses of target organs were performed. The results demonstrated critical contamination of fish from the Paraopeba River. Increased expression of Metallothioneins - MTs, Heat Shock Protein - HSP70, and inducible nitric oxide synthase - iNOS, as well as greater rates of histological changes in the liver, spleen, and gonads, were observed in <em>P. costatus</em>. These findings demonstrate that, despite past contamination, the metals present in mining tailings have significantly increased the contamination of the Paraopeba River basin.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"108 ","pages":"Article 104473"},"PeriodicalIF":4.3,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141044643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlorpyrifos-induced suppression of the antioxidative defense system leads to cytotoxicity and genotoxicity in macrophages 毒死蜱诱导的抗氧化防御系统抑制导致巨噬细胞的细胞毒性和基因毒性

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-15 DOI: 10.1016/j.etap.2024.104468

Yin-Che Lu , Chen-Yu Chiang , Shih-Pin Chen , Yu-Wei Hsu , Wen-Ying Chen , Chun-Jung Chen , Yu-Hsiang Kuan , Sheng-Wen Wu

{"title":"Chlorpyrifos-induced suppression of the antioxidative defense system leads to cytotoxicity and genotoxicity in macrophages","authors":"Yin-Che Lu , Chen-Yu Chiang , Shih-Pin Chen , Yu-Wei Hsu , Wen-Ying Chen , Chun-Jung Chen , Yu-Hsiang Kuan , Sheng-Wen Wu","doi":"10.1016/j.etap.2024.104468","DOIUrl":"10.1016/j.etap.2024.104468","url":null,"abstract":"<div><p>Chlorpyrifos, widely used for pest control, is known to have various harmful effects, although its toxic effects in macrophages and the mechanisms underlying its toxicity remain unclear. The present study investigated the toxic effects of chlorypyrifos in a macrophage cell line. Here, we found that chlorpyrifos induced cytotoxicity and genotoxicity in RAW264.7 macrophages. Moreover, chlorpyrifos induced intracellular ROS production, subsequently leading to lipid peroxidation. Chlorpyrifos reduced the activation of antioxidative enzymes including superoxide dismutase, catalase, and glutathione peroxidase. Chlorpyrifos upregulated HO-1 expression and activated the Keap1-Nrf2 pathway, as indicated by enhanced Nrf2 phosphorylation and Keap1 degradation. Chlorpyrifos exerted effects on the following in a dose-dependent manner: cytotoxicity, genotoxicity, lipid peroxidation, intracellular ROS production, antioxidative enzyme activity reduction, HO-1 expression, Nrf2 phosphorylation, and Keap1 degradation. Notably, N-acetyl-L-cysteine successfully inhibited chlorpyrifos-induced intracellular ROS generation, cytotoxicity, and genotoxicity. Thus, chlorpyrifos may induce cytotoxicity and genotoxicity by promoting intracellular ROS production and suppressing the antioxidative defense system activation in macrophages.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"108 ","pages":"Article 104468"},"PeriodicalIF":4.3,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141047288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of genotoxic damage, production reactive oxygen and nitrogen species in Plasmodium yoelii yoelii exposed to sodium metavanadate 评估暴露于偏钒酸钠的yoelii yoelii疟原虫的基因毒性损伤、活性氧和氮物种的产生情况

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-09 DOI: 10.1016/j.etap.2024.104465

Brenda Casarrubias-Tabarez , Norma Rivera-Fernández , Norberto Alarcón-Herrera , Gabriela Guerrero-Palomo , Marcela Rojas-Lemus , Nelly López-Valdez , Jhony Anacleto-Santos , Adriana Gonzalez-Villalva , Martha Ustarroz-Cano , Teresa I. Fortoul

{"title":"Evaluation of genotoxic damage, production reactive oxygen and nitrogen species in Plasmodium yoelii yoelii exposed to sodium metavanadate","authors":"Brenda Casarrubias-Tabarez , Norma Rivera-Fernández , Norberto Alarcón-Herrera , Gabriela Guerrero-Palomo , Marcela Rojas-Lemus , Nelly López-Valdez , Jhony Anacleto-Santos , Adriana Gonzalez-Villalva , Martha Ustarroz-Cano , Teresa I. Fortoul","doi":"10.1016/j.etap.2024.104465","DOIUrl":"https://doi.org/10.1016/j.etap.2024.104465","url":null,"abstract":"<div><p>Malaria represents the greatest global health burden among all parasitic diseases, with drug resistance representing the primary obstacle to control efforts. Sodium metavanadate (NaVO<sub>3</sub>) exhibits antimalarial activity against the Plasmodium <em>yoelii yoelii</em> (<em>Pyy</em>), yet its precise antimalarial mechanism remains elusive. This study aimed to assess the antimalarial potential of NaVO<sub>3</sub>, evaluate its genotoxicity, and determine the production of reactive oxygen and nitrogen species (ROS/RNS) in <em>Pyy.</em> CD-1 mice were infected and divided into two groups: one treated orally with NaVO<sub>3</sub> (10 mg/kg/day for 4 days) and the other untreated. A 50% decrease in parasitemia was observed in treated mice. All experimental days demonstrated DNA damage in exposed parasites, along with an increase in ROS and RNS on the fifth day, suggesting a possible parasitostatic effect. The results indicate that DNA is a target of NaVO<sub>3</sub>, but further studies are necessary to fully elucidate the mechanisms underlying its antimalarial activity.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"108 ","pages":"Article 104465"},"PeriodicalIF":4.3,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140906645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between exposure to phthalates and liver function among women undergoing assisted reproductive technology 接受辅助生殖技术的妇女接触邻苯二甲酸盐与肝功能之间的关系

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-09 DOI: 10.1016/j.etap.2024.104463

Yi Wang , Li Yin , Yao-Yao Du , Hong-Mei Liao , Juan Li , Wen Yao , Xiao-Qiong Yuan , Qing-Chun Guo , Tao-Ran Deng , Na Guo , Min Zhang , Qiang Zeng , Chong Liu , Yu-Feng Li

{"title":"Associations between exposure to phthalates and liver function among women undergoing assisted reproductive technology","authors":"Yi Wang , Li Yin , Yao-Yao Du , Hong-Mei Liao , Juan Li , Wen Yao , Xiao-Qiong Yuan , Qing-Chun Guo , Tao-Ran Deng , Na Guo , Min Zhang , Qiang Zeng , Chong Liu , Yu-Feng Li","doi":"10.1016/j.etap.2024.104463","DOIUrl":"https://doi.org/10.1016/j.etap.2024.104463","url":null,"abstract":"<div><p>Phthalates can induce hepatotoxicity in animal studies. We aimed to assess the associations of individual and mixture of urinary phthalate metabolites with serum liver function indicators among 764 women undergoing assisted reproductive technology (ART). In linear models, we observed inverse correlations between urinary mono-benzyl phthalate and serum total protein (TP) as well as globulin (β=–0.27 and –0.23, respectively, <em>P</em><0.05). Additionally, negative associations were identified between mono-isobutyl phthalate and mono-butyl phthalate (MBP) and aspartate aminotransferase-to-alanine transaminase ratio (AST/ALT) (<em>P</em><0.05). MBP and the sum of all phthalate metabolites (∑all.phth.m) were positively associated with bilirubin, with β ranging from 0.14 to 0.47. Most phthalate metabolites were also positively related to gamma-glutamyl transferase (GGT) (all <em>P</em><0.05). In Bayesian kernel machine regression models, phthalate mixture was positively associated with bilirubin and GGT, whereas inversely associated with AST/ALT and TP. Our results suggest that phthalate exposure may impair liver function among women undergoing ART.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"108 ","pages":"Article 104463"},"PeriodicalIF":4.3,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140906644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0