Environmental toxicology and pharmacology最新文献_第10页

Genetic alteration profiling in middle-aged women acutely exposed during the mechanical processing of dental nanocomposites 牙科纳米复合材料机械加工过程中急性暴露的中年妇女的基因改变图谱。

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-06 DOI: 10.1016/j.etap.2024.104462

Andrea Rossnerova , Irena Chvojkova , Fatima Elzeinova , Daniela Pelclova , Pavlina Klusackova , Vladimir Zdimal , Lucie Ondrackova , Pavel Bradna , Adela Roubickova , Zuzana Simova , Pavel Rossner Jr.

{"title":"Genetic alteration profiling in middle-aged women acutely exposed during the mechanical processing of dental nanocomposites","authors":"Andrea Rossnerova , Irena Chvojkova , Fatima Elzeinova , Daniela Pelclova , Pavlina Klusackova , Vladimir Zdimal , Lucie Ondrackova , Pavel Bradna , Adela Roubickova , Zuzana Simova , Pavel Rossner Jr.","doi":"10.1016/j.etap.2024.104462","DOIUrl":"10.1016/j.etap.2024.104462","url":null,"abstract":"<div><p>Nanoparticles (NPs) have become an important part of everyday life, including their application in dentistry. Aside from their undoubted benefits, questions regarding their risk to human health, and/or genome have arisen. However, studies concerning cytogenetic effects are completely absent. A group of women acutely exposed to an aerosol released during dental nanocomposite grinding was sampled before and after the work. Exposure monitoring including nano (PM0.1) and respirable (PM4) fractions was performed. Whole-chromosome painting for autosomes #1, #4, and gonosome X was applied to estimate the pattern of cytogenetic damage including structural and numerical alterations. The results show stable genomic frequency of translocations (F<sub>G</sub>/100), in contrast to a significant 37.8% (<em>p</em><0.05) increase of numerical aberrations caused by monosomies (<em>p</em><0.05), but not trisomies. Monosomies were mostly observed for chromosome X. In conclusion, exposure to nanocomposites in stomatology may lead to an increase in numerical aberrations which can be dangerous for dividing cells.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1382668924001029/pdfft?md5=fc2235f777d0a9363b6c48a967245de1&pid=1-s2.0-S1382668924001029-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxic heavy metals in a landfill environment (Vientiane, Laos): Fish species and associated health risk assessment 垃圾填埋场环境中的有毒重金属（老挝万象）：鱼类物种及相关健康风险评估。

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-03 DOI: 10.1016/j.etap.2024.104460

Vongdala Noudeng , Dek Vimean Pheakdey , Tran Dang Xuan

{"title":"Toxic heavy metals in a landfill environment (Vientiane, Laos): Fish species and associated health risk assessment","authors":"Vongdala Noudeng , Dek Vimean Pheakdey , Tran Dang Xuan","doi":"10.1016/j.etap.2024.104460","DOIUrl":"10.1016/j.etap.2024.104460","url":null,"abstract":"<div><p>Leachates from municipal landfills introduce toxic heavy metals into water, causing bioaccumulation. This study assesses metal levels and potential human health risks associated with consuming <em>Anabas testudineus</em> and <em>Channa striata</em>. Inductively coupled plasma mass spectrometry detected Cd, Cu, Cr, Ni, Pb, and Zn in both fish species. Leachate metal concentrations meet international discharge standards, Cd, Cr, and Pb in the fish exceed the international accepted values. Gastrointestinal tract+liver samples show significant variation between species, particularly in Cd and Pb. EDI, THQ/HI, and TR for the both species fall below TDIs, lower than the limit of 1, and within the acceptable range of the US-EPA permissible limit, respectively. Fish consumption appears safe regarding carcinogenic risk, but exceeding metal limits could impact heavy metals accumulation in the local food chain. Raising public awareness is crucial, and governmental agencies and environmental organizations should enhance waste treatment technologies and enact relevant health legislation.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational second-hand smoke exposure: A comparative shotgun proteomics study on nasal epithelia from healthy restaurant workers 职业性二手烟暴露：对健康餐馆员工鼻腔上皮细胞的散弹枪蛋白质组学比较研究。

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-04-27 DOI: 10.1016/j.etap.2024.104459

Sofia Neves , Solange Pacheco , Fátima Vaz , Peter James , Tânia Simões , Deborah Penque

{"title":"Occupational second-hand smoke exposure: A comparative shotgun proteomics study on nasal epithelia from healthy restaurant workers","authors":"Sofia Neves , Solange Pacheco , Fátima Vaz , Peter James , Tânia Simões , Deborah Penque","doi":"10.1016/j.etap.2024.104459","DOIUrl":"10.1016/j.etap.2024.104459","url":null,"abstract":"<div><p>Non-smokers exposed to second-hand smoke (SHS) present risk of developing tobacco smoke-associated pathologies. To investigate the airway molecular response to SHS exposure that could be used in health risk assessment, comparative shotgun proteomics was performed on nasal epithelium from a group of healthy restaurant workers, non-smokers (never and former) exposed and not exposed to SHS in the workplace. HIF1α-glycolytic targets (GAPDH, TPI) and proteins related to xenobiotic metabolism, cell proliferation and differentiation leading to cancer (ADH1C, TUBB4B, EEF2) showed significant modulation in non-smokers exposed. In never smokers exposed, enrichment of glutathione metabolism pathway and EEF2-regulating protein synthesis in genotoxic response were increased, while in former smokers exposed, proteins (LYZ, ATP1A1, SERPINB3) associated with tissue damage/regeneration, apoptosis inhibition and inflammation that may lead to asthma, COPD or cancer, were upregulated. The identified proteins are potential response and susceptibility/risk biomarkers for SHS exposure.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1382668924000991/pdfft?md5=f407274cb52fe88eb3110afe8e6841eb&pid=1-s2.0-S1382668924000991-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phthalate esters in clothing: A review 服装中的邻苯二甲酸酯：综述

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-04-25 DOI: 10.1016/j.etap.2024.104457

Natalia Aldegunde-Louzao , Manuel Lolo-Aira , Carlos Herrero-Latorre

{"title":"Phthalate esters in clothing: A review","authors":"Natalia Aldegunde-Louzao , Manuel Lolo-Aira , Carlos Herrero-Latorre","doi":"10.1016/j.etap.2024.104457","DOIUrl":"10.1016/j.etap.2024.104457","url":null,"abstract":"<div><p>Phthalate esters (PAEs) are widely used as plasticizers to enhance the flexibility and durability of different consumer products, including clothing. However, concerns have been raised about the potential adverse health effects associated with the presence of phthalates in textiles, such as endocrine disruption, reproductive toxicity and potential carcinogenicity. Based on examination of more than 120 published articles, this paper presents a comprehensive review of studies concerning the phthalate content in clothing and other textile products, with special emphasis on those conducted in the last decade (2014–2023). The types and role of PAEs as plasticizers, the relevant legislation in different countries (emphasizing the importance of monitoring PAE levels in clothing to protect consumer health) and the analytical methods used for PAE determination are critically evaluated. The review also discusses the models used to evaluate exposure to PAEs and the associated health risks. Finally, the study limitations and challenges related to determining the phthalate contents of textile products are considered.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1382668924000978/pdfft?md5=8986d1e9b2fbef942ddc055177bb0fc8&pid=1-s2.0-S1382668924000978-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140768596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multi-approach analysis of the toxicity of a commercial formulation of monensin on Rhinella arenarum embryos and larvae 用多种方法分析莫能菌素商用制剂对犀牛胚胎和幼虫的毒性

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-04-24 DOI: 10.1016/j.etap.2024.104454

Julieta Peluso , Agostina Martínez Chehda , Carolina M. Aronzon

{"title":"A multi-approach analysis of the toxicity of a commercial formulation of monensin on Rhinella arenarum embryos and larvae","authors":"Julieta Peluso , Agostina Martínez Chehda , Carolina M. Aronzon","doi":"10.1016/j.etap.2024.104454","DOIUrl":"https://doi.org/10.1016/j.etap.2024.104454","url":null,"abstract":"<div><p>Monensin, an antibacterial commonly used in animal fattening, can enter aquatic ecosystems and harm non-target organisms. Since there are no previous studies about the effects of monensin on amphibians, the aim of the present study was to evaluate the lethal and sublethal toxicity of a commercial formulation of monensin (CFM) through standardized bioassays with embryos and larvae of the amphibian <em>Rhinella arenarum</em>. Oxidative stress (catalase and glutathione S-transferase activities, and reduced glutathione and lipid peroxidation levels), cholinesterasic effect (acetylcholinesterase and butyrylcholinesterase activities) and mutagenicity (micronuclei frequency) biomarkers were evaluated. The CFM produced teratogenic effects, with a teratogenic index of 6.21. Embryos (504 h-LC50: 273.33 µg/L) were more sensitive than larvae, as no significant mortality was observed on larvae exposed up to 3000 µg/L for 504 h. However, oxidative stress, cholinesterasic effect and mutagenicity biomarkers were altered on larvae exposed for 96 h to environmentally relevant concentrations (4, 12 and 20 µg/L of monensin active ingredient). The CFM caused adverse effects on the exposed organisms, primarily on embryos, leading to lethal and sublethal effects, which could impact the wildlife when it reaches aquatic ecosystems.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140649159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to heavy metals, antioxidant status, and the interaction of single nucleotide polymorphisms in the genes CAT rs7943316, GSTP1 rs1695, as well as GSTM1 and GSTT1 genes, among workers in occupational settings 职业环境中工人的重金属暴露、抗氧化状态以及 CAT rs7943316、GSTP1 rs1695、GSTM1 和 GSTT1 基因中单核苷酸多态性的相互作用。

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-04-23 DOI: 10.1016/j.etap.2024.104452

Sosan Andleeb Khan , Syed Muhammad Nurulain , Rashid Nazir Qureshi , Amina Zafar , Zarish Riaz , Aneela Shoukat , Zahid Muneer , Nazia Bibi , Saqlain Raza , Sabir Hussain , Syed Tahir Abbas Shah

{"title":"Exposure to heavy metals, antioxidant status, and the interaction of single nucleotide polymorphisms in the genes CAT rs7943316, GSTP1 rs1695, as well as GSTM1 and GSTT1 genes, among workers in occupational settings","authors":"Sosan Andleeb Khan , Syed Muhammad Nurulain , Rashid Nazir Qureshi , Amina Zafar , Zarish Riaz , Aneela Shoukat , Zahid Muneer , Nazia Bibi , Saqlain Raza , Sabir Hussain , Syed Tahir Abbas Shah","doi":"10.1016/j.etap.2024.104452","DOIUrl":"10.1016/j.etap.2024.104452","url":null,"abstract":"<div><p>Individuals working in diverse fields are consistently exposed to work-related pollutants that can impact their overall health. The current study investigated the presence of pollutants in seven different occupational groups and their impact on human health. Biochemical and genetic approaches were employed. Heavy metals were determined by ICP-MS technique. Oxidative stress biochemical markers and molecular analysis of the glutathione transferases gene SNPs (<em>GSTT1, GSTM1, GSTP1</em>), catalase (<em>CAT</em>, rs7943316), and superoxide dismutase (<em>SOD</em>, rs17880487) was carried out. The results revealed a significantly higher quantity of Cd among five occupational groups. Catalase, malonaldehyde, and glutathione was significantly dysregulated. Molecular analysis of the gene SNPs suggests a probable relationship between the antioxidants and the phenotypic expression of the <em>CAT, GSTP1, GSTT1,</em> and <em>GSTM1</em> SNPs. It is concluded that chronic exposure to occupational contaminants like Cd affects human health through oxidative stress in association with some of their gene SNPs.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140765107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to environmental pollutants and genetic variants related to oxidative stress and xenobiotic metabolism—Association with prostate cancer 暴露于环境污染物以及与氧化应激和异种生物代谢有关的基因变异--与前列腺癌的关系。

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-04-23 DOI: 10.1016/j.etap.2024.104455

Beatriz Álvarez-González , Antonio F. Hernández , Alberto Zafra-Gómez , Lucia Chica-Redecillas , Sergio Cuenca-López , Fernando Vázquez-Alonso , Luis Javier Martínez-González , María Jesús Álvarez-Cubero

{"title":"Exposure to environmental pollutants and genetic variants related to oxidative stress and xenobiotic metabolism—Association with prostate cancer","authors":"Beatriz Álvarez-González , Antonio F. Hernández , Alberto Zafra-Gómez , Lucia Chica-Redecillas , Sergio Cuenca-López , Fernando Vázquez-Alonso , Luis Javier Martínez-González , María Jesús Álvarez-Cubero","doi":"10.1016/j.etap.2024.104455","DOIUrl":"10.1016/j.etap.2024.104455","url":null,"abstract":"<div><p>This study assessed whether genetic variants coding for certain enzymes involved in xenobiotic detoxification, antioxidant defences and DNA repair, along with exposure to environmental chemicals, were associated with an increased prostate cancer (PCa) risk. The study population consisted of 300 men (150 PCa cases and 150 controls) which underwent prostate biopsy as their serum prostate specific antigen (PSA) levels were greater than 4 ng/ml. Genetic variants in <em>GSTM1, GSTP1, SOD2</em>, <em>CAT</em>, <em>GPX1</em>, <em>XRCC1</em> were determined and data for chemical exposures was obtained through a structured questionnaire and by biomonitoring in a subsample of cases and controls. High serum PSA levels were associated with a greater risk of PCa, while physical exercise appears to exert a protective effect against its development. In addition, elevated urinary levels of certain organic pollutants, such as benzo(a)pyrene (BaP), bisphenol A (BPA), and ethyl-paraben (EPB), were associated with an increased risk of PCa.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140795916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biopesticide spinosad: Unraveling ecotoxicological effects on zebrafish, Danio rerio 生物农药 Spinosad：揭示对斑马鱼 Danio rerio 的生态毒理影响。

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-04-23 DOI: 10.1016/j.etap.2024.104458

Inês Amaral , Sara C. Antunes , Daniela Rebelo , António Paulo Carvalho , Sara Rodrigues

{"title":"Biopesticide spinosad: Unraveling ecotoxicological effects on zebrafish, Danio rerio","authors":"Inês Amaral , Sara C. Antunes , Daniela Rebelo , António Paulo Carvalho , Sara Rodrigues","doi":"10.1016/j.etap.2024.104458","DOIUrl":"10.1016/j.etap.2024.104458","url":null,"abstract":"<div><p>Biopesticides are natural compounds considered more safe and sustainable for the environment. Spinosad (SPI) is a bioinsecticide used in marketed worldwide, to eradicate a variety of pests. This study aimed to assess the impacts of the SPI on the non-target organism zebrafish (<em>Danio rerio</em>). Several concentrations of SPI were tested to evaluate the acute (0.07–1.0 mg/L) and chronic (0.006–0.100 mg/L) ecotoxicological effects. To evaluate sub-individual effects, antioxidant defense, lipid peroxidation, energy sources, and cholinergic biomarkers were quantified. In both exposures, SPI induced significant effects on antioxidant defense indicating oxidative stress, disrupting energy pathways, and exhibiting neurotoxic effects, under environmentally relevant conditions. Integrated Biomarker Response (IBRv2) showed that with increasing SPI concentrations, an increase in impacts on organisms was recorded. This study demonstrates the vulnerability of a non-target organism to SPI, a bioinsecticide considered environmentally safe. Further research is essential to fully understand the implications of spinosad to aquatic biota.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S138266892400098X/pdfft?md5=b74891714d84e1b646efd6de0ace0ef8&pid=1-s2.0-S138266892400098X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140794814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulating responses of indicator genes in cellular homeostasis, immune defense and apoptotic process in the Macrophthalmus japonicus exposed to di(2-ethylhexyl) phthalate as a plastic additive 调节暴露于作为塑料添加剂的邻苯二甲酸二（2-乙基己酯）的日本鲣鱼的细胞稳态、免疫防御和细胞凋亡过程中的指示基因的反应

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-04-22 DOI: 10.1016/j.etap.2024.104456

Kiyun Park , Ihn-Sil Kwak

{"title":"Modulating responses of indicator genes in cellular homeostasis, immune defense and apoptotic process in the Macrophthalmus japonicus exposed to di(2-ethylhexyl) phthalate as a plastic additive","authors":"Kiyun Park , Ihn-Sil Kwak","doi":"10.1016/j.etap.2024.104456","DOIUrl":"https://doi.org/10.1016/j.etap.2024.104456","url":null,"abstract":"<div><p>Di(2-ethylhexyl) phthalate (DEHP), have been increasingly used as plasticizers to manufacture soft and flexible materials and ubiquitously found in water and sediments in the aquatic ecosystem. The aim of the present study was to evaluate the effect of DEHP exposure on cellular homeostasis (<em>HSF1</em> and seven <em>HSPs</em>), immune responses (<em>ILF</em>), and apoptotic responses (<em>p53</em>, <em>BAX</em>, <em>Bcl-2</em>). DEHP exposure upregulated the expression of <em>HSF1</em> and <em>ILF</em>. Moreover, it altered the expression levels of <em>HSPs</em> (upregulation of <em>HSP70</em>, <em>HSP90</em>, <em>HSP40</em>, <em>HSP83</em>, and <em>HSP67B2</em> and downregulation of <em>HSP60</em> and <em>HSP21</em>) in conjunction with <em>HSF1</em> and <em>ILF</em> in the gills and hepatopancreas of <em>M. japonicus</em> exposed to DEHP. At the protein level, DEHP exposure changed apoptotic signals in both tissues of <em>M. japonicus</em>. These findings indicate that chronic exposures to several DEHP concentrations could disturb cellular balance, damage the inflammatory and immune systems, and induce apoptotic cell death, thereby affecting the survival of <em>M. japonicus</em>.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140649160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aluminum and ABC transporter activity 铝和 ABC 转运体的活性

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-04-20 DOI: 10.1016/j.etap.2024.104451

Goezde Oezen , Lisa Kraus , Eva-Maria Schentarra , Jan Stephan Bolten , Joerg Huwyler , Gert Fricker

{"title":"Aluminum and ABC transporter activity","authors":"Goezde Oezen , Lisa Kraus , Eva-Maria Schentarra , Jan Stephan Bolten , Joerg Huwyler , Gert Fricker","doi":"10.1016/j.etap.2024.104451","DOIUrl":"https://doi.org/10.1016/j.etap.2024.104451","url":null,"abstract":"<div><p>Aluminum is the third most common element on Earth´s crust and despite its wide use in our workaday life it has been associated with several health risks after overexposure. In the present study the impact of aluminum salts upon ABC transporter activity was studied in the P-GP-expressing human blood-brain barrier cell line hCMEC/D3, in MDCKII cells overexpressing BCRP and MRP2, respectively, and in freshly isolated, functionally intact kidney tubules from Atlantic killifish (<em>Fundulus heteroclitus</em>), which express the analog ABC transporters, P-gp, Bcrp and Mrp2. In contrast to previous findings with heavy metals salts (cadmium(II) chloride or mercury(II) chloride), which have a strong inhibitory effect on ABC transporter activity, or zinc(II) chloride and sodium arsenite, which have a stimulatory effect upon ABC transport function, the results indicate no modulatory effect of aluminum salts on the efflux activity of the human ABC transporters P-GP, BCRP and MRP2 nor on the analog transporters P-gp, Bcrp and Mrp2.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1382668924000917/pdfft?md5=32d65d22a6a281187003502b793af55b&pid=1-s2.0-S1382668924000917-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140631429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0