Environmental toxicology and pharmacology最新文献_第10页

From indoors to outdoors: Impact of waste anesthetic gases on occupationally exposed professionals and related environmental hazards – A narrative review and update 从室内到室外：麻醉废气对职业暴露专业人员的影响及相关环境危害--叙述性综述和更新。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104624

Mariane A.P. Silva , Lorena I.M. Carvalho , Maria Vitória Destro , Leandro G. Braz , Mariana G. Braz

{"title":"From indoors to outdoors: Impact of waste anesthetic gases on occupationally exposed professionals and related environmental hazards – A narrative review and update","authors":"Mariane A.P. Silva , Lorena I.M. Carvalho , Maria Vitória Destro , Leandro G. Braz , Mariana G. Braz","doi":"10.1016/j.etap.2024.104624","DOIUrl":"10.1016/j.etap.2024.104624","url":null,"abstract":"<div><div>Waste anesthetic gases (WAGs) are trace-concentration inhaled anesthetics that exist worldwide because they are released into the ambient air of operating rooms (ORs) and post-anesthesia care units. WAGs cause indoor contamination, especially in ORs lacking proper scavenging systems, and occupational exposure, while promoting climate change through greenhouse gas/ozone-depleting effects. Despite these controversial features, WAGs continue to pose occupational health hazards. Occupational exposure to WAGs has been linked to oxidative stress and cytotoxic, genotoxic and mutagenic potential. This review aims to analyze and update the literature on WAG monitoring, the impact of WAGs on occupationally exposed personnel and their effect on the environment. The awareness of exposed professionals in human and veterinary medicine is crucial. The implementation of biomonitoring practices and WAG occupational exposure limiting policies is needed. Promoting a sustainable healthcare system is also important for mitigating the impact of WAGs on global warming.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104624"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the impact of neonicotinoids on aquatic non-target species: A comprehensive review 评价新烟碱类杀虫剂对水生非目标物种的影响：综述。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104606

Ahamadul Hoque Mandal , Auroshree Sadhu , Surajit Ghosh , Nimai Chandra Saha , Camilla Mossotto , Paolo Pastorino , Shubhajit Saha , Caterina Faggio

{"title":"Evaluating the impact of neonicotinoids on aquatic non-target species: A comprehensive review","authors":"Ahamadul Hoque Mandal , Auroshree Sadhu , Surajit Ghosh , Nimai Chandra Saha , Camilla Mossotto , Paolo Pastorino , Shubhajit Saha , Caterina Faggio","doi":"10.1016/j.etap.2024.104606","DOIUrl":"10.1016/j.etap.2024.104606","url":null,"abstract":"<div><div>Neonicotinoid insecticides (NNIs) are the fastest-growing class in agricultural protection. They target nicotinic acetylcholine receptors (nAChR) in pests, stimulating the nervous system at low doses and causing paralysis and death at higher concentrations. NNIs are used in crop protection, seed treatment, forestry, agriculture, and flea control in domestic cattle. Effective at lower concentrations and offering long-term control, NNIs are favoured for their systemic activity. However, due to their water solubility, mobility, and moderate persistence, NNIs easily contaminate adjacent aquatic environments via runoff, leaching, or spray drift. While less toxic to vertebrates, their widespread use poses threats to aquatic and terrestrial organisms, causing neurotoxicity, nephrotoxicity, cytotoxicity, genotoxicity, immunotoxicity, hepatotoxicity, endocrine disruption, and reproductive malformations. This review synthesizes research to address knowledge gaps on the environmental impact of NNIs and proposes policies to mitigate their harmful effects on aquatic non-target species.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104606"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing H2O2-induced susceptibility in Galleria mellonella larvae: A robust model for exploring oxidative stress and biomarkers 利用h2o2诱导的mellonella幼虫的敏感性：一个探索氧化应激和生物标志物的强大模型。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104596

L.M.M. Mattos , R.N. Silva , L.G. Santos , L. Giovanini , V.S. Cruz , N.M.B. Barreto , D. Perrone , A.L.S. Santos , M.D. Pereira

{"title":"Harnessing H2O2-induced susceptibility in Galleria mellonella larvae: A robust model for exploring oxidative stress and biomarkers","authors":"L.M.M. Mattos , R.N. Silva , L.G. Santos , L. Giovanini , V.S. Cruz , N.M.B. Barreto , D. Perrone , A.L.S. Santos , M.D. Pereira","doi":"10.1016/j.etap.2024.104596","DOIUrl":"10.1016/j.etap.2024.104596","url":null,"abstract":"<div><div>Oxidative stress plays a crucial role in various pathological conditions. This study introduces an enhanced model using hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced stress in <em>Galleria mellonella</em> larvae, offering a cost-effective and ethically sound alternative for oxidative stress research. The model bridges in vitro and in vivo studies to identify biomarkers like lipid peroxidation, protein carbonylation, hemocyte count, and antioxidant enzyme activities. Our results show that while <em>G. mellonella</em> larvae tolerated high doses of H<sub>2</sub>O<sub>2</sub>, increased susceptibility occurred with prolonged toxicosis and higher concentrations. Acute H<sub>2</sub>O<sub>2</sub> exposure (5.0 M/1st day) led to elevated lipid and protein oxidation and decreased superoxide dismutase activity and hemocyte count, while catalase activity and total antioxidant capacity increased. Despite these defenses, the larvae's antioxidant capacity was insufficient under severe oxidative stress, reducing survival. This study highlights <em>G. mellonella</em> larvae as a promising model for examining reactive oxygen species (ROS)-induced oxidative stress.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104596"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative toxicities of commonly used agricultural insecticides to four honey bee species (Hymenoptera: Apidae) in Vietnam 越南常用农业杀虫剂对四种蜜蜂（膜翅目：蜂科）的毒性比较。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104605

Thai H. Pham , Ngoc T. Phan , Duy D. Trinh , Ha N. Duong , Phuong T. Tran , Khanh D. Nguyen , Gadi V.P. Reddy , Chuleui Jung , Neelendra K. Joshi

{"title":"Comparative toxicities of commonly used agricultural insecticides to four honey bee species (Hymenoptera: Apidae) in Vietnam","authors":"Thai H. Pham , Ngoc T. Phan , Duy D. Trinh , Ha N. Duong , Phuong T. Tran , Khanh D. Nguyen , Gadi V.P. Reddy , Chuleui Jung , Neelendra K. Joshi","doi":"10.1016/j.etap.2024.104605","DOIUrl":"10.1016/j.etap.2024.104605","url":null,"abstract":"<div><div>Beekeeping for honey production is a vital economic activity in Vietnam, significantly contributing to the nation's agricultural exports and poverty alleviation. However, the widespread use of pesticides, compounded by insufficient regulations, poses serious challenges to the industry and threatens bee health. This study examined the oral toxicities of five commonly used agricultural insecticides including bifenthrin, imidacloprid, thiacloprid, thiamethoxam, and chlorantraniliprole, on four honey bee species prevalent in Vietnam: the Asian honey bee (<em>Apis cerana</em>), the European honey bee (<em>A. mellifera</em>), the giant honey bee (<em>A. dorsata</em>), and the red dwarf honey bee (<em>A. florea</em>). Our results indicated significant variability in toxicity among the pesticides and honey bee species, with the managed species <em>A. cerana</em> showing the highest tolerance across all tested insecticides. In contrast, the wild species <em>A. dorsata</em> and <em>A. florea</em> were significantly more sensitive. These findings highlight the need to develop a pesticide risk assessment and improve pesticide regulations that consider the impacts on a broader range of honey bee species beyond <em>A. mellifera</em>.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104605"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive tetracycline, ciprofloxacin and sulfamethoxazole toxicity evaluation to earthworm Dendrobaena veneta through life-cycle, behavioral and biochemical parameters 四环素、环丙沙星、磺胺甲恶唑对蚯蚓生命周期、行为及生化指标的综合毒性评价

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104609

Jūratė Žaltauskaitė , Diana Miškelytė, Gintarė Sujetovienė, Austra Dikšaitytė, Giedrė Kacienė, Irena Januškaitienė, Renata Dagiliūtė

{"title":"Comprehensive tetracycline, ciprofloxacin and sulfamethoxazole toxicity evaluation to earthworm Dendrobaena veneta through life-cycle, behavioral and biochemical parameters","authors":"Jūratė Žaltauskaitė , Diana Miškelytė, Gintarė Sujetovienė, Austra Dikšaitytė, Giedrė Kacienė, Irena Januškaitienė, Renata Dagiliūtė","doi":"10.1016/j.etap.2024.104609","DOIUrl":"10.1016/j.etap.2024.104609","url":null,"abstract":"<div><div>Veterinary antibiotics are widely spread in the environment, however, the knowledge about their impact on soil key species is still limited. This study evaluated the short-term and long-term effects of tetracycline (TC), ciprofloxacin (CIP) and sulfamethoxazole (SMX) (1–500 mg kg) on earthworm <em>Dendrobaena veneta</em> by measuring multiple parameters (survival, growth, reproduction, behavior and biochemical responses). Neither antibiotic induced acute toxicity and low mortality was observed after chronic exposure. TC and CIP had a negligible effect on the earthworm’s weight from the 6th week of exposure, SMX inhibited the earthworm growth when was present in the range of 50–500 mg kg<sup>−1</sup>. In parallel, SMX reduced earthworm reproduction at environmentally relevant concentrations. Antibiotics altered superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) and gluthathione-S-transferase (GST) activities and induced lipid peroxidation. Overall, earthworms showed no apparent acute response at environmentally relevant concentrations except for avoidance behavior; after long-term exposure earthworms experienced biochemical, physiological, and reproductive impairments and reduced survival at high soil contamination.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104609"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicity assessment of effluent from a potato-processing industry in Cyprinus carpio 鲤鱼马铃薯加工业废水的毒性评价。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104616

Carine Baggiotto , Marciano Friedrich , Vania Lucia Loro , Tiele Medianeira Rizzetti , Renato Zanella , Jossiele Wesz Leitemperger , Bárbara Estevao Clasen , Rosana de Cassia De Souza Schneider , Francisco Rossarolla Forgiarini

{"title":"Toxicity assessment of effluent from a potato-processing industry in Cyprinus carpio","authors":"Carine Baggiotto , Marciano Friedrich , Vania Lucia Loro , Tiele Medianeira Rizzetti , Renato Zanella , Jossiele Wesz Leitemperger , Bárbara Estevao Clasen , Rosana de Cassia De Souza Schneider , Francisco Rossarolla Forgiarini","doi":"10.1016/j.etap.2024.104616","DOIUrl":"10.1016/j.etap.2024.104616","url":null,"abstract":"<div><div>Potato (<em>Solanum tuberosum)</em> cultivation faces the challenge of excessive pesticide use. During processing, the disposal of large volumes of contaminated water into water bodies can result in severe environmental damage, such as fish deaths. This study aimed to evaluate the toxicological effects of chemical compounds present in the effluent from a potato-processing industry using the test organism <em>Cyprinus carpio</em>. The liver, gills, muscles, and brain were analyzed for biochemical parameters such as catalase (CAT), superoxide dismutase (SOD), acetylcholinesterase (AChE), and lipid peroxidation (TBARS). The highest quantities of pesticides found in the effluent were atrazine, azoxystrobin, fipronil, flutolanil, imidacloprid, tebuconazole, and thiamethoxam. Fish were exposed to the effluent for 7, 14, and 28 days in the laboratory. The CAT enzyme increased activity in the gills at 7 (p-value=0.000) and 14 days (p-value=0.003). Lipid peroxidation showed an increase in the gills at seven days (p-value=0.0281) and in the liver at 7 (p-value=0.000) and 14 days (p-value=0.000). There was also a significant increase (p-value=0.000) in AChE activity in the muscle at all periods. This result highlights the environmental risk and toxicity of potato effluent containing pesticide residues, which can cause biochemical damage to <em>C. carpio</em> and other living organisms.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104616"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing azithromycin's ecological toll: Unveiling multifaceted impacts on Poecilia reticulata THROUGH biomarker analysis 评估阿奇霉素的生态代价：通过生物标志物分析揭示对网状水蛭的多方面影响。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104617

Gabriela Pustiglione Marinsek , Manuela Agullo Tagliamento , Isabelly Cristina Correia dos Santos Oliveira , Anna Capaldo , Paloma Kachel Gusso-Choueri , Caio César Ribeiro , Ana Carolina Cruz Feitosa , Denis Moledo de Souza Abessa , Marcos Antônio Oliveira , Renata de Britto Mari

{"title":"Assessing azithromycin's ecological toll: Unveiling multifaceted impacts on Poecilia reticulata THROUGH biomarker analysis","authors":"Gabriela Pustiglione Marinsek , Manuela Agullo Tagliamento , Isabelly Cristina Correia dos Santos Oliveira , Anna Capaldo , Paloma Kachel Gusso-Choueri , Caio César Ribeiro , Ana Carolina Cruz Feitosa , Denis Moledo de Souza Abessa , Marcos Antônio Oliveira , Renata de Britto Mari","doi":"10.1016/j.etap.2024.104617","DOIUrl":"10.1016/j.etap.2024.104617","url":null,"abstract":"<div><div>This study investigates the impact of environmentally relevant concentrations of azithromycin on <em>Poecilia reticulata</em>, through biomarkers at different levels. To this end, the somatic indexes of <em>P. reticulata</em> were evaluated, and liver and gill samples were collected and analyzed for biochemical and histopathological alterations. Azithromycin caused significant effects in <em>P. reticulata</em>, such as increased hepatosomatic index, altered redox responses, particularly in gills, indicating oxidative stress, and notable tissue damage in the liver and gills in a dose-dependent response manner. Principal Component Analysis highlighted differences between control and exposed groups, demonstrating the azithromycin's influence on organismal homeostasis. This research underscores the importance of understanding azithromycin action in nontarget organisms of aquatic environments.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104617"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engraftment after pediatric hematopoietic stem cell transplantation and its association with recipient and donor phthalate and bisphenol A exposure levels: A cohort study 儿童造血干细胞移植后的植入及其与受体和供体邻苯二甲酸盐和双酚A暴露水平的关系：一项队列研究。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-12-27 DOI: 10.1016/j.etap.2024.104625

Sıddika Songül Yalçın , Esin Okman , Bülent Barış Kuşkonmaz , Suzan Yalçın , Osman Aykut , Duygu Uçkan Çeti̇nkaya

{"title":"Engraftment after pediatric hematopoietic stem cell transplantation and its association with recipient and donor phthalate and bisphenol A exposure levels: A cohort study","authors":"Sıddika Songül Yalçın , Esin Okman , Bülent Barış Kuşkonmaz , Suzan Yalçın , Osman Aykut , Duygu Uçkan Çeti̇nkaya","doi":"10.1016/j.etap.2024.104625","DOIUrl":"10.1016/j.etap.2024.104625","url":null,"abstract":"<div><div>Phthalates and bisphenols, ubiquitous compounds found in various everyday products, have garnered attention due to their potential health-disrupting effects. This study aimed to (1) investigate urinary phthalate metabolites and bisphenol A (BPA) levels in donors and recipients prior to allogeneic hematopoietic stem cell transplantation (HSCT) and monitor changes in these compounds in pediatric recipients at different time points (day-9, day 0, day+7, day+28, day+90), and (2) assess their association with engraftment success. Urine samples from pediatric recipients and donors were collected for analysis of phthalate metabolites and BPA in 34 donor-recipient pairs. Monomethyl phthalate metabolite was not detectable in any of the urine samples. A notable increase in phthalate metabolites and BPA levels was observed in recipients starting from day+28. Granulocyte engraftment time showed a positive correlation with donor urinary levels of mono-n-butyl phthalate (MBP), mono-2-ethylhexyl phthalate (MEHP), and monobenzyl phthalate metabolites with recipient MBP levels measured on day-9. Moreover, donor urinary MBP and MEHP levels were also linked to delayed platelet engraftment. No relationship was observed between engraftment timing and the urine levels of monoethyl phthalate metabolite or BPA in donor-recipient pairs. In cases of mucositis, MEHP and MEP levels on day 0 were higher compared to the non-mucositis group. No relationship was identified between hemorrhagic cystitis and the levels of urine phthalate metabolites or BPA. These findings highlight the potential role of plasticizer exposure in influencing engraftment outcomes, although no significant associations were found between MEP or BPA levels and engraftment.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"114 ","pages":"Article 104625"},"PeriodicalIF":4.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of detoxification of xenobiotic aromatic amine dyes by N-acetyltransferase 1 (NAT1) enzyme on human keratinocytes cells through structural modification N-acetyltransferase 1（NAT1）酶通过结构修饰增强人类角朊细胞对异生物芳香胺染料的解毒作用。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-12-25 DOI: 10.1016/j.etap.2024.104622

Gopalakrishnan Venkatesan , Huan-Qing Yang , Hong Chen , Paul Bigliardi , Giorgia Pastorin

{"title":"Enhancement of detoxification of xenobiotic aromatic amine dyes by N-acetyltransferase 1 (NAT1) enzyme on human keratinocytes cells through structural modification","authors":"Gopalakrishnan Venkatesan , Huan-Qing Yang , Hong Chen , Paul Bigliardi , Giorgia Pastorin","doi":"10.1016/j.etap.2024.104622","DOIUrl":"10.1016/j.etap.2024.104622","url":null,"abstract":"<div><div>The metabolic conversion of aromatic amines to N-acetylated forms in skin and keratinocytes depends on N-acetyltransferase-1 (NAT1). Common hair color ingredient such as para-phenylenediamine (PPD) causes allergic contact dermatitis. We explored how different electronic substituents on PPD aided NAT1 enzyme biotransform oxidative arylamine (AA) compounds G1-G13 by N-acetylation, NAT-1 activity assays, metabolism, and in vitro clearance investigations in human keratinocytes, while identifying NAT-1 protein levels by Western blot and qRT-PCR. Electron-donating groups (EDG) compounds G2,G3,and G8, N-acetylate at a higher rate (58–62 nmol/mg/min), increase NAT1 activity by 20–25 %, and showed 3.4–3.8 times faster elimination and clearance rates than electron withdrawing groups (EWG) compounds G6 and G11. We found that chemicals substituted with EDG at ortho position increase aromatic system electron density, improving N-acetylation and detoxification on HaCaT cells. Our research facilitates the effective identification of aromatic amine hair dyes characterized by rapid metabolism, detoxification, and environmental safety.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"114 ","pages":"Article 104622"},"PeriodicalIF":4.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-disciplinary investigation identifies increased potency of ethyl-parathion inhaled within a soil-dust matrix to cause acetylcholinesterase-dependent molecular impacts 多学科研究发现在土壤-粉尘基质中吸入乙基对硫磷的效力增加，导致乙酰胆碱酯酶依赖的分子影响。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-12-20 DOI: 10.1016/j.etap.2024.104615

Kurt A. Gust , Saroj K. Amar , Chet P. Gut , Renee M. Styles , Ranju R. Karna , R. Arden James , David M. Holtzapple , Joshua.L. Stricker , Shawn M. McInturf , Elizabeth A. Phillips , Cary Honnold , Xiao Luo , Karen L. Mumy , David R. Mattie , Mark A. Chappell , Michael L. Mayo

{"title":"Multi-disciplinary investigation identifies increased potency of ethyl-parathion inhaled within a soil-dust matrix to cause acetylcholinesterase-dependent molecular impacts","authors":"Kurt A. Gust , Saroj K. Amar , Chet P. Gut , Renee M. Styles , Ranju R. Karna , R. Arden James , David M. Holtzapple , Joshua.L. Stricker , Shawn M. McInturf , Elizabeth A. Phillips , Cary Honnold , Xiao Luo , Karen L. Mumy , David R. Mattie , Mark A. Chappell , Michael L. Mayo","doi":"10.1016/j.etap.2024.104615","DOIUrl":"10.1016/j.etap.2024.104615","url":null,"abstract":"<div><div>Neurotoxicity investigations of inhaled organophosphorus pesticide (OP), ethyl-parathion (EP), were conducted in Sprague Dawley rats comparing exposures to EP volatilized at 0, 1, 10, and 20 mg/m<sup>3</sup> versus EP incorporated into soil dust (5 mg/m<sup>3</sup>) at 0, 0.0095, 0.09, and 0.185 mg/mg<sup>3</sup>. All exposures were sublethal, caused no respiratory effects, and no effects on balance and coordination behavior. Both volatilized and dust-incorporated EP exposures significantly decreased acetylcholinesterase (AChE) activity in plasma and hippocampus tissue. Correspondingly, plasma and hippocampal dopamine levels spiked in these exposures suggesting compensatory cholinergic / dopaminergic signal balancing. The EP exposures significantly increased expression of pro-inflammatory genes, including MAPK-14, IL6, IL1β, and TNF-α, while global RNA-seq results identified significant enrichment of inflammation, oxidative stress, and apoptosis pathways. Remarkably, dust-incorporated EP impacted similar molecular endpoints as volatilized EP but at concentrations two orders of magnitude lower highlighting potentially increased potency of EP incorporated into soil dust.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"114 ","pages":"Article 104615"},"PeriodicalIF":4.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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