Long-term joint exposure of outdoor air pollutants and impaired kidney function in Korean adults: A mixture analysis based on a nationwide sample (2007–2019)

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-05-06 DOI:10.1016/j.etap.2025.104712

Seong-Uk Baek , Jin-Ha Yoon

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Abstract

We explored the association between exposure to air pollutant mixture and renal function. A nationwide sample of 69,066 Korean adults was analyzed. The 1-year moving averages of the concentrations of PM₁₀, PM_2.5, SO₂, NO₂, CO, and O₃ were estimated using the air pollution modeling. The outcome was estimated glomerular filtration rate (eGFR) value. Quantile-based G-computation analyses were performed to determine how a simultaneous increase in the air pollutant mixture by one quartile was associated with changes in eGFR levels. The mean of eGFR was 88.9 among the sample. In the quantile-based G-computation model, one-quartile increase in the levels of air pollutant mixture was linked to a decrease in eGFR by −0.85 (95 % CI: −1.14, −0.57), with CO and PM_2.5 contributing 52.3 % and 37.3 %, respectively, to the negative association between the pollutant mixture and eGFR. Our results suggest that long-term exposure to air pollutant mixtures is linked to impaired renal function.

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韩国成年人长期暴露于室外空气污染物和肾功能受损：基于全国样本的混合分析（2007-2019）

我们探讨暴露于空气污染物混合物与肾功能之间的关系。对全国69066名成年人进行了分析。使用空气污染模型估计了PM10、PM2.5、SO₂、NO₂、CO和O₃浓度的1年移动平均值。结果是估计肾小球滤过率（eGFR）值。进行了基于分位数的g计算分析，以确定空气污染物混合物同时增加一个四分位数与eGFR水平变化之间的关系。样本中eGFR平均值为88.9。在基于分位数的g计算模型中，空气污染物混合水平每增加四分位数，eGFR就会下降- 0.85(95% % CI: - 1.14, - 0.57)，其中CO和PM2.5对污染物混合物和eGFR之间的负相关分别贡献了52.3% %和37.3% %。我们的研究结果表明，长期暴露于空气污染物混合物与肾功能受损有关。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.