Environmental toxicology and pharmacology最新文献_第9页

LncRNA 51A: A promising diagnostic biomarker for assessing cognitive decline in occupationally exposed aluminum workers LncRNA 51A：评估职业暴露于铝的工人认知能力下降情况的有望诊断生物标志物。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-08-31 DOI: 10.1016/j.etap.2024.104548

Hailun Fang , Juan Li , Lei Zhang , Baichun Li , Jing Song , Xiaoting Lu , Qiao Niu , Linping Wang

{"title":"LncRNA 51A: A promising diagnostic biomarker for assessing cognitive decline in occupationally exposed aluminum workers","authors":"Hailun Fang , Juan Li , Lei Zhang , Baichun Li , Jing Song , Xiaoting Lu , Qiao Niu , Linping Wang","doi":"10.1016/j.etap.2024.104548","DOIUrl":"10.1016/j.etap.2024.104548","url":null,"abstract":"<div><h3>Objective</h3><p>To assess the diagnostic utility of lncRNA 51 A in detecting cognitive decline among aluminum-exposed workers occupationally.</p></div><div><h3>Methods</h3><p>921 male workers from an aluminum manufacturing facility underwent cognitive assessments, measurement of plasma aluminum levels and quantification of lncRNA 51 A levels. Receiver Operating Characteristic (ROC) curves were constructed to assess the diagnostic potential of lncRNA 51 A. Bayesian network model was utilized to predict the likelihood of cognitive decline among the study population.</p></div><div><h3>Results</h3><p>Significant differences in lncRNA 51 A levels, plasma aluminum concentration and MMSE scores were observed between cognitive normal and decline groups. The lncRNA 51 A expression was negatively correlated with MMSE scores. The area under the curve (AUC) was 0.894, with 89.3 % sensitivity and 73.9 % specificity. The Bayesian network model indicated varying probabilities of cognitive decline based on lncRNA 51 A expression levels.</p></div><div><h3>Conclusion</h3><p>Plasma lncRNA 51 A shows potential as an excellent biomarker for cognitive decline diagnosis in aluminum-exposed workers.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"111 ","pages":"Article 104548"},"PeriodicalIF":4.2,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polybrominated diphenyl ethers in paired dust-breast milk samples: Levels, predictors of contamination, and health risk assessment for infants and mothers 成对粉尘-母乳样本中的多溴联苯醚：含量、污染预测因素以及婴儿和母亲健康风险评估。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-08-30 DOI: 10.1016/j.etap.2024.104547

Karla Jagić , Marija Dvoršćak , Blanka Tariba Lovaković , Darija Klinčić

{"title":"Polybrominated diphenyl ethers in paired dust-breast milk samples: Levels, predictors of contamination, and health risk assessment for infants and mothers","authors":"Karla Jagić , Marija Dvoršćak , Blanka Tariba Lovaković , Darija Klinčić","doi":"10.1016/j.etap.2024.104547","DOIUrl":"10.1016/j.etap.2024.104547","url":null,"abstract":"<div><p>An integrated study on the levels of 7 polybrominated diphenyl ethers (PBDEs) in house dust and breast milk samples from women (N = 30) living in these households was conducted. ∑PBDEs ranged from <LOD to 523 ng g<sup>−1</sup> dust (median 4.9 ng g<sup>−1</sup> dust), and from 0.16 to 6.3 ng g<sup>−1</sup> lipid weight (lw) (median 0.49 ng g<sup>−1</sup> lw), in house dust and breast milk samples, respectively. Statistically significant correlations were observed between the mass fractions of BDE-153 from breast milk, and BDE-47, BDE-99 and BDE-100 from house dust, congeners that all originate from the “penta” formulation, indicating its dominance as PBDE exposure source in the examined household dusts. The number of electronic and electrical devices, and age of the building were positive, and the number of upholstered furniture and household area were negative predictors of PBDE dust levels. Mothers age was negative predictor of the PBDE levels in breast milk, possibly due to dilution of PBDEs in total body fat accumulated over the years. The results of health risk assessment suggest that detected PBDE levels don’t pose non-carcinogenic risk to the study population.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"111 ","pages":"Article 104547"},"PeriodicalIF":4.2,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temperature-dependent in vitro hepatocytotoxicity of insecticides in bats 杀虫剂对蝙蝠的体外肝细胞毒性与温度有关。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-08-30 DOI: 10.1016/j.etap.2024.104544

Monika Nemcova , Jan Zukal , Veronika Seidlova , Sarka Bednarikova , Barbora Havelkova , Heliana Dundarova , Jiri Pikula

{"title":"Temperature-dependent in vitro hepatocytotoxicity of insecticides in bats","authors":"Monika Nemcova , Jan Zukal , Veronika Seidlova , Sarka Bednarikova , Barbora Havelkova , Heliana Dundarova , Jiri Pikula","doi":"10.1016/j.etap.2024.104544","DOIUrl":"10.1016/j.etap.2024.104544","url":null,"abstract":"<div><p>Heterothermic insectivorous bats are supposed to experience differential adverse effects of insecticidal pollutants depending on their seasonal and/or daily variation of metabolic and detoxification rates. Here, we investigated effects of imidacloprid, cypermethrin and fipronil on <em>Nyctalus noctula</em> bat-derived hepatocytes through cytotoxicity, cell inhibition and death at different concentrations (0.01, 0.1, 1, 10, 100, 1000 μg/ml), exposure times (10, 24, 48 hrs), incubation temperatures simulating hibernation (8 °C), daily torpor (20 °C), normothermy (37 °C) and active flight (40 °C), and cytochrome P450 addition. Toxic effects were significantly influenced by temperature (p < 0.05), with strong cytotoxicity after 10 hour exposure to fipronil or cypermethrin at 37 and 40 °C, cell replication inhibition (all insecticides at 8 °C) and cellular stimulation, with slight culture proliferation after 48 hours (all insecticides at 40 °C). Replacing protected chiropterans with cell cultures is a way to assess and extrapolate risks of insecticides for bats.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"111 ","pages":"Article 104544"},"PeriodicalIF":4.2,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological changes in the fetal kidney induced by exposure to fluoride during pregnancy 孕期接触氟引起的胎儿肾脏形态变化

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-08-28 DOI: 10.1016/j.etap.2024.104545

Esaú Montañez-Rodriguez , Sabino Hazael Avila-Rojas , Ariana Guadalupe Jimenez-Dorantes , Juan Carlos León-Contreras , Rogelio Hernandez-Pando , José Manuel Arreola-Guerra , Casimiro Gerarduzzi , María Estela Meléndez-Camargo , Luz M. Del Razo , Olivier Christophe Barbier

{"title":"Morphological changes in the fetal kidney induced by exposure to fluoride during pregnancy","authors":"Esaú Montañez-Rodriguez , Sabino Hazael Avila-Rojas , Ariana Guadalupe Jimenez-Dorantes , Juan Carlos León-Contreras , Rogelio Hernandez-Pando , José Manuel Arreola-Guerra , Casimiro Gerarduzzi , María Estela Meléndez-Camargo , Luz M. Del Razo , Olivier Christophe Barbier","doi":"10.1016/j.etap.2024.104545","DOIUrl":"10.1016/j.etap.2024.104545","url":null,"abstract":"<div><p>To determine if fluoride’s established negative impact on adult kidney health begins during gestation, an intergenerational model of Wistar rats was exposed to two doses of fluoride (2.5 or 5.0 mg/kg/day via gavage) 20 days before mating and during gestation (20 days). The results revealed that fluoride was distributed to the amniotic fluid and fetus, resulting in lower weight, more pronounced fetal restriction, and decreased creatinine, osmolarity, and amniotic fluid volume. At the kidney level, less development in the nephrogenic and cortical zones was observed in the fluoride treatment groups, with an imbalance in the number of glomeruli and \"S\" shaped bodies, an increase in the immunoexpression of the marker of proliferation Ki-67 in the nephrogenic zone, an increase in the expression of Wnt4 and more maturation of the renal tubules, indicating that fluoride exposure during pregnancy alters kidney development and promotes early maturation of tubular segments.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"110 ","pages":"Article 104545"},"PeriodicalIF":4.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1382668924001856/pdfft?md5=25219f651b799cc7d47616137bd5aeac&pid=1-s2.0-S1382668924001856-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tiny pills, big impacts: A systematic review on the endocrine disrupting effects of paediatric pharmaceuticals 小药丸，大影响：关于儿科药品内分泌干扰效应的系统综述。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-08-28 DOI: 10.1016/j.etap.2024.104549

L. Tourvieilhe , F. Salvo , V. Bréant , B. Kassai , A. Portefaix

{"title":"Tiny pills, big impacts: A systematic review on the endocrine disrupting effects of paediatric pharmaceuticals","authors":"L. Tourvieilhe , F. Salvo , V. Bréant , B. Kassai , A. Portefaix","doi":"10.1016/j.etap.2024.104549","DOIUrl":"10.1016/j.etap.2024.104549","url":null,"abstract":"<div><p>Endocrine disrupting chemicals (EDCs) may impact children's health, with medicines as a possible exposure source. Objective: to assess the potential impact of substances in paediatric medications and essential oils on children as EDC. It is a systematic review of five databases including Medline following the PECOT approach. The review focused on publications about children exposed to medication (active ingredients or excipients of interest) and having developed clinical signs of endocrine dysfunction. Out of 946 studies identified, 28 studies were included. They revealed that parabens, lavender essential oils and anti-epileptics are the most identified pharmaceutical products. The reported outcomes relate to puberty, thyroid disorders, obesity and growth. The evidence indicates potential risks, but the overall quality of available data is limited. This systematic review exposes a lack of robust evidence linking paediatric medication exposure to EDC, predominantly relying on case reports. It cautions about potential conflicts of interest.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"111 ","pages":"Article 104549"},"PeriodicalIF":4.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-exposure to multiple heavy metals and metalloid induces dose dependent modulation in antioxidative, inflammatory, DNA damage and apoptic pathways progressing to renal dysfunction in mice 小鼠同时暴露于多种重金属和类金属会诱导剂量依赖性的抗氧化、炎症、DNA 损伤和凋亡通路调节，进而导致肾功能障碍。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-08-28 DOI: 10.1016/j.etap.2024.104537

Damini Singh , Priyanka Bist , Sangeeta Choudhary

引用次数: 0

Lethal effects and sex-specific tolerance of copper and cadmium in the buff-tailed bumble bee 水尾熊蜂对铜和镉的致死效应和性别耐受性

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-08-26 DOI: 10.1016/j.etap.2024.104546

Antoine Gekière , Luna Breuer , Luca Dorio , Maryse Vanderplanck , Denis Michez

{"title":"Lethal effects and sex-specific tolerance of copper and cadmium in the buff-tailed bumble bee","authors":"Antoine Gekière , Luna Breuer , Luca Dorio , Maryse Vanderplanck , Denis Michez","doi":"10.1016/j.etap.2024.104546","DOIUrl":"10.1016/j.etap.2024.104546","url":null,"abstract":"<div><p>Exposure to environmental pollutants, including trace metals, is a major driver of bee decline worldwide. While pesticides undergo standardised risk assessments (i.e., LD<sub>50</sub>) and the implementation of online databases, no such approaches exist for trace metals. Here, using acute oral exposure, we determined the LC<sub>50</sub>, LD<sub>50</sub>, and mass-standardised LD<sub>50</sub> of copper and cadmium, essential and non-essential metals, respectively, in workers and males of the buff-tailed bumble bee. We also evaluated gut damage and sucrose consumption in workers post-exposure. Cadmium was more toxic than copper for workers at same doses, although both metals induced severe gut melanisation and reduced sucrose consumption at high concentrations. Males displayed higher tolerance to cadmium, but it was correlated to their higher body mass, emphasising the necessity for reporting mass-standardised LD<sub>50</sub> for genuine sex comparisons in risk assessments. Our findings advocate for the establishment of databases focusing on metal-induced lethal effects on model bee species.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"110 ","pages":"Article 104546"},"PeriodicalIF":4.2,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142083776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studies of the interaction of graphene oxide (GO) with endothelial cells under static and flow conditions 研究氧化石墨烯 (GO) 在静态和流动条件下与内皮细胞的相互作用。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-08-24 DOI: 10.1016/j.etap.2024.104541

B. Dabrowski, G. Ulanowicz, Z. Brzozka, A. Zuchowska

{"title":"Studies of the interaction of graphene oxide (GO) with endothelial cells under static and flow conditions","authors":"B. Dabrowski, G. Ulanowicz, Z. Brzozka, A. Zuchowska","doi":"10.1016/j.etap.2024.104541","DOIUrl":"10.1016/j.etap.2024.104541","url":null,"abstract":"<div><p>Graphene oxide, due to its unique properties, has several potential applications in biomedicine, especially as a drug carrier. Despite emerging studies on its cytotoxicity and uptake into cells, there are still gaps in knowledge on this area. When analyzing the internalization of nanomaterials, many different factors must be considered, including particle size, surface modifications, and interactions with biological fluids that can change their properties. In the present study, we evaluated the effects of graphene oxide fractions in different sizes and samples incubated in human serum on endothelial cells (HUVECs). In addition, the study was conducted in both macroscale and microscale using <em>Cell-on-a-Chip</em> technology to better replicate <em>in vivo</em> conditions. Our findings indicate that samples incubated with serum reduce the efficiency of fraction uptake into cells. It was also observed that the uptake efficiency of graphene oxide (GO) fractions is higher in the microscale (in more real to <em>in vivo</em> environment) compared to the macroscale. Our research has shown that in order to determine the correct interaction of new materials into mammalian cells, it is necessary to take into account many different biochemical and physical factors.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"110 ","pages":"Article 104541"},"PeriodicalIF":4.2,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1382668924001819/pdfft?md5=cf6888dfa090bc0bbc7c99ee4cb6bd4a&pid=1-s2.0-S1382668924001819-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing reproductive effects and epigenetic responses in Austrolebias charrua exposed to Roundup Transorb®: Insights from miRNA profiling and molecular interaction analysis 评估暴露于Roundup Transorb®的Austrolebias charrua的生殖影响和表观遗传反应：从 miRNA 图谱和分子相互作用分析中获得的启示。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-08-22 DOI: 10.1016/j.etap.2024.104539

Antônio D. Pagano , Leandro S. Nunes , William B. Domingues , Tony L.R. da Silveira , Mateus T. Kütter , Augusto Schneider , Frederico S. Kremer , Antonio S.V. Junior , Marta G. Amaral , Natiéli M. Gonçalves , Dionet K. Bellido-Quispe , Matheus V. Volcan , Patrícia G. Costa , Adalto Bianchini , Danillo Pinhal , Vinicius F. Campos , Mariana H. Remião

{"title":"Assessing reproductive effects and epigenetic responses in Austrolebias charrua exposed to Roundup Transorb®: Insights from miRNA profiling and molecular interaction analysis","authors":"Antônio D. Pagano , Leandro S. Nunes , William B. Domingues , Tony L.R. da Silveira , Mateus T. Kütter , Augusto Schneider , Frederico S. Kremer , Antonio S.V. Junior , Marta G. Amaral , Natiéli M. Gonçalves , Dionet K. Bellido-Quispe , Matheus V. Volcan , Patrícia G. Costa , Adalto Bianchini , Danillo Pinhal , Vinicius F. Campos , Mariana H. Remião","doi":"10.1016/j.etap.2024.104539","DOIUrl":"10.1016/j.etap.2024.104539","url":null,"abstract":"<div><p>This study examines the effects of Roundup Transorb® (RDT) exposure on reproductive functions and ovarian miRNA expression in <em>Austrolebias charrua</em>. Exposure to RDT (at 0.065 or 5 mg. L<sup>−1</sup> for 96 h) significantly disrupts fertility, evidenced by changes in fertilization rates and egg diameter. Profiling of ovarian miRNAs identified a total 205 miRNAs in <em>A. charrua</em>. Among these, three miRNAs were upregulated (miR-10b-5p, miR-132–3p, miR-100–5p), while ten miRNAs were downregulated (miR-499–5p, miR-375, miR-205–5p, miR-206–3p, miR-203a-3p, miR-133b-3p, miR-203b-5p, miR-184, miR-133a-3p, miR-2188–5p) compared to non-exposed fish. This study reveals that differentially expressed miRNAs are linked to molecular pathways such as steroid hormone biosynthesis, lipid and carbohydrate metabolism, bioenergetics, and antioxidant defense. It also analyzes molecular interactions between miRNAs and target genes during RDT exposure in annual killifish, providing insights into biomarkers in ecotoxicology. Moreover, it provides scope for developing environmental health assessment models based on epigenomic endpoints, supporting the protection of biodiversity and ecosystem services through the quantification of stress responses in living organisms exposed to pesticides.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"110 ","pages":"Article 104539"},"PeriodicalIF":4.2,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morin attenuates sepsis-induced acute kidney injury by regulating inflammatory responses, oxidative stress and tubular regeneration (morin and sepsis-induced acute kidney injury) 莫林通过调节炎症反应、氧化应激和肾小管再生减轻败血症诱发的急性肾损伤（莫林与败血症诱发的急性肾损伤）。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-08-22 DOI: 10.1016/j.etap.2024.104543

Aya M. Shehata , Nagui H. Fares , Basma H. Amin , Asmaa A. Mahmoud , Yomna I. Mahmoud

{"title":"Morin attenuates sepsis-induced acute kidney injury by regulating inflammatory responses, oxidative stress and tubular regeneration (morin and sepsis-induced acute kidney injury)","authors":"Aya M. Shehata , Nagui H. Fares , Basma H. Amin , Asmaa A. Mahmoud , Yomna I. Mahmoud","doi":"10.1016/j.etap.2024.104543","DOIUrl":"10.1016/j.etap.2024.104543","url":null,"abstract":"<div><p>Sepsis-associated acute kidney injury (AKI) is a health complication, encompassing excessive inflammatory response, oxidative stress, and tubular necrosis; leading to kidney failure and death. Sepsis treatments are nonspecific and palliative. In this study, we evaluated the effect of morin, a flavonoid with known nephroprotective capabilities, on sepsis-induced AKI by dividing eighty male mice into: normal, morin-treated, septic, and septic mice treated with morin. Half of the groups were sacrified 3 days post sepsis induction, while the rest was sacrified on the 7th day. Treating septic mice with morin resulted in the amelioration of sepsis-associated pathophysiological renal alterations and the increase of the survival and recovery rates compared with those of septic control group. These findings indicate that morin has a therapeutic effect against sepsis-associated AKI via its anti-inflammatory, antioxidant and regenerative effects. Thus, it could be used as potential pharmacological intervention for preventing renal complications of sepsis.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"111 ","pages":"Article 104543"},"PeriodicalIF":4.2,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0