伊维菌素诱导斑马鱼幼体神经系统的早期发育损伤。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-05-15 DOI:10.1016/j.etap.2025.104719

Yixuan Jiang , Lin Su , Bo Peng , Weiguo Wang , Yang Zhang

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引用次数: 0

摘要

伊维菌素具有良好的抗寄生虫活性，在畜牧业中被广泛使用。然而，它的广泛使用给环境带来了压力。本研究旨在评价伊维菌素对水生生物神经系统的安全性。主要探讨伊维菌素对斑马鱼幼体神经发育的影响。结果表明，伊维菌素能诱导斑马鱼幼鱼发育异常，主要表现为头部水肿。进一步的结果表明，斑马鱼幼虫的细胞密度降低，大脑中的神经元细胞数量减少。伊维菌素还会损害神经嵴发育并诱导细胞凋亡。在运动行为方面，伊维菌素诱导斑马鱼幼虫运动减少。最后，结果表明伊维菌素能够诱导斑马鱼幼体神经发育相关基因的异常表达。本研究希望引起人们对伊维菌素在水生生物中的安全性的更多关注。

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Ivermectin induced early developmental damage to the nervous system of zebrafish larvae

Ivermectin has good antiparasitic activity and is heavily used in animal husbandry. However, its extensive use puts pressure on the environment. This study focused on evaluating the safety of ivermectin on the nervous system of aquatic organisms. The effects of ivermectin on the neurological development of zebrafish larvae were mainly explored. The results showed that ivermectin was able to induce developmental abnormalities in zebrafish larvae, which were mainly manifested as head edema. Further results showed that zebrafish larvae had reduced cellular densities and decreased numbers of neuronal cells in the brain. Ivermectin also impaired neural crest development and induced apoptosis. In locomotor behavior, ivermectin induced diminished locomotion in zebrafish larvae. Finally, the results showed that ivermectin was able to induce abnormal expression of genes related to neural development in zebrafish larvae. This study hopes to draw more attention to the safety of ivermectin for aquatic organisms.

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.