The influence of chlorpyrifos contamination on oxidative stress status of Lamellidens marginalis: A multibiomarker approach

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-05-16 DOI:10.1016/j.etap.2025.104723

Sayantan Mahapatra, Biboshwan De, Sritama Baag, Sumit Mandal

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Abstract

The present study aims to investigate the impact of chlorpyrifos on the oxidative stress responses in the freshwater bivalve Lamellidens marginalis. To assess the extent of chlorpyrifos induced stress, physiological parameters including respiration and excretion rates alongside a battery of biomarkers like superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST), and lipid peroxidation (LPO) were evaluated. These parameters were monitored at various time points over 14 days in a mesocosm study. Furthermore, an integrated biomarker response (IBR) approach was employed to coalesce biomarker data. The results showed a significant impact on the physiological activities and biomarker levels of L. marginalis. While most antioxidant and detoxifying enzymes activities were increased, catalase levels decreased significantly, leading to intense lipid peroxidation. Our findings confirm the susceptibility of L. marginalis even under short-term exposure and accentuate the potential threat of chlorpyrifos contamination in freshwater systems.

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毒死蜱污染对边缘薄叶草氧化应激状态的影响：一种多生物标志物方法。

本研究旨在探讨毒死蜱对淡水双壳类叶藻氧化应激反应的影响。为了评估毒死蜱诱导应激的程度，生理参数包括呼吸和排泄率以及一系列生物标志物，如超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽-s转移酶（GST）和脂质过氧化（LPO）进行了评估。在一项中观研究中，在14天内的不同时间点监测这些参数。此外，采用综合生物标志物反应（IBR）方法合并生物标志物数据。结果表明，这对边草的生理活性和生物标志物水平有显著影响。虽然大多数抗氧化和解毒酶活性升高，但过氧化氢酶水平显著降低，导致脂质过氧化反应强烈。我们的研究结果证实了边际L. L.在短期暴露下的易感性，并强调了毒死蜱污染对淡水系统的潜在威胁。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.