Environmental toxicology and pharmacology最新文献_第8页

Thymol’s modulation of cellular macromolecules, oxidative stress, DNA damage, and NF-kB/caspase-3 signaling in the liver of imidacloprid-exposed rats 百里酚对暴露于吡虫啉的大鼠肝脏中的细胞大分子、氧化应激、DNA损伤和NF-kB/Caspase-3信号转导的调节作用

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-06-03 DOI: 10.1016/j.etap.2024.104492

Fathy Elsayed Abdelgawad , Ghada I. Abd El-Rahman , Amany Behairy , Yasmina M. Abd-Elhakim , Taghred M. Saber , Mohamed M.M. Metwally , Samaa Salah Abd El-Fatah , Mariam M. Samaha , Taisir Saber , Mohamed Abdelrahman Aglan

{"title":"Thymol’s modulation of cellular macromolecules, oxidative stress, DNA damage, and NF-kB/caspase-3 signaling in the liver of imidacloprid-exposed rats","authors":"Fathy Elsayed Abdelgawad , Ghada I. Abd El-Rahman , Amany Behairy , Yasmina M. Abd-Elhakim , Taghred M. Saber , Mohamed M.M. Metwally , Samaa Salah Abd El-Fatah , Mariam M. Samaha , Taisir Saber , Mohamed Abdelrahman Aglan","doi":"10.1016/j.etap.2024.104492","DOIUrl":"10.1016/j.etap.2024.104492","url":null,"abstract":"<div><p>We evaluated whether thymol (THY) (30 mg/kg b.wt) could relieve the adverse effects of the neonicotinoid insecticide imidacloprid (IMD) (22.5 mg/kg b.wt) on the liver in a 56-day oral experiment and the probable underlying mechanisms. THY significantly suppressed the IMD-associated increase in hepatic enzyme leakage. Besides, the IMD-induced dyslipidemia was considerably corrected by THY. Moreover, THY significantly repressed the IMD-induced hepatic oxidative stress, lipid peroxidation, DNA damage, and inflammation. Of note, the Feulgen, mercuric bromophenol blue, and PAS-stained hepatic tissue sections analysis declared that treatment with THY largely rescued the IMD-induced depletion of the DNA, total proteins, and polysaccharides. Moreover, THY treatment did not affect the NF-kB p65 immunoexpression but markedly downregulated the Caspase-3 in the hepatocytes of the THY+IMD-treated group than the IMD-treated group. Conclusively, THY could efficiently protect against IMD-induced hepatotoxicity, probably through protecting cellular macromolecules and antioxidant, antiapoptotic, and anti-inflammatory activities.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hazard identification of endocrine-disrupting carcinogens (EDCs) in relation to cancers in humans 干扰内分泌的致癌物质（EDCs）与人类癌症的危害识别。

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-31 DOI: 10.1016/j.etap.2024.104480

Neha Sharma , Vinay Kumar , Vimal S. , Mridul Umesh , Preeti Sharma , Basheer Thazeem , Komalpreet Kaur , Jithin Thomas , Ritu Pasrija , Divya Utreja

{"title":"Hazard identification of endocrine-disrupting carcinogens (EDCs) in relation to cancers in humans","authors":"Neha Sharma , Vinay Kumar , Vimal S. , Mridul Umesh , Preeti Sharma , Basheer Thazeem , Komalpreet Kaur , Jithin Thomas , Ritu Pasrija , Divya Utreja","doi":"10.1016/j.etap.2024.104480","DOIUrl":"10.1016/j.etap.2024.104480","url":null,"abstract":"<div><p>Endocrine disrupting chemicals or carcinogens have been known for decades for their endocrine signal disruption. Endocrine disrupting chemicals are a serious concern and they have been included in the top priority toxicants and persistent organic pollutants. Therefore, researchers have been working for a long time to understand their mechanisms of interaction in different human organs. Several reports are available about the carcinogen potential of these chemicals. The presented review is an endeavor to understand the hazard identification associated with endocrine disrupting carcinogens in relation to the human body. The paper discusses the major endocrine disrupting carcinogens and their potency for carcinogenesis. It discusses human exposure, route of entry, carcinogenicity and mechanisms. In addition, the paper discusses the research gaps and bottlenecks associated with the research. Moreover, it discusses the limitations associated with the analytical techniques for detection of endocrine disrupting carcinogens.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141201614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indole-3-acetic acid induced cardiogenesis impairment in in-vivo zebrafish via oxidative stress and downregulation of cardiac morphogenic factors 吲哚-3-乙酸通过氧化应激和心脏形态形成因子的下调诱导体内斑马鱼心脏形成障碍。

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-29 DOI: 10.1016/j.etap.2024.104479

S.P. Ramya Ranjan Nayak , Seenivasan Boopathi , Bader O. Almutairi , Selvaraj Arokiyaraj , M.K. Kathiravan , Jesu Arockiaraj

{"title":"Indole-3-acetic acid induced cardiogenesis impairment in in-vivo zebrafish via oxidative stress and downregulation of cardiac morphogenic factors","authors":"S.P. Ramya Ranjan Nayak , Seenivasan Boopathi , Bader O. Almutairi , Selvaraj Arokiyaraj , M.K. Kathiravan , Jesu Arockiaraj","doi":"10.1016/j.etap.2024.104479","DOIUrl":"10.1016/j.etap.2024.104479","url":null,"abstract":"<div><p>Plant growth regulators (PGRs) are increasingly used to promote sustainable agriculture, but their unregulated use raises concerns about potential environmental risks. Indole-3-acetic acid (IAA), a commonly used PGR, has been the subject of research on its developmental toxicity in the in-vivo zebrafish model. IAA exposure to zebrafish embryos caused oxidative stress, lipid peroxidation, and cellular apoptosis. The study also revealed that critical antioxidant genes including <em>sod</em>, <em>cat</em>, and <em>bcl2</em> were downregulated, while pro-apoptotic genes such as <em>bax</em> and <em>p53</em> were upregulated. IAA exposure also hampered normal cardiogenesis by downregulating <em>myl7</em>, <em>amhc</em>, and <em>vmhc</em> genes and potentially influencing zebrafish neurobehavior. The accumulation of IAA was confirmed by HPLC analysis of IAA-exposed zebrafish tissues. These findings underscore the need for further study on the potential ecological consequences of IAA use and the need for sustainable agricultural practices.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biochar dust emission: Is it a health concern? Preliminary results for toxicity assessment 生物炭粉尘排放：会影响健康吗？毒性评估的初步结果。

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-27 DOI: 10.1016/j.etap.2024.104477

Silvana Pinelli , Stefano Rossi , Alessio Malcevschi , Michele Miragoli , Massimo Corradi , Luisella Selis , Sara Tagliaferri , Francesca Rossi , Delia Cavallo , Cinzia Lucia Ursini , Diana Poli , Paola Mozzoni

{"title":"Biochar dust emission: Is it a health concern? Preliminary results for toxicity assessment","authors":"Silvana Pinelli , Stefano Rossi , Alessio Malcevschi , Michele Miragoli , Massimo Corradi , Luisella Selis , Sara Tagliaferri , Francesca Rossi , Delia Cavallo , Cinzia Lucia Ursini , Diana Poli , Paola Mozzoni","doi":"10.1016/j.etap.2024.104477","DOIUrl":"10.1016/j.etap.2024.104477","url":null,"abstract":"<div><p>Biochar is currently garnering interest as an alternative to commercial fertilizer and as a tool to counteract global warming. However, its use is increasingly drawing attention, particularly concerning the fine dust that can be developed during its manufacture, transport, and use. This work aimed to assess the toxicity of fine particulate Biochar (<PM<sub>10</sub>) via <em>in-vitro</em> and <em>in-vivo</em> experiments as a first step for the evaluation of toxicity values. As <em>in-vitro</em> experiments, cell lines showed inhibition of proliferation following the reduction of expression genes involved in cell cycle control, increase in the production of ROS and IL-8, and decrease in intracellular ATP. <em>In-vivo</em> rat exposure induced hyperemia, edema, and inflammatory phenomena with infiltrations of neutrophil granulocytes and macrophages at the alveolar and bronchiolar levels. Both <em>in-vitro</em> and <em>in-vivo</em> studies highlighted how exposure to Biochar particulates leads to an inflammatory condition and oxidative stress.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1382668924001170/pdfft?md5=ad4b88cede3a9815979f6c28c4ee0785&pid=1-s2.0-S1382668924001170-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weathered polyethylene microplastics induced immunomodulation in zebrafish 风化聚乙烯微塑料诱导斑马鱼的免疫调节。

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-25 DOI: 10.1016/j.etap.2024.104478

Thilagam Harikrishnan , Pandi Paramasivam , Anusuya Sankar , Madhavan Sakthivel , Elumalai Sanniyasi , Thiagarajan Raman , Muthukumar Thangavelu , Gopalakrishnan Singaram , Govarthanan Muthusamy

{"title":"Weathered polyethylene microplastics induced immunomodulation in zebrafish","authors":"Thilagam Harikrishnan , Pandi Paramasivam , Anusuya Sankar , Madhavan Sakthivel , Elumalai Sanniyasi , Thiagarajan Raman , Muthukumar Thangavelu , Gopalakrishnan Singaram , Govarthanan Muthusamy","doi":"10.1016/j.etap.2024.104478","DOIUrl":"10.1016/j.etap.2024.104478","url":null,"abstract":"<div><p>Microplastics are pollutants of emerging concern and the aquatic biota consumes microplastics (MPs), which has a range of toxicological and environmental effects on aquatic organisms that are not the intended targets. The current study looked into how weathered polyethylene (wPE) MPs affected <em>Danio albolineatus</em> immunological and haematological markers. In this experiment, fish of both sexes were placed in control and exposure groups, and they were exposed for 40 d at the sublethal level (1 μg L<sup>-1</sup>) of fragmented wPE, which contained 1074 ± 52 MPs per litre. Similarly, fish exposed to wPE MPs showed significant modifications in lysozyme, antimicrobial, and antiprotease activity, as well as differential counts. Results of the present study show that the male fish were more susceptible than female fish after 40 d of chronic exposure. Further studies are needed to ascertain how the innate and humoral immune systems of the fish respond to MPs exposure.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141159137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glyphosate contamination of drinking water and the occurrence of oxidative stress: Exposure assessment to rural Brazilian populations 饮用水中的草甘膦污染与氧化应激的发生：巴西农村人口的接触评估

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-23 DOI: 10.1016/j.etap.2024.104476

Rafaella Ferreira Nascimento Nunes , Luiz Paulo Aguiar Marciano , Geovana Sousa Oliveira , Naiane Silva Cardoso , Fernanda Borges de Araújo Paula , Marcia Sarpa , Isarita Martins

{"title":"Glyphosate contamination of drinking water and the occurrence of oxidative stress: Exposure assessment to rural Brazilian populations","authors":"Rafaella Ferreira Nascimento Nunes , Luiz Paulo Aguiar Marciano , Geovana Sousa Oliveira , Naiane Silva Cardoso , Fernanda Borges de Araújo Paula , Marcia Sarpa , Isarita Martins","doi":"10.1016/j.etap.2024.104476","DOIUrl":"10.1016/j.etap.2024.104476","url":null,"abstract":"<div><p>Studies reported that continuous application of glyphosate can cause disturbance in aquatic/terrestrial environments. As such, the objective of this study is to discuss the risk of exposure to the herbicide in drinking water and to assess the oxidative stress in the consumers rural populations of Casimiro de Abreu/ RJ and Paraguaçu/ MG, Brazil. For this, water samples (n=69) were analysed from the home of volunteers, by FMOC derivatizing- LC-FLD method. The oxidative stress was analysed determining lipid peroxidation (MAD) and defense enzymes (SOD and CAT) in serum samples from rural population (n=42) compared to urban residents (n= 42). Results of the analysis from drinking water, despite the low and moderate risk, by the hazard quotient (HQ), revealed that the population is environmentally exposed to the glyphosate. The relevant findings showed that is important to implement monitoring/ biomonitoring programs to prevent pollution and toxic effects in the rural populations.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141133075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occurrence of pharmaceuticals in rice (Oryza sativa L.) plant through wastewater irrigation 通过废水灌溉在水稻（Oryza sativa L.）植株中发现药物。

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-20 DOI: 10.1016/j.etap.2024.104475

Khalid Sayed , Wan Hanna Melini Wan-Mohtar , Zarimah Mohd Hanafiah , Aziza Sultana Bithi , Nurulhikma Md Isa , Teh Sabariah Binti Abd Manan

{"title":"Occurrence of pharmaceuticals in rice (Oryza sativa L.) plant through wastewater irrigation","authors":"Khalid Sayed , Wan Hanna Melini Wan-Mohtar , Zarimah Mohd Hanafiah , Aziza Sultana Bithi , Nurulhikma Md Isa , Teh Sabariah Binti Abd Manan","doi":"10.1016/j.etap.2024.104475","DOIUrl":"10.1016/j.etap.2024.104475","url":null,"abstract":"<div><p>The present investigation focuses on the identification of popular PhACs in roots, leaves and rice grains, which are cultivated in soil irrigated with waters and wastewater. The present study reveals the presence of PhACs in rice grains from different brands which are available in the current market, which has thus motivated these experiments. The rice plants were cultivated in garden containers and irrigated with three different water sources. All PhAC compounds were recovered within an 89–111 % range using the extraction technique, reproducibility, and sensitivity (LOQ <25 µg/g). Further, PhAC compounds were identified using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QqTOF-MS). Interestingly, several PhAC compounds were detected in rice grains, aligning with hypotheses and findings from published literature. A total of ten (10) PhACs were found in the root, leaf, and rice grain of the 20 popular PhACs that were targeted. The annual exposure and medical dose equivalent for individual PhACs was negligible. According to our knowledge, this study is the first to show the accumulation of several categories (cocktail) of PhACs in rice grains and show the approximate human health risk assessment by its consumption. The study's results provide valuable insights for researchers, policymakers, and agricultural practitioners working on sustainable agriculture and public health.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-administration of resveratrol rescued lead-induced toxicity in Drosophila melanogaster 联合施用白藜芦醇可缓解黑腹果蝇铅诱导的毒性。

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-18 DOI: 10.1016/j.etap.2024.104470

R. Abdulazeez , S.M. Highab , U.F. Onyawole , M.T. Jeje , H. Musa , D.M. Shehu , I.S. Ndams

{"title":"Co-administration of resveratrol rescued lead-induced toxicity in Drosophila melanogaster","authors":"R. Abdulazeez , S.M. Highab , U.F. Onyawole , M.T. Jeje , H. Musa , D.M. Shehu , I.S. Ndams","doi":"10.1016/j.etap.2024.104470","DOIUrl":"10.1016/j.etap.2024.104470","url":null,"abstract":"<div><p>Lead toxicity poses a significant environmental concern linked to diverse health issues. This study explores the potential mitigating effects of resveratrol on lead-induced toxicity in <em>Drosophila melanogaster</em>. Adult fruit flies, aged three days, were orally exposed to lead (60 mg/L), Succimer (10 mg), and varying concentrations of resveratrol (50, 100, and 150 mg). The investigation encompassed the assessment of selected biological parameters, biochemical markers, oxidative stress indicators, and antioxidant enzymes. Resveratrol exhibited a dose-dependent enhancement of egg-laying, eclosion rate, filial generation output, locomotor activity, and life span in <em>D. melanogaster</em>, significantly to 150 mg of diet. Most of the investigated biochemical parameters were significantly rescued in lead-exposed fruit flies when co-treated with resveratrol (p < 0.05). However, oxidative stress remained unaffected by resveratrol. The findings suggest that resveratrol effectively protects against lead toxicity in <em>Drosophila melanogaster</em> and may hold therapeutic potential as an agent for managing lead poisoning in humans.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute exposure and biomarkers assessment in rainbow trout exposed to selected pharmaceuticals 虹鳟鱼接触特定药物后的急性暴露和生物标志物评估

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-17 DOI: 10.1016/j.etap.2024.104472

C. André, J. Auclair, F. Gagné

{"title":"Acute exposure and biomarkers assessment in rainbow trout exposed to selected pharmaceuticals","authors":"C. André, J. Auclair, F. Gagné","doi":"10.1016/j.etap.2024.104472","DOIUrl":"10.1016/j.etap.2024.104472","url":null,"abstract":"<div><p>Pharmaceuticals released from municipal effluents discharges pose a risk to aquatic organisms. The toxicity of 5 pharmaceuticals with distinct therapeutic actions were assessed in rainbow trout: olanzapine (antipsychotic), erythromycin (antibiotic), mycophenoate (immunosuppression), pinaverium (anti-inflammatory) and trazodone (sedative). Juveniles were exposed to these drugs for 96 h at concentrations between 64 µg/L up to 40 mg/L to reach lethality. Survival was determined and a suite of biomarkers was analyzed for drug biotransformation, oxidative stress/damage and metabolic activity at sublethal concentrations. The data revealed the following toxicity: olanzapine >trazodone>mycophenolate>pinaverium∼erythromycin based on mortality. The data also revealed that toxicity was associated to mass, pKa and hydrophobicity and the following sublethal effects: GST, LPO and DNA strand breaks. Pharmaceuticals with lower molecular weight, physiological pKa, moderate hydrophobicity, low biotransformation and DNA strand breaks were generally more toxic to fish. However, this should be considered as a general guide in identifying toxic pharmaceuticals in non-target organisms.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141048847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral profile alterations and predation susceptibility of Japanese medaka fish exposed to phenytoin, an antiepileptic drug 暴露于苯妥英（一种抗癫痫药物）的日本青鳉的行为特征变化和捕食易感性

IF 4.3 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-05-17 DOI: 10.1016/j.etap.2024.104474

Ayaka Sawada , Uaciquete Dorcas , Yoshifumi Horie

{"title":"Behavioral profile alterations and predation susceptibility of Japanese medaka fish exposed to phenytoin, an antiepileptic drug","authors":"Ayaka Sawada , Uaciquete Dorcas , Yoshifumi Horie","doi":"10.1016/j.etap.2024.104474","DOIUrl":"10.1016/j.etap.2024.104474","url":null,"abstract":"<div><p>Antiepileptic drugs, such as phenytoin, are often leaked into aquatic systems through sewage facilities due to their low metabolic rate. Fish, such as the Japanese medaka (<em>Oryzias latipes</em>), demonstrate abnormal swimming behavior such as equilibrium abnormalities, rotational behavior, and vertical swimming, when exposed to phenytoin. Therefore, it is hypothesized that predator avoidance may be hindered. This study aimed to investigate the effects of phenytoin exposure-induced behavioral abnormalities in predator avoidance in Japanese medaka. The results showed that individuals with behavioral abnormalities had a reduced ability to avoid danger. Furthermore, the fish demonstrated a delayed recognition reaction to approaching predators. Additionally, predatory fish, such as silver pike characin (<em>Ctenolucius hujeta</em>), were more likely to prey upon abnormal individuals. In conclusion, the fish exposed to phenytoin demonstrated behavioral changes that increased its predation risk. This study is the first to determine the effects of behavioral abnormalities in Japanese medaka which was induced after phenytoin exposure on predator risk avoidance.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141025424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0