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Integrated biomarker assessment of sublethal effects of a tebuconazole-based fungicide in Rhinella arenarum larvae 基于替布康唑的杀菌剂对砂鼻菌幼虫亚致死效应的综合生物标志物评估
IF 4.2 3区 环境科学与生态学
Environmental toxicology and pharmacology Pub Date : 2026-01-01 DOI: 10.1016/j.etap.2025.104921
Mercedes Acquaroni, Cristina Pérez Coll, Gabriela Svartz
{"title":"Integrated biomarker assessment of sublethal effects of a tebuconazole-based fungicide in Rhinella arenarum larvae","authors":"Mercedes Acquaroni,&nbsp;Cristina Pérez Coll,&nbsp;Gabriela Svartz","doi":"10.1016/j.etap.2025.104921","DOIUrl":"10.1016/j.etap.2025.104921","url":null,"abstract":"<div><div>Agricultural intensification increases agrochemical use, exposing aquatic organisms to sublethal toxicants capable of disrupting key physiological pathways. This study assessed the biochemical and physiological responses of <em>Rhinella arenarum</em> larvae exposed to a commercial tebuconazole-based fungicide (Trigal®, 43 % active ingredient). Acute (96 h) exposures to 0.005, 0.01, and 0.05 mg/L were performed to evaluate biomarkers related to oxidative stress, neurotoxicity, and genotoxicity. The integrated biomarker response (IBR) index was used to combine these endpoints into a single global measure of physiological stress. Tebuconazole caused oxidative imbalance, with CAT, GST, and GSH activities inhibited by 20–60 % across all concentrations, while SOD increased 24 % at 0.05 mg/L. Lipid peroxidation and micronuclei frequency rose by 3-fold at 0.01–0.05 mg/L, indicating redox disruption and membrane damage. Significant BChE inhibition further evidenced neurophysiological impairment. The IBR index revealed a concentration-dependent increase, with the highest value observed at 0.05 mg/L, indicating a clear overall biological effect of exposure. Given the ecological role of amphibians as key components of food webs, these findings suggest that tebuconazole may impair larval performance and ultimately reduce recruitment in amphibian populations exposed to agricultural runoff.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"121 ","pages":"Article 104921"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145880390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sublethal fipronil exposure impairs development and behavior in Drosophila melanogaster 亚致死氟虫腈暴露损害黑腹果蝇的发育和行为
IF 4.2 3区 环境科学与生态学
Environmental toxicology and pharmacology Pub Date : 2026-01-01 Epub Date: 2025-12-24 DOI: 10.1016/j.etap.2025.104917
Heloísa Pereira Santos , Andressa Paladini , Cristiane Lenz Dalla Corte
{"title":"Sublethal fipronil exposure impairs development and behavior in Drosophila melanogaster","authors":"Heloísa Pereira Santos ,&nbsp;Andressa Paladini ,&nbsp;Cristiane Lenz Dalla Corte","doi":"10.1016/j.etap.2025.104917","DOIUrl":"10.1016/j.etap.2025.104917","url":null,"abstract":"<div><div>The use of pesticides, particularly insecticides, is integral to modern agriculture. Fipronil, a widely used phenylpyrazole insecticide, is classified as a class II toxicant, indicating high toxicity by ingestion and contact. This study evaluated the morphometric and toxicological effects of fipronil on <em>D. melanogaster</em> development. Embryos were exposed orally from the embryonic stage to adulthood at 16, 40, 81, 163, 327, and 490 nM. The highest concentration reduced adult emergence from pupae, while survival decline at the three highest concentrations. Locomotor behavior was impaired at 81 nM in both sexes. Fipronil induced 24-h mortality in adult flies at concentrations ≥ 327 nM, with a median lethal concentration (LC<sub>50</sub>) of 442 nM. Canonical variate analysis (CVA) revealed sex-dependent differences and shape changes at 16 and 40 nM compared with controls. Overall, these findings indicate fipronil toxicity in <em>D. melanogaster</em> and suggest that this model can help anticipate effects in other invertebrates.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"121 ","pages":"Article 104917"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145823315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urinary concentrations of di-butyl phthalate isomers and reproductive hormonal parameters in adult men: A systematic review with dose-response meta-analysis 成年男性尿中邻苯二甲酸二丁酯异构体浓度和生殖激素参数:一项剂量-反应荟萃分析的系统综述
IF 4.2 3区 环境科学与生态学
Environmental toxicology and pharmacology Pub Date : 2026-01-01 Epub Date: 2025-12-09 DOI: 10.1016/j.etap.2025.104900
Tiberiu M. Nita , David Vernez , Pascal Wild , Nelly Pitteloud , Nancy B. Hopf
{"title":"Urinary concentrations of di-butyl phthalate isomers and reproductive hormonal parameters in adult men: A systematic review with dose-response meta-analysis","authors":"Tiberiu M. Nita ,&nbsp;David Vernez ,&nbsp;Pascal Wild ,&nbsp;Nelly Pitteloud ,&nbsp;Nancy B. Hopf","doi":"10.1016/j.etap.2025.104900","DOIUrl":"10.1016/j.etap.2025.104900","url":null,"abstract":"<div><h3>Background</h3><div>Male reproductive decline has been linked to phthalate exposure. Di-butyl phthalate isomers (DnBP and DiBP) are endocrine disruptors with inconsistent evidence regarding effects on the hypothalamic-pituitary-gonadal/thyroid (HPG/T) axis.</div></div><div><h3>Objective</h3><div>To perform a dose-response meta-analysis of associations between DnBP and DiBP exposure and HPG/T-axis hormones.</div></div><div><h3>Methods</h3><div>Five databases were searched. The associations between urinary DBP metabolite concentrations (mono-n-butyl phthalate [MnBP], mono-iso-butyl phthalate [MiBP], or nonspecific DBP metabolites [∑DBPm]) and hormone levels (TT, fT, SHBG, LH, FSH, E2, INHB, and TSH) were analyzed using meta-regressions (unadjusted [UA], covariate-adjusted [CA], fertility-adjusted [FA]).</div></div><div><h3>Results</h3><div>From 10,410 records, 19 studies (N = 12,128) were considered. MiBP was negatively correlated with LH (UA: β=-0.117, p = 0.02; CA: β=-0.094, p = 0.012; FA: β=-0.125, p = 0.009), positively with E2 (CA: β=0.084, p = 0.045), and SHBG (CA: β=0.09, p = 0.034; FA: β=0.091, p = 0.015). MnBP was positively associated with TSH (UA: β=0.152, p = 0.001; CA: β=0.188, p = 0.006).</div></div><div><h3>Conclusions</h3><div>DBP-isomers exposure is associated with altered HPG/T-axis hormone levels.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"121 ","pages":"Article 104900"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of acetamiprid on DNA methylation, transcriptomics, and neurogenesis in human mesenchymal stem cells 对乙酰脒对人间充质干细胞DNA甲基化、转录组学和神经发生的影响
IF 4.2 3区 环境科学与生态学
Environmental toxicology and pharmacology Pub Date : 2026-01-01 Epub Date: 2025-12-11 DOI: 10.1016/j.etap.2025.104904
Xiaofeng Chen , Yucheng Zhu , Minghan Li , Chunyan Zhou , Fang Luo , Zechang Li , Jiangyu Zhang , Liguo Xing , Wei Liu
{"title":"Effects of acetamiprid on DNA methylation, transcriptomics, and neurogenesis in human mesenchymal stem cells","authors":"Xiaofeng Chen ,&nbsp;Yucheng Zhu ,&nbsp;Minghan Li ,&nbsp;Chunyan Zhou ,&nbsp;Fang Luo ,&nbsp;Zechang Li ,&nbsp;Jiangyu Zhang ,&nbsp;Liguo Xing ,&nbsp;Wei Liu","doi":"10.1016/j.etap.2025.104904","DOIUrl":"10.1016/j.etap.2025.104904","url":null,"abstract":"<div><div>Acetamiprid (ACE), a Neonicotinoid insecticides (NEOs), is highly selective for insect nicotinic acetylcholine receptors (nAChRs). However, increasing evidence of hazards was reported in mammals. We investigated the effects of ACE on both global DNA methylation and epigenetic change, transcriptomic dysregulation, and neural differentiation. ACE decreased AluYb8 methylation levels in human mesenchymal stem cells. TET2 expression was enhanced suggesting that it was involved in the active DNA demethylation caused by ACE. Global DNA methylation pattern identified 87 significant differentially methylated positions (DMPs) and transcriptomic analysis identified 385 differentially expressed genes (DEGs). Pathways related to the psychiatric system, including Alzheimer's disease and TGF-β, were significantly enriched. ACE inhibited the expression of neurogenesis marker MAP2 and SNCA, which was repressed by TETs inhibitor Bobcat339. Our results suggested that exposure to ACE disturbed DNA methylation, and resulted in the impaired neural differentiation revealed by abnormal expression of neuronal and PD-related marker protein.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"121 ","pages":"Article 104904"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arsenic and lead exposure in vietnamese gold mining communities: A case study of metabolic enzyme impacts 越南金矿社区的砷和铅暴露:代谢酶影响的案例研究。
IF 4.2 3区 环境科学与生态学
Environmental toxicology and pharmacology Pub Date : 2026-01-01 Epub Date: 2025-12-15 DOI: 10.1016/j.etap.2025.104911
Phuoc-Cuong Le , Le Van Hao , Tan Nhat , Hoang-Son Le , Thi Xuan Thuy Le
{"title":"Arsenic and lead exposure in vietnamese gold mining communities: A case study of metabolic enzyme impacts","authors":"Phuoc-Cuong Le ,&nbsp;Le Van Hao ,&nbsp;Tan Nhat ,&nbsp;Hoang-Son Le ,&nbsp;Thi Xuan Thuy Le","doi":"10.1016/j.etap.2025.104911","DOIUrl":"10.1016/j.etap.2025.104911","url":null,"abstract":"<div><div>This study assesses seasonal heavy-metal contamination from gold mining in the Bong Mieu River basin (central Viet Nam) and examines its association with human xenobiotic-metabolizing enzyme phenotypes. In sediments, As and Pb consistently exceeded Vietnamese sediment quality limits, by 4.1–25.4 × for As and 2.3–7.8 × for Pb, whereas other metals generally remained within regulatory thresholds. River water exhibited widespread Pb exceedances at all sites and occasional. As exceedances, with higher concentrations in the dry season. Regression analyses indicated strong water–sediment coupling for As, Pb, Hg, Cd, and Zn, supporting shared transport and accumulation processes. Season-resolved Pearson correlations, HCA, PCA, and APCS-MLR source apportionment revealed a dominant mining-derived multi-metal signal year-round, intensified and spatially mixed under monsoon hydrology. Enzyme phenotypes varied with the mixed-metal exposure gradient: sites with higher As/Pb burdens showed higher frequencies of slow NAT2 and intermediate/slow CYP450 phenotypes, and longer residence was associated with higher NAT2 rapid-phenotype frequency.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"121 ","pages":"Article 104911"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polystyrene microplastics modulate the toxic effects of bisphenol A in the early stages of zebrafish development 聚苯乙烯微塑料在斑马鱼发育的早期阶段调节双酚A的毒性作用。
IF 4.2 3区 环境科学与生态学
Environmental toxicology and pharmacology Pub Date : 2026-01-01 Epub Date: 2025-12-29 DOI: 10.1016/j.etap.2025.104919
Alessandra La Pietra , Teresa Mobilio , Gianluca Fasciolo , Simone Moggio , Angela Belletti , Gabriella Di Natale , Marco Trifuoggi , Paola Venditti , Ida Ferrandino
{"title":"Polystyrene microplastics modulate the toxic effects of bisphenol A in the early stages of zebrafish development","authors":"Alessandra La Pietra ,&nbsp;Teresa Mobilio ,&nbsp;Gianluca Fasciolo ,&nbsp;Simone Moggio ,&nbsp;Angela Belletti ,&nbsp;Gabriella Di Natale ,&nbsp;Marco Trifuoggi ,&nbsp;Paola Venditti ,&nbsp;Ida Ferrandino","doi":"10.1016/j.etap.2025.104919","DOIUrl":"10.1016/j.etap.2025.104919","url":null,"abstract":"<div><div>One of the characteristics of polystyrene microplastics (PS-MPs) is their hydrophobic surface, which allows them to carry other pollutants such as bisphenol A (BPA), known to be endocrine disruptor. This study investigated the co-exposure of 1 µm PS-MPs at 1.0 mgL<sup>−1</sup> with BPA at 25.0 µM on zebrafish development. The results on the toxicity parameters showed that PS-MPs and BPA during co-exposure had antagonist effects reducing their effects compared to single exposure, in hatching, neurotoxicity and heart rate. This trend was confirmed by an improvement in the expression of developmental genes observed in the co-exposed group. However, in redox homeostasis analysis emerged that, when together, PS-MPs exacerbated the effects of BPA compared to single exposure in redox homeostasis analysis. The findings showed a dual role of PS-MPs in modulating the effects of BPA providing new information on the risk associated with their simultaneous presence in the aquatic environment.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"121 ","pages":"Article 104919"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occurrence, compositional profiles, and human exposure of siloxanes in dust and human hair from a university campus in Hainan, China 中国海南某大学校园粉尘和头发中硅氧烷的出现、成分和人体暴露
IF 4.2 3区 环境科学与生态学
Environmental toxicology and pharmacology Pub Date : 2026-01-01 Epub Date: 2025-12-10 DOI: 10.1016/j.etap.2025.104901
Wenming Chen, Xinmei Wang, Liying Wang, Yingxuan Wu, Jun Wu, Chuanbiao Xu, Jiliang Zhang
{"title":"Occurrence, compositional profiles, and human exposure of siloxanes in dust and human hair from a university campus in Hainan, China","authors":"Wenming Chen,&nbsp;Xinmei Wang,&nbsp;Liying Wang,&nbsp;Yingxuan Wu,&nbsp;Jun Wu,&nbsp;Chuanbiao Xu,&nbsp;Jiliang Zhang","doi":"10.1016/j.etap.2025.104901","DOIUrl":"10.1016/j.etap.2025.104901","url":null,"abstract":"<div><div>Siloxanes, common in cosmetics and personal care products, carry environmental and health risks due to persistence and bioaccumulation. This study measured 17 siloxanes in dust and human hair from a university campus in Hainan Province, China, confirming widespread contamination. In dust samples, the ƩSiloxane concentrations ranged from 58.6 to 12,359 ng/g, with ƩLinear significantly predominating over ƩCyclic. In human hair, ƩSiloxane concentrations ranged from 4.60 to 14,205 ng/g, also showing higher ƩLinear levels compared to ƩCyclic. The primary siloxanes in both matrices were L10, L9, and L11. Dust and hair siloxanes correlated significantly, identifying dust as a major source. Gender differences were observed, with female students showing higher siloxane concentrations in hair and greater exposure doses through dust ingestion (4.88 ng/kg bw/d) compared to male students (2.05 ng/kg bw/d). Given the higher exposure doses observed compared to other common organic pollutants, the potential health risks associated with siloxane exposure warrant further investigation.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"121 ","pages":"Article 104901"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What lies beneath the ice? How gadolinium affects Cyclops abyssorum during Alpine winters 冰下是什么?钆对高山冬季独眼巨眼的影响。
IF 4.2 3区 环境科学与生态学
Environmental toxicology and pharmacology Pub Date : 2026-01-01 Epub Date: 2025-12-15 DOI: 10.1016/j.etap.2025.104912
Alice Gabetti , Camilla Mossotto , Francesca Provenza , Serena Anselmi , Alessandra Maganza , Giuseppe Esposito , Maria Vittoria Riina , Alessandra Griglione , Stefania Squadrone , Monia Renzi , Antonia Concetta Elia , Marino Prearo , Paolo Pastorino
{"title":"What lies beneath the ice? How gadolinium affects Cyclops abyssorum during Alpine winters","authors":"Alice Gabetti ,&nbsp;Camilla Mossotto ,&nbsp;Francesca Provenza ,&nbsp;Serena Anselmi ,&nbsp;Alessandra Maganza ,&nbsp;Giuseppe Esposito ,&nbsp;Maria Vittoria Riina ,&nbsp;Alessandra Griglione ,&nbsp;Stefania Squadrone ,&nbsp;Monia Renzi ,&nbsp;Antonia Concetta Elia ,&nbsp;Marino Prearo ,&nbsp;Paolo Pastorino","doi":"10.1016/j.etap.2025.104912","DOIUrl":"10.1016/j.etap.2025.104912","url":null,"abstract":"<div><div>The increasing anthropogenic release of gadolinium (Gd) from medical contrast agents raises concern regarding its fate and ecotoxicological effects in freshwater ecosystems. Gd may reach alpine lakes through atmospheric deposition, entering environments already fragile due to extreme conditions. This study examined the sublethal effects of Gd on the alpine copepod <em>Cyclops abyssorum</em> under simulated winter conditions (4 °C, darkness). Organisms were exposed for 14 days to 1–150 µg/L Gd, and oxidative stress biomarkers were measured. Glutathione peroxidase activity increased with concentration, while malondialdehyde indicated lipid peroxidation. Superoxide dismutase and glutathione S-transferase showed non-linear responses, suggesting physiological thresholds or enzyme inhibition. The Threshold-based Integrative Biomarker Response (IBR-T) index revealed progressively higher stress at intermediate and high exposures. Overall, the results indicate that Gd can induce oxidative stress in cold-adapted zooplankton, emphasizing the importance of assessing contaminant risks in alpine lakes using non-model species and realistic exposure scenarios.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"121 ","pages":"Article 104912"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Filtered diesel exhaust via whole body exposure disrupts male reproductive function through dysregulated endocrine axis and subdued testicular GSTs in juvenile Wistar rats 过滤后的柴油废气通过全身暴露,通过内分泌轴失调和睾丸GSTs抑制破坏雄性生殖功能
IF 4.2 3区 环境科学与生态学
Environmental toxicology and pharmacology Pub Date : 2026-01-01 Epub Date: 2025-12-11 DOI: 10.1016/j.etap.2025.104902
Swarnabha Sarkar , Aditya Dontham , Ravindran Revand , Abhishek Kandpal , Debabrata Dasgupta , Bahni Ray , Mayank Kumar , Asmita Patil
{"title":"Filtered diesel exhaust via whole body exposure disrupts male reproductive function through dysregulated endocrine axis and subdued testicular GSTs in juvenile Wistar rats","authors":"Swarnabha Sarkar ,&nbsp;Aditya Dontham ,&nbsp;Ravindran Revand ,&nbsp;Abhishek Kandpal ,&nbsp;Debabrata Dasgupta ,&nbsp;Bahni Ray ,&nbsp;Mayank Kumar ,&nbsp;Asmita Patil","doi":"10.1016/j.etap.2025.104902","DOIUrl":"10.1016/j.etap.2025.104902","url":null,"abstract":"<div><div>The aftermath of air pollution comprising diesel exhaust on male reproduction necessitates comprehensive understanding. As an extension of our previous findings, the present study was designed to investigate the role of whole body exposure to filtered fraction of diesel exhaust on the male reproductive health of juvenile Wistar rats. The rats were subjected to clean air (CAG-J)/filtered diesel exhaust (FDG-J) exposure (n = 8/group) separately in an indigenously developed whole body exposure chamber, for 6 weeks (6 h/day and 5 days/week). Results showed a significant decline testicular weights, sperm concentration, % motility, serum testosterone, LH levels in serum and testes along with testicular GSTs with alterations in histoarchitecture of testicular tissue in FDG-J. Furthermore, we observed a significant increase in % sperm morphological defects, testicular testosterone, 17 β-estradiol, and serum prolactin. These findings demonstrate that disrupted endocrine regulation and oxidant/antioxidant balance can affect testicular function in younger males.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"121 ","pages":"Article 104902"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging contaminants and their influence on plants: An in-depth review 新出现的污染物及其对植物的影响综述
IF 4.2 3区 环境科学与生态学
Environmental toxicology and pharmacology Pub Date : 2026-01-01 Epub Date: 2025-11-20 DOI: 10.1016/j.etap.2025.104872
Sadia Aziz , Sania Zaib , Azhar Iqbal , Muhammad Asif Chuadhry , Shaheen Shahzad , Bikram Dhara , Athanasios Alexiou , Partha Biswas , Mohamed M. Abdel-Daim , Shabana Bibi
{"title":"Emerging contaminants and their influence on plants: An in-depth review","authors":"Sadia Aziz ,&nbsp;Sania Zaib ,&nbsp;Azhar Iqbal ,&nbsp;Muhammad Asif Chuadhry ,&nbsp;Shaheen Shahzad ,&nbsp;Bikram Dhara ,&nbsp;Athanasios Alexiou ,&nbsp;Partha Biswas ,&nbsp;Mohamed M. Abdel-Daim ,&nbsp;Shabana Bibi","doi":"10.1016/j.etap.2025.104872","DOIUrl":"10.1016/j.etap.2025.104872","url":null,"abstract":"<div><div>In recent years, soil pollution from emerging contaminants has attracted significant global attention. These contaminants comprise a wide range of substances, including industrial by-products, pharmaceuticals, personal care products, pesticides, microplastics, phthalates, nanomaterials, and their transformation products. Their diverse nature and persistence in environment pose serious threats to soil functionality, plant health. Every year, the production and discharge of these compounds contribute to their extensive distribution worldwide. Many of these emerging contaminants exhibit strong soil adsorption and bioaccumulation capacity within food webs, leading to their persistence in both terrestrial and aquatic systems leading to complex, often unpredictable ecological consequences. This review synthesizes recent findings on the sources and environmental impacts of emerging contaminants, with a particular focus on plants. It highlights their effects on plant growth, the mechanisms of phytotoxicity, and the broader implications for crop productivity, soil health, and agricultural sustainability. By elucidating the interactions between these contaminants and plant systems, this work also underscores the need for effective mitigation strategies to protect ecosystems, food security, and human well-being.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"121 ","pages":"Article 104872"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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