暴露于空气中多氯联苯与子宫平滑肌瘤、子宫内膜异位症和多囊卵巢综合征的风险：一项基于登记的丹麦队列研究。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-05-31 DOI:10.1016/j.etap.2025.104738

Sandra Søgaard Tøttenborg , Lauren Anne Wise , Amelia Kent Wesselink , Henriette Svarre Nielsen , Kajsa Ugelvig Petersen , Matthew P. Fox , Marie Frederiksen , Esben Meulengracht Flachs , Harald William Meyer , Karin Sørig Hougaard , Jens Peter Bonde , Laura Deen

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引用次数: 0

摘要

目的：评估从建筑材料中暴露于低氯多氯联苯是否与女性居民UL、子宫内膜异位症和多囊卵巢综合征的发病率增加有关。方法：我们研究了1970-2018年丹麦两个部分多氯联苯污染住房区的21,619名居民。结合基于登记的搬迁历史和室内空气测量，我们量化了年累积暴露（PCByear）。全国登记册确定了结果诊断；Cox回归与时变暴露估计风险比（HR）。结果：在约38万人年的研究中，我们发现了662例UL， 199例子宫内膜异位症和190例PCOS。中位暴露量为56.3 PCByear（5-95百分位数：0.3- 4952）。PCByear每4×interquartile范围增加的调整HR （880ng/m3×year）显示与UL （HR 0.99, 95% CI 0.96-1.02）、子宫内膜异位症（HR 0.96, 95% CI 0.90-1.02）或PCOS （HR 0.98, 95% CI 0.93-1.03）无关。讨论：这是关于住宅多氯联苯暴露的妇科风险的第一项研究，没有发现任何影响，尽管暴露错误分类和结果确定不足可能导致结果偏向零。

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查看原文本刊更多论文

Exposure to airborne polychlorinated biphenyls and risk of uterine leiomyomata, endometriosis, and polycystic ovarian syndrome: A register-based Danish cohort study

Objective

To assess whether exposure to lower-chlorinated PCBs from building materials is associated with increased incidence of UL, endometriosis, and PCOS in female residents.

Methods

We studied 21,619 residents of two Danish partially PCB-contaminated housing areas from 1970 to 2018. Combining register-based relocation history with indoor air measurements, we quantified annual cumulative exposure (PCB_year). Nationwide registers identified outcome diagnoses; Cox regression with time-varying exposure estimated hazard ratios (HR).

Results

During ≈ 380,000 person-years, we identified 662 incident UL, 199 endometriosis, and 190 PCOS cases. Median exposure was 56.3 PCB_year (5–95 percentile: 0.3–4952). Adjusted HRs per 4 ×interquartile range increase in PCB_year (880 ng/m³×year) showed no association with UL (HR 0.99, 95 % CI 0.96–1.02), endometriosis (0.96, 95 % CI 0.90–1.02), or PCOS (HR 0.98, 95 % CI 0.93–1.03).

Discussion

This first study of gynecological risks from residential PCB exposure found no effect, though exposure misclassification and outcome underascertainment may have biased results towards the null.

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.