Environmental toxicology and pharmacology最新文献_第2页

Spray paint-derived microplastics and incorporated substances as ecotoxicological contaminants in the neotropical bumblebee Bombus atratus 喷漆衍生的微塑料和掺杂物质是新热带熊蜂Bombus atratus体内的生态毒理学污染物。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-06 DOI: 10.1016/j.etap.2024.104586

Guilherme Andrade Neto Schmitz Boeing , Michele Provase , Elisabete Tsukada , Raquel F. Salla , Walter Ruggeri Waldman , Fábio Camargo Abdalla

{"title":"Spray paint-derived microplastics and incorporated substances as ecotoxicological contaminants in the neotropical bumblebee Bombus atratus","authors":"Guilherme Andrade Neto Schmitz Boeing , Michele Provase , Elisabete Tsukada , Raquel F. Salla , Walter Ruggeri Waldman , Fábio Camargo Abdalla","doi":"10.1016/j.etap.2024.104586","DOIUrl":"10.1016/j.etap.2024.104586","url":null,"abstract":"<div><div>While bumblebees may be exposed to microplastics (MPs), the effects on them are not well studied. Therefore, in this research, we assessed the cytotoxicity of pristine and photodegraded spray paint-derived MPs on the midgut, Malpighian tubules, and hepato-nephrocitic system cells of <em>Bombus atratus</em> workers exposed to 50 mg.L<sup>−1</sup> MPs for 96 hours. Histological and histochemical analyses revealed that pristine MPs caused subtle cellular changes, while the exposure to photodegraded MPs led to significant vacuolization, nuclear condensation, and pyknosis. These effects are possibly linked to the release of potentially toxic elements (PTEs) like Copper, Manganese, and Iron from photodegraded MPs, which exceeded Brazil's CONAMA safety limits. Photodegraded MPs also reduced body weight, disrupting homeostasis and potentially decreasing bumblebee’s fitness. These findings highlight the importance of studying the toxicity of environmentally realistic MPs, as plastic composition and weathering significantly influence their harmful effects.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104586"},"PeriodicalIF":4.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pollen contaminated with a triple-action fungicide induced oxidative stress and reduced longevity though with less impact on lifespan in honey bees from well fed colonies 被三效杀真菌剂污染的花粉会诱发氧化应激并降低蜜蜂的寿命，但对喂养良好蜂群的蜜蜂寿命影响较小。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-04 DOI: 10.1016/j.etap.2024.104587

Thais R.R. Alves , Matheus F. Trivellato , Tainá A.L. Freitas , Aline Y. Kato , Cássia R.A. Gomes , Yara M.M. Ferraz , Jéssica A. Serafim , David De Jong , Evandro P. Prado , Eduardo F. Vicente , Ricardo O. Orsi , Gener T. Pereira , Camila A. Miranda , Fábio E. Mingatto , Daniel Nicodemo

{"title":"Pollen contaminated with a triple-action fungicide induced oxidative stress and reduced longevity though with less impact on lifespan in honey bees from well fed colonies","authors":"Thais R.R. Alves , Matheus F. Trivellato , Tainá A.L. Freitas , Aline Y. Kato , Cássia R.A. Gomes , Yara M.M. Ferraz , Jéssica A. Serafim , David De Jong , Evandro P. Prado , Eduardo F. Vicente , Ricardo O. Orsi , Gener T. Pereira , Camila A. Miranda , Fábio E. Mingatto , Daniel Nicodemo","doi":"10.1016/j.etap.2024.104587","DOIUrl":"10.1016/j.etap.2024.104587","url":null,"abstract":"<div><div>Experiments were conducted to determine the effects of a triple-action fungicide on bees and whether improved nutrition can ameliorate eventual negative impacts. In cage tests, newly-emerged bees from well fed and from nutritionally-restricted honey bee colonies were fed for five days with pollen from sunflowers that had been sprayed or not with a commercial fungicide containing bixafen, prothioconazole and trifloxystrobin. Bees from well-fed colonies were significantly larger and consumed more uncontaminated pollen. They also exhibited increased glutathione peroxidase activity and higher concentrations of pyridine nucleotides, both of which are involved in antioxidase defense. However, pollen contaminated with fungicide led to an increase in lipoperoxidation, regardless of nutritional status. Bee longevity was reduced by both fungicide contamination of the pollen diet and poor nutritional condition. The fungicide adversely affected bees fed with contaminated pollen, though nutritional supplementation of the bee colonies that reared the bees partially compensated for these effects.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104587"},"PeriodicalIF":4.2,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constructing an adverse outcome pathway framework for the impact of maternal exposure to PM2.5 on liver development and injury in offspring 构建母体暴露于 PM2.5 对后代肝脏发育和损伤影响的不良后果路径框架。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-11-01 DOI: 10.1016/j.etap.2024.104585

Kexin Zhang , Li Tian , Qinglin Sun , Jianong Lv , Ruiyang Ding , Yang Yu , Yang Li , Junchao Duan

{"title":"Constructing an adverse outcome pathway framework for the impact of maternal exposure to PM2.5 on liver development and injury in offspring","authors":"Kexin Zhang , Li Tian , Qinglin Sun , Jianong Lv , Ruiyang Ding , Yang Yu , Yang Li , Junchao Duan","doi":"10.1016/j.etap.2024.104585","DOIUrl":"10.1016/j.etap.2024.104585","url":null,"abstract":"<div><div>Ambient fine particulate matter (PM<sub>2.5</sub>) is a significant contributor to air pollution. PM<sub>2.5</sub> exposure poses a substantial hazard to public health. In recent years, the adverse effects of maternal PM<sub>2.5</sub> exposure on fetal health have gradually gained public attention. As the largest organ in the body, the liver has many metabolic and secretory functions. Liver development, as well as factors that interfere with its growth and function, are of concern. This review utilized the adverse outcome pathway (AOP) framework as the analytical approach to demonstrate the link between maternal PM<sub>2.5</sub> exposure and potential neonatal liver injury from the molecular to the population level. The excessive generation of reactive oxygen species (ROS), subsequent endoplasmic reticulum (ER) stress, and oxidative stress were regarded as the essential components in this framework, as they could trigger adverse developmental outcomes in the offspring through DNA damage, autophagy dysfunction, mitochondrial injury, and other pathways. To the best of our knowledge, this is the first article based on an AOP framework that elaborates on the influence of maternal exposure to PM<sub>2.5</sub> on liver injury occurrence and adverse effects on liver development in offspring. Therefore, this review offered mechanistic insights into the developmental toxicity of PM<sub>2.5</sub> in the liver, which provided a valuable basis for future studies and prevention strategies.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104585"},"PeriodicalIF":4.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microplastic contamination in the aquaculture icon Oreochromis mossambicus: Prevalence, characteristics, and comprehensive overview 水产养殖图标 Oreochromis mossambicus 中的微塑料污染：普遍性、特征和综合概述。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-10-31 DOI: 10.1016/j.etap.2024.104584

Pradeep Kumkar , Chandani R. Verma , Sachin M. Gosavi , Martin Lexa , Sanjay S. Kharat , Radek Rinn , Lukáš Kalous

{"title":"Microplastic contamination in the aquaculture icon Oreochromis mossambicus: Prevalence, characteristics, and comprehensive overview","authors":"Pradeep Kumkar , Chandani R. Verma , Sachin M. Gosavi , Martin Lexa , Sanjay S. Kharat , Radek Rinn , Lukáš Kalous","doi":"10.1016/j.etap.2024.104584","DOIUrl":"10.1016/j.etap.2024.104584","url":null,"abstract":"<div><div>The global production of plastics has surged to 368 million tonnes annually, leading to significant plastic waste accumulation, projected to reach 12,000 Mt by 2050, impacting aquatic ecosystems. Fish, crucial for their protein and nutrients, are particularly vulnerable to microplastic (MP) ingestion. As a major aquaculture producer and fish consumer, India faces rising plastic pollution in freshwater, which disrupts fish health and growth, posing a significant threat to the sustainability and productivity of aquaculture systems and potential health risks. This study focuses on Mozambique tilapia (<em>Oreochromis mossambicus</em>), valued for its widespread aquaculture use, rapid growth, and nutritional benefits. Our research reveals significant MP contamination (69.23 %) in Mozambique tilapia, with over 80 % from the Ulhas River and 60 % from the Bhima River contaminated and females showing higher susceptibility. These findings emphasise the need for further research on MP impacts on human health and the development of mitigation strategies.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104584"},"PeriodicalIF":4.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of chronic arsenic exposure with cellular immune profile in MINIMat adolescents: A birth cohort in Bangladesh 慢性砷暴露与 MINIMat 青少年细胞免疫特征的关系：孟加拉国出生队列

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-10-30 DOI: 10.1016/j.etap.2024.104583

Farjana Haque , Evana Akhtar , Bikash Chandra Chanda , Anjuman Ara , Md.Ahsanul Haq , Protim Sarker , Maria Kippler , Yukiko Wagatsuma , Ondine S. von Ehrenstein , Rubhana Raqib

{"title":"Association of chronic arsenic exposure with cellular immune profile in MINIMat adolescents: A birth cohort in Bangladesh","authors":"Farjana Haque , Evana Akhtar , Bikash Chandra Chanda , Anjuman Ara , Md.Ahsanul Haq , Protim Sarker , Maria Kippler , Yukiko Wagatsuma , Ondine S. von Ehrenstein , Rubhana Raqib","doi":"10.1016/j.etap.2024.104583","DOIUrl":"10.1016/j.etap.2024.104583","url":null,"abstract":"<div><div>Chronic arsenic exposure is known to affect the immune system. We aimed to evaluate the association between arsenic exposure and immune cell profile in 15 years old adolescents (n=389) in rural Bangladesh, with chronic exposure to groundwater arsenic. Single blood and urine were collected. Urinary arsenic (U-As) concentration was measured using atomic absorption spectrometry. Peripheral blood mononuclear cells (PBMC) were analyzed by flow cytometry. Non-linear association was found between U-As (median, 24.9 µg/L) and immune cells with a cut-off at U-As 20 µg/L. U-As (<20 µg/L) were significantly associated with increases in CD8<sup>+</sup>T (21 %), na<sup>ï</sup>ve CD8<sup>+</sup>T (42 %) and early B cells (40 %), and classical monocytes (55 %), but reduction in CD3<sup>+</sup>T cells (37<sup>%</sup>) and intermediate-monocytes (56 %). U-As (>20 µg/L) were associated with a 3 % reduction in memory B cells. Arsenic exposure was associated with altered immune cell profile in adolescents likely rendering them vulnerable to adverse health effects in later life.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104583"},"PeriodicalIF":4.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regeneration of zebrafish retina following toxic injury 斑马鱼视网膜毒性损伤后的再生。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-10-29 DOI: 10.1016/j.etap.2024.104582

Alessandra La Pietra, Anna Rita Bianchi, Teresa Capriello, Teresa Mobilio, Annamaria Guagliardi, Anna De Maio, Ida Ferrandino

{"title":"Regeneration of zebrafish retina following toxic injury","authors":"Alessandra La Pietra, Anna Rita Bianchi, Teresa Capriello, Teresa Mobilio, Annamaria Guagliardi, Anna De Maio, Ida Ferrandino","doi":"10.1016/j.etap.2024.104582","DOIUrl":"10.1016/j.etap.2024.104582","url":null,"abstract":"<div><div>The structure of the zebrafish retina appears to be very similar to that of mammals, that is why it is used as a model for studying the eye. Indeed, the zebrafish retina can regenerate itself through mechanisms of Müller cell reprogramming. In this research, adult zebrafish were exposed to aluminum to cause damage in the retina and thus evaluate the regenerative capacity of the damaged tissue. Histological and histochemical analyses assessed the retinal structure and the neurodegenerative process, respectively. An expression analysis of PARPs was carried out to verify whether a potential oxidative DNA damage happens. In addition, some genes involved in the regeneration process (<em>pax6a</em>, <em>pax2a</em>, <em>ngn1</em>, and <em>notch1a</em>) were analyzed. The data confirmed the toxicity of aluminum which caused retinal neurodegeneration, but also highlighted the ability of zebrafish to regenerate the retinal structure, repairing the damage and confirming its use as a good model for translational studies.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104582"},"PeriodicalIF":4.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the impact of gadolinium contamination on the marine bivalve Donax trunculus: Implications for environmental health 评估钆污染对海洋双壳类动物 Donax trunculus 的影响：对环境健康的影响。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-10-28 DOI: 10.1016/j.etap.2024.104580

Silvia Secco , Marta Cunha , Giovanni Libralato , Marco Trifuoggi , Antonella Giarra , Amadeu M.V.M. Soares , Rosa Freitas , Massimiliano Scalici

{"title":"Evaluating the impact of gadolinium contamination on the marine bivalve Donax trunculus: Implications for environmental health","authors":"Silvia Secco , Marta Cunha , Giovanni Libralato , Marco Trifuoggi , Antonella Giarra , Amadeu M.V.M. Soares , Rosa Freitas , Massimiliano Scalici","doi":"10.1016/j.etap.2024.104580","DOIUrl":"10.1016/j.etap.2024.104580","url":null,"abstract":"<div><div>Gadolinium (Gd), commonly used in contrast agents for medical imaging, has been detected in hospital wastewater and aquatic environments, raising environmental concerns. This study examined the accumulation and cellular impacts of Gd in the clam species <em>Donax trunculus</em>, commonly used as bioindicator of contamination. Gadolinium accumulation in clams increased with exposure and over time. Biological responses varied with Gd levels: low concentrations (10 and 50 µg/L) led to low metabolic activity and glycogen content, but high antioxidant activities and lipid peroxidation levels (LPO); high concentrations (250 and 500 µg/L) resulted in increased metabolic activity, while antioxidant enzyme activity was inhibited and LPO levels were the lowest. Metabolic activity decreased after two weeks, suggesting limited long-term metabolic resilience. The study underscores <em>D. trunculus</em> as an effective early warning species for Gd pollution and highlights the ecological risks of rising Gd levels, emphasizing the need for environmental monitoring and regulation.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"112 ","pages":"Article 104580"},"PeriodicalIF":4.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of volatile organic compound exposure and metabolic syndrome 挥发性有机化合物暴露与代谢综合征的关系。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-10-24 DOI: 10.1016/j.etap.2024.104581

Hee Byung Koh, Jae Ho Chung, Sung Jin Moon

引用次数: 0

Microplastic ingestion and co-exposure to Nosema ceranae and flupyradifurone reduce the survival of honey bees (Apis mellifera L.) 摄入微塑料以及同时接触陶瓷鼻疽病毒和氟吡拉呋喃酮会降低蜜蜂（Apis mellifera L.）的存活率

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-10-01 DOI: 10.1016/j.etap.2024.104571

Rossella Tiritelli , Laura Zavatta , Rafaela Tadei , Elaine Cristina Mathias da Silva , Fabio Sgolastra , Giovanni Cilia

{"title":"Microplastic ingestion and co-exposure to Nosema ceranae and flupyradifurone reduce the survival of honey bees (Apis mellifera L.)","authors":"Rossella Tiritelli , Laura Zavatta , Rafaela Tadei , Elaine Cristina Mathias da Silva , Fabio Sgolastra , Giovanni Cilia","doi":"10.1016/j.etap.2024.104571","DOIUrl":"10.1016/j.etap.2024.104571","url":null,"abstract":"<div><div>Bees are exposed to several threats, including pathogens (i.e. <em>Nosema ceranae</em>), pesticides and environmental contaminants. The new insecticide flupyradifurone, and the microplastics in the environment, have raised significant concerns on bee health. This study evaluated the simultaneous effects of microplastics, flupyradifurone, and <em>N. ceranae</em> on honey bee health, focusing on survival rates, <em>N. ceranae</em> replication, daily food consumption, and bee midgut histological alterations. Results showed a significant decrease in bee longevity across all treatments compared to the control, with the combination of flupyradifurone, microplastics, and <em>N. ceranae</em> having the most severe impact. Microplastics and flupyradifurone exposure also increased <em>N. ceranae</em> proliferation, especially in bees subjected to both stressors. Histological analysis revealed reduced regenerative cell nests in the midgut and changes in the nuclear matrix, indicating stress responses. Overall, the simultaneous presence of both biotic and abiotic stressors in nature can synergistically interact, leading to harmful effects on bees.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"111 ","pages":"Article 104571"},"PeriodicalIF":4.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioaccumulation, transformation and toxicity of imidacloprid and dinotefuran in Eisenia fetida under single and binary exposure scenarios 在单一和二元暴露情景下，吡虫啉和克百威在胎生鳗体内的生物累积、转化和毒性。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-10-01 DOI: 10.1016/j.etap.2024.104570

Haiyun Zhang , Meng Zhang , Hanlin Zhang , Xiaofang Shen , Weiguang Lv , Xilong Wang , Juanqin Zhang , Xiaoying Guo

{"title":"Bioaccumulation, transformation and toxicity of imidacloprid and dinotefuran in Eisenia fetida under single and binary exposure scenarios","authors":"Haiyun Zhang , Meng Zhang , Hanlin Zhang , Xiaofang Shen , Weiguang Lv , Xilong Wang , Juanqin Zhang , Xiaoying Guo","doi":"10.1016/j.etap.2024.104570","DOIUrl":"10.1016/j.etap.2024.104570","url":null,"abstract":"<div><div>Earthworms (<em>Eisenia fetida</em>) were exposed to individual and binary mixture of imidacloprid (IMI) and dinotefuran (DIN) at 0.05 and 0.5 mg/kg for 28 days to investigate their bioaccumulation, transformation and toxicity. IMI was more easily absorbed by earthworms than DIN, and worms didn’t accumulate or generate toxic metabolites. The obvious accumulation of neonicotinoids during later period caused significant neural dysfunction, especially when exposed to high-concentration IMI. Meanwhile, oxidative stress indicated by decreased SOD/CAT activity (33.2 %-68.1 %) and increased MDA (38.4 %-55.0 %) was induced by binary exposure with high-concentration IMI. By contrast, coelomocytes responded earlier and more strongly than oxidative responses. Coelomocytes’ viability and mitochondrial membrane potential were inhibited (23.6 %-91.7 %) mainly by IMI and binary exposure. Coelomocytes’ lactate dehydrogenase activity exerted a fluctuating pattern, suggesting irregular disturbance on cellular functions. This study highlights the role of coelomocytes and the need to consider binary/multiple scenarios and transformation of neonicotinoids in their risk assessment to earthworms.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"111 ","pages":"Article 104570"},"PeriodicalIF":4.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0