Environmental toxicology and pharmacology最新文献_第2页

Significant metabolic alterations in mouse dams exposed to an environmental mixture of polychlorinated biphenyls (PCBs) during gestation and lactation: Insights into PCB and metabolite profiles 妊娠期和哺乳期暴露于多氯联苯（PCBs）环境混合物的小鼠母体发生了显著的代谢变化：洞察多氯联苯和代谢物概况。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-09-19 DOI: 10.1016/j.etap.2024.104567

Xueshu Li , Youjun P. Suh , Rebecca J. Wilson , Pamela J. Lein , Julia Y. Cui , Hans-Joachim Lehmler

{"title":"Significant metabolic alterations in mouse dams exposed to an environmental mixture of polychlorinated biphenyls (PCBs) during gestation and lactation: Insights into PCB and metabolite profiles","authors":"Xueshu Li , Youjun P. Suh , Rebecca J. Wilson , Pamela J. Lein , Julia Y. Cui , Hans-Joachim Lehmler","doi":"10.1016/j.etap.2024.104567","DOIUrl":"10.1016/j.etap.2024.104567","url":null,"abstract":"<div><div>Polychlorinated biphenyls (PCBs) and their metabolites are linked to developmental neurotoxicity, but their levels in the gestational and lactational environment remain unexplored. This study investigated the effects of dietary exposure to the Fox River Mixture (FRM) on serum levels of PCBs and their metabolites in female C57BL/6 J mice. Mice were exposed to 0.1, 1.0, or 6.0 mg/kg body weight/day of FRM beginning two weeks before mating and throughout gestation and lactation. Serum samples collected from the dams at weaning were analyzed using gas chromatograph-tandem mass spectrometry and nontarget liquid chromatography-high resolution mass spectrometry. Results showed complex and dose-dependent differences in PCB and metabolite profiles. Untargeted metabolomics revealed alterations in metabolites involved in glucuronidation. Network analysis suggested disturbances in heme and amino acid metabolism associated with higher chlorinated PCBs. These findings suggested that PCBs and metabolites present in the gestational and lactation environment of mice may contribute to developmental neurotoxicity in rodents.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic alteration of uterine Leukemia Inhibitory Factor gene after glyphosate or a glyphosate-based herbicide exposure in rats 大鼠接触草甘膦或草甘膦类除草剂后子宫白血病抑制因子基因的表观遗传学改变

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-09-12 DOI: 10.1016/j.etap.2024.104564

Ailín Almirón , Virginia Lorenz , Florencia Doná , Jorgelina Varayoud , María Mercedes Milesi

{"title":"Epigenetic alteration of uterine Leukemia Inhibitory Factor gene after glyphosate or a glyphosate-based herbicide exposure in rats","authors":"Ailín Almirón , Virginia Lorenz , Florencia Doná , Jorgelina Varayoud , María Mercedes Milesi","doi":"10.1016/j.etap.2024.104564","DOIUrl":"10.1016/j.etap.2024.104564","url":null,"abstract":"<div><p>Glyphosate-based herbicides (GBHs) or its active ingredient, glyphosate (Gly), induce implantation failure in rats. We aimed to elucidate a mechanism of action of these compounds assessing the transcriptional and epigenetic status of the receptivity marker, leukemia inhibitory factor (<em>Lif</em>) gene. F0 rats were orally exposed to GBH or Gly at 3.8 or 3.9 mg Gly/kg/day, respectively, from gestational day (GD) 9 until weaning. F1 females were mated and uterine samples collected at GD5. Methylation-sensitive restriction enzymes (MSRE) sites and transcription factors were <em>in silico</em> predicted in regulatory regions of <em>Lif</em> gene. DNA methylation status and histone modifications (histone 3 and 4 acetylation (H3Ac and H4Ac) and H3 lysine-27-trimethylation (H3K27me3)) were assessed. GBH and Gly decreased <em>Lif</em> mRNA levels and caused DNA hypermethylation. GBH increased H3Ac levels, whereas Gly reduced them; both compounds enhanced H3K27me3 levels. Finally, both GBH and Gly induced similar epigenetic alterations in the regulatory regions of <em>Lif</em>.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Miltefosine induces reproductive toxicity during sperm capacitation by altering PI3K/AKT signaling pathway 米替福新通过改变 PI3K/AKT 信号通路诱导精子获能过程中的生殖毒性

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-09-10 DOI: 10.1016/j.etap.2024.104565

Eun-Ju Jung , Woo-Jin Lee , Jeong-Won Bae , Woo-Sung Kwon

{"title":"Miltefosine induces reproductive toxicity during sperm capacitation by altering PI3K/AKT signaling pathway","authors":"Eun-Ju Jung , Woo-Jin Lee , Jeong-Won Bae , Woo-Sung Kwon","doi":"10.1016/j.etap.2024.104565","DOIUrl":"10.1016/j.etap.2024.104565","url":null,"abstract":"<div><p>Miltefosine is the first and only drug approved for the treatment of leishmaniasis. It is also known as a PI3K/AKT signaling pathway inhibitor utilized in anti-cancer or anti-viral therapies. However, the impact of miltefosine on male fertility has not been fully understood. Therefore, this study was performed to investigate the effects of miltefosine on sperm function during capacitation. Duroc spermatozoa were exposed to 0, 2.5, 5, 10, 20, 40, and 80 μM miltefosine and induced for capacitation. Our results showed that miltefosine dramatically increased the expression of PI3K/AKT signaling pathway-associated proteins. Sperm motility, motion kinetics, capacitation, and tyrosine phosphorylation were significantly suppressed by miltefosine. However, intracellular ATP levels and cell viability were not significantly affected. Our findings suggest that miltefosine may disrupt sperm function by abnormally increasing the levels of PI3K/AKT signaling pathway-associated proteins. Therefore, the harmful effects of miltefosine on male reproduction should be considered when using this drug.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated multiscale analysis reveals complex gender-specific changes in lymphocytes of smokers 综合多尺度分析揭示了吸烟者淋巴细胞中复杂的性别特异性变化

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-09-10 DOI: 10.1016/j.etap.2024.104566

Anne-Cécile Ribou , Florence Riera , Fabienne Durand , Laurent Henry

{"title":"Integrated multiscale analysis reveals complex gender-specific changes in lymphocytes of smokers","authors":"Anne-Cécile Ribou , Florence Riera , Fabienne Durand , Laurent Henry","doi":"10.1016/j.etap.2024.104566","DOIUrl":"10.1016/j.etap.2024.104566","url":null,"abstract":"<div><p>Environmental stressors induce specific physiological responses that can be measured in the blood, notably by morphological changes in lymphocytes. Tobacco being the best-known stress in terms of its impact on health, we studied the physiological properties of peripheral blood lymphocytes in a population of 33 healthy non-smokers and smokers. Proteasome amount, mitochondria energy levels, changes in membrane properties and cell and nuclear size were analyzed to obtain 28 parameters from two fluorescence-based techniques: flow cytometry and cell imaging. The results showed that none of the parameters alone identified gender and smoking status, but that statistical analysis of these parameters, whether or not combined with a third set of data, hematological data, can. Statistical analysis of selected parameters clearly discriminates between male and female samples, as well as smokers and non-smokers. Effects of tobacco smoke pollutants are more pronounced in female smokers than in other groups.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1382668924002060/pdfft?md5=c2791ae4eb19b37c83a65aae55c7ce1e&pid=1-s2.0-S1382668924002060-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of effects of polystyrene micro- and nanoplastics on activity and expression of human drug transporters 聚苯乙烯微塑料和纳米塑料对人体药物转运体的活性和表达没有影响

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-09-10 DOI: 10.1016/j.etap.2024.104563

Valentin Tastet , Marc Le Vée , Alexis Verger , Nolwenn Brandhonneur , Arnaud Bruyère , Olivier Fardel

{"title":"Lack of effects of polystyrene micro- and nanoplastics on activity and expression of human drug transporters","authors":"Valentin Tastet , Marc Le Vée , Alexis Verger , Nolwenn Brandhonneur , Arnaud Bruyère , Olivier Fardel","doi":"10.1016/j.etap.2024.104563","DOIUrl":"10.1016/j.etap.2024.104563","url":null,"abstract":"<div><p>Micro- and nanoplastics (MPs/NPs) constitute emerging and widely-distributed environmental contaminants to which humans are highly exposed. They possibly represent a threat for human health. In order to identify cellular/molecular targets for these plastic particles, we have analysed the effects of exposure to manufactured polystyrene (PS) MPs and NPs on <em>in vitro</em> activity and expression of human membrane drug transporters, known to interact with chemical pollutants. PS MPs and NPs, used at various concentrations (1, 10 or 100 µg/mL), failed to inhibit efflux activities of the ATP-binding cassette (ABC) transporters P-glycoprotein, MRPs and BCRP in ABC transporter-expressing cells. Furthermore, PS particles did not impair the transport of P-glycoprotein or BCRP substrates across intestinal Caco-2 cell monolayers. Uptake activities of solute carriers (SLCs) such as OCT1 and OCT2 (handling organic cations) or OATP1B1, OATP1B3, OATP2B1, OAT1 and OAT3 (handling organic anions) were additionally not altered by PS MPs/NPs in HEK-293 cells overexpressing these SLCs. mRNA expression of ABC transporters and of the SLCs OCT1 and OATP2B1 in Caco-2 cells and human hepatic HepaRG cells were finally not impaired by a 48-h exposure to MPs/NPs. Altogether, these data indicate that human drug transporters are unlikely to be direct and univocal targets for synthetic PS MPs/NPs.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1382668924002035/pdfft?md5=4dfd6e7edfb017440af51db88ecdc5eb&pid=1-s2.0-S1382668924002035-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arsenic induced cardiotoxicity: An approach for molecular markers, epigenetic predictors and targets 砷诱发的心脏毒性：分子标记、表观遗传学预测因子和目标的方法。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-09-07 DOI: 10.1016/j.etap.2024.104558

Sakshi Ramesh Mahadik , Annem Ravi Teja Reddy , Khushboo Choudhary , Lokesh Nama , Mohini Santosh Jamdade , Sanjiv Singh , Krishna Murti , Nitesh Kumar

{"title":"Arsenic induced cardiotoxicity: An approach for molecular markers, epigenetic predictors and targets","authors":"Sakshi Ramesh Mahadik , Annem Ravi Teja Reddy , Khushboo Choudhary , Lokesh Nama , Mohini Santosh Jamdade , Sanjiv Singh , Krishna Murti , Nitesh Kumar","doi":"10.1016/j.etap.2024.104558","DOIUrl":"10.1016/j.etap.2024.104558","url":null,"abstract":"<div><p>Arsenic, a ubiquitous environmental toxicant, has been acknowledged as a significant issue for public health due to its widespread pollution of drinking water and food supplies. The present review aimed to study the toxicity associated with the cardiac system. Prolonged exposure to arsenic has been associated with several harmful health outcomes, especially cardiotoxicity. Arsenic-induced cardiotoxicity encompasses a range of cardiovascular abnormalities, including cardiac arrhythmias, ischemic heart disease, and cardiomyopathy. To tackle this toxicity, understanding the molecular markers, epigenetic predictors, and targets involved in arsenic-induced cardiotoxicity is essential for creating preventative and therapeutic approaches. For preventive measures against this heavy metal poisoning of groundwater, it is crucial to regularly monitor water quality, re-evaluate scientific findings, and educate the public about the possible risks. This review thoroughly summarised what is currently known in this field, highlighting the key molecular markers, epigenetic modifications, and potential therapeutic targets associated with arsenic-induced cardiotoxicity.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effects between microplastics and glyphosate on honey bee larvae 微塑料和草甘膦对蜜蜂幼虫的协同效应。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-09-07 DOI: 10.1016/j.etap.2024.104550

G.A. Mitton , M. Corona , M. Alburaki , A.E. Iglesias , F. Ramos , G. Fuentes , M.M. Vázquez , F.M. Mitton , P. Chan , SR Ruffinengo , M.D. Maggi

{"title":"Synergistic effects between microplastics and glyphosate on honey bee larvae","authors":"G.A. Mitton , M. Corona , M. Alburaki , A.E. Iglesias , F. Ramos , G. Fuentes , M.M. Vázquez , F.M. Mitton , P. Chan , SR Ruffinengo , M.D. Maggi","doi":"10.1016/j.etap.2024.104550","DOIUrl":"10.1016/j.etap.2024.104550","url":null,"abstract":"<div><p>Microplastic (MPs) pollution has emerged as a global ecological concern, however, the impact of MPs exposure, particularly in conjunction with other pollutants such as glyphosate (GLY) on honey bee remains unknown. This study investigated the effects of exposure to different concentrations of MPs and their combination with GLY on honey bee larvae development, or during the larvae period, regulation of major detoxification, antioxidant and immune genes, and oxidative stress biomarkers. Results revealed that combined exposure to MPs and GLY decreased larvae survivorship and weight, while exposure to MPs alone showed no significant differences. Both MPs and GLY alone downregulated the <em>defensin-1</em> gene, but only combined exposure with GLY downregulated the <em>hymenoptaecin</em> gene and increased catalase enzyme activity. The data suggest a synergistic effect of MPs and GLY, leading to immunosuppression and reduced larvae survival and weight. These findings highlight potential risks of two prevalent environmental pollutants on honey bee health.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drugs in the environment - Impact on plants: A review 环境中的药物--对植物的影响：综述。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-09-07 DOI: 10.1016/j.etap.2024.104557

Barbara Pawłowska, Robert Biczak

引用次数: 0

In vitro endocrine and cardiometabolic toxicity associated with artificial turf materials 与人造草皮材料有关的体外内分泌和心脏代谢毒性。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-09-06 DOI: 10.1016/j.etap.2024.104562

Kyle R. Siegel , Brooklynn R. Murray , Jeff Gearhart , Christopher D. Kassotis

{"title":"In vitro endocrine and cardiometabolic toxicity associated with artificial turf materials","authors":"Kyle R. Siegel , Brooklynn R. Murray , Jeff Gearhart , Christopher D. Kassotis","doi":"10.1016/j.etap.2024.104562","DOIUrl":"10.1016/j.etap.2024.104562","url":null,"abstract":"<div><p>Artificial turf, a consumer product growing in usage in the United States, contains diverse chemicals, some of which are endocrine disruptive. Endocrine effects from turf material extracts have been primarily limited to one component, crumb rubber, of these multi-material products. We present <em>in vitro</em> bioactivities from non-weathered and weathered turf sample extracts, including multiple turf components. All weathered samples were collected from real-world turf fields. Non-weathered versus weathered differentially affected the androgen (AR), estrogen (ER), glucocorticoid (GR), and thyroid receptors (TR) in reporter bioassays. While weathered extracts more efficaciously activated peroxisome proliferator activated receptor γ (PPARγ), this did not translate to greater <em>in vitro</em> adipogenic potential. All turf extracts activated the aryl hydrocarbon receptor (AhR). High AhR-efficacy extracts induced modest rat cardiomyoblast toxicity in an AhR-dependent manner. Our data demonstrate potential endocrine and cardiometabolic effects from artificial turf material extracts, warranting further investigation into potential exposures and human health effects.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1382668924002023/pdfft?md5=6c3dd10e8d644e1d36750efce3c964d0&pid=1-s2.0-S1382668924002023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impacts of microplastics on zebrafish behavior depend on initial personality state 微塑料对斑马鱼行为的影响取决于初始人格状态

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2024-09-02 DOI: 10.1016/j.etap.2024.104561

Nawal Al Jabri, Raeid M.M. Abed, Aziz Al Habsi, Aliya Ansari, Michael J. Barry

{"title":"The impacts of microplastics on zebrafish behavior depend on initial personality state","authors":"Nawal Al Jabri, Raeid M.M. Abed, Aziz Al Habsi, Aliya Ansari, Michael J. Barry","doi":"10.1016/j.etap.2024.104561","DOIUrl":"10.1016/j.etap.2024.104561","url":null,"abstract":"<div><p>Microplastic pollution is associated with inflammation, gut dysbiosis and behavioral changes in fish. Fish have distinct personality traits but the role of personality in behavioral toxicology is rarely considered. We classified zebrafish on four behavioral axes: boldness, anxiety, sociability and exploration tendency then exposed them to low- or high- concentrations of two types of polyethylene microplastics (low- and high-density) for 28 days. Behaviors, antioxidant enzymes (catalase and superoxide dismutase), and gut microbiome were then measured. There were direct effects of microplastics on boldness, anxiety and sociability. However, fish retained their initial behavioral tendencies. Exposure to all microplastic treatments reduced average swimming speed and decreased the time spent motionless. Microplastic exposure did not affect antioxidant enzymes but did cause significant changes in the composition of the gut microbiome. This study demonstrates that environmentally realistic concentrations of microplastics can alter fish behavior, but much of the variance in response can be explained by personality.</p></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0