Environmental toxicology and pharmacology最新文献

{"title":"Environmental and biological measurements of the anesthetic isoflurane and its possible toxic effects in veterinarians","authors":"Tony F. Grassi ,&nbsp;Mariane A.P. Silva ,&nbsp;Maria V. Destro ,&nbsp;Bruno S. De Martinis ,&nbsp;Leandro G. Braz ,&nbsp;Mariana G. Braz","doi":"10.1016/j.etap.2025.104639","DOIUrl":"10.1016/j.etap.2025.104639","url":null,"abstract":"<div><div>We evaluated both environmental (workplace) and biological (urine) exposure to the anesthetic isoflurane concerning the effects of such exposure on the hematological, hepatic, and renal parameters in veterinarians. Samples were collected from exposed and nonexposed (volunteers) groups to assess hematological and several biochemical markers, and isoflurane was measured in the workplace air and veterinarian’s urine. Isoflurane was detected at high levels in the air and urine. No differences were observed in hematological parameters between the groups, although the number of monocytes increased among veterinarians, values were within the normal range. No significant differences were found in the hepatic enzymes or renal parameters between the groups, and all marker levels were within the normal range. In conclusion, urinary isoflurane is a suitable internal biomarker for monitoring occupational exposure and is associated with veterinary workplace measurements, and that occupational exposure is not associated with abnormal hematological or biochemical changes in veterinarians.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"114 ","pages":"Article 104639"},"PeriodicalIF":4.2,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum levels of glycosylated hemoglobin, insulin, total protein and their association with somatoform disorder in environmentally exposed populations in Kazakhstan","authors":"Geir Bjørklund ,&nbsp;Yuliya Semenova","doi":"10.1016/j.etap.2025.104637","DOIUrl":"10.1016/j.etap.2025.104637","url":null,"abstract":"<div><div>Biochemical blood parameters may serve as biomarkers of environmental pollution, with somatoform disorder (SD) being of interest. This study examined serum glycosylated hemoglobin (HbA1C), insulin, total protein, and SD prevalence in populations from polluted areas in Kazakhstan. It assessed the predictive value of these parameters for SD, along with other risk factors. A cross-sectional study of 1881 individuals (ages 18–52) in Kazakhstan used the PHQ-15 questionnaire to assess SD. HbA1C was measured via immunoturbidimetry, insulin via immunoassay, and total protein via colorimetry. HbA1C levels &gt; 6.5 % identified undiagnosed diabetes in 2.4 % of control residents, with higher rates in Ust-Kamenogorsk (10.6 %), Berezovka/Aksay (4.8 %), and Borodulikha/Abay (3.7 %). Pollutant-exposed populations had higher rates of hyperinsulinemia. Moderate to severe SD was more common in Ust-Kamenogorsk (26.6 %) and Berezovka/Aksay (27.2 %) than in controls, with lower rates in Borodulikha/Abay (16.7 %). Age, HbA1c levels, and residence near the condensate gas extraction plant significantly increased the odds of having moderate to severe SD, while being male and of Kazakh ethnicity significantly decreased the odds. The study links environmental exposure to increased rates of SD, diabetes, and insulin resistance.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"114 ","pages":"Article 104637"},"PeriodicalIF":4.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of cytotoxicity and genotoxicity of diesel exhaust PM2.5 generated from diesel and dual natural gas-diesel engines","authors":"Juan Sebastian Pino ,&nbsp;Pedro N. Alvarado ,&nbsp;Ana Maria Larrea ,&nbsp;Winston Rojas ,&nbsp;Natalia Gomez-Lopera","doi":"10.1016/j.etap.2025.104638","DOIUrl":"10.1016/j.etap.2025.104638","url":null,"abstract":"<div><div>Diesel exhaust particles (DEPs) are atmospheric pollutants associated with adverse health effects. In response to their impact, natural gas (NG) has emerged as a promising alternative fuel due to its cleaner combustion. Although the cytotoxicity and genotoxicity of DEPs from diesel or NG engines have been extensively studied, the impact of dual natural gas-diesel systems remains unexplored. This study evaluated the toxicity of DEPs (PM2.5) emitted by an engine in diesel mode and dual natural gas-diesel mode on cellular parameters such as viability, apoptosis, oxidative stress, and DNA damage. The results showed that diesel DEPs reduced cell viability by up to 31 %, compared to a 19.2 % reduction with dual-mode DEPs. Apoptosis induction was also higher with diesel DEPs, with a 7 % increase compared to the dual mode. While dual-mode DEPs increased the production of reactive oxygen species (ROS) without causing DNA damage, diesel DEPs generated high ROS levels and measurable DNA damage. These differences could be attributed to the physicochemical characteristics of each mode, as diesel DEPs contained higher concentrations of polycyclic aromatic hydrocarbons (PAHs). This study addresses a research gap by quantifying the health effects of emissions from dual-fuel engines and highlights the potential of these systems to reduce DEP-induced toxicity.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"114 ","pages":"Article 104638"},"PeriodicalIF":4.2,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastics can alter structural configurations of human non-canonical G-quadruplex DNA","authors":"Sagar Bag ,&nbsp;Souvik Ghosal ,&nbsp;Sudipta Bhowmik","doi":"10.1016/j.etap.2025.104626","DOIUrl":"10.1016/j.etap.2025.104626","url":null,"abstract":"<div><div>Microplastics (MP) with a diameter of less than 150 μm can enter the lymph and bloodstream systems, induce cellular toxicity and damage DNA. G-quadruplexes (GQs) are tetraplex DNA secondary structures found in the human genomes that play important roles in replication, transcription and genomic integrity. Comprehending the biological and molecular processes underlying the activities of MPs could aid in estimating potential hazards to humans. In this investigation, polystyrene microplastics (PS-MPs) and polyethylene microplastics (PE-MPs) have been selected because these two MPs are environmentally most prevalent and they are of different sizes. Several biophysical strategies were employed to identify that PS-MPs are the most potent MPs that bind to CMYC GQ DNA (present in the promoter of CMYC gene, important for cellular growth and proliferation) and may alter their structure. This study helps to understand the potential threat MPs possesses by interacting with key DNA structures.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"114 ","pages":"Article 104626"},"PeriodicalIF":4.2,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142935468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicity of 2,2’,4,4’-tetrabromodiphenyl ether (BDE-47) on oligodendrocytes during embryonic zebrafish development","authors":"Ryann Henry,&nbsp;Reagan Vander Heide,&nbsp;Nicole M. Roy","doi":"10.1016/j.etap.2025.104627","DOIUrl":"10.1016/j.etap.2025.104627","url":null,"abstract":"<div><div>Polybrominated diphenyl ethers (PBDEs) are flame retardants heavily utilized across plastic, textile and electronic industries. Although these PBDEs are effective in protecting property and human life from fire, their high production volumes have led PBDEs to become pervasive environmental contaminants and pose an ecological and health risk as high levels have been noted in environmental media including water and sediment, wildlife and human tissue. Here we investigate the developmental neurotoxicity of 2,2’,4,4’-tetrabromodiphenyl ether (BDE-47), one of the more dominant PBDE congeners found in human tissue, on oligodendrocytes in the hindbrain and spinal cord. We utilized the zebrafish vertebrate model system and investigated low (5 µM) and high concentrations (20 µM) of BDE-47. We find that by 6 days post-fertilization, BDE-47 negatively affects oligodendrocyte development in the hindbrain and spinal cord in a concentration dependent manner.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"114 ","pages":"Article 104627"},"PeriodicalIF":4.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic carbendazim exposure disrupts behavioral responses and redox-regulatory mechanisms in non-target detritivore Nauphoeta cinerea nymphs","authors":"Adeboye A. Olaseni ,&nbsp;Gbemisola T. Oyedele ,&nbsp;Cynthia N. Ikeji ,&nbsp;Christiana K. Jimoh ,&nbsp;Babajide O. Ajayi ,&nbsp;Joao B.T. Rocha ,&nbsp;Isaac A. Adedara ,&nbsp;Ebenezer O. Farombi","doi":"10.1016/j.etap.2024.104618","DOIUrl":"10.1016/j.etap.2024.104618","url":null,"abstract":"<div><div>Carbendazim is widely applied in agriculture to control various fungal diseases during pre-harvest and post-harvest processes owing to its efficacy and cost-effectiveness. However, environmental and food contamination by carbendazim has become a global health issue. Indeed, the declining biodiversity of beneficial insects owing to agricultural intensification is currently of keen concern to the scientific community. The toxicological responses of Nauphoeta cinerea nymphs, a non-target insect, to ecologically realistic concentrations of carbendazim at 0, 0.25, 2.5, 5.0 and 25 μg/L for 50 uninterrupted days were assessed. Neurobehavioral data generated by video-tracking software revealed that chronic nymphal exposure to carbendazim significantly diminished the path efficiency, body rotation, maximum speed, turn angle and distance traveled but increased the immobility time, total time of freezing and episodes of freezing in insects. The deterioration in the locomotor and exploratory abilities of carbendazim-exposed insects was substantiated by high heat map intensity and reduced track plots. Further, chronic carbendazim exposure diminished acetylcholinesterase activity in head of the insects. Chronic carbendazim exposure significantly decreased antioxidant defense mechanisms but increased nitric oxide, hydrogen peroxide and lipid peroxidation levels in fat body, midgut and head of exposed insects. Activities of acid and alkaline phosphatases which play important roles in detoxification and metabolic processes were also markedly decreased in carbendazim-exposed insects when compared with control. Altogether, carbendazim represents an ecological threat to non-target insects through induction of oxido-inflammatory injury, providing valuable insights into the behavioral dysfunction and toxicological mechanisms of carbendazim in beneficial insects.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104618"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molluscicidal assessment of certain toxicants: Impact on biochemical alterations and electrophoretic protein patterns in Massylaea vermiculata (O. F. Müller, 1774) snails","authors":"Sahar I.M. Abd El-Wahed ,&nbsp;Hesham A.M. Ibrahim","doi":"10.1016/j.etap.2024.104619","DOIUrl":"10.1016/j.etap.2024.104619","url":null,"abstract":"<div><div><em>Massylaea vermiculata</em> snails are a significant gastropod pest in Egypt, threatening agriculture. Due to increasing concerns about conventional pesticides, it is imperative to find effective alternatives that are less harmful. We assessed the molluscicidal activity of abamectin, methoxyfenozide, and spinosad using the leaf-dipping method in vitro and the effect of LC₅₀ of these compounds on biochemical aspects and protein electrophoresis. Results showed that these compounds exhibited molluscicidal activity, with LC₅₀ values of 0.21, 0.63, and 0.65 mg/l for abamectin, methoxyfenozide and spinosad, respectively. Biochemical assays on treated snails showed increased aspartate and alanine aminotransferase and alkaline phosphatase activities and reduced total protein compared to controls. For the most effective compound (abamectin), these values were 195.36, 105.82, 276.76, and 2.49, compared to control values of 88.00, 47.67, 124.67, and 5.52, after 10 days post-treatment. Protein electrophoresis revealed variations in protein bands. Thus, these compounds can be effective within integrated control programs.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104619"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixture of neonicotinoid and fungicide affects foraging activity of honeybees","authors":"Antonia Schuhmann,&nbsp;Ricarda Scheiner","doi":"10.1016/j.etap.2024.104613","DOIUrl":"10.1016/j.etap.2024.104613","url":null,"abstract":"<div><div>The use of plant protection products (PPPs) is a major factor contributing to global insect decline. We here use the honeybee (<em>Apis mellifera</em>) as a model to study combined effects of the last neonicotinoid in the EU (acetamiprid) and different fungicides on live-long foraging flights using radio frequency identification. The mixture of the sterol-biosynthesis-inhibiting fungicide difenoconazole and the insecticide acetamiprid significantly reduced the number of foraging trips per day compared to the control and each PPP alone, while a mixture of the insecticide with the non-sterol-biosynthesis inhibiting fungicide boscalid/dimoxystrobin did not affect behaviour. This potential synergistic effect of the fungicide/insecticide mixture supports the notion that some fungicides can enhance the effect of insecticides, which did not lead to significant changes in behaviour when applied on their own. Our results emphasize the need for more studies on the interaction of different PPPs.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104613"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Optical Coherence Tomography (OCT) to evaluate the adverse effects of 2,4-D dimethylammonium on morphological changes in Riceland Prawn (Macrobrachium lanchesteri)","authors":"Chutima Thanomsit ,&nbsp;Sugunya Kumla ,&nbsp;Jadsada Saetiew ,&nbsp;Jiraporn Saenjae ,&nbsp;Phochit Nanthanawat ,&nbsp;Jakkaphun Nanuam ,&nbsp;Panomsak Meemon","doi":"10.1016/j.etap.2024.104608","DOIUrl":"10.1016/j.etap.2024.104608","url":null,"abstract":"<div><div>2,4-D dimethylammonium, a widely used herbicide, accumulates in aquatic animals, posing risks to both their populations and human consumers. This study evaluated the effects of 2,4-D on Riceland prawn (Macrobrachium lanchesteri) using Optical Coherence Tomography (OCT) to assess morphological changes. The activity of acetylcholinesterase (AChE), catalase (CAT), and glutathione S-transferase (GST) was also measured. Toxicity increased with both concentration and exposure duration. OCT revealed swelling in the gill region, tissue abnormalities, and muscle damage in the abdominal somite, telson, and uropod, along with tissue separation and degradation. Histological analysis confirmed muscle degeneration, hemocyte infiltration, and swelling. AChE expression was undetectable at 400 and 450 µL/L after 96 hours, with a molecular weight of 71 kDa. CAT and GST activities decreased at higher herbicide concentrations, further demonstrating the harmful effects of 2,4-D on prawn health.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104608"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of APOE4 on neurological symptoms after exposure to K. brevis neurotoxin","authors":"Gregory J. Aldrich ,&nbsp;Aurore Nkiliza ,&nbsp;Scott Ferguson ,&nbsp;Daniel Niedospial ,&nbsp;Dakota Helgager ,&nbsp;Andrew P. Keegan ,&nbsp;Daniel Paris ,&nbsp;Barbara Kirkpatrick ,&nbsp;Fiona Crawford ,&nbsp;Michael Mullan ,&nbsp;Laila Abdullah","doi":"10.1016/j.etap.2024.104621","DOIUrl":"10.1016/j.etap.2024.104621","url":null,"abstract":"<div><h3>Introduction</h3><div>The harmful alga <em>Karenia brevis</em> (K. brevis) releases brevetoxins (PbTx) that cause respiratory and neurological symptoms. The apolipoprotein E (APOE) ε4 allele has been linked to poor neurological outcomes after exposure to environmental toxicants. This study explores the influence of the ε4 allele on the relationship between K. brevis in coastal waters and neurological symptoms reported by Southwest Florida residents.</div></div><div><h3>Methods</h3><div>A Surrogate Brevetoxin Exposure (SBE_air) index was developed to estimate aerosolized PbTx exposure. Data on past medical history and symptoms and blood for analyzing APOE genotypes were collected from 244 participants.</div></div><div><h3>Results</h3><div>Compared to non-carriers, ε4 carriers more frequently reported experiencing memory problems and fatigue during red tide blooms, independent of conditions like dementia and chronic fatigue syndrome.</div></div><div><h3>Conclusion</h3><div>This study suggests that the ε4 allele may exacerbate neurological symptoms from aerosolized PbTx, highlighting the need for strategies to better understand the impact of PbTx on the brain.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104621"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}