Environmental toxicology and pharmacology最新文献

{"title":"Serum biomarkers of phthalate exposure, adipose tissue metabolites and 20-years incidence of elevated LDL levels: An exploratory exposome study in the GraMo cohort","authors":"Celia Pérez-Díaz ,&nbsp;Axel Raux ,&nbsp;Justine Massias ,&nbsp;Bruno Le Bizec ,&nbsp;Jean Philippe-Antignac ,&nbsp;Yann Guitton ,&nbsp;Inmaculada Salcedo-Bellido ,&nbsp;Eduardo Linares Ruiz ,&nbsp;Francisco M. Pérez-Carrascosa ,&nbsp;Pilar Requena ,&nbsp;Juan Pedro Arrebola ,&nbsp;German Cano-Sancho","doi":"10.1016/j.etap.2026.104956","DOIUrl":"10.1016/j.etap.2026.104956","url":null,"abstract":"<div><div>Several phthalates are considered metabolic-disrupting chemicals since they may alter adipose tissue and lipid metabolism, although human evidence remains limited. This study explored metabolic signatures in adipose tissue associated with phthalate exposure, and their relationship with the 20-year incidence of elevated low-density lipoprotein (LDL) levels in adults from the GraMo cohort. 72 adipose tissue and serum samples were collected from patients in two public hospitals in Granada, Spain. Adipose tissue was analysed using targeted and non-targeted metabolomic and lipidomic approaches. 32 phthalate biomarkers were measured in serum. A meet-in-the-middle approach identified metabolites associated with both exposure and outcome, with pathway analysis conducted using Mummichog. Phthalates were inversely associated with unsaturated phosphatidylcholines and fatty acids, and positively associated with saturated lipids. These lipid changes were, in turn, linked to elevated LDL incidence. Our findings suggest an impact of phthalates on lipid metabolism, but warrant further confirmation.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"122 ","pages":"Article 104956"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of environmental particulates on zebrafish embryo development and gene expression","authors":"Pinnakarn Techapichetvanich ,&nbsp;Varissara Chantho ,&nbsp;Siwapech Sillapaprayoon ,&nbsp;Chatchai Muanprasat ,&nbsp;Phisit Khemawoot ,&nbsp;Wittaya Pimtong","doi":"10.1016/j.etap.2026.104948","DOIUrl":"10.1016/j.etap.2026.104948","url":null,"abstract":"<div><div>Particulate matter (PM) poses risks to environmental and human health, yet its toxicity mechanisms in aquatic organisms remain unclear. This study investigated the effects of 2 PM types, a standard reference material (S-PM10, NIST, USA) and particulates from the Mae Moh Power Plant, Thailand (MMPS), on zebrafish embryo development and gene expression. Embryos were exposed to various concentrations, and mortality, hatching rates, and morphological abnormalities were assessed. S-PM10, with irregular morphology and broad particle size, induced developmental defects and reduced hatching. MMPS, characterized by uniform, spherical particles, caused higher mortality. qRT-PCR revealed that S-PM10 significantly upregulated oxidative stress (<em>sod1</em>, <em>gstp2</em>) and apoptosis (<em>bax</em>, <em>casp3a</em>) genes. In contrast, MMPS downregulated oxidative stress markers but upregulated apoptosis-related genes. These results suggest particle morphology and size influence toxicity profiles, S-PM10 triggers developmental disruption, while MMPS induces acute lethality. This study underscores the importance of particle characteristics and molecular responses in evaluating PM toxicity.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"122 ","pages":"Article 104948"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146033935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-acetylcysteine reduces incidence and duration of linezolid-associated thrombocytopenia in critically ill patients: A randomized controlled trial","authors":"Mohamed Abdeltawab ,&nbsp;Abdel-Hameed Ebid ,&nbsp;Osama Ahmed ,&nbsp;Mohamed A. Mobarez ,&nbsp;Mahmoud Ibrahim","doi":"10.1016/j.etap.2026.104944","DOIUrl":"10.1016/j.etap.2026.104944","url":null,"abstract":"<div><div>Linezolid-associated thrombocytopenia (LAT) limits its use in critically ill patients. This double-blind, randomized, placebo-controlled trial evaluated intravenous N-acetylcysteine (IV NAC) for LAT prevention in 250 critically ill adults receiving linezolid for ≥ 48 h. Patients received IV NAC (600 mg every 12 h) or placebo. The primary endpoint was LAT incidence (platelet count &lt;150 × 10 ³/mm³ or &gt;50 % reduction from baseline). NAC significantly reduced LAT incidence (16.8 % vs. 41.6 %; p &lt; 0.001), platelet transfusions (1.6 % vs. 11.2 %; p = 0.003), and linezolid discontinuations (6.4 % vs. 32.0 %; p &lt; 0.001). NAC delayed LAT onset (adjusted hazard ratio 0.24; p &lt; 0.001) and accelerated platelet recovery (adjusted hazard ratio 3.88; p = 0.011), with greatest benefit in moderate-severity cases. These findings suggest IV NAC may offer a preventive benefit against LAT in critically ill patients, though multicenter validation is needed to confirm generalizability across diverse clinical settings.</div></div><div><h3>Clinical Trial Registration</h3><div><span><span>https://clinicaltrials.gov/study/NCT05944458</span><svg><path></path></svg></span>. Registered on July 6, 2023.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"122 ","pages":"Article 104944"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146033386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding molecular mechanisms driving cadmium-induced mitochondrial dysfunction in human metabolic liver disease","authors":"Rahul Kumar ,&nbsp;Ashwin Chinala ,&nbsp;Rama R. Gullapalli","doi":"10.1016/j.etap.2026.104943","DOIUrl":"10.1016/j.etap.2026.104943","url":null,"abstract":"<div><div>Cadmium (Cd) is an anthropogenic toxic heavy metal pollutant with a biological half-life on the order of decades. Chronic Cd exposures through industrial sources, cigarette smoke (1° and 2°), and contaminated food and/or water sources lead to progressive bioaccumulation, particularly in the human liver and kidneys. In hepatocytes, Cd is a potent inducer of mitochondrial dysfunction and oxidative stress. Cd exposures initiate a cascade of reactive oxygen species (ROS) production, triggering redox imbalances, acute and chronic inflammation, and, in extreme exposures, cellular death. While mitochondria are well recognized as central targets of Cd toxicity, the precise mechanisms linking Cd-induced mitochondrial damage driving chronic liver and metabolic diseases remains incompletely understood. Emerging evidence implicates Cd exposure as a direct inhibitor of the mitochondrial electron transport chain (ETC) complexes and disruption of calcium homeostasis as key, converging pathways of hepatocellular injury. And yet, their specific molecular underpinnings are still unknown. This review focuses on how Cd exposures perturb mitochondrial bioenergetics, calcium signaling, and lipid signaling and metabolism within the hepatocytes specifically. Subsequently, we examine how these molecular-level alterations may contribute to the pathogenesis of chronic liver disease. In this review article, we present a cohesive framework to highlight Cd exposures as a critical (and a model) environmental heavy metal driver of chronic hepatocellular mitochondrial injury. Prolonged heavy metal exposures (such as Cd) have significant implications for long-term human hepatic health and metabolic disorders, such as metabolic (dysfunction) associated liver injury (MASLD), a key emerging pandemic of chronic human liver disease.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"122 ","pages":"Article 104943"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of mercury and risk analysis of consumption of the Amazonian tambaqui fish Colossoma macropomum from the production system of the Amazon region","authors":"Enzo de Oliveira Novaes ,&nbsp;Adriano Teixeira de Oliveira ,&nbsp;Paloma de Almeida Rodrigues ,&nbsp;Letícia Torrão Araruna ,&nbsp;Júlia Vianna de Pinho ,&nbsp;Flavia Dayana Felix Farias ,&nbsp;Lucas Maia Garcês ,&nbsp;Barbara Franz ,&nbsp;Carlos Adam Conte-Junior","doi":"10.1016/j.etap.2025.104920","DOIUrl":"10.1016/j.etap.2025.104920","url":null,"abstract":"<div><div>The present study aimed to determine the mercury (Hg) levels and risk analysis of consumption of tambaqui <em>Colossoma macropomum</em> in fish farms in the Amazon region. In total 212 tambaqui muscle samples were collected from 10 fish farms in 5 states (Amazonas, Pará, Amapá, Roraima, and Rondônia). The Hg in tambaqui muscles in the Amazon region revealed that Amazonas and Amapá had the highest values. The monthly estimate of tambaqui consumption per month showed that children had the highest values compared to young people and adults. Meanwhile, in the states of Amazonas and Amapá, especially among children, the maximum monthly intake of tambaqui should be lower than in other localities. For the hazard quality, only tambaqui evaluated in fish farms in the states of Roraima, Rondônia and Pará presented safety levels. Therefore, routine biomonitoring of fish farms is crucial, especially tambaqui farms, as the main fish species farmed in Brazil.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"122 ","pages":"Article 104920"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing qsar models of ionic liquid toxicity for different microorganisms to design environmentally friendly ionic liquids and elucidate mechanisms of toxicity","authors":"F.J. Hernández-Fernández ,&nbsp;J. Hernández-Fernández ,&nbsp;L.J. Lozano ,&nbsp;E. Iniesta-López ,&nbsp;A. Hernández-Fernández ,&nbsp;J. Quesada-Medina ,&nbsp;V. Caballero ,&nbsp;A.P. de los Ríos","doi":"10.1016/j.etap.2026.104950","DOIUrl":"10.1016/j.etap.2026.104950","url":null,"abstract":"<div><div>The increasing interest in ionic liquids (ILs) as alternative solvents for biocatalytic and industrial applications is limited by concerns regarding their potential toxicity. In this study, we compiled one of the most comprehensive ecotoxicity datasets to date for Vibrio fischeri, Daphnia magna, and Pseudokirchneriella subcapitata. Using Partial Least Squares (PLS)-based Quantitative Structure–Activity Relationship (QSAR) models, we established predictive correlations between IL structural features and ecotoxicity. The models demonstrated high robustness and predictive power, enabling identification of key molecular descriptors driving toxicity. Results consistently indicate that longer alkyl side chains in cations, higher hydrophobicity, and aromatic ring structures are associated with increased toxicity, whereas the incorporation of heteroatoms (O, OH, CN) or non-aromatic rings reduces toxicity. Anions generally exert a lower influence compared to cations, although certain highly fluorinated species substantially increase toxicity. The comparative analysis across microorganisms highlights both shared and species-specific structural determinants. These findings provide valuable insights into IL toxicity mechanisms, particularly the role of membrane accumulation and disruption, and establish design rules for the development of safer, environmentally benign ionic liquids suitable for green chemistry and biotechnological processes.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"122 ","pages":"Article 104950"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the effects of uracil-based pesticides on hepatic metabolic dysfunctions in low-cost three-dimensional multicellular spheroids","authors":"Ana Caroline Pimentel de Oliveira ,&nbsp;Letícia Ramos Molica ,&nbsp;Karen C.M. Moraes","doi":"10.1016/j.etap.2025.104903","DOIUrl":"10.1016/j.etap.2025.104903","url":null,"abstract":"<div><div>Pesticides are used worldwide and cause several pathologies as metabolic dysfunction-associated steatotic liver disease. Steatosis is a mark of the disease beginning; however, the mechanisms by which pesticides act on this dysfunction require further understanding. Thus, this work presents a sensitive and responsive low-cost hepatic multicellular spheroid useful to detail metabolic routes in hepatic dysfunction. Using those spheroids, the effects of pesticides bromacil and terbacil were assessed. Pesticides doses near the acceptable daily intake in Brazil changes energetic, oxidative and the one-carbon metabolism. Moreover, pesticide-specific effects were observed as increased expression of <em>FASN</em>, <em>PPAR</em>s, <em>CYP1A1</em>, <em>AHR</em>, <em>DNMT</em>s among others, and changes in the methylation pattern of DNA, RNA and histones. Combined, the results were alarming, considering the long-lasting effects of the evaluated pesticides in agriculture fields. In addition, we can suggest that our spheroid model could be useful for large scale investigation of the effects of pesticides in liver metabolism.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"121 ","pages":"Article 104903"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of bisphenol PH and seven other bisphenol A alternatives on human haemostasis in vitro","authors":"Marcel Hrubša ,&nbsp;Alina Soloviova ,&nbsp;Patrícia Harčárová ,&nbsp;Catherine Gunaseelan ,&nbsp;Zuzana Lomozová ,&nbsp;Eduard Jirkovský ,&nbsp;Alejandro Carazo ,&nbsp;Marija Sollner Dolenc ,&nbsp;Lucija Peterlin Mašič ,&nbsp;Přemysl Mladěnka","doi":"10.1016/j.etap.2025.104897","DOIUrl":"10.1016/j.etap.2025.104897","url":null,"abstract":"<div><div>Recognition of bisphenol A’s toxicity has meant substitution by new analogues, which are poorly investigated. We determined the impact of bisphenol A and 8 of its analogues on platelet aggregation, coagulation, and their toxicity to erythrocytes. Erythrocyte lysis assays revealed bisphenol toxicity towards both human and rat erythrocytes with high TC₅₀s &gt; 100 μM. Bisphenol A and bisphenol PH acted as antiplatelet compounds. Bisphenol PH was particularly potent (IC₅₀ of 0.42 ± 0.14 μM; 0.16 ± 0.05 μg/ml) in arachidonic acid-based platelet aggregation. Mechanistically, bisphenol PH blocked cyclooxygenase 1, in a similar manner to the antiplatelet drug acetylsalicylic acid. In terms of the coagulation cascade, only weak effects were found for some of the selected compounds, and the tested bisphenols did not impact coagulation or demonstrate erythrocytic toxicity at biologically achievable concentrations. Contrarily, the negative impact of bisphenol PH on platelets, with a possible subsequent risk of bleeding, might have biological relevance.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"121 ","pages":"Article 104897"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal immune-inflammatory markers mediate the association between urinary phthalate metabolites and preeclampsia","authors":"Lin Tao ,&nbsp;Lulu Dai ,&nbsp;Shimin Xiong ,&nbsp;Dengqing Liao ,&nbsp;Yuan-zhong Zhou ,&nbsp;Xubo Shen","doi":"10.1016/j.etap.2025.104908","DOIUrl":"10.1016/j.etap.2025.104908","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to comprehensively investigate the associations among maternal immune-inflammatory markers and urinary phthalate (PAE) metabolites during pregnancy, focusing on their potential links with preeclampsia and related reproductive outcomes.</div></div><div><h3>Method</h3><div>A propensity score-matched case-control design was adopted, enrolling 61 cases and 118 controls matched based on propensity scores. To assess associations, dose-response relationships, and mediating effects, multiple statistical methods were employed, including logistic regression, restricted cubic splines (RCS), Bayesian kernel machine regression (BKMR), and structural equation modeling (SEM).</div></div><div><h3>Results</h3><div>Maternal urinary metabolites of PAEs (MEHP, MEHHP) and the systemic immune-inflammation index (SII) were significantly higher in the case group than in the control group. Logistic regression analysis revealed positive associations between MEHP, MOP, MEHHP, SII, and preeclampsia (all odds ratios [OR] &gt; 1, P &lt; 0.05). RCS analysis revealed nonlinear dose-response relationships for MOP and SII, with threshold concentrations of 2.57 μg/L creatinine (MOP) and 977.24 μg/L (SII). BKMR results indicated a nonlinear positive correlation between PAE metabolites, immune-inflammatory markers, and spontaneous abortion. SEM models confirmed mediating effects of immune-inflammatory markers: SII mediated the associations between MEHP, MOP, MEHHP and preeclampsia with mediation rates (95 %CI) of 8.73 % [1.33 %–22.34 %], 25.31 % [11.72 %–36.00 %], and 6.50 % [0.36 %–21.39 %], respectively; AISI mediated the MEHP-preeclampsia association (0.27 % [0.20 %–1.19 %]); and MLR and PLR mediated the MEHHP-preeclampsia association (2.54 % [1.53 %–8.80 %] and 7.59 % [1.20 %–12.52 %], respectively).</div></div><div><h3>Conclusion</h3><div>Maternal urinary PAE metabolites during pregnancy are associated with an increased risk of preeclampsia, and maternal immune-inflammatory markers partially mediate this relationship. These findings provide insights into the potential mechanisms linking prenatal PAE exposure to adverse pregnancy outcomes.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"121 ","pages":"Article 104908"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of per- and poly-fluoroalkyl substances (PFAS) exposure with testosterone levels in the male population","authors":"Humaira H. Rahman ,&nbsp;Weston R. Stokey ,&nbsp;Stuart H. Munson-McGee","doi":"10.1016/j.etap.2025.104906","DOIUrl":"10.1016/j.etap.2025.104906","url":null,"abstract":"<div><div>Human exposure to per- and poly-fluoroalkyl substances <strong>(</strong>PFAS) occurs from environmentally contaminated food and water. PFAS are a health concern because they are associated with various neurological, developmental, and endocrine disorders. Despite causes of infertility being equal, male causes are less studied, with etiologies ranging from genetic to anatomic to physiologic dysfunctions. This study aimed to investigate a correlation between six subtypes of PFAS with low male testosterone levels. Data from the National Health and Nutrition Examination Survey (NHANES) cycles 2013–2016 were utilized to assess serum PFAS and testosterone levels. This study observed age, marital status, body mass index, smoking status, alcohol consumption, and diabetic status being significantly correlated with low testosterone levels. PFNA exposure was observed to have a strong inverse relationship with male testosterone levels in low/medium (ORs 0.518, 0.571, 0.322, 0.455) and low/high-medium exposure levels (ORs 0.262, 0.262, 0.321, and 0.310), indicating exposure-dependent effects on testosterone levels.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"121 ","pages":"Article 104906"},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}