Environmental toxicology and pharmacology最新文献_第4页

Urinary biomonitoring of exposure to glyphosate and its metabolite amino-methyl phosphonic acid among farmers and non-farmers in Morocco 摩洛哥农民和非农民接触草甘膦及其代谢物氨基甲基膦酸的尿液生物监测。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104620

Zineb ben Khadda , Simona Gabriela Bungau , Souleiman El Balkhi , Said Ezrari , Andrei-Flavius Radu , Tarik Sqalli Houssaini , Sanae Achour

{"title":"Urinary biomonitoring of exposure to glyphosate and its metabolite amino-methyl phosphonic acid among farmers and non-farmers in Morocco","authors":"Zineb ben Khadda , Simona Gabriela Bungau , Souleiman El Balkhi , Said Ezrari , Andrei-Flavius Radu , Tarik Sqalli Houssaini , Sanae Achour","doi":"10.1016/j.etap.2024.104620","DOIUrl":"10.1016/j.etap.2024.104620","url":null,"abstract":"<div><div>Glyphosate, a widely used herbicide in global agriculture, poses potential health risks due to environmental and dietary exposure. This study evaluated urinary concentrations of glyphosate and its metabolite, amino-methyl phosphonic acid (AMPA), among farmers and non-farmers in Morocco's Fez-Meknes region, using liquid chromatography-tandem mass spectrometry. Glyphosate was detected in 57.14 % of farmers, 35.41 % of indirectly exposed residents, and 24 % of controls, while AMPA was present in 5.35 % of farmers only. Average glyphosate levels were 0.176 μg/L in farmers, 0.098 μg/L in indirectly exposed individuals, and 0.069 μg/L in controls, with AMPA averaging 0.253 μg/L in farmers. Sociodemographic factors, such as education level, farm residence, and herbicide storage, significantly influenced glyphosate levels, while reusing pesticide containers strongly correlated with elevated glyphosate and AMPA concentrations. Estimated daily intakes (EDIs), hazard quotients (HQs), and a hazard index (HI) were calculated to analyze the obtained data from a health risk perspective. Farmers had higher EDIGM values for AMPA (0.303 µg/d/kg) and Glyphosate (0.140 µg/d/kg) compared to the control group, which had significantly lower values of 0.110 µg/d/kg for AMPA and 0.080 µg/d/kg for Glyphosate. The HQs were calculated considering 0.5 mg/kg BW/day as an acceptable daily intake (ADI), which EFSA has established as a health-based reference value for both analytes. The values obtained were lower than 1, indicating that the health risk from Glyphosate and AMPA exposure was considered acceptable for the studied population.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104620"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic damage in elasmobranchs: A review 板鳃类的遗传损伤研究进展。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104607

Mateus Brandão Marques , Ricardo Luvizotto-Santos , Rachel Ann Hauser-Davis

{"title":"Genetic damage in elasmobranchs: A review","authors":"Mateus Brandão Marques , Ricardo Luvizotto-Santos , Rachel Ann Hauser-Davis","doi":"10.1016/j.etap.2024.104607","DOIUrl":"10.1016/j.etap.2024.104607","url":null,"abstract":"<div><div>DNA integrity is crucial for organismal health, and assessing DNA damage in aquatic organisms is essential for identifying environmental threats and informing conservation efforts. Pollutants such as metals, hydrocarbons, agrochemicals, pharmaceuticals, and climate change are linked to genetic damage, oxidative stress, and mutagenesis in several species, such as elasmobranchs (sharks and rays). Most studies focus on bivalves, crustaceans, and bony fish, with fewer assessments being carried out in cartilaginous fish. Concerning elasmobranchs, studies employing the micronucleus test and nuclear anomaly assays have aided in understanding how this group responds to contamination by organic and inorganic pollutants. Notably, each species deals differently with these contaminants, presenting varied DNA damage levels, including low levels of response, probably associated to feeding habits, trophic position, maturation stage, sex and metabolism. Further investigations should be conducted in elasmobranchs to elucidate these variations and better understand DNA damage in this important ecological group.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104607"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polycyclic aromatic hydrocarbons in human granulosa cells: first in vivo presence and positive correlation with body mass index and in vitro ovarian cell steroidogenesis regulation 人类颗粒细胞中的多环芳烃：首次在体内存在，并与体重指数和体外卵巢细胞类固醇生成调节呈正相关。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104611

Patrycja Kurowska , Lucille Berthet , Christelle Ramé , Małgorzata Węgiel , Anna Maślanka , Fabrice Guérif , Pascal Froment , Agnieszka Rak , Joelle Dupont

{"title":"Polycyclic aromatic hydrocarbons in human granulosa cells: first in vivo presence and positive correlation with body mass index and in vitro ovarian cell steroidogenesis regulation","authors":"Patrycja Kurowska , Lucille Berthet , Christelle Ramé , Małgorzata Węgiel , Anna Maślanka , Fabrice Guérif , Pascal Froment , Agnieszka Rak , Joelle Dupont","doi":"10.1016/j.etap.2024.104611","DOIUrl":"10.1016/j.etap.2024.104611","url":null,"abstract":"<div><div>Polycyclic Aromatic Hydrocarbons (PAHs) exposure leads to disorders reported in female infertility patients. Our hypothesis is that PAHs accumulate in granulosa cells (Gc) according to body mass index (BMI) and directly affects its functions. All 16 high-priority PAHs were in human FF, Gc and blood plasma with the highest concentration in Gc (GC–MS/MS). Their highest concentration was in obese Gc, except for acenaphthene and acenaphthylene, and positively correlated with BMI. In FF, we noted only positive correlation between naphthalene and BMI, whereas in blood plasma positive correlation between naphthalene, acenaphthene, pyrene and BMI. Phenanthrene and naphthalene but not fluoranthene inhibited totally steroidogenesis (ELISA), <em>CYP19A1</em> mRNA expression (real-time PCR) and increased oxidative stress index and catalase expression in Gc independently on BMI. While all studied PAHs decreased Gc proliferation (BrdU assay) and viability (Cell Count kit-8 assay). Thus, Gc PAHs concentrations are positively correlated with BMI and alter ovarian functions.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104611"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular pathway disturbances elicited by realistic dexamethasone concentrations in gills of mussel Mytilus galloprovincialis as assessed by a multi-biomarker approach 通过多生物标志物方法评估贻贝（Mytilus galloprovincialis）鳃中实际地塞米松浓度引起的细胞通路干扰。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104598

Giuseppe De Marco , Antonio Cristaldi , Maria Concetta Eliso , Gea Oliveri Conti , Mariachiara Galati , Barbara Billè , Mery Terranova , Vincenzo Parrino , Tiziana Cappello , Margherita Ferrante , Maria Maisano

{"title":"Cellular pathway disturbances elicited by realistic dexamethasone concentrations in gills of mussel Mytilus galloprovincialis as assessed by a multi-biomarker approach","authors":"Giuseppe De Marco , Antonio Cristaldi , Maria Concetta Eliso , Gea Oliveri Conti , Mariachiara Galati , Barbara Billè , Mery Terranova , Vincenzo Parrino , Tiziana Cappello , Margherita Ferrante , Maria Maisano","doi":"10.1016/j.etap.2024.104598","DOIUrl":"10.1016/j.etap.2024.104598","url":null,"abstract":"<div><div>The growing usage of glucocorticoids for a variety of diseases raises concerns since these drugs, including the anti-inflammatory dexamethasone (DEX), are frequently found in the environment. The impact of DEX was evaluated on mussels <em>Mytilus galloprovincialis</em> (Lamarck, 1819) by exposure to environmental concentrations (C1: 4 ng/L; C2: 40 ng/L; C3: 400 ng/L; C4: 2000 ng/L), and sampling at 3 (T3), 6 (T6), and 12 (T12) days. A multi-biomarker approach was applied on gills, involved in gas exchange, feed filtering, and osmoregulation. A dose- and time-dependent uptake of DEX was recorded, besides haemocyte infiltration, increased neutral and acid mucopolysaccharides, and a general pro-oxidant effect witnessed by lipid peroxidation and altered antioxidant system. Metabolomics revealed rise in protein turnover and energy demand by fluctuations in free amino acids (alanine, glycine) and energy-related metabolites (succinate, ATP/ADP). It is necessary to reduce DEX dosage from the environment by recovery strategies and effective eco-pharmacovigilance programs.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104598"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects on lethal concentration 50 % hematological parameters and plasma components of Starry flounder, Platichthys stellatus exposed to hexavalent chromium 星鲽暴露于六价铬对致死浓度 50%血液学参数和血浆成分的影响

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104610

Yun-A. Ryu , Cheol Young Choi , Ju-Chan Kang , Jun-Hwan Kim

{"title":"Effects on lethal concentration 50 % hematological parameters and plasma components of Starry flounder, Platichthys stellatus exposed to hexavalent chromium","authors":"Yun-A. Ryu , Cheol Young Choi , Ju-Chan Kang , Jun-Hwan Kim","doi":"10.1016/j.etap.2024.104610","DOIUrl":"10.1016/j.etap.2024.104610","url":null,"abstract":"<div><div>Starry flounders (<em>Platichthys stellatus</em>, mean weight 105 ± 14 g, mean total length 20.2 ± 0.7 cm) were exposed to hexavalent chromium concentrations of 0, 5, 10, 20, 40, and 80 mg Cr<sup>6 +</sup>/L for 96 hours. The half-lethal concentration (LC<sub>50</sub>) of <em>P. stellatus</em> induced by acute exposure to waterborne hexavalent chromium for 96 hours was found to be 58.84 mg Cr<sup>6+</sup>/L. In hematological parameters, red blood cell counts (RBCs), hemoglobin and hematocrit were significantly increased (<em>P</em> < 0.05). Major plasma components also changed significantly due to exposure to waterborne hexavalent chromium. Calcium in plasma inorganic components significantly increased, and glucose and cholesterol in plasma organic components also showed significant increases (<em>P</em> < 0.05). <em>P</em>lasma enzyme components such as AST, ALT and ALP were significantly increased (<em>P</em> < 0.05) at high levels of waterborne hexavalent chromium exposure. The results of this study suggest that acute exposure to waterborne hexavalent chromium in <em>P. stellatus</em> affects survival rates, hematological properties and plasma components.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104610"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Susceptibility of solitary bees to agrochemicals highlights gaps in bee risk assessment 独居蜜蜂对农用化学品的易感性突出了蜜蜂风险评估的空白。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104614

Roberto Catania , Rodrigo Cupertino Bernardes , Marta Bonforte , Lívia Maria Negrini Ferreira , Maria Augusta Pereira Lima , Dariusz Teper , Lucia Zappalà , Gaetana Mazzeo

{"title":"Susceptibility of solitary bees to agrochemicals highlights gaps in bee risk assessment","authors":"Roberto Catania , Rodrigo Cupertino Bernardes , Marta Bonforte , Lívia Maria Negrini Ferreira , Maria Augusta Pereira Lima , Dariusz Teper , Lucia Zappalà , Gaetana Mazzeo","doi":"10.1016/j.etap.2024.104614","DOIUrl":"10.1016/j.etap.2024.104614","url":null,"abstract":"<div><div>Ground-nesting solitary bees are the most abundant bee species in the xeric areas of the world, but the effects of agrochemicals on them have been little studied. Herein, we evaluated the topical toxicity of an insecticide, a herbicide, and an essential oil on Mediterranean ground-nesting bees (<em>Andrena impunctata</em>, <em>A</em>. <em>nigroolivacea</em>, <em>A</em>. <em>stabiana</em>, and <em>A</em>. <em>vetula</em>), and on the managed <em>Apis mellifera</em>, <em>Bombus terrestris</em>, and <em>Osmia bicornis</em>. We tested the lethal effects of commercial formulations of acetamiprid, glyphosate and a biopesticide based on sweet orange essential oil, and evaluated the locomotor behaviours of managed bees exposed to the same treatments. Although potential differences in pre-experimental conditions of wild bees may have influenced susceptibility, smaller bees, based on the measurements of weight, body length, and inter-tegular distance, were more susceptible to agrochemicals than the larger ones. For the majority of the tested species, acetamiprid was the most toxic compound. Treated bees also showed neuronal symptoms after acetamiprid exposure and locomotor alterations that varied among species and agrochemicals. Our results show how the susceptibility of bees varies between species in relation to their body size, highlighting the need for additional model species in current bee risk assessments.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104614"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to PCB52 (2,2′,5,5′-tetrachlorobiphenyl) blunts induction of the gene for uncoupling protein 1 (UCP1) in white adipose 接触 PCB52（2,2′,5,5′-四氯联苯）会减弱白色脂肪中解偶联蛋白 1（UCP1）基因的诱导作用

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104612

Francoise A. Gourronc , Amanda J. Bullert , Brynn Kyleakin Helm-Kwasny , Andrea Adamcakova-Dodd , Hui Wang , Xuefang Jing , Xueshu Li , Peter S. Thorne , Hans-Joachim Lehmler , James A. Ankrum , Aloysius J. Klingelhutz

{"title":"Exposure to PCB52 (2,2′,5,5′-tetrachlorobiphenyl) blunts induction of the gene for uncoupling protein 1 (UCP1) in white adipose","authors":"Francoise A. Gourronc , Amanda J. Bullert , Brynn Kyleakin Helm-Kwasny , Andrea Adamcakova-Dodd , Hui Wang , Xuefang Jing , Xueshu Li , Peter S. Thorne , Hans-Joachim Lehmler , James A. Ankrum , Aloysius J. Klingelhutz","doi":"10.1016/j.etap.2024.104612","DOIUrl":"10.1016/j.etap.2024.104612","url":null,"abstract":"<div><div>Polychlorinated biphenyls (PCBs) are linked to cancer, learning disabilities, liver and cardiovascular disease, and diabetes. Older schools often contain high levels of PCBs, and inhalation is a major source of exposure. Technical PCB mixtures, called Aroclors, and individual dioxin-like PCBs impair adipocyte function, which can lead to type II diabetes. To determine how PCB52, a non-dioxin like PCB congener found in school air, affects adipose, adolescent male and female rats were exposed to PCB52 by nose-only inhibition for 4 h per day for 28 consecutive days. Transcriptomic analysis of white adipose revealed sex-specific differences in gene expression between PCB52- and sham-exposed males and females. Exposed females showed mitochondrial gene changes, including downregulation of the thermogenic uncoupling gene, <em>Ucp1</em>. Human preadipocytes/adipocytes exposed to PCB52 or its main metabolite, 4-OH-PCB52, also showed reduced norepinephrine-induced <em>UCP1</em> expression. These findings suggest that PCB52 inhalation disrupts thermogenesis in adipose tissue, potentially contributing to metabolic syndrome.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104612"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From indoors to outdoors: Impact of waste anesthetic gases on occupationally exposed professionals and related environmental hazards – A narrative review and update 从室内到室外：麻醉废气对职业暴露专业人员的影响及相关环境危害--叙述性综述和更新。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104624

Mariane A.P. Silva , Lorena I.M. Carvalho , Maria Vitória Destro , Leandro G. Braz , Mariana G. Braz

{"title":"From indoors to outdoors: Impact of waste anesthetic gases on occupationally exposed professionals and related environmental hazards – A narrative review and update","authors":"Mariane A.P. Silva , Lorena I.M. Carvalho , Maria Vitória Destro , Leandro G. Braz , Mariana G. Braz","doi":"10.1016/j.etap.2024.104624","DOIUrl":"10.1016/j.etap.2024.104624","url":null,"abstract":"<div><div>Waste anesthetic gases (WAGs) are trace-concentration inhaled anesthetics that exist worldwide because they are released into the ambient air of operating rooms (ORs) and post-anesthesia care units. WAGs cause indoor contamination, especially in ORs lacking proper scavenging systems, and occupational exposure, while promoting climate change through greenhouse gas/ozone-depleting effects. Despite these controversial features, WAGs continue to pose occupational health hazards. Occupational exposure to WAGs has been linked to oxidative stress and cytotoxic, genotoxic and mutagenic potential. This review aims to analyze and update the literature on WAG monitoring, the impact of WAGs on occupationally exposed personnel and their effect on the environment. The awareness of exposed professionals in human and veterinary medicine is crucial. The implementation of biomonitoring practices and WAG occupational exposure limiting policies is needed. Promoting a sustainable healthcare system is also important for mitigating the impact of WAGs on global warming.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104624"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the impact of neonicotinoids on aquatic non-target species: A comprehensive review 评价新烟碱类杀虫剂对水生非目标物种的影响：综述。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104606

Ahamadul Hoque Mandal , Auroshree Sadhu , Surajit Ghosh , Nimai Chandra Saha , Camilla Mossotto , Paolo Pastorino , Shubhajit Saha , Caterina Faggio

{"title":"Evaluating the impact of neonicotinoids on aquatic non-target species: A comprehensive review","authors":"Ahamadul Hoque Mandal , Auroshree Sadhu , Surajit Ghosh , Nimai Chandra Saha , Camilla Mossotto , Paolo Pastorino , Shubhajit Saha , Caterina Faggio","doi":"10.1016/j.etap.2024.104606","DOIUrl":"10.1016/j.etap.2024.104606","url":null,"abstract":"<div><div>Neonicotinoid insecticides (NNIs) are the fastest-growing class in agricultural protection. They target nicotinic acetylcholine receptors (nAChR) in pests, stimulating the nervous system at low doses and causing paralysis and death at higher concentrations. NNIs are used in crop protection, seed treatment, forestry, agriculture, and flea control in domestic cattle. Effective at lower concentrations and offering long-term control, NNIs are favoured for their systemic activity. However, due to their water solubility, mobility, and moderate persistence, NNIs easily contaminate adjacent aquatic environments via runoff, leaching, or spray drift. While less toxic to vertebrates, their widespread use poses threats to aquatic and terrestrial organisms, causing neurotoxicity, nephrotoxicity, cytotoxicity, genotoxicity, immunotoxicity, hepatotoxicity, endocrine disruption, and reproductive malformations. This review synthesizes research to address knowledge gaps on the environmental impact of NNIs and proposes policies to mitigate their harmful effects on aquatic non-target species.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104606"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing H2O2-induced susceptibility in Galleria mellonella larvae: A robust model for exploring oxidative stress and biomarkers 利用h2o2诱导的mellonella幼虫的敏感性：一个探索氧化应激和生物标志物的强大模型。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-01-01 DOI: 10.1016/j.etap.2024.104596

L.M.M. Mattos , R.N. Silva , L.G. Santos , L. Giovanini , V.S. Cruz , N.M.B. Barreto , D. Perrone , A.L.S. Santos , M.D. Pereira

{"title":"Harnessing H2O2-induced susceptibility in Galleria mellonella larvae: A robust model for exploring oxidative stress and biomarkers","authors":"L.M.M. Mattos , R.N. Silva , L.G. Santos , L. Giovanini , V.S. Cruz , N.M.B. Barreto , D. Perrone , A.L.S. Santos , M.D. Pereira","doi":"10.1016/j.etap.2024.104596","DOIUrl":"10.1016/j.etap.2024.104596","url":null,"abstract":"<div><div>Oxidative stress plays a crucial role in various pathological conditions. This study introduces an enhanced model using hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced stress in <em>Galleria mellonella</em> larvae, offering a cost-effective and ethically sound alternative for oxidative stress research. The model bridges in vitro and in vivo studies to identify biomarkers like lipid peroxidation, protein carbonylation, hemocyte count, and antioxidant enzyme activities. Our results show that while <em>G. mellonella</em> larvae tolerated high doses of H<sub>2</sub>O<sub>2</sub>, increased susceptibility occurred with prolonged toxicosis and higher concentrations. Acute H<sub>2</sub>O<sub>2</sub> exposure (5.0 M/1st day) led to elevated lipid and protein oxidation and decreased superoxide dismutase activity and hemocyte count, while catalase activity and total antioxidant capacity increased. Despite these defenses, the larvae's antioxidant capacity was insufficient under severe oxidative stress, reducing survival. This study highlights <em>G. mellonella</em> larvae as a promising model for examining reactive oxygen species (ROS)-induced oxidative stress.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"113 ","pages":"Article 104596"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0