Environmental toxicology and pharmacology最新文献_第4页

In vitro and in vivo evaluation of propylene glycol ethers metabolism in humans 人体丙二醇醚代谢的体外和体内评价

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-18 DOI: 10.1016/j.etap.2025.104795

Hélène P. De Luca , Myriam Borgatta , Sophie Werner , Pascal Wild , Sylvain Le Gludic , Laura Suter-Dick , Nancy B. Hopf

{"title":"In vitro and in vivo evaluation of propylene glycol ethers metabolism in humans","authors":"Hélène P. De Luca , Myriam Borgatta , Sophie Werner , Pascal Wild , Sylvain Le Gludic , Laura Suter-Dick , Nancy B. Hopf","doi":"10.1016/j.etap.2025.104795","DOIUrl":"10.1016/j.etap.2025.104795","url":null,"abstract":"<div><div>Propylene glycol ethers (PGEs) consist of a major α-isomer (secondary alcohol group) and a minor β-isomer (primary alcohol group). Animal studies have reported toxic effects of the β-isomer metabolites, but human metabolism of PGEs remains poorly understood. We aimed to characterize the metabolism of two common PGEs in humans. Nine participants were exposed under controlled conditions (4 h) to propylene glycol ethyl ether (PGEE) or propylene glycol propyl ether (PGPE) (<35 ppm). Blood and urine samples were collected, and the respective β-isomers metabolites; 2-ethoxypropanoic acid (2-EPA) and 2-propoxypropanoic acid (2-PPA) were quantified. The 2-PPA blood absorption rate was 0.0005 ± 0.0002 µg/mL/h*ppm followed by rapid urinary elimination (half-life: 2 h) and slower secondary elimination (half-life: 10 h). No dose-response was observed for 2-EPA; therefore, β-PGEE metabolism was investigated <em>in vitro</em> using human liver S9 fractions. We provide 2-EPA hepatic kinetic and enzyme kinetic parameters. We recommend using of 2-PPA as a biomarker for PGPE exposures.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104795"},"PeriodicalIF":4.2,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bee species and the impact of insecticides and pollutants 蜜蜂种类以及杀虫剂和污染物的影响。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-16 DOI: 10.1016/j.etap.2025.104794

Michael D. Coleman, Sandra V. Verstraeten

引用次数: 0

Silent smoke, silent stress: Mussels as sentinels of cigarette pollution in coastal waters 无声的烟雾，无声的压力：贻贝作为沿海水域香烟污染的哨兵。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-13 DOI: 10.1016/j.etap.2025.104791

Guilherme Mendes , Marta Cunha , Amadeu M.V.M. Soares , Rosa Freitas

{"title":"Silent smoke, silent stress: Mussels as sentinels of cigarette pollution in coastal waters","authors":"Guilherme Mendes , Marta Cunha , Amadeu M.V.M. Soares , Rosa Freitas","doi":"10.1016/j.etap.2025.104791","DOIUrl":"10.1016/j.etap.2025.104791","url":null,"abstract":"<div><div>Cigarette butts are a major source of marine litter, releasing contaminants such as nicotine and its metabolite cotinine into aquatic ecosystems. This study assessed sublethal biochemical responses of <em>Mytilus galloprovincialis</em> exposed for 28 days to environmentally relevant concentrations (0.5, 5.0, 10 μg/L) of both compounds. Biomarkers in gills and digestive gland tissues were analysed, covering energy metabolism, antioxidant and detoxification enzymes, cellular damage, and neurotoxicity. Gills exhibited stronger antioxidant responses, whereas digestive gland showed enhanced metabolic and detoxification activity. Nicotine induced more consistent antioxidant capacity than cotinine, potentially explaining higher lipid peroxidation in cotinine treatments. Principal coordinates analysis revealed distinct response patterns by contaminant type and dose. Findings support the role of mussels as bioindicators of tobacco-related pollution and underline the sublethal risks of cigarette-derived contaminants to coastal ecosystems. Further research should address long-term ecological effects to guide mitigation strategies for this pervasive pollutant.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104791"},"PeriodicalIF":4.2,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gestational exposure to organophosphate pesticides and maternal urine metabolomic profile in the GENEIDA birth cohort 妊娠期暴露于有机磷农药和孕妇尿液代谢组学在GENEIDA出生队列

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-13 DOI: 10.1016/j.etap.2025.104793

Inmaculada López-Flores , Beatriz González-Alzaga , Desirée Romero-Molina , Antonio F. Hernández , Octavio Pérez-Luzardo , Andrea Acosta-Dacal , Ana Macías-Montes , Luis A. Henríquez-Hernández , Luis D. Boada , Dolors Pelegrí , Juan R. González , Marina Lacasaña

{"title":"Gestational exposure to organophosphate pesticides and maternal urine metabolomic profile in the GENEIDA birth cohort","authors":"Inmaculada López-Flores , Beatriz González-Alzaga , Desirée Romero-Molina , Antonio F. Hernández , Octavio Pérez-Luzardo , Andrea Acosta-Dacal , Ana Macías-Montes , Luis A. Henríquez-Hernández , Luis D. Boada , Dolors Pelegrí , Juan R. González , Marina Lacasaña","doi":"10.1016/j.etap.2025.104793","DOIUrl":"10.1016/j.etap.2025.104793","url":null,"abstract":"<div><div>Early developmental exposure to organophosphate (OP) pesticides has been linked to adverse health effects, though the underlying molecular pathways remain unclear. This study examined urinary metabolomic profiles of 387 pregnant women in their first and third trimesters using UPLC-MS/MS to identify metabolic disruptions associated with OPs exposure measured via dialkyl phosphate (DAPs) metabolites, including total, methyl and ethyl forms. Multiple linear regression models, adjusted for covariates and corrected for multiple comparisons revealed that first trimester OP exposure was significantly associated with 4-pyridoxic acid, a vitamin B6 metabolite. In the third trimester, OP exposure was linked to metabolites related to amino acid metabolism, synaptic function, cytochrome P450-mediated detoxification, cancer and immune pathways. These findings suggest that OP exposure may disrupt maternal metabolic processes during pregnancy, potentially affecting foetal development. This study highlights potential targets for future hypothesis-driven studies and potential interventions to mitigate OP pesticide exposure during pregnancy.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104793"},"PeriodicalIF":4.2,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic damage assessment in buccal epithelium cells of plastic greenhouse workers exposed to different pesticides: A cytogenetic biomonitoring study in Mersin, Turkiye 暴露于不同农药的塑料大棚工人口腔上皮细胞的遗传损伤评估：土耳其梅尔沁的细胞遗传学生物监测研究

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-12 DOI: 10.1016/j.etap.2025.104792

Ayla ÇELİK , Emir Han ALTUN , Zuleykha HAJIYEVA , Aysun GÖKMEN , Gizem BARUT

{"title":"Genetic damage assessment in buccal epithelium cells of plastic greenhouse workers exposed to different pesticides: A cytogenetic biomonitoring study in Mersin, Turkiye","authors":"Ayla ÇELİK , Emir Han ALTUN , Zuleykha HAJIYEVA , Aysun GÖKMEN , Gizem BARUT","doi":"10.1016/j.etap.2025.104792","DOIUrl":"10.1016/j.etap.2025.104792","url":null,"abstract":"<div><div>Pesticides are extensively used in agriculture to safeguard crops; however, this widespread use poses serious health risks, especially for plastic greenhouse workers. This study investigates the genotoxicity of pesticide exposure in 32 non-smoking female greenhouse workers aged 20–40 in Mersin, Türkiye. Using the Buccal Micronucleus Assay (BM-ASSAY), researchers assessed genetic damage, cell proliferation, and cell death. The exposed group was compared to a control group of 32 non-smoking women of the same age not exposed to genotoxic agents. Results showed significantly higher frequencies of micronuclei (MN), karyolysis (KL), binucleated cells (BN), broken egg (BE), and karyorrhexis (KR) in the exposed group (p < 0.001 and p < 0.05). The study also calculated the repair index to evaluate epithelial tissue recovery capacity. These findings highlight the importance of biomonitoring as a tool for detecting early genetic damage. The study emphasizes the urgent need for improved safety measures and ongoing health monitoring to protect greenhouse workers from long-term pesticide-related risks.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104792"},"PeriodicalIF":4.2,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro enantioselective inhibition of key human CYP450 enzymes by the chiral fungicide penconazole 手性杀菌剂戊康唑对人CYP450关键酶的体外对映选择性抑制作用。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-11 DOI: 10.1016/j.etap.2025.104790

Maike Felipe Santos Barbetta , Giovanni Stoppa Baviera , Icaro Salgado Perovani , Leandro Oka Duarte , Anderson Rodrigo Moraes de Oliveira

{"title":"In vitro enantioselective inhibition of key human CYP450 enzymes by the chiral fungicide penconazole","authors":"Maike Felipe Santos Barbetta , Giovanni Stoppa Baviera , Icaro Salgado Perovani , Leandro Oka Duarte , Anderson Rodrigo Moraes de Oliveira","doi":"10.1016/j.etap.2025.104790","DOIUrl":"10.1016/j.etap.2025.104790","url":null,"abstract":"<div><div>Penconazole (PEN) is a chiral triazole fungicide widely used in vineyards. Despite its detection in human urine and documented toxicological effect in non-targeted organisms, data on PEN’s effects in humans is scarce. This study investigated the <em>in vitro</em> inhibitory effects of racemic PEN and its isolated enantiomers on major CYP450 isoforms using human liver microsomes. PEN inhibited all tested CYP450 enzymes, with CYP1A2, CYP2C9, and CYP3A4/5 being the most sensitive (K<sub>i</sub> values: 0.73–8.1 µmol L⁻¹). Notably, the <em>R</em>-(+)-PEN enantiomer exhibited stronger inhibition of CYP1A2 and CYP2D6, indicating enantioselective interactions. <em>In vivo</em> extrapolation indicated that PEN could significantly inhibit CYP3A4/5, the primary isoform involved in metabolism of xenobiotics, and should not be overlooked. These findings provide critical insights into human toxicity of PEN and contribute to understanding its toxicological and environment impact, especially from an enantioselective perspective in drug-pesticide interactions.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104790"},"PeriodicalIF":4.2,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental and caste-specific expression patterns of ATP-binding cassette (ABC) transporters in honey bees (Apis mellifera) 蜜蜂atp结合盒（ABC）转运体的发育和种姓特异性表达模式[j]。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-10 DOI: 10.1016/j.etap.2025.104789

Angela M. Encerrado-Manriquez , Zeke T. Spooner , Tina T. Truong , Julia D. Fine , Sascha C.T. Nicklisch

{"title":"Developmental and caste-specific expression patterns of ATP-binding cassette (ABC) transporters in honey bees (Apis mellifera)","authors":"Angela M. Encerrado-Manriquez , Zeke T. Spooner , Tina T. Truong , Julia D. Fine , Sascha C.T. Nicklisch","doi":"10.1016/j.etap.2025.104789","DOIUrl":"10.1016/j.etap.2025.104789","url":null,"abstract":"<div><div>While honey bees play a vital role in global crop production, they face increasing exposure to xenobiotic chemicals during commercial pollination. Multidrug-resistance (MDR)-type ATP-binding cassette (ABC) transporters provide the first line of defense against xenobiotic chemicals. This study investigated the gene expression profiles of 12 ABC transporters involved in chemical detoxification across three honey bee castes and 13 life stages using quantitative real-time PCR. Six ABC genes showed increased expression during worker bee development and were identified as MDR-like transporters (<em>Ame</em>-ABCB1, <em>Ame</em>-ABCB6, <em>Ame</em>-ABCC4a-c, <em>Ame</em>-ABCG1). Four transporters showed pupal-specific expression during metamorphosis. Queens exhibited significantly reduced MDR transporter expression compared to workers between 1.7-fold lower (ABCB6) and 17.5-fold lower (ABCB1). Drones showed intermediate expression levels. Queen ovaries demonstrated tissue-specific upregulation of select transporters. These findings reveal a vulnerability hierarchy (foragers > drones > queens) and suggest caste-specific trade-offs between reproduction and chemical defense in honey bee superorganisms.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104789"},"PeriodicalIF":4.2,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to manganese during late intrauterine development and lactation: Long-term effects on male reproductive function. 宫内发育晚期和哺乳期暴露于锰：对男性生殖功能的长期影响。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-09 DOI: 10.1016/j.etap.2025.104784

Ana Priscila Gomes-Silva , Paloma da Cunha de Medeiros , Laís Nogueira da Silva , Marcella Da Silva Araújo Santiago , Tailisi Hoppe Trevizani , Rubens Cesar Lopes Figueira , Lucas Buruaem Moreira , Juliana Elaine Perobelli

{"title":"Exposure to manganese during late intrauterine development and lactation: Long-term effects on male reproductive function.","authors":"Ana Priscila Gomes-Silva , Paloma da Cunha de Medeiros , Laís Nogueira da Silva , Marcella Da Silva Araújo Santiago , Tailisi Hoppe Trevizani , Rubens Cesar Lopes Figueira , Lucas Buruaem Moreira , Juliana Elaine Perobelli","doi":"10.1016/j.etap.2025.104784","DOIUrl":"10.1016/j.etap.2025.104784","url":null,"abstract":"<div><div>This study evaluated the long-term effects of manganese (Mn) exposure during late intrauterine development and lactation on male reproductive function in rats. Pregnant rats received oral treatments from gestational day 13 to lactational day 15: control (saline), Mn-9 (9 mg/kg MnCl₂), and Mn-90 (90 mg/kg MnCl₂). Male offspring were assessed on postnatal days (PND) 50 and 90. Oxidative damage to germ cell DNA/RNA and increased acidophilic germ cells were observed in Mn-9 and Mn-90 on PND 50, along with seminiferous epithelium detachment and degeneration in Mn-exposed groups on PND 90. Altered spermatogenesis dynamics and reduced LH and FSH levels were also noted. Histological changes in the epididymis were evident in Mn-exposed groups on both ages. In summary, despite no apparent effects on general health or metabolic organs, Mn exposure caused oxidative damages, histological alterations, and disrupted hormone levels, ultimately impairing spermatogenesis and sperm quality in rats.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104784"},"PeriodicalIF":4.2,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of emergency contraception (ulipristal acetate) on growth, sexual differentiation, and reproduction in Oryzias latipes 紧急避孕（醋酸乌普利司）对水稻生长、性别分化和繁殖的影响。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-09 DOI: 10.1016/j.etap.2025.104786

Yuto Chihaya , Yoshifumi Horie

{"title":"Effect of emergency contraception (ulipristal acetate) on growth, sexual differentiation, and reproduction in Oryzias latipes","authors":"Yuto Chihaya , Yoshifumi Horie","doi":"10.1016/j.etap.2025.104786","DOIUrl":"10.1016/j.etap.2025.104786","url":null,"abstract":"<div><div>Pharmaceuticals used to relieve symptoms of human illnesses may not be completely removed by sewage treatment facilities, resulting in environmental runoff. Pharmaceuticals leaking into the environment can adversely affect wildlife. Ulipristal acetate (UPA), an emergency contraceptive (EC), is used both as EC and to treat uterine fibroids. This study aimed to clarify the effects of UPA on the growth, sexual differentiation, and reproduction of Japanese medaka. No statistically significant difference was observed in the hatching rate, growth, or reproduction between the control and UPA-exposed groups. In addition, investigation of the effect of UPA on sexual differentiation of Japanese medaka revealed no individuals with testis-ova or ovo-testis or individuals with sex change at concentrations of 1, 10, or 100 µg/L. This study is the first to examine the effects of UPA on growth, gonadal sex differentiation, and reproduction in fish. Our results indicate that UPA has no effect on Japanese medaka and is thus an ecosystem-friendly emergency contraceptive.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104786"},"PeriodicalIF":4.2,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual and multiple exposures to metal oxide nanomaterials: Unveiling histological and oxidative stress dynamics in Mytilus galloprovincialis 双重和多重暴露于金属氧化物纳米材料：揭示紫贻贝的组织学和氧化应激动力学。

IF 4.2 3区环境科学与生态学

Environmental toxicology and pharmacology Pub Date : 2025-08-09 DOI: 10.1016/j.etap.2025.104785

Selin Ertürk Gürkan , Mert Gürkan , Elif Kutlu , Ece Büşra Yanik , Volkan Saritunç , Berkay Güneş

{"title":"Dual and multiple exposures to metal oxide nanomaterials: Unveiling histological and oxidative stress dynamics in Mytilus galloprovincialis","authors":"Selin Ertürk Gürkan , Mert Gürkan , Elif Kutlu , Ece Büşra Yanik , Volkan Saritunç , Berkay Güneş","doi":"10.1016/j.etap.2025.104785","DOIUrl":"10.1016/j.etap.2025.104785","url":null,"abstract":"<div><div>Due to their increasing industrial applications, metal oxide nanoparticles (NPs) have emerged as significant environmental pollutants with potential ecotoxicological effects on aquatic organisms. This study evaluated the acute effects of binary and ternary mixtures of ZnFe₂O₄ (10 mg/L), SiO₂ (10 mg/L), and NiO (100 mg/L) NPs on <em>Mytilus galloprovincialis</em>. Following 96-hour exposures, oxidative stress biomarkers (SOD, CAT, GST, MDA) and histopathological alterations were assessed in gill and digestive gland tissues. Notably, the ternary mixture induced significant elevations in MDA levels. Among binary combinations, SiO₂–NiO NPs enhanced antioxidant responses, whereas NiO–ZnFe₂O₄ NPs caused pronounced tissue damage. The results underscore that NPs in the environment may not act independently but rather interact additively or synergistically, thereby amplifying their toxic potential. These findings highlight the need to consider mixture effects in ecotoxicological risk assessments, reflecting the complex and multicomponent nature of nanoparticle pollution in real-world aquatic environments.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"118 ","pages":"Article 104785"},"PeriodicalIF":4.2,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0