紧急避孕（醋酸乌普利司）对水稻生长、性别分化和繁殖的影响。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-08-09 DOI:10.1016/j.etap.2025.104786

Yuto Chihaya , Yoshifumi Horie

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引用次数: 0

摘要

用于缓解人类疾病症状的药物可能不会被污水处理设施完全去除，从而导致环境径流。药物泄漏到环境中会对野生动物产生不利影响。醋酸Ulipristal （UPA）是一种紧急避孕药（EC），既用作EC，也用于治疗子宫肌瘤。本研究旨在阐明UPA对日本medaka的生长、性别分化和繁殖的影响。在对照组和暴露于upa组之间，在孵化率、生长或繁殖方面没有观察到统计学上的显著差异。此外，研究了UPA在1、10和100 μ g/L浓度下对日本水母性别分化的影响，未发现睾丸-卵子或卵-睾丸个体或性别变化个体。本研究首次研究了UPA对鱼类生长、性腺性别分化和繁殖的影响。我们的研究结果表明，UPA对日本medaka没有影响，因此是一种生态友好的紧急避孕药。

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Effect of emergency contraception (ulipristal acetate) on growth, sexual differentiation, and reproduction in Oryzias latipes

Pharmaceuticals used to relieve symptoms of human illnesses may not be completely removed by sewage treatment facilities, resulting in environmental runoff. Pharmaceuticals leaking into the environment can adversely affect wildlife. Ulipristal acetate (UPA), an emergency contraceptive (EC), is used both as EC and to treat uterine fibroids. This study aimed to clarify the effects of UPA on the growth, sexual differentiation, and reproduction of Japanese medaka. No statistically significant difference was observed in the hatching rate, growth, or reproduction between the control and UPA-exposed groups. In addition, investigation of the effect of UPA on sexual differentiation of Japanese medaka revealed no individuals with testis-ova or ovo-testis or individuals with sex change at concentrations of 1, 10, or 100 µg/L. This study is the first to examine the effects of UPA on growth, gonadal sex differentiation, and reproduction in fish. Our results indicate that UPA has no effect on Japanese medaka and is thus an ecosystem-friendly emergency contraceptive.

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.