宫内发育晚期和哺乳期暴露于锰：对男性生殖功能的长期影响。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-08-09 DOI:10.1016/j.etap.2025.104784

Ana Priscila Gomes-Silva , Paloma da Cunha de Medeiros , Laís Nogueira da Silva , Marcella Da Silva Araújo Santiago , Tailisi Hoppe Trevizani , Rubens Cesar Lopes Figueira , Lucas Buruaem Moreira , Juliana Elaine Perobelli

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引用次数: 0

摘要

本研究评估了大鼠宫内发育晚期和哺乳期锰暴露对雄性生殖功能的长期影响。妊娠大鼠从妊娠第13天至哺乳期第15天口服：对照组（生理盐水）、Mn-9 （9mg/kg MnCl₂）和Mn-90 （90mg/kg MnCl₂）。雄性子代在出生后50和90天（PND）进行评估。Mn-9和Mn-90在PND 50上观察到生殖细胞DNA/RNA的氧化损伤和嗜酸性生殖细胞的增加，同时在PND 90上观察到mn暴露组的精原上皮脱离和变性。精子发生动力学的改变和LH和FSH水平的降低也被注意到。两个年龄段的锰暴露组的附睾组织学变化都很明显。总之，尽管对一般健康或代谢器官没有明显影响，但锰暴露会引起氧化损伤、组织学改变和激素水平紊乱，最终损害大鼠的精子发生和精子质量。

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Exposure to manganese during late intrauterine development and lactation: Long-term effects on male reproductive function.

This study evaluated the long-term effects of manganese (Mn) exposure during late intrauterine development and lactation on male reproductive function in rats. Pregnant rats received oral treatments from gestational day 13 to lactational day 15: control (saline), Mn-9 (9 mg/kg MnCl₂), and Mn-90 (90 mg/kg MnCl₂). Male offspring were assessed on postnatal days (PND) 50 and 90. Oxidative damage to germ cell DNA/RNA and increased acidophilic germ cells were observed in Mn-9 and Mn-90 on PND 50, along with seminiferous epithelium detachment and degeneration in Mn-exposed groups on PND 90. Altered spermatogenesis dynamics and reduced LH and FSH levels were also noted. Histological changes in the epididymis were evident in Mn-exposed groups on both ages. In summary, despite no apparent effects on general health or metabolic organs, Mn exposure caused oxidative damages, histological alterations, and disrupted hormone levels, ultimately impairing spermatogenesis and sperm quality in rats.

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.