Contribution of ambient airborne particles on the susceptibility to respiratory viral infections

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-08-19 DOI:10.1016/j.etap.2025.104797

Chloé Chivé , Lydie Martín-Faivre , Vincent Michoud , Armelle Baeza-Squiban , Ignacio Garcia-Verdugo

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Abstract

The respiratory tract is the primary entry point for inhaled particles from anthropogenic or biological origin such as respiratory viruses. Ambient particulate matter (PM) has adverse effects on the respiratory tract through mechanisms eliciting inflammatory responses, oxidative stress, and other pathophysiological effects. At the same time, respiratory viruses cause a range of infections. By compromising the integrity of the respiratory barrier and by modulating the host immune response, PM may facilitate viral entry and replication, thereby enhancing the pathogenicity of respiratory viruses. While epidemiological studies suggest that PM exposure may influence susceptibility to and severity of viral infection, the underlying mechanisms are not fully understood. This review aims to synthesise experimental studies that investigate how PM exposure may modulate virus infection and antiviral defence. These findings will be contextualised by an overview of the characteristics and effects of PM, the major respiratory viruses, and innate lung immunity.

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环境空气颗粒对呼吸道病毒感染易感性的贡献

呼吸道是人为或生物来源的吸入颗粒（如呼吸道病毒）的主要入口。环境颗粒物（PM）通过引发炎症反应、氧化应激和其他病理生理效应的机制对呼吸道产生不利影响。同时，呼吸道病毒引起一系列感染。通过破坏呼吸道屏障的完整性和调节宿主免疫反应，PM可能促进病毒进入和复制，从而增强呼吸道病毒的致病性。虽然流行病学研究表明，PM暴露可能影响病毒感染的易感性和严重程度，但其潜在机制尚未完全了解。这篇综述的目的是综合实验研究，调查如何PM暴露可能调节病毒感染和抗病毒防御。这些发现将通过概述PM，主要呼吸道病毒和先天性肺免疫的特征和影响来进行背景分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.